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Eugeny I Rogaev - One of the best experts on this subject based on the ideXlab platform.
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The evolution of Homo Sapiens denisova and Homo Sapiens neanderthalensis miRNA targeting genes in the prenatal and postnatal brain
BMC Genomics, 2015Co-Authors: Konstantin V Gunbin, Dmitry A Afonnikov, Nikolay A Kolchanov, Anatoly P Derevianko, Eugeny I RogaevAbstract:Background As the evolution of miRNA genes has been found to be one of the important factors in formation of the modern type of man, we performed a comparative analysis of the evolution of miRNA genes in two archaic hominines, Homo Sapiens neanderthalensis and Homo Sapiens denisova , and elucidated the expression of their target mRNAs in bain. Results A comparative analysis of the genomes of primates, including species in the genus Homo , identified a group of miRNA genes having fixed substitutions with important implications for the evolution of Homo Sapiens neanderthalensis and Homo Sapiens denisova . The mRNAs targeted by miRNAs with mutations specific for Homo Sapiens denisova exhibited enhanced expression during postnatal brain development in modern humans. By contrast, the expression of mRNAs targeted by miRNAs bearing variations specific for Homo Sapiens neanderthalensis was shown to be enhanced in prenatal brain development. Conclusions Our results highlight the importance of changes in miRNA gene sequences in the course of Homo Sapiens denisova and Homo Sapiens neanderthalensis evolution. The genetic alterations of miRNAs regulating the spatiotemporal expression of multiple genes in the prenatal and postnatal brain may contribute to the progressive evolution of brain function, which is consistent with the observations of fine technical and typological properties of tools and decorative items reported from archaeological Denisovan sites. The data also suggest that differential spatial-temporal regulation of gene products promoted by the subspecies-specific mutations in the miRNA genes might have occurred in the brains of Homo Sapiens denisova and Homo Sapiens neanderthalensis , potentially contributing to the cultural differences between these two archaic hominines.
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The evolution of Homo Sapiens denisova and Homo Sapiens neanderthalensis miRNA targeting genes in the prenatal and postnatal brain.
BMC genomics, 2015Co-Authors: Konstantin V Gunbin, Dmitry A Afonnikov, Nikolay A Kolchanov, Anatoly P Derevianko, Eugeny I RogaevAbstract:As the evolution of miRNA genes has been found to be one of the important factors in formation of the modern type of man, we performed a comparative analysis of the evolution of miRNA genes in two archaic hominines, Homo Sapiens neanderthalensis and Homo Sapiens denisova, and elucidated the expression of their target mRNAs in bain. A comparative analysis of the genomes of primates, including species in the genus Homo, identified a group of miRNA genes having fixed substitutions with important implications for the evolution of Homo Sapiens neanderthalensis and Homo Sapiens denisova. The mRNAs targeted by miRNAs with mutations specific for Homo Sapiens denisova exhibited enhanced expression during postnatal brain development in modern humans. By contrast, the expression of mRNAs targeted by miRNAs bearing variations specific for Homo Sapiens neanderthalensis was shown to be enhanced in prenatal brain development. Our results highlight the importance of changes in miRNA gene sequences in the course of Homo Sapiens denisova and Homo Sapiens neanderthalensis evolution. The genetic alterations of miRNAs regulating the spatiotemporal expression of multiple genes in the prenatal and postnatal brain may contribute to the progressive evolution of brain function, which is consistent with the observations of fine technical and typological properties of tools and decorative items reported from archaeological Denisovan sites. The data also suggest that differential spatial-temporal regulation of gene products promoted by the subspecies-specific mutations in the miRNA genes might have occurred in the brains of Homo Sapiens denisova and Homo Sapiens neanderthalensis, potentially contributing to the cultural differences between these two archaic hominines.
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The evolution of Homo Sapiens denisova and Homo Sapiens neanderthalensis miRNA targeting genes in the prenatal and postnatal brain.
