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James R. Churilla - One of the best experts on this subject based on the ideXlab platform.
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The associations between increasing degrees of Homeostatic Model Assessment for insulin resistance and muscular strengthening activities among euglycaemic US adults
Diabetes & vascular disease research, 2015Co-Authors: William R. Boyer, Tammie M. Johnson, Eugene C. Fitzhugh, Michael R. Richardson, James R. ChurillaAbstract:Purpose:To examine the associations between the Homeostatic Model Assessment for insulin resistance and self-reported muscular strengthening activity in a nationally representative sample of euglycaemic US adults.Methods:Sample included euglycaemic adults (⩾20 years of age (n = 2009)) from the 1999 to 2004 National Health and Nutrition Examination Survey. Homeostatic Model Assessment for insulin resistance was categorized into quartiles and was the primary independent variable of interest. No reported muscular strengthening activity was the dependent variable.Results:Following adjustment for covariates, those with Homeostatic Model Assessment for insulin resistance values in fourth (odds ratio: 2.04, 95% confidence interval: 1.35−3.06, p
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the associations between increasing degrees of Homeostatic Model Assessment for insulin resistance and muscular strengthening activities among euglycaemic us adults
Diabetes and Vascular Disease Research, 2015Co-Authors: William R. Boyer, Tammie M. Johnson, Eugene C. Fitzhugh, Michael R. Richardson, James R. ChurillaAbstract:Purpose:To examine the associations between the Homeostatic Model Assessment for insulin resistance and self-reported muscular strengthening activity in a nationally representative sample of euglycaemic US adults.Methods:Sample included euglycaemic adults (⩾20 years of age (n = 2009)) from the 1999 to 2004 National Health and Nutrition Examination Survey. Homeostatic Model Assessment for insulin resistance was categorized into quartiles and was the primary independent variable of interest. No reported muscular strengthening activity was the dependent variable.Results:Following adjustment for covariates, those with Homeostatic Model Assessment for insulin resistance values in fourth (odds ratio: 2.04, 95% confidence interval: 1.35−3.06, p < 0.001) quartile were found to have significantly greater odds of reporting no muscular strengthening activity. Following further adjustment for non-muscular strengthening activity specific aerobic leisure-time physical activity, results remained significant for the four...
William R. Boyer - One of the best experts on this subject based on the ideXlab platform.
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The associations between increasing degrees of Homeostatic Model Assessment for insulin resistance and muscular strengthening activities among euglycaemic US adults
Diabetes & vascular disease research, 2015Co-Authors: William R. Boyer, Tammie M. Johnson, Eugene C. Fitzhugh, Michael R. Richardson, James R. ChurillaAbstract:Purpose:To examine the associations between the Homeostatic Model Assessment for insulin resistance and self-reported muscular strengthening activity in a nationally representative sample of euglycaemic US adults.Methods:Sample included euglycaemic adults (⩾20 years of age (n = 2009)) from the 1999 to 2004 National Health and Nutrition Examination Survey. Homeostatic Model Assessment for insulin resistance was categorized into quartiles and was the primary independent variable of interest. No reported muscular strengthening activity was the dependent variable.Results:Following adjustment for covariates, those with Homeostatic Model Assessment for insulin resistance values in fourth (odds ratio: 2.04, 95% confidence interval: 1.35−3.06, p
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the associations between increasing degrees of Homeostatic Model Assessment for insulin resistance and muscular strengthening activities among euglycaemic us adults
Diabetes and Vascular Disease Research, 2015Co-Authors: William R. Boyer, Tammie M. Johnson, Eugene C. Fitzhugh, Michael R. Richardson, James R. ChurillaAbstract:Purpose:To examine the associations between the Homeostatic Model Assessment for insulin resistance and self-reported muscular strengthening activity in a nationally representative sample of euglycaemic US adults.Methods:Sample included euglycaemic adults (⩾20 years of age (n = 2009)) from the 1999 to 2004 National Health and Nutrition Examination Survey. Homeostatic Model Assessment for insulin resistance was categorized into quartiles and was the primary independent variable of interest. No reported muscular strengthening activity was the dependent variable.Results:Following adjustment for covariates, those with Homeostatic Model Assessment for insulin resistance values in fourth (odds ratio: 2.04, 95% confidence interval: 1.35−3.06, p < 0.001) quartile were found to have significantly greater odds of reporting no muscular strengthening activity. Following further adjustment for non-muscular strengthening activity specific aerobic leisure-time physical activity, results remained significant for the four...
