The Experts below are selected from a list of 2310 Experts worldwide ranked by ideXlab platform
Kaori Ando - One of the best experts on this subject based on the ideXlab platform.
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highly z selective synthesis of α β unsaturated nitriles using the horner wadsworth emmons Reaction
ChemInform, 2013Co-Authors: Kaori Ando, Miho Okumura, Shigeo NagayaAbstract:The novel reagent (I) renders possible the conversion of aldehydes into the desired α,β-unsaturated nitriles.
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highly z selective synthesis of α β unsaturated nitriles using the horner wadsworth emmons Reaction
Tetrahedron Letters, 2013Co-Authors: Kaori Ando, Miho Okumura, Shigeo NagayaAbstract:Abstract A new HWE reagent, ( o - t BuC 6 H 4 O) 2 P(O)CH 2 CN ( 2e ), reacts with various types of aldehydes to give Z -α,β-unsaturated nitriles with 86% to >99% Z -selectivity. Especially, the Reaction of 2e with bulkier aldehydes, both aromatic and aliphatic, gave the Z -olefins with extremely high selectivity. The combination of t -BuOK and 18-crown-6 (1 equiv) is the base of choice for aromatic aldehydes and t -BuOK is generally the base of choice for aliphatic aldehydes.
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highly e selective solvent free horner wadsworth emmons Reaction catalyzed by dbu
ChemInform, 2011Co-Authors: Kaori Ando, Kyohei YamadaAbstract:A simple, safe and environmentally friendly method for the title synthesis of the compounds (III) and (V) without the use of any expensive catalysts or bases is presented.
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highly e selective solvent free horner wadsworth emmons Reaction catalyzed by dbu
Green Chemistry, 2011Co-Authors: Kaori Ando, Kyohei YamadaAbstract:The solvent-free Horner–Wadsworth–Emmons Reaction of triethyl phosphonoacetate with a variety of aldehydes was catalyzed by DBU in the presence of K2CO3 to give E-α,β-unsaturated esters highly selectively (99 : 1 for most of the Reactions). The Reaction with ketones gave trisubstituted olefins with good to high E-selectivity by DBU-Cs2CO3.
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z selective intramolecular horner wadsworth emmons Reaction for the synthesis of macrocyclic alkenes
Tetrahedron Letters, 2011Co-Authors: Kaori Ando, Kaori SatoAbstract:Abstract The Z -selective intramolecular Horner–Wadsworth–Emmons Reaction of the substrates 7 – 12 (RO) 2 P(O)CHR′CO 2 Et (R′ = (CH 2 ) n CHO) (R = Ph or o - t BuC 6 H 4 ) gives the 13–18-membered cyclic alkenes selectively (up to Z : E = 97:3) in good yields using NaH in THF under high dilution conditions.
Yoshimitsu Nagao - One of the best experts on this subject based on the ideXlab platform.
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reinvestigation of the synthesis of isoliquiritigenin application of horner wadsworth emmons Reaction and claisen schmidt condensation
ChemInform, 2012Co-Authors: Shigeki Sano, Yoshinori Okubo, Atsushi Handa, Michiyasu Nakao, Syuji Kitaike, Yoshimitsu Nagao, Hisao KakegawaAbstract:The convenient synthesis of the title compound (IV) is realized via the Claisen—Schmidt condensation of the compounds (I) and (II) or via the Horner—Wadsworth—Emmons (HWE) Reaction with the compounds (V) and (VI).
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reinvestigation of the synthesis of isoliquiritigenin application of horner wadsworth emmons Reaction and claisen schmidt condensation
Chemical & Pharmaceutical Bulletin, 2011Co-Authors: Shigeki Sano, Yoshinori Okubo, Atsushi Handa, Michiyasu Nakao, Syuji Kitaike, Yoshimitsu Nagao, Hisao KakegawaAbstract:Isoliquiritigenin [ILG, (E)-1] was readily prepared via the Horner-Wadsworth-Emmons Reactions using β-ketophosphonates 5a, b. An improved protocol for the synthesis of (E)-1 via the Claisen-Schmidt condensation was also presented.