BMC Genomics, 2015Co-Authors: Konstantin V Gunbin, Dmitry A Afonnikov, Nikolay A Kolchanov, Anatoly P Derevianko, Eugeny I RogaevAbstract:Background As the evolution of miRNA genes has been found to be one of the important factors in formation of the modern type of man, we performed a comparative analysis of the evolution of miRNA genes in two archaic hominines, Homo Sapiens neanderthalensis and Homo Sapiens denisova, and elucidated the expression of their target mRNAs in bain.
Konstantin V Gunbin - One of the best experts on this subject based on the ideXlab platform.
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The evolution of Homo Sapiens denisova and Homo Sapiens neanderthalensis miRNA targeting genes in the prenatal and postnatal brain
BMC Genomics, 2015Co-Authors: Konstantin V Gunbin, Dmitry A Afonnikov, Nikolay A Kolchanov, Anatoly P Derevianko, Eugeny I RogaevAbstract:Background As the evolution of miRNA genes has been found to be one of the important factors in formation of the modern type of man, we performed a comparative analysis of the evolution of miRNA genes in two archaic hominines, Homo Sapiens neanderthalensis and Homo Sapiens denisova , and elucidated the expression of their target mRNAs in bain. Results A comparative analysis of the genomes of primates, including species in the genus Homo , identified a group of miRNA genes having fixed substitutions with important implications for the evolution of Homo Sapiens neanderthalensis and Homo Sapiens denisova . The mRNAs targeted by miRNAs with mutations specific for Homo Sapiens denisova exhibited enhanced expression during postnatal brain development in modern humans. By contrast, the expression of mRNAs targeted by miRNAs bearing variations specific for Homo Sapiens neanderthalensis was shown to be enhanced in prenatal brain development. Conclusions Our results highlight the importance of changes in miRNA gene sequences in the course of Homo Sapiens denisova and Homo Sapiens neanderthalensis evolution. The genetic alterations of miRNAs regulating the spatiotemporal expression of multiple genes in the prenatal and postnatal brain may contribute to the progressive evolution of brain function, which is consistent with the observations of fine technical and typological properties of tools and decorative items reported from archaeological Denisovan sites. The data also suggest that differential spatial-temporal regulation of gene products promoted by the subspecies-specific mutations in the miRNA genes might have occurred in the brains of Homo Sapiens denisova and Homo Sapiens neanderthalensis , potentially contributing to the cultural differences between these two archaic hominines.
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The evolution of Homo Sapiens denisova and Homo Sapiens neanderthalensis miRNA targeting genes in the prenatal and postnatal brain.
BMC genomics, 2015Co-Authors: Konstantin V Gunbin, Dmitry A Afonnikov, Nikolay A Kolchanov, Anatoly P Derevianko, Eugeny I RogaevAbstract:As the evolution of miRNA genes has been found to be one of the important factors in formation of the modern type of man, we performed a comparative analysis of the evolution of miRNA genes in two archaic hominines, Homo Sapiens neanderthalensis and Homo Sapiens denisova, and elucidated the expression of their target mRNAs in bain. A comparative analysis of the genomes of primates, including species in the genus Homo, identified a group of miRNA genes having fixed substitutions with important implications for the evolution of Homo Sapiens neanderthalensis and Homo Sapiens denisova. The mRNAs targeted by miRNAs with mutations specific for Homo Sapiens denisova exhibited enhanced expression during postnatal brain development in modern humans. By contrast, the expression of mRNAs targeted by miRNAs bearing variations specific for Homo Sapiens neanderthalensis was shown to be enhanced in prenatal brain development. Our results highlight the importance of changes in miRNA gene sequences in the course of Homo Sapiens denisova and Homo Sapiens neanderthalensis evolution. The genetic alterations of miRNAs regulating the spatiotemporal expression of multiple genes in the prenatal and postnatal brain may contribute to the progressive evolution of brain function, which is consistent with the observations of fine technical and typological properties of tools and decorative items reported from archaeological Denisovan sites. The data also suggest that differential spatial-temporal regulation of gene products promoted by the subspecies-specific mutations in the miRNA genes might have occurred in the brains of Homo Sapiens denisova and Homo Sapiens neanderthalensis, potentially contributing to the cultural differences between these two archaic hominines.