Pier Marco Piatti - One of the best experts on this subject based on the ideXlab platform.
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Homeostatic Model Assessment for insulin resistance index trajectories in hiv infected patients treated with different first line antiretroviral regimens
Journal of Medical Virology, 2019Co-Authors: Nicola Gianotti, Camilla Muccini, Laura Galli, Andrea Poli, Vincenzo Spagnuolo, Andrea Andolina, Nadia Galizzi, Marco Ripa, Emanuela Messina, Pier Marco PiattiAbstract:OBJECTIVE To describe the trajectories of the Homeostatic Model Assessment for insulin resistance (HOMA-IR) index in a cohort of HIV-1 infected patients during their first-line antiretroviral (ART) regimen. METHODS Retrospective analysis of naive patients who started ART from 2007 at the Infectious Diseases Unit of the San Raffaele Hospital, Milan. We included patients treated with two nucleoside reverse transcriptase inhibitors (NRTIs, tenofovir, abacavir, lamivudine or emtricitabine), and one anchor drug (ritonavir-boosted protease inhibitor [PI/r], non-NRTI [NNRTI], or integrase strand transfer inhibitor [InSTI]), and with HOMA-IR assessed both before and after the start of ART. Univariate and multivariate mixed linear Models estimated HOMA-IR changes during ART. RESULTS Among 618 patients included in the study, 218 received InSTI-, 210 PI/r-, and 190 NNRTI-based regimens. Median follow-up was 27.4 (16.3-41.2) months. Adjusted mean change in HOMA-IR index was significantly higher (P = .041) in patients treated with InSTI-based regimens [0.160 (95% CI: 0.003-0.321) units per year] compared with NNRTI-based regimens [-0.005 (95% CI: -0.184-0.074) units per year]; no difference was observed between patients treated with NNRTI- and PI/r-based regimens or between INSTI-based and PI/r-based regimens. CONCLUSION InSTI-based first-line ARTs were independently associated with greater increases in HOMA-IR index.
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Homeostatic Model Assessment for insulin resistance index trajectories in HIV‐infected patients treated with different first‐line antiretroviral regimens
Journal of medical virology, 2019Co-Authors: Nicola Gianotti, Camilla Muccini, Laura Galli, Andrea Poli, Vincenzo Spagnuolo, Andrea Andolina, Nadia Galizzi, Marco Ripa, Emanuela Messina, Pier Marco PiattiAbstract:OBJECTIVE To describe the trajectories of the Homeostatic Model Assessment for insulin resistance (HOMA-IR) index in a cohort of HIV-1 infected patients during their first-line antiretroviral (ART) regimen. METHODS Retrospective analysis of naive patients who started ART from 2007 at the Infectious Diseases Unit of the San Raffaele Hospital, Milan. We included patients treated with two nucleoside reverse transcriptase inhibitors (NRTIs, tenofovir, abacavir, lamivudine or emtricitabine), and one anchor drug (ritonavir-boosted protease inhibitor [PI/r], non-NRTI [NNRTI], or integrase strand transfer inhibitor [InSTI]), and with HOMA-IR assessed both before and after the start of ART. Univariate and multivariate mixed linear Models estimated HOMA-IR changes during ART. RESULTS Among 618 patients included in the study, 218 received InSTI-, 210 PI/r-, and 190 NNRTI-based regimens. Median follow-up was 27.4 (16.3-41.2) months. Adjusted mean change in HOMA-IR index was significantly higher (P = .041) in patients treated with InSTI-based regimens [0.160 (95% CI: 0.003-0.321) units per year] compared with NNRTI-based regimens [-0.005 (95% CI: -0.184-0.074) units per year]; no difference was observed between patients treated with NNRTI- and PI/r-based regimens or between INSTI-based and PI/r-based regimens. CONCLUSION InSTI-based first-line ARTs were independently associated with greater increases in HOMA-IR index.
