The Experts below are selected from a list of 264 Experts worldwide ranked by ideXlab platform
Elena Vicini - One of the best experts on this subject based on the ideXlab platform.
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recent progress in understanding the Hormonal Regulation of phosphodiesterases
Endocrine Reviews, 1995Co-Authors: Marco Conti, Georges Nemoz, Claudio Sette, Elena ViciniAbstract:I. Introduction LAYER after layer of novel regulatory circuits have been added to the map charting the signal transduction pathways that transport information throughout the cell. New components of these pathways are found at a breathtaking pace, and new functions for old components are continuously uncovered. It is now recognized that the complexity of these pathways resembles the intricacy and integration of the pathways of intermediate metabolism. This is especially true for the cyclic nucleotide-dependent signal transduction and its components, including cyclic nucleotide phosphodiesterases (PDEs).These are the enzymes that with cyclases control the intracellular concentration of cyclic nucleotides. With the development of new molecular tools, a wealth of new information has accumulated on the structure and function of these enzymes. Four years ago we reviewed the current knowledge on the mechanisms of Hormonal Regulation of PDEs (1). Here, we update this survey, reporting the most recent developments...
Aaron J. W. Hsueh - One of the best experts on this subject based on the ideXlab platform.
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Molecular mechanisms in the Hormonal Regulation of plasminogen activator activity in ovarian granulosa cells and cumulus-oocyte complexes.
Progress in Clinical and Biological Research, 2012Co-Authors: Aaron J. W. Hsueh, Stefan B. Cajander, Tor NyAbstract:Molecular mechanisms in the Hormonal Regulation of plasminogen activator activity in ovarian granulosa cells and cumulus-oocyte complexes.
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Hormonal Regulation of apoptosis in early antral follicles follicle stimulating hormone as a major survival factor
Endocrinology, 1996Co-Authors: Sangyoung Chun, Karen M Eisenhauer, Sawako Minami, Hakan Billig, Emerald Perlas, Aaron J. W. HsuehAbstract:Hormonal Regulation of apoptosis has been studied in cultured preovulatory follicles. Because early antral follicles are most vulnerable to undergo atretic degeneration under physiological conditions in vivo, the present studies were designed to investigate the Hormonal Regulation of apoptosis using in vitro culture of early antral follicles. Rats were implanted with diethylstilbestrol at 24 days of age to stimulate the development of early antral follicles, and ovaries were collected at day 27 of age. Early antral follicles were dissected and cultured (four per vial) for 24 h with or without Hormonal treatments. After culture, DNA was extracted from follicles, and the degree of apoptotic DNA fragmentation was determined using 3'-end labeling and gel electrophoresis. In situ analysis of apoptotic DNA fragmentation revealed that granulosa cells in these follicles are the main cell type undergoing apoptosis. Follicles cultured in the absence of hormones showed a 12-fold increase in the level of apoptotic DN...
Robert E Braun - One of the best experts on this subject based on the ideXlab platform.
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Hormonal Regulation of spermatogenesis
International Journal of Andrology, 2004Co-Authors: Robert W Holdcraft, Robert E BraunAbstract:Summary Proper functioning of the mammalian testis is dependent upon an array of Hormonal messengers acting through endocrine, paracrine, and autocrine pathways. Within the testis, the primary messengers are the gonadotrophins, follicle stimulating hormone and luteinizing hormone, and the androgens. Abundant evidence indicates that the role of the gonadotrophins is to maintain proper functioning of testicular somatic cells. It is the androgens, primarily testosterone, which act through the somatic cells to regulate germ cell differentiation. Despite extensive research in this area, little is known about the cellspecific requirements for androgens and even less is understood about the downstream effectors of androgen signalling. However, recent work using cell-specific ablation of androgen receptor function has demonstrated a clear requirement for androgen signalling at multiple, discrete time points during spermatogenesis. These models also provide useful tools for identifying the targets of androgen receptor activity. The purpose of this review is to provide a brief overview of recent advances in our understanding of Hormonal Regulation of spermatogenesis, with an emphasis on the role of testosterone within the testis, and to pose important questions for future research in this field.
Marco Conti - One of the best experts on this subject based on the ideXlab platform.
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recent progress in understanding the Hormonal Regulation of phosphodiesterases
Endocrine Reviews, 1995Co-Authors: Marco Conti, Georges Nemoz, Claudio Sette, Elena ViciniAbstract:I. Introduction LAYER after layer of novel regulatory circuits have been added to the map charting the signal transduction pathways that transport information throughout the cell. New components of these pathways are found at a breathtaking pace, and new functions for old components are continuously uncovered. It is now recognized that the complexity of these pathways resembles the intricacy and integration of the pathways of intermediate metabolism. This is especially true for the cyclic nucleotide-dependent signal transduction and its components, including cyclic nucleotide phosphodiesterases (PDEs).These are the enzymes that with cyclases control the intracellular concentration of cyclic nucleotides. With the development of new molecular tools, a wealth of new information has accumulated on the structure and function of these enzymes. Four years ago we reviewed the current knowledge on the mechanisms of Hormonal Regulation of PDEs (1). Here, we update this survey, reporting the most recent developments...
Robert W Holdcraft - One of the best experts on this subject based on the ideXlab platform.
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Hormonal Regulation of spermatogenesis
International Journal of Andrology, 2004Co-Authors: Robert W Holdcraft, Robert E BraunAbstract:Summary Proper functioning of the mammalian testis is dependent upon an array of Hormonal messengers acting through endocrine, paracrine, and autocrine pathways. Within the testis, the primary messengers are the gonadotrophins, follicle stimulating hormone and luteinizing hormone, and the androgens. Abundant evidence indicates that the role of the gonadotrophins is to maintain proper functioning of testicular somatic cells. It is the androgens, primarily testosterone, which act through the somatic cells to regulate germ cell differentiation. Despite extensive research in this area, little is known about the cellspecific requirements for androgens and even less is understood about the downstream effectors of androgen signalling. However, recent work using cell-specific ablation of androgen receptor function has demonstrated a clear requirement for androgen signalling at multiple, discrete time points during spermatogenesis. These models also provide useful tools for identifying the targets of androgen receptor activity. The purpose of this review is to provide a brief overview of recent advances in our understanding of Hormonal Regulation of spermatogenesis, with an emphasis on the role of testosterone within the testis, and to pose important questions for future research in this field.