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The evolution of Homo Sapiens denisova and Homo Sapiens neanderthalensis miRNA targeting genes in the prenatal and postnatal brain.
BMC Genomics, 2015Co-Authors: Konstantin V Gunbin, Dmitry A Afonnikov, Nikolay A Kolchanov, Anatoly P Derevianko, Eugeny I RogaevAbstract:Background As the evolution of miRNA genes has been found to be one of the important factors in formation of the modern type of man, we performed a comparative analysis of the evolution of miRNA genes in two archaic hominines, Homo Sapiens neanderthalensis and Homo Sapiens denisova, and elucidated the expression of their target mRNAs in bain.
Oshan Wedage - One of the best experts on this subject based on the ideXlab platform.
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Specialized rainforest hunting by Homo Sapiens ~45,000 years ago
Nature communications, 2019Co-Authors: Oshan Wedage, James Blinkhorn, Noel Amano, Michelle C. Langley, Katerina Douka, Alison Crowther, Siran Deraniyagala, Nikos Kourampas, Ian A. Simpson, Nimal PereraAbstract:Defining the distinctive capacities of Homo Sapiens relative to other hominins is a major focus for human evolutionary studies. It has been argued that the procurement of small, difficult-to-catch, agile prey is a hallmark of complex behavior unique to our species; however, most research in this regard has been limited to the last 20,000 years in Europe and the Levant. Here, we present detailed faunal assemblage and taphonomic data from Fa-Hien Lena Cave in Sri Lanka that demonstrates specialized, sophisticated hunting of semi-arboreal and arboreal monkey and squirrel populations from ca. 45,000 years ago, in a tropical rainforest environment. Facilitated by complex osseous and microlithic technologies, we argue these data highlight that the early capture of small, elusive mammals was part of the plastic behavior of Homo Sapiens that allowed it to rapidly colonize a series of extreme environments that were apparently untouched by its hominin relatives.
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specialized rainforest hunting by Homo Sapiens 45 000 years ago
Nature Communications, 2019Co-Authors: James Blinkhorn, Oshan Wedage, Noel Amano, Michelle C. Langley, Katerina Douka, Alison Crowther, Siran DeraniyagalaAbstract:Defining the distinctive capacities of Homo Sapiens relative to other hominins is a major focus for human evolutionary studies. It has been argued that the procurement of small, difficult-to-catch, agile prey is a hallmark of complex behavior unique to our species; however, most research in this regard has been limited to the last 20,000 years in Europe and the Levant. Here, we present detailed faunal assemblage and taphonomic data from Fa-Hien Lena Cave in Sri Lanka that demonstrates specialized, sophisticated hunting of semi-arboreal and arboreal monkey and squirrel populations from ca. 45,000 years ago, in a tropical rainforest environment. Facilitated by complex osseous and microlithic technologies, we argue these data highlight that the early capture of small, elusive mammals was part of the plastic behavior of Homo Sapiens that allowed it to rapidly colonize a series of extreme environments that were apparently untouched by its hominin relatives.
Dmitry A Afonnikov - One of the best experts on this subject based on the ideXlab platform.
