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Jaafar M. Alghazo - One of the best experts on this subject based on the ideXlab platform.

  • optimized fpga implementation of the thyroid Hormone Secretion mechanism using cad tools
    Journal of Medical Systems, 2017
    Co-Authors: Jaafar M. Alghazo
    Abstract:

    The goal of this paper is to implement the Secretion mechanism of the Thyroid Hormone (TH) based on bio-mathematical differential eqs. (DE) on an FPGA chip. Hardware Descriptive Language (HDL) is used to develop a behavioral model of the mechanism derived from the DE. The Thyroid Hormone Secretion mechanism is simulated with the interaction of the related stimulating and inhibiting Hormones. Synthesis of the simulation is done with the aid of CAD tools and downloaded on a Field Programmable Gate Arrays (FPGAs) Chip. The chip output shows identical behavior to that of the designed algorithm through simulation. It is concluded that the chip mimics the Thyroid Hormone Secretion mechanism. The chip, operating in real-time, is computer-independent stand-alone system.

  • Optimized FPGA Implementation of the Thyroid Hormone Secretion Mechanism Using CAD Tools
    Journal of Medical Systems, 2017
    Co-Authors: Jaafar M. Alghazo
    Abstract:

    The goal of this paper is to implement the Secretion mechanism of the Thyroid Hormone (TH) based on bio-mathematical differential eqs. (DE) on an FPGA chip. Hardware Descriptive Language (HDL) is used to develop a behavioral model of the mechanism derived from the DE. The Thyroid Hormone Secretion mechanism is simulated with the interaction of the related stimulating and inhibiting Hormones. Synthesis of the simulation is done with the aid of CAD tools and downloaded on a Field Programmable Gate Arrays (FPGAs) Chip. The chip output shows identical behavior to that of the designed algorithm through simulation. It is concluded that the chip mimics the Thyroid Hormone Secretion mechanism. The chip, operating in real-time, is computer-independent stand-alone system.

Jean Louis Vincent - One of the best experts on this subject based on the ideXlab platform.

Scott A. Rivkees - One of the best experts on this subject based on the ideXlab platform.

C Štrbák - One of the best experts on this subject based on the ideXlab platform.

  • Hypo-osmolarity stimulates and high sodium concentration inhibits thyrotropin-releasing Hormone Secretion from rat hypothalamus.
    Neuroscience, 1999
    Co-Authors: Maria Nikodemova, M.a Greer, C Štrbák
    Abstract:

    Abstract The hypothalamic paraventricular nucleus, representing cell bodies in which thyrotropin-releasing Hormone is synthesized, and the median eminence, representing nerve terminals, were incubated in vitro . Various hypo- and hyperosmotic solutions were tested to determine osmotic sensitivity of thyrotropin-releasing Hormone Secretion. High KCl (56 mM) causing membrane depolarization was used as a non-specific control stimulus to induce thyrotropin-releasing Hormone Secretion. A 30% decrease of medium osmolarity (from 288 to 202 mOsmol/l) increased thyrotropin-releasing Hormone Secretion from both the paraventricular nucleus and median eminence. A 30% decrease of medium NaCl content by its replacement with choline chloride did not affect basal thyrotropin-releasing Hormone Secretion. Increasing medium osmolarity with biologically inactive l -glucose did not affect basal or KCl-induced thyrotropin-releasing Hormone Secretion from either structure. Medium made hyperosmotic (350–450 mOsmol/l) by increasing the NaCl concentration resulted in a dose-dependent decrease of basal thyrotropin-releasing Hormone Secretion and abolished KCl-induced thyrotropin-releasing Hormone Secretion. If an osmotically equivalent amount of choline chloride was substituted for NaCl, there was no effect on thyrotropin-releasing Hormone Secretion, indicating a specific action of Na + . This study indicates a specific sensitivity to high concentrations of Na + ions of both thyrotropin-releasing Hormone-producing parvocellular paraventricular neurons and of thyrotropin-releasing Hormone-containing nerve terminals in the median eminence.

Serge Brimioulle - One of the best experts on this subject based on the ideXlab platform.