The Experts below are selected from a list of 8667 Experts worldwide ranked by ideXlab platform
Michael A. Repka - One of the best experts on this subject based on the ideXlab platform.
-
Pharmaceutical applications of Hot-Melt extrusion: part I.
Drug development and industrial pharmacy, 2020Co-Authors: Michael M. Crowley, Sunil Kumar Battu, Sampada B Upadhye, Sridhar Thumma, Michael A. Repka, James W Mcginity, Feng Zhang, Charles MartinAbstract:Interest in Hot-Melt extrusion techniques for pharmaceutical applications is growing rapidly with well over 100 papers published in the pharmaceutical scientific literature in the last 12 years. Hot-Melt extrusion (HME) has been a widely applied technique in the plastics industry and has been demonstrated recently to be a viable method to prepare several types of dosage forms and drug delivery systems. Hot-Melt extruded dosage forms are complex mixtures of active medicaments, functional excipients, and processing aids. HME also offers several advantages over traditional pharmaceutical processing techniques including the absence of solvents, few processing steps, continuous operation, and the possibility of the formation of solid dispersions and improved bioavailability. This article, Part I, reviews the pharmaceutical applications of Hot-Melt extrusion, including equipment, principles of operation, and process technology. The raw materials processed using this technique are also detailed and the physicochemical properties of the resultant dosage forms are described. Part II of this review will focus on various applications of HME in drug delivery such as granules, pellets, immediate and modified release tablets, transmucosal and transdermal systems, and implants.
-
Development of an Ointment Formulation Using Hot-Melt Extrusion Technology
Aaps Pharmscitech, 2015Co-Authors: Ajinkya M. Bhagurkar, Muralikrishnan Angamuthu, Hemlata Patil, Roshan V. Tiwari, Abhijeet Maurya, Seyed Meysam Hashemnejad, Santanu Kundu, S. Narasimha Murthy, Michael A. RepkaAbstract:Ointments are generally prepared either by fusion or by levigation methods. The current study proposes the use of Hot-Melt extrusion (HME) processing for the preparation of a polyethylene glycol base ointment. Lidocaine was used as a model drug. A modified screw design was used in this process, and parameters such as feeding rate, barrel temperature, and screw speed were optimized to obtain a uniform product. The product characteristics were compared with an ointment of similar composition prepared by conventional fusion method. The rheological properties, drug release profile, and texture characteristics of the Hot-Melt extruded product were similar to the conventionally prepared product. This study demonstrates a novel application of the Hot-Melt extrusion process in the manufacturing of topical semi-solids.
-
Applications of Hot-Melt extrusion for drug delivery
Expert Opinion on Drug Delivery, 2008Co-Authors: Michael A. Repka, Sunil Kumar Battu, Ramesh Srirangam, Soumyajit Majumdar, Sampada B UpadhyeAbstract:In today's pharmaceutical arena, it is estimated that more than 40% of new chemical entities produced during drug discovery efforts exhibit poor solubility characteristics. However, over the last decade Hot-Melt extrusion (HME) has emerged as a powerful processing technology for drug delivery and has opened the door to a host of molecules previously considered unviable as drugs. HME is considered to be an efficient technique in developing solid molecular dispersions and has been demonstrated to provide sustained, modified and targeted drug delivery resulting in improved bioavailability. This article reviews the range of HME applications for pharmaceutical dosage forms, such as tablets, capsules, films and implants for drug delivery through oral, transdermal, transmucosal, transungual, as well as other routes of administration. Interest in HME as a pharmaceutical process continues to grow and the potential of automation and reduction of capital investment and labor costs have made this technique worthy of consideration as a drug delivery solution.
-
Pharmaceutical applications of Hot-Melt extrusion: Part II
Drug Development and Industrial Pharmacy, 2007Co-Authors: Michael A. Repka, Michael M. Crowley, Sunil Kumar Battu, Sampada B Upadhye, Sridhar Thumma, Charles Martin, Feng Zhang, James W McginityAbstract:The advent of high through-put screening in the drug discovery process has resulted in compounds with high lipophilicity and poor solubility. Increasing the solubility of such compounds poses a major challenge to formulation scientists. Various approaches have been adopted to address this including preparation of solid dispersions and solid solutions. Hot-Melt extrusion is an efficient technology for producing solid molecular dispersions with considerable advantages over solvent-based processes such as spray drying and co-precipitation. Hot-Melt extrusion has been demonstrated to provide sustained, modified, and targeted drug delivery. Improvements in bioavailability utilizing the Hot-Melt extrusion technique demonstrate the value of the technology as a potential drug delivery processing tool. The interest in Hot-Melt extrusion technology for pharmaceutical applications is evident from the increasing number of patents and publications in the scientific literature. Part II of this article reviews the myriad of Hot-Melt extrusion applications for pharmaceutical dosage forms including granules, pellets, tablets, implants, transmucosal, and transdermal systems.
-
Hot-Melt Extrusion technique: A Review
ISRN pharmaceutics, 2007Co-Authors: Jörg Breitenbach, Zhang Feng Crowley, Michael M., Joshua S Boateng, Sunil Kumar Battu, Sampada B Upadhye, Martin J. Snowden, Dennis Douroumis, Mohammed Maniruzzaman, Michael A. Repka, Sridhar ThummaAbstract:Hot-Melt extrusion is one of the most widely applied processing technology in the plastic, rubber and food industry. Today this technology has found its place in the array of pharmaceutical manufacturing operations. Melt extrusion process are currently applied in the pharmaceutical field for the manufacture of a variety of dosage forms and formulations such as granules, pellets, tablets, suppositories, implants, stents, transdermal systems and ophthalmic inserts. This review article in detail describes the mel extrusion equipment and process. Industrial application of this process along with specific areas on pharmaceutical industry is ilustrated. This article concludes with the overview of published examples of the melt extrusion process.