Toshiaki Hanafusa - One of the best experts on this subject based on the ideXlab platform.
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Decreased β-Cell Function Is Associated with Reduced Skeletal Muscle Mass in Japanese Subjects without Diabetes.
PloS one, 2016Co-Authors: Satoshi Sakai, Keiji Tanimoto, Ayumi Imbe, Yuiko Inaba, Kanako Shishikura, Yoshimi Tanimoto, Takahisa Ushiroyama, Jungo Terasaki, Toshiaki HanafusaAbstract:Background Decreased insulin secretion has a great impact on the incidence of type 2 diabetes in Japanese subjects. It is not clear whether β-cell function is related to muscle mass in subjects without diabetes. We investigated the relationship between β-cell function and skeletal muscle mass in Japanese subjects without diabetes. Methods The study included 1098 subjects (538 men and 560 women) aged 40 to 79 years, without diabetes (fasting glucose lower than 126 mg/dL and glycosylated hemoglobin lower than 6.5%), who consulted Osaka Medical College Health Science Clinic for a medical examination. Appendicular muscle mass was measured by bioelectrical impedance analysis. Appendicular muscle mass index was calculated as appendicular muscle mass divided by height squared (kg/m2). The Homeostatic Model Assessment of β-cell function was used to assess β-cell function. The Homeostatic Model Assessment of insulin resistance was used as a measure of insulin resistance. The association between appendicular muscle mass index and clinical parameters of β-cell function and insulin resistance was examined. Results Log-transformed Homeostatic Model Assessment of β-cell function and Log-transformed Homeostatic Model Assessment of insulin resistance showed a normal distribution. In both men and women, there was a significant positive correlation between appendicular muscle mass index and clinical parameters of β-cell function and insulin resistance. Tertile analysis, following stratification according to appendicular muscle mass index, found that low appendicular muscle mass index was significantly associated with the Log Homeostatic Model Assessment of β-cell function and Log-transformed Homeostatic Model Assessment of insulin resistance. Conclusion This study shows that decreased β cell function is associated with reduced skeletal muscle mass in Japanese subjects without diabetes.
Andrea Giustina - One of the best experts on this subject based on the ideXlab platform.
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Long-term effects of the combination of pegvisomant with somatostatin analogs (SSA) on glucose homeostasis in non-diabetic patients with active acromegaly partially resistant to SSA
Pituitary, 2007Co-Authors: Laura De Marinis, Antonio Bianchi, Alessandra Fusco, Vincenzo Cimino, Marilda Mormando, L. Tilaro, Gherardo Mazziotti, Alfredo Pontecorvi, Andrea GiustinaAbstract:Several recent studies have reported beneficial effects of pegvisomant monotherapy on glucose homeostasis for acromegalic patients resistant to somatostatin analogs (SSA). The aim of our longitudinal study was to test whether these beneficial effects on glucose homeostasis would also occur during combined pegvisomant + SSA treatment amongst partially SSA-resistant acromegalic patients. Ten non-diabetic, partially SSA-resistant acromegalic patients underwent a 12-month SSA+pegvisomant treatment after SSA-only therapy. Glucose homeostasis was evaluated at disease diagnosis, at the end of the SSA treatment and after 6 and 12 months of combined SSA+pegvisomant treatment. The addition of pegvisomant treatment was accompanied by a significant improvement in insulin and glycemic responses to the oral glucose tolerance test, without any significant changes in fasting plasma glucose, glycosylated haemoglobin, Homeostatic Model Assessment-derived insulin resistance index and Homeostatic Model Assessment-derived β-cell function. Moreover, the number of patients with glucose intolerance did not significantly change during the 12-month combined treatment, notwithstanding the significant decrease in serum IGF-1 values. Therefore, our findings suggest that the combined pegvisomant and SSA treatment may not be able to restore normal clinical and biochemical glycometabolic features occurring in acromegalic patients resistant to SSA, while a slight but significant improvement in some biochemical features may be expected.