The Experts below are selected from a list of 31890 Experts worldwide ranked by ideXlab platform
Anthony J. Sinskey - One of the best experts on this subject based on the ideXlab platform.
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antibiotic biosynthesis following Horizontal Gene Transfer new milestone for novel natural product discovery
Expert Opinion on Drug Discovery, 2010Co-Authors: Kazuhiko Kurosawa, Daniel P. Maceachran, Anthony J. SinskeyAbstract:Bacteria obtain a significant proportion of their Genetic diversity via acquisition of DNA from distantly related organisms, a phenomenon known as Horizontal Gene Transfer. The focus of Horizontal Gene Transfer investigations has been primarily on the impact of this phenomenon on the ecological and/or pathogenic characteristics of bacterial species, with very little effort devoted to investigating Horizontal Gene Transfer as a means of drug discovery. Here, we describe a novel approach to harness the power of Horizontal Gene Transfer to produce novel chemotherapeutic molecules, a process that is easily scalable. We describe the state of the art in this field and discuss the current limiting factors associated with this phenomenon. Utilising a Horizontal Gene Transfer method, we have identified and characterised a novel antimicrobial compound. Production of this antibiotic, termed rhodostreptomycin, is associated with the Transfer of DNA from a species of Streptomyces to Rhodococcus by an as yet identified...
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Antibiotic biosynthesis following Horizontal Gene Transfer: new milestone for novel natural product discovery?
Expert Opinion on Drug Discovery, 2010Co-Authors: Kazuhiko Kurosawa, Daniel P. Maceachran, Anthony J. SinskeyAbstract:Bacteria obtain a significant proportion of their Genetic diversity via acquisition of DNA from distantly related organisms, a phenomenon known as Horizontal Gene Transfer. The focus of Horizontal Gene Transfer investigations has been primarily on the impact of this phenomenon on the ecological and/or pathogenic characteristics of bacterial species, with very little effort devoted to investigating Horizontal Gene Transfer as a means of drug discovery. Here, we describe a novel approach to harness the power of Horizontal Gene Transfer to produce novel chemotherapeutic molecules, a process that is easily scalable. We describe the state of the art in this field and discuss the current limiting factors associated with this phenomenon. Utilising a Horizontal Gene Transfer method, we have identified and characterised a novel antimicrobial compound. Production of this antibiotic, termed rhodostreptomycin, is associated with the Transfer of DNA from a species of Streptomyces to Rhodococcus by an as yet identified mechanism. We believe that Horizontal Gene Transfer may represent the future of natural product discovery and engineering.
Kazuhiko Kurosawa - One of the best experts on this subject based on the ideXlab platform.
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antibiotic biosynthesis following Horizontal Gene Transfer new milestone for novel natural product discovery
Expert Opinion on Drug Discovery, 2010Co-Authors: Kazuhiko Kurosawa, Daniel P. Maceachran, Anthony J. SinskeyAbstract:Bacteria obtain a significant proportion of their Genetic diversity via acquisition of DNA from distantly related organisms, a phenomenon known as Horizontal Gene Transfer. The focus of Horizontal Gene Transfer investigations has been primarily on the impact of this phenomenon on the ecological and/or pathogenic characteristics of bacterial species, with very little effort devoted to investigating Horizontal Gene Transfer as a means of drug discovery. Here, we describe a novel approach to harness the power of Horizontal Gene Transfer to produce novel chemotherapeutic molecules, a process that is easily scalable. We describe the state of the art in this field and discuss the current limiting factors associated with this phenomenon. Utilising a Horizontal Gene Transfer method, we have identified and characterised a novel antimicrobial compound. Production of this antibiotic, termed rhodostreptomycin, is associated with the Transfer of DNA from a species of Streptomyces to Rhodococcus by an as yet identified...
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Antibiotic biosynthesis following Horizontal Gene Transfer: new milestone for novel natural product discovery?