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The evolution of Homo Sapiens denisova and Homo Sapiens neanderthalensis miRNA targeting genes in the prenatal and postnatal brain
BMC Genomics, 2015Co-Authors: Konstantin V Gunbin, Dmitry A Afonnikov, Nikolay A Kolchanov, Anatoly P Derevianko, Eugeny I RogaevAbstract:Background As the evolution of miRNA genes has been found to be one of the important factors in formation of the modern type of man, we performed a comparative analysis of the evolution of miRNA genes in two archaic hominines, Homo Sapiens neanderthalensis and Homo Sapiens denisova , and elucidated the expression of their target mRNAs in bain. Results A comparative analysis of the genomes of primates, including species in the genus Homo , identified a group of miRNA genes having fixed substitutions with important implications for the evolution of Homo Sapiens neanderthalensis and Homo Sapiens denisova . The mRNAs targeted by miRNAs with mutations specific for Homo Sapiens denisova exhibited enhanced expression during postnatal brain development in modern humans. By contrast, the expression of mRNAs targeted by miRNAs bearing variations specific for Homo Sapiens neanderthalensis was shown to be enhanced in prenatal brain development. Conclusions Our results highlight the importance of changes in miRNA gene sequences in the course of Homo Sapiens denisova and Homo Sapiens neanderthalensis evolution. The genetic alterations of miRNAs regulating the spatiotemporal expression of multiple genes in the prenatal and postnatal brain may contribute to the progressive evolution of brain function, which is consistent with the observations of fine technical and typological properties of tools and decorative items reported from archaeological Denisovan sites. The data also suggest that differential spatial-temporal regulation of gene products promoted by the subspecies-specific mutations in the miRNA genes might have occurred in the brains of Homo Sapiens denisova and Homo Sapiens neanderthalensis , potentially contributing to the cultural differences between these two archaic hominines.
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The evolution of Homo Sapiens denisova and Homo Sapiens neanderthalensis miRNA targeting genes in the prenatal and postnatal brain.
BMC genomics, 2015Co-Authors: Konstantin V Gunbin, Dmitry A Afonnikov, Nikolay A Kolchanov, Anatoly P Derevianko, Eugeny I RogaevAbstract:As the evolution of miRNA genes has been found to be one of the important factors in formation of the modern type of man, we performed a comparative analysis of the evolution of miRNA genes in two archaic hominines, Homo Sapiens neanderthalensis and Homo Sapiens denisova, and elucidated the expression of their target mRNAs in bain. A comparative analysis of the genomes of primates, including species in the genus Homo, identified a group of miRNA genes having fixed substitutions with important implications for the evolution of Homo Sapiens neanderthalensis and Homo Sapiens denisova. The mRNAs targeted by miRNAs with mutations specific for Homo Sapiens denisova exhibited enhanced expression during postnatal brain development in modern humans. By contrast, the expression of mRNAs targeted by miRNAs bearing variations specific for Homo Sapiens neanderthalensis was shown to be enhanced in prenatal brain development. Our results highlight the importance of changes in miRNA gene sequences in the course of Homo Sapiens denisova and Homo Sapiens neanderthalensis evolution. The genetic alterations of miRNAs regulating the spatiotemporal expression of multiple genes in the prenatal and postnatal brain may contribute to the progressive evolution of brain function, which is consistent with the observations of fine technical and typological properties of tools and decorative items reported from archaeological Denisovan sites. The data also suggest that differential spatial-temporal regulation of gene products promoted by the subspecies-specific mutations in the miRNA genes might have occurred in the brains of Homo Sapiens denisova and Homo Sapiens neanderthalensis, potentially contributing to the cultural differences between these two archaic hominines.
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The evolution of Homo Sapiens denisova and Homo Sapiens neanderthalensis miRNA targeting genes in the prenatal and postnatal brain.
BMC Genomics, 2015Co-Authors: Konstantin V Gunbin, Dmitry A Afonnikov, Nikolay A Kolchanov, Anatoly P Derevianko, Eugeny I RogaevAbstract:Background As the evolution of miRNA genes has been found to be one of the important factors in formation of the modern type of man, we performed a comparative analysis of the evolution of miRNA genes in two archaic hominines, Homo Sapiens neanderthalensis and Homo Sapiens denisova, and elucidated the expression of their target mRNAs in bain.
Nikolay A Kolchanov - One of the best experts on this subject based on the ideXlab platform.