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e selective horner wadsworth emmons Reaction of aryl alkyl ketones with bis 2 2 2 trifluoroethyl phosphonoacetic acid
Tetrahedron Letters, 2003Co-Authors: Shigeki Sano, Yuka Takemoto, Yoshimitsu NagaoAbstract:Abstract The stereoselective Horner–Wadsworth–Emmons Reaction of aryl alkyl ketones with bis(2,2,2-trifluoroethyl)phosphonoacetic acid utilizing lithium hexamethyldisilazide in DMF afforded ( E )-α,β-unsaturated carboxylic acids as the major products.
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e selective horner wadsworth emmons Reaction of aldehydes with bis 2 2 2 trifluoroethyl phosphonoacetic acid
Arkivoc, 2003Co-Authors: Shigeki Sano, Yuka Takemoto, Yoshimitsu NagaoAbstract:The stereoselective Horner–Wadsworth–Emmons Reaction of aldehydes with bis-(2,2,2trifluoroethyl)phosphonoacetic acid utilizing i-PrMgBr afforded (E)-α,β-unsaturated carboxylic acids as the major products. bis-(2,2,2-Trifluoroethyl)phosphonoacetic acid was prepared by enzymatic hydrolysis of the corresponding methyl ester with porcine liver esterase.
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toward z selective horner wadsworth emmons Reaction of aldehydes with 2 fluoro 2 diethylphosphonoacetic acid
Tetrahedron Letters, 2002Co-Authors: Shigeki Sano, Rie Teranishi, Yoshimitsu NagaoAbstract:Abstract The stereoselective Horner–Wadsworth–Emmons Reaction of aldehydes with 2-fluoro-2-diethylphosphonoacetic acid utilizing i -PrMgBr afforded ( Z )-α-fluoro-α,β-unsaturated carboxylic acids as the major products.
Shigeki Sano - One of the best experts on this subject based on the ideXlab platform.
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synthesis of allenyl esters by horner wadsworth emmons Reactions of ketenes mediated by isopropylmagnesium bromide
ChemInform, 2016Co-Authors: Shigeki Sano, Tomoya Matsumoto, Teppei Yano, Munehisa Toguchi, M NakaoAbstract:The synthesis of conjugated allenyl esters (tri-substituted allenes) was achieved by magnesium(II)-mediated Horner–Wadsworth–Emmons Reaction of methyl bis(2,2,2-trifluoroethyl)phosphonoacetate with disubstituted ketenes. In addition, a novel access to α-fluorinated allenyl carboxamides (tetrasubstituted allenes) is presented.
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a novel synthetic approach to glycerophospholipids via horner wadsworth emmons Reaction of mixed phosphonoacetate
Tetrahedron Letters, 2015Co-Authors: Shigeki Sano, Atsushi Handa, Hayato Sumiyoshi, Rie Tokizane, Michiyasu NakaoAbstract:A novel synthetic approach to glycerophospholipids featuring the use of Horner–Wadsworth–Emmons reagents as masked glycerophospholipids has been developed. Based on this method, phosphatidic acid (PA), phosphatidylethanolamine (PE), and phosphatidylcholine (PC) containing palmitoyl moieties were readily synthesized from a mixed phosphonoacetate as a common key intermediate.
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reinvestigation of the synthesis of isoliquiritigenin application of horner wadsworth emmons Reaction and claisen schmidt condensation
ChemInform, 2012Co-Authors: Shigeki Sano, Yoshinori Okubo, Atsushi Handa, Michiyasu Nakao, Syuji Kitaike, Yoshimitsu Nagao, Hisao KakegawaAbstract:The convenient synthesis of the title compound (IV) is realized via the Claisen—Schmidt condensation of the compounds (I) and (II) or via the Horner—Wadsworth—Emmons (HWE) Reaction with the compounds (V) and (VI).