Expert Opinion on Drug Discovery, 2010Co-Authors: Kazuhiko Kurosawa, Daniel P. Maceachran, Anthony J. SinskeyAbstract:Bacteria obtain a significant proportion of their Genetic diversity via acquisition of DNA from distantly related organisms, a phenomenon known as Horizontal Gene Transfer. The focus of Horizontal Gene Transfer investigations has been primarily on the impact of this phenomenon on the ecological and/or pathogenic characteristics of bacterial species, with very little effort devoted to investigating Horizontal Gene Transfer as a means of drug discovery. Here, we describe a novel approach to harness the power of Horizontal Gene Transfer to produce novel chemotherapeutic molecules, a process that is easily scalable. We describe the state of the art in this field and discuss the current limiting factors associated with this phenomenon. Utilising a Horizontal Gene Transfer method, we have identified and characterised a novel antimicrobial compound. Production of this antibiotic, termed rhodostreptomycin, is associated with the Transfer of DNA from a species of Streptomyces to Rhodococcus by an as yet identified mechanism. We believe that Horizontal Gene Transfer may represent the future of natural product discovery and engineering.
Rup Lal - One of the best experts on this subject based on the ideXlab platform.
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Evolution of mercuric reductase (merA) Gene: a case of Horizontal Gene Transfer.
Microbiology, 2010Co-Authors: Devi Lal, Rup LalAbstract:In the present study the role of Horizontal Gene Transfer events in providing the mercury resistance is depicted. merA Gene is key Gene in mer operon and has been used for this swtudy. PhyloGenetic analysis of aligned merA Gene sequences shows broad similarities to the established 16S rRNA Gene phylogeny. But there is no separation of bacterial merA Gene from archael merA Gene which suggests that merA Gene in both these groups share considerable sequence homology. However, inconsistencies between merA Gene and 16S rRNA Gene phyloGenetic trees are apparent for some taxa. These discrepancies in the phyloGenetic trees for merA Gene and 16S rRNA Gene have lead to the suggestion that Horizontal Gene Transfer (HGT) is a major contributor for its evolution. The close association among members of different groups in merA Gene tree, as supported by high bootstrap values, deviations in GC content and codon usage pattern indicate the possibility that Horizontal Gene Transfer events might have taken place during the evolution of this Gene.
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Evolution of mercuric reductase (merA) Gene: a case of Horizontal Gene Transfer.
Mikrobiologiia, 2010Co-Authors: Devi Lal, Rup LalAbstract:In the present study the role of Horizontal Gene Transfer events in providing the mercury resistance is depicted. merA is key Gene in mer operon and has been used for this study. PhyloGenetic analysis of aligned merA sequences shows broad similarities to the established 16S rRNA phylogeny. But there is no separation of bacterial merA from archael merA which suggests that merA Gene in both these groups share considerable sequence homology. However, inconsistencies between merA and 16S rRNA Gene phyloGenetic trees are apparent for some taxa. These discrepancies in the phyloGenetic trees for merA Gene and 16S rRNA Gene have lead to the suggestion that Horizontal Gene Transfer (HGT) is a major contributor for its evolution. The close association among members of different groups in merA Gene tree, as supported by high bootstrap values, deviations in GC content and codon usage pattern indicate the possibility that Horizontal Gene Transfer events might have taken place during the evolution of this Gene.
Daniel P. Maceachran - One of the best experts on this subject based on the ideXlab platform.
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antibiotic biosynthesis following Horizontal Gene Transfer new milestone for novel natural product discovery
Expert Opinion on Drug Discovery, 2010Co-Authors: Kazuhiko Kurosawa, Daniel P. Maceachran, Anthony J. SinskeyAbstract:Bacteria obtain a significant proportion of their Genetic diversity via acquisition of DNA from distantly related organisms, a phenomenon known as Horizontal Gene Transfer. The focus of Horizontal Gene Transfer investigations has been primarily on the impact of this phenomenon on the ecological and/or pathogenic characteristics of bacterial species, with very little effort devoted to investigating Horizontal Gene Transfer as a means of drug discovery. Here, we describe a novel approach to harness the power of Horizontal Gene Transfer to produce novel chemotherapeutic molecules, a process that is easily scalable. We describe the state of the art in this field and discuss the current limiting factors associated with this phenomenon. Utilising a Horizontal Gene Transfer method, we have identified and characterised a novel antimicrobial compound. Production of this antibiotic, termed rhodostreptomycin, is associated with the Transfer of DNA from a species of Streptomyces to Rhodococcus by an as yet identified...
