The Experts below are selected from a list of 121266 Experts worldwide ranked by ideXlab platform
N Chauhan - One of the best experts on this subject based on the ideXlab platform.
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reliability of point of care prothrombin time testing in a community clinic a randomized crossover comparison with Hospital Laboratory testing
British Journal of Haematology, 2002Co-Authors: C Shiach, Bonnie Campbell, L Poller, M Keown, N ChauhanAbstract:The success in achieving therapeutic international normalized ratio (INR) targets in the control of warfarin using a whole-blood point-of-care testing (POCT) monitor (CoaguChek) in a community clinic was compared with Hospital Laboratory coagulometer prothrombin time (PT) testing in a randomized crossover study. Forty-six patients were randomized into two groups. At each visit, capillary blood was taken for the POCT monitor and venous blood for the Laboratory coagulometer. In Group 1, for 6 months, dosage was based on the CoaguChek and for the second 6 months on the coagulometer. In the second group, the order was reversed. Dosages were determined using the dawn ac computer programme. Success was assessed by the percentage of time patients were maintained within the INR targets. Agreement between Laboratory and monitor INR, and patient satisfaction were also assessed. Results with the POCT monitor compared well with the Hospital coagulometer. Time in INR target range between the groups was similar, with 60.9% on the POCT monitor and 59.3% with the Laboratory coagulometer in Group 1 and in Group 2, respectively, 64.3% and 63.4% with no significant difference in mean INR. An INR above 4.0 gave some discrepant results. International Sensitivity Index calibrations of the two test systems indicated that the INRs were dependable. Patient questionnaires showed greater satisfaction with community POCT monitoring.
Frank Martens - One of the best experts on this subject based on the ideXlab platform.
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establishing age sex related serum creatinine reference intervals from Hospital Laboratory data based on different statistical methods
Clinica Chimica Acta, 2008Co-Authors: Hans Pottel, Nicolas Vrydags, Boris Mahieu, Emmanuel Vandewynckele, Kathleen Croes, Frank MartensAbstract:Abstract Background This is a retrospective study on a large Hospital database to establish age- and sex-related mean values and reference ranges for serum creatinine (Scr), obtained with an IDMS-traceable, enzymatic method, in a Caucasian population. Methods The database was filtered for unique entries to reduce the presence of correlated and pathological data. Three different statistical methods, a non-parametric method, the Bhattacharya procedure and a non-linear fit of the cumulative Gaussian distribution were used to estimate the serum creatinine–age dependency for men and women, from birth till 100 years of age. Results Scr increases with age, equal for boys and girls, up to 14 years and with a much steeper slope for boys than for girls between 14 and 20 years. We show that the Scr–age pattern is constant between 20 and 70 years with a mean of 0.90 mg/dL [0.63–1.16 mg/dL] for men and 0.70 mg/dL [0.48–0.93 mg/dL] for women. Above 70, Scr starts to slowly increase again. Conclusions Indirect methods confirm the available reference intervals from healthy-volunteer studies and add information on age-periods not covered by these studies. As such, indirect methods can be used complementary to healthy-volunteer studies.
Steen Sørensen - One of the best experts on this subject based on the ideXlab platform.
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Mining of Hospital Laboratory information systems: a model study defining age- and gender-specific reference intervals and trajectories for plasma creatinine in a pediatric population.