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The evolution of Homo Sapiens denisova and Homo Sapiens neanderthalensis miRNA targeting genes in the prenatal and postnatal brain
BMC Genomics, 2015Co-Authors: Konstantin V Gunbin, Dmitry A Afonnikov, Nikolay A Kolchanov, Anatoly P Derevianko, Eugeny I RogaevAbstract:Background As the evolution of miRNA genes has been found to be one of the important factors in formation of the modern type of man, we performed a comparative analysis of the evolution of miRNA genes in two archaic hominines, Homo Sapiens neanderthalensis and Homo Sapiens denisova , and elucidated the expression of their target mRNAs in bain. Results A comparative analysis of the genomes of primates, including species in the genus Homo , identified a group of miRNA genes having fixed substitutions with important implications for the evolution of Homo Sapiens neanderthalensis and Homo Sapiens denisova . The mRNAs targeted by miRNAs with mutations specific for Homo Sapiens denisova exhibited enhanced expression during postnatal brain development in modern humans. By contrast, the expression of mRNAs targeted by miRNAs bearing variations specific for Homo Sapiens neanderthalensis was shown to be enhanced in prenatal brain development. Conclusions Our results highlight the importance of changes in miRNA gene sequences in the course of Homo Sapiens denisova and Homo Sapiens neanderthalensis evolution. The genetic alterations of miRNAs regulating the spatiotemporal expression of multiple genes in the prenatal and postnatal brain may contribute to the progressive evolution of brain function, which is consistent with the observations of fine technical and typological properties of tools and decorative items reported from archaeological Denisovan sites. The data also suggest that differential spatial-temporal regulation of gene products promoted by the subspecies-specific mutations in the miRNA genes might have occurred in the brains of Homo Sapiens denisova and Homo Sapiens neanderthalensis , potentially contributing to the cultural differences between these two archaic hominines.
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The evolution of Homo Sapiens denisova and Homo Sapiens neanderthalensis miRNA targeting genes in the prenatal and postnatal brain.
BMC genomics, 2015Co-Authors: Konstantin V Gunbin, Dmitry A Afonnikov, Nikolay A Kolchanov, Anatoly P Derevianko, Eugeny I RogaevAbstract:As the evolution of miRNA genes has been found to be one of the important factors in formation of the modern type of man, we performed a comparative analysis of the evolution of miRNA genes in two archaic hominines, Homo Sapiens neanderthalensis and Homo Sapiens denisova, and elucidated the expression of their target mRNAs in bain. A comparative analysis of the genomes of primates, including species in the genus Homo, identified a group of miRNA genes having fixed substitutions with important implications for the evolution of Homo Sapiens neanderthalensis and Homo Sapiens denisova. The mRNAs targeted by miRNAs with mutations specific for Homo Sapiens denisova exhibited enhanced expression during postnatal brain development in modern humans. By contrast, the expression of mRNAs targeted by miRNAs bearing variations specific for Homo Sapiens neanderthalensis was shown to be enhanced in prenatal brain development. Our results highlight the importance of changes in miRNA gene sequences in the course of Homo Sapiens denisova and Homo Sapiens neanderthalensis evolution. The genetic alterations of miRNAs regulating the spatiotemporal expression of multiple genes in the prenatal and postnatal brain may contribute to the progressive evolution of brain function, which is consistent with the observations of fine technical and typological properties of tools and decorative items reported from archaeological Denisovan sites. The data also suggest that differential spatial-temporal regulation of gene products promoted by the subspecies-specific mutations in the miRNA genes might have occurred in the brains of Homo Sapiens denisova and Homo Sapiens neanderthalensis, potentially contributing to the cultural differences between these two archaic hominines.
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The evolution of Homo Sapiens denisova and Homo Sapiens neanderthalensis miRNA targeting genes in the prenatal and postnatal brain.
BMC Genomics, 2015Co-Authors: Konstantin V Gunbin, Dmitry A Afonnikov, Nikolay A Kolchanov, Anatoly P Derevianko, Eugeny I RogaevAbstract:Background As the evolution of miRNA genes has been found to be one of the important factors in formation of the modern type of man, we performed a comparative analysis of the evolution of miRNA genes in two archaic hominines, Homo Sapiens neanderthalensis and Homo Sapiens denisova, and elucidated the expression of their target mRNAs in bain.
