The Experts below are selected from a list of 186663 Experts worldwide ranked by ideXlab platform
Immaculata De Vivo - One of the best experts on this subject based on the ideXlab platform.
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a prospective study of telomere length and the risk of skin cancer
Journal of Investigative Dermatology, 2009Co-Authors: Abrar A Qureshi, Jennifer Prescott, Li Ye, David J Hunter, Immaculata De VivoAbstract:Telomere length is important in tumorigenesis. Using quantitative real-time PCR, we prospectively measured relative telomere length in a nested case–control study within the Nurses’ Health Study: 218 melanoma cases, 285 squamous-cell carcinoma (SCC) cases, 300 basal-cell carcinoma (BCC) cases, and 870 controls. We observed that shorter telomeres were associated with a decreased number of moles (P=0.002) and a decreased risk of melanoma. Women in the second and first Quartiles, those with the shortest telomere length, had an odds ratio (OR) for melanoma of 0.54 (95% confidence interval (CI), 0.29–1.01) and 0.59 (95% CI, 0.31–1.13), respectively, compared with those in the fourth Quartile (P, trend=0.09). There was no clear trend between telomere length and SCC risk. In contrast, we found that shorter telomere length was associated with an increased risk of BCC. Compared with those in the fourth Quartile, women in the first Quartile had an OR of 1.85 (95% CI, 0.94–3.62) (P, trend=0.09). The opposing associations observed should be interpreted with caution, and further research is needed to confirm these possible associations.
Jennifer Prescott - One of the best experts on this subject based on the ideXlab platform.
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a prospective study of telomere length and the risk of skin cancer
Journal of Investigative Dermatology, 2009Co-Authors: Abrar A Qureshi, Jennifer Prescott, Li Ye, David J Hunter, Immaculata De VivoAbstract:Telomere length is important in tumorigenesis. Using quantitative real-time PCR, we prospectively measured relative telomere length in a nested case–control study within the Nurses’ Health Study: 218 melanoma cases, 285 squamous-cell carcinoma (SCC) cases, 300 basal-cell carcinoma (BCC) cases, and 870 controls. We observed that shorter telomeres were associated with a decreased number of moles (P=0.002) and a decreased risk of melanoma. Women in the second and first Quartiles, those with the shortest telomere length, had an odds ratio (OR) for melanoma of 0.54 (95% confidence interval (CI), 0.29–1.01) and 0.59 (95% CI, 0.31–1.13), respectively, compared with those in the fourth Quartile (P, trend=0.09). There was no clear trend between telomere length and SCC risk. In contrast, we found that shorter telomere length was associated with an increased risk of BCC. Compared with those in the fourth Quartile, women in the first Quartile had an OR of 1.85 (95% CI, 0.94–3.62) (P, trend=0.09). The opposing associations observed should be interpreted with caution, and further research is needed to confirm these possible associations.
David J Hunter - One of the best experts on this subject based on the ideXlab platform.
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a prospective study of telomere length and the risk of skin cancer
Journal of Investigative Dermatology, 2009Co-Authors: Abrar A Qureshi, Jennifer Prescott, Li Ye, David J Hunter, Immaculata De VivoAbstract:Telomere length is important in tumorigenesis. Using quantitative real-time PCR, we prospectively measured relative telomere length in a nested case–control study within the Nurses’ Health Study: 218 melanoma cases, 285 squamous-cell carcinoma (SCC) cases, 300 basal-cell carcinoma (BCC) cases, and 870 controls. We observed that shorter telomeres were associated with a decreased number of moles (P=0.002) and a decreased risk of melanoma. Women in the second and first Quartiles, those with the shortest telomere length, had an odds ratio (OR) for melanoma of 0.54 (95% confidence interval (CI), 0.29–1.01) and 0.59 (95% CI, 0.31–1.13), respectively, compared with those in the fourth Quartile (P, trend=0.09). There was no clear trend between telomere length and SCC risk. In contrast, we found that shorter telomere length was associated with an increased risk of BCC. Compared with those in the fourth Quartile, women in the first Quartile had an OR of 1.85 (95% CI, 0.94–3.62) (P, trend=0.09). The opposing associations observed should be interpreted with caution, and further research is needed to confirm these possible associations.
Mustafa Caliskan - One of the best experts on this subject based on the ideXlab platform.
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relationship between elevated morning blood pressure surge uric acid and cardiovascular outcomes in hypertensive patients
Journal of Clinical Hypertension, 2014Co-Authors: Osman Turak, Baris Afsar, Firat Ozcan, Ugur Canpolat, Enis Grbovic, Mehmet Ali Mendi, Fatih Oksuz, Dimitrie Siriopol, Adrian Covic, Mustafa CaliskanAbstract:Early morning blood pressure surge (MBPS) is a risk factor for cardiovascular events (CVEs), but the relationship with uric acid is not well understood. The authors aimed to determine the association between MBPS and increased uric acid and the effect of elevated MBPS and uric acid combination on CVEs. A total of 921 patients underwent 24-hour ambulatory blood pressure monitoring and were followed for a median of 40 months. During this period, 103 (11.2%) CVEs occurred. There was a significant relationship between increasing Quartiles of serum uric acid level and increasing values of MBPS (P<.0001). Patients in the highest Quartile stratified by elevated MBPS and serum uric acid level had a 3.55 odds of major CVE compared with patients in the lowest Quartile. Serum uric acid is associated with MBPS and development of new CVEs.
Sylvia Wassertheilsmoller - One of the best experts on this subject based on the ideXlab platform.
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association between annual visit to visit blood pressure variability and stroke in postmenopausal women data from the women s health initiative
Hypertension, 2012Co-Authors: Daichi Shimbo, Jonathan D Newman, Aaron K Aragaki, Michael J Lamonte, Anthony A Bavry, Matthew A Allison, Joann E Manson, Sylvia WassertheilsmollerAbstract:Accumulating evidence suggests that increased visit-to-visit variability (VVV) of blood pressure is associated with stroke. No study has examined the association between VVV of blood pressure and stroke in postmenopausal women, and scarce data exist as to whether this relation is independent of the temporal trend of blood pressure. We examined the association of VVV of blood pressure with stroke in 58228 postmenopausal women enrolled in the Women's Health Initiative. Duplicate blood pressure readings, which were averaged, were taken at baseline and at each annual visit. VVV was defined as the SD for the participant's mean systolic blood pressure (SBP) across visits (SD) and about the participant's regression line with SBP regressed across visits (SDreg). Over a median follow-up of 5.4 years, 997 strokes occurred. In an adjusted model including mean SBP over time, the hazard ratios (95% CI) of stroke for higher Quartiles of SD of SBP compared with the lowest Quartile (referent) were 1.39 (1.03-1.89) for Quartile 2, 1.52 (1.13-2.03) for Quartile 3, and 1.72 (1.28-2.32) for Quartile 4 (P trend 0.001). The relation was similar for SDreg of SBP Quartiles in a model that additionally adjusted for the temporal trend in SBP (P trend 0.001). The associations did not differ by stroke type (ischemic versus hemorrhagic). There was a significant interaction between mean SBP and SDreg on stroke with the strongest association seen below 120 mmHg. In postmenopausal women, greater VVV of SBP was associated with increased risk of stroke, particularly in the lowest range of mean SBP. (Hypertension. 2012;60: 625-630.) ● Online Data Supplement