Clinical chemistry and laboratory medicine, 2015Co-Authors: Karen Søeby, Peter Bjødstrup Jensen, Thomas Werge, Steen SørensenAbstract:BACKGROUND The knowledge of physiological fluctuation and variation of even commonly used biochemical quantities in extreme age groups and during development is sparse. This challenges the clinical interpretation and utility of Laboratory tests in these age groups. To explore the utility of Hospital Laboratory data as a source of information, we analyzed enzymatic plasma creatinine as a model analyte in two large pediatric Hospital samples. METHODS Plasma creatinine measurements from 9700 children aged 0-18 years were obtained from Hospital Laboratory databases and partitioned into high-resolution gender- and age-groups. Normal probability plots were used to deduce parameters of the normal distributions from healthy creatinine values in the mixed Hospital datasets. Furthermore, temporal trajectories were generated from repeated measurements to examine developmental patterns in periods of changing creatinine levels. RESULTS Creatinine shows great age dependence from birth throughout childhood. We computed and replicated 95% reference intervals in narrow gender and age bins and showed them to be comparable to those determined in healthy population studies. We identified pronounced transitions in creatinine levels at different time points after birth and around the early teens, which challenges the establishment and usefulness of reference intervals in those age groups. CONCLUSIONS The study documents that Hospital Laboratory data may inform on the developmental aspects of creatinine, on periods with pronounced heterogeneity and valid reference intervals. Furthermore, part of the heterogeneity in creatinine distribution is likely due to differences in biological and chronological age of children and should be considered when using age-specific reference intervals.
C Shiach - One of the best experts on this subject based on the ideXlab platform.
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reliability of point of care prothrombin time testing in a community clinic a randomized crossover comparison with Hospital Laboratory testing
British Journal of Haematology, 2002Co-Authors: C Shiach, Bonnie Campbell, L Poller, M Keown, N ChauhanAbstract:The success in achieving therapeutic international normalized ratio (INR) targets in the control of warfarin using a whole-blood point-of-care testing (POCT) monitor (CoaguChek) in a community clinic was compared with Hospital Laboratory coagulometer prothrombin time (PT) testing in a randomized crossover study. Forty-six patients were randomized into two groups. At each visit, capillary blood was taken for the POCT monitor and venous blood for the Laboratory coagulometer. In Group 1, for 6 months, dosage was based on the CoaguChek and for the second 6 months on the coagulometer. In the second group, the order was reversed. Dosages were determined using the dawn ac computer programme. Success was assessed by the percentage of time patients were maintained within the INR targets. Agreement between Laboratory and monitor INR, and patient satisfaction were also assessed. Results with the POCT monitor compared well with the Hospital coagulometer. Time in INR target range between the groups was similar, with 60.9% on the POCT monitor and 59.3% with the Laboratory coagulometer in Group 1 and in Group 2, respectively, 64.3% and 63.4% with no significant difference in mean INR. An INR above 4.0 gave some discrepant results. International Sensitivity Index calibrations of the two test systems indicated that the INRs were dependable. Patient questionnaires showed greater satisfaction with community POCT monitoring.
Hans Pottel - One of the best experts on this subject based on the ideXlab platform.
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establishing age sex related serum creatinine reference intervals from Hospital Laboratory data based on different statistical methods
Clinica Chimica Acta, 2008Co-Authors: Hans Pottel, Nicolas Vrydags, Boris Mahieu, Emmanuel Vandewynckele, Kathleen Croes, Frank MartensAbstract:Abstract Background This is a retrospective study on a large Hospital database to establish age- and sex-related mean values and reference ranges for serum creatinine (Scr), obtained with an IDMS-traceable, enzymatic method, in a Caucasian population. Methods The database was filtered for unique entries to reduce the presence of correlated and pathological data. Three different statistical methods, a non-parametric method, the Bhattacharya procedure and a non-linear fit of the cumulative Gaussian distribution were used to estimate the serum creatinine–age dependency for men and women, from birth till 100 years of age. Results Scr increases with age, equal for boys and girls, up to 14 years and with a much steeper slope for boys than for girls between 14 and 20 years. We show that the Scr–age pattern is constant between 20 and 70 years with a mean of 0.90 mg/dL [0.63–1.16 mg/dL] for men and 0.70 mg/dL [0.48–0.93 mg/dL] for women. Above 70, Scr starts to slowly increase again. Conclusions Indirect methods confirm the available reference intervals from healthy-volunteer studies and add information on age-periods not covered by these studies. As such, indirect methods can be used complementary to healthy-volunteer studies.