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reinvestigation of the synthesis of isoliquiritigenin application of horner wadsworth emmons Reaction and claisen schmidt condensation
Chemical & Pharmaceutical Bulletin, 2011Co-Authors: Shigeki Sano, Yoshinori Okubo, Atsushi Handa, Michiyasu Nakao, Syuji Kitaike, Yoshimitsu Nagao, Hisao KakegawaAbstract:Isoliquiritigenin [ILG, (E)-1] was readily prepared via the Horner-Wadsworth-Emmons Reactions using β-ketophosphonates 5a, b. An improved protocol for the synthesis of (E)-1 via the Claisen-Schmidt condensation was also presented.
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e selective horner wadsworth emmons Reaction of aryl alkyl ketones with bis 2 2 2 trifluoroethyl phosphonoacetic acid
Tetrahedron Letters, 2003Co-Authors: Shigeki Sano, Yuka Takemoto, Yoshimitsu NagaoAbstract:Abstract The stereoselective Horner–Wadsworth–Emmons Reaction of aryl alkyl ketones with bis(2,2,2-trifluoroethyl)phosphonoacetic acid utilizing lithium hexamethyldisilazide in DMF afforded ( E )-α,β-unsaturated carboxylic acids as the major products.
Kyohei Yamada - One of the best experts on this subject based on the ideXlab platform.
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highly e selective solvent free horner wadsworth emmons Reaction catalyzed by dbu
ChemInform, 2011Co-Authors: Kaori Ando, Kyohei YamadaAbstract:A simple, safe and environmentally friendly method for the title synthesis of the compounds (III) and (V) without the use of any expensive catalysts or bases is presented.
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highly e selective solvent free horner wadsworth emmons Reaction catalyzed by dbu
Green Chemistry, 2011Co-Authors: Kaori Ando, Kyohei YamadaAbstract:The solvent-free Horner–Wadsworth–Emmons Reaction of triethyl phosphonoacetate with a variety of aldehydes was catalyzed by DBU in the presence of K2CO3 to give E-α,β-unsaturated esters highly selectively (99 : 1 for most of the Reactions). The Reaction with ketones gave trisubstituted olefins with good to high E-selectivity by DBU-Cs2CO3.
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solvent free horner wadsworth emmons Reaction using dbu
ChemInform, 2010Co-Authors: Kaori Ando, Kyohei YamadaAbstract:The Reaction of phosphonates with aldehydes provides α,β-unsaturated esters and ketones with excellent (E)-selectivity (<95:5) in the case of (III) and (X).
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solvent free horner wadsworth emmons Reaction using dbu
Tetrahedron Letters, 2010Co-Authors: Kaori Ando, Kyohei YamadaAbstract:Abstract The solvent-free Horner–Wadsworth–Emmons Reaction with a variety of aldehydes using 1.5 equiv of DBU gave E -α,β-unsaturated esters and ketones in high yields. The E -selectivity was high and the used DBU was recovered.
Santanu Mukherjee - One of the best experts on this subject based on the ideXlab platform.
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a catalytic michael horner wadsworth emmons cascade Reaction for enantioselective synthesis of thiochromenes
ChemInform, 2013Co-Authors: Abhijnan Ray Choudhury, Santanu MukherjeeAbstract:An enantioselective sulfa-Michael/Horner—Wadsworth—Emmons Reaction cascade is developed using a bifunctional urea catalyst.
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a catalytic michael horner wadsworth emmons cascade Reaction for enantioselective synthesis of thiochromenes
Advanced Synthesis & Catalysis, 2013Co-Authors: Abhijnan Ray Choudhury, Santanu MukherjeeAbstract:A catalytic enantioselective sulfa-Michael/Horner-Wadsworth-Emmons Reaction cascade has been developed, taking advantage of phosphonate as an electrophilic activator and a traceless binding site. Using a chiral bifunctional urea derivative as the catalyst, a variety of aryl and heteroaryl substituted thiochromenes was obtained in excellent yield with a high level of enantioselectivity.