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Antibiotic biosynthesis following Horizontal Gene Transfer: new milestone for novel natural product discovery?
Expert Opinion on Drug Discovery, 2010Co-Authors: Kazuhiko Kurosawa, Daniel P. Maceachran, Anthony J. SinskeyAbstract:Bacteria obtain a significant proportion of their Genetic diversity via acquisition of DNA from distantly related organisms, a phenomenon known as Horizontal Gene Transfer. The focus of Horizontal Gene Transfer investigations has been primarily on the impact of this phenomenon on the ecological and/or pathogenic characteristics of bacterial species, with very little effort devoted to investigating Horizontal Gene Transfer as a means of drug discovery. Here, we describe a novel approach to harness the power of Horizontal Gene Transfer to produce novel chemotherapeutic molecules, a process that is easily scalable. We describe the state of the art in this field and discuss the current limiting factors associated with this phenomenon. Utilising a Horizontal Gene Transfer method, we have identified and characterised a novel antimicrobial compound. Production of this antibiotic, termed rhodostreptomycin, is associated with the Transfer of DNA from a species of Streptomyces to Rhodococcus by an as yet identified mechanism. We believe that Horizontal Gene Transfer may represent the future of natural product discovery and engineering.
Devi Lal - One of the best experts on this subject based on the ideXlab platform.
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Evolution of mercuric reductase (merA) Gene: a case of Horizontal Gene Transfer.
Microbiology, 2010Co-Authors: Devi Lal, Rup LalAbstract:In the present study the role of Horizontal Gene Transfer events in providing the mercury resistance is depicted. merA Gene is key Gene in mer operon and has been used for this swtudy. PhyloGenetic analysis of aligned merA Gene sequences shows broad similarities to the established 16S rRNA Gene phylogeny. But there is no separation of bacterial merA Gene from archael merA Gene which suggests that merA Gene in both these groups share considerable sequence homology. However, inconsistencies between merA Gene and 16S rRNA Gene phyloGenetic trees are apparent for some taxa. These discrepancies in the phyloGenetic trees for merA Gene and 16S rRNA Gene have lead to the suggestion that Horizontal Gene Transfer (HGT) is a major contributor for its evolution. The close association among members of different groups in merA Gene tree, as supported by high bootstrap values, deviations in GC content and codon usage pattern indicate the possibility that Horizontal Gene Transfer events might have taken place during the evolution of this Gene.
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Evolution of mercuric reductase (merA) Gene: a case of Horizontal Gene Transfer.
Mikrobiologiia, 2010Co-Authors: Devi Lal, Rup LalAbstract:In the present study the role of Horizontal Gene Transfer events in providing the mercury resistance is depicted. merA is key Gene in mer operon and has been used for this study. PhyloGenetic analysis of aligned merA sequences shows broad similarities to the established 16S rRNA phylogeny. But there is no separation of bacterial merA from archael merA which suggests that merA Gene in both these groups share considerable sequence homology. However, inconsistencies between merA and 16S rRNA Gene phyloGenetic trees are apparent for some taxa. These discrepancies in the phyloGenetic trees for merA Gene and 16S rRNA Gene have lead to the suggestion that Horizontal Gene Transfer (HGT) is a major contributor for its evolution. The close association among members of different groups in merA Gene tree, as supported by high bootstrap values, deviations in GC content and codon usage pattern indicate the possibility that Horizontal Gene Transfer events might have taken place during the evolution of this Gene.