James W Mcginity - One of the best experts on this subject based on the ideXlab platform.
-
Pharmaceutical applications of Hot-Melt extrusion: part I.
Drug development and industrial pharmacy, 2020Co-Authors: Michael M. Crowley, Sunil Kumar Battu, Sampada B Upadhye, Sridhar Thumma, Michael A. Repka, James W Mcginity, Feng Zhang, Charles MartinAbstract:Interest in Hot-Melt extrusion techniques for pharmaceutical applications is growing rapidly with well over 100 papers published in the pharmaceutical scientific literature in the last 12 years. Hot-Melt extrusion (HME) has been a widely applied technique in the plastics industry and has been demonstrated recently to be a viable method to prepare several types of dosage forms and drug delivery systems. Hot-Melt extruded dosage forms are complex mixtures of active medicaments, functional excipients, and processing aids. HME also offers several advantages over traditional pharmaceutical processing techniques including the absence of solvents, few processing steps, continuous operation, and the possibility of the formation of solid dispersions and improved bioavailability. This article, Part I, reviews the pharmaceutical applications of Hot-Melt extrusion, including equipment, principles of operation, and process technology. The raw materials processed using this technique are also detailed and the physicochemical properties of the resultant dosage forms are described. Part II of this review will focus on various applications of HME in drug delivery such as granules, pellets, immediate and modified release tablets, transmucosal and transdermal systems, and implants.
-
Hot-Melt extrusion – basic principles and pharmaceutical applications
Drug Development and Industrial Pharmacy, 2014Co-Authors: Bo Lang, James W Mcginity, Robert O. WilliamsAbstract:AbstractOriginally adapted from the plastics industry, the use of Hot-Melt extrusion has gained favor in drug delivery applications both in academia and the pharmaceutical industry. Several commercial products made by Hot-Melt extrusion have been approved by the FDA, demonstrating its commercial feasibility for pharmaceutical processing. A significant number of research articles have reported on advances made regarding the pharmaceutical applications of the Hot-Melt extrusion processing; however, only limited articles have been focused on general principles regarding formulation and process development. This review provides an in-depth analysis and discussion of the formulation and processing aspects of Hot-Melt extrusion. The impact of physicochemical properties of drug substances and excipients on formulation development using a Hot-Melt extrusion process is discussed from a material science point of view. Hot-Melt extrusion process development, scale-up, and the interplay of formulation and process att...
-
Pharmaceutical applications of Hot-Melt extrusion: Part II
Drug Development and Industrial Pharmacy, 2007Co-Authors: Michael A. Repka, Michael M. Crowley, Sunil Kumar Battu, Sampada B Upadhye, Sridhar Thumma, Charles Martin, Feng Zhang, James W McginityAbstract:The advent of high through-put screening in the drug discovery process has resulted in compounds with high lipophilicity and poor solubility. Increasing the solubility of such compounds poses a major challenge to formulation scientists. Various approaches have been adopted to address this including preparation of solid dispersions and solid solutions. Hot-Melt extrusion is an efficient technology for producing solid molecular dispersions with considerable advantages over solvent-based processes such as spray drying and co-precipitation. Hot-Melt extrusion has been demonstrated to provide sustained, modified, and targeted drug delivery. Improvements in bioavailability utilizing the Hot-Melt extrusion technique demonstrate the value of the technology as a potential drug delivery processing tool. The interest in Hot-Melt extrusion technology for pharmaceutical applications is evident from the increasing number of patents and publications in the scientific literature. Part II of this article reviews the myriad of Hot-Melt extrusion applications for pharmaceutical dosage forms including granules, pellets, tablets, implants, transmucosal, and transdermal systems.
-
Pharmaceutical Applications of Hot-Melt Extrusion: Part I
Drug Development and Industrial Pharmacy, 2007Co-Authors: Michael M. Crowley, Sunil Kumar Battu, Sampada B Upadhye, Sridhar Thumma, Michael A. Repka, James W Mcginity, Feng Zhang, Charles R. MartinAbstract:Interest in Hot-Melt extrusion techniques for pharmaceutical applications is growing rapidly with well over 100 papers published in the pharmaceutical scientific literature in the last 12 years. Hot-Melt extrusion (HME) has been a widely applied technique in the plastics industry and has been demonstrated recently to be a viable method to prepare several types of dosage forms and drug delivery systems. Hot-Melt extruded dosage forms are complex mixtures of active medicaments, functional excipients, and processing aids. HME also offers several advantages over traditional pharmaceutical processing techniques including the absence of solvents, few processing steps, continuous operation, and the possibility of the formation of solid dispersions and improved bioavailability. This article, Part I, reviews the pharmaceutical applications of Hot-Melt extrusion, including equipment, principles of operation, and process technology. The raw materials processed using this technique are also detailed and the physicoch...
-
Production of spherical pellets by a Hot-Melt extrusion and spheronization process.
International journal of pharmaceutics, 2002Co-Authors: Christopher R. Young, John J. Koleng, James W McginityAbstract:Controlled-release theophylline containing spherical pellets were successfully produced by a Hot-Melt extrusion (HME) and spheronization process. A powder blend of anhydrous theophylline, Eudragit Preparation 4135 F, microcrystalline cellulose and polyethylene glycol 8000 powder was sieved, blended and then melt-extruded in a Randcastle Microtruder. The Hot-Melt extruded pellets were prepared by first cutting a thin, extruded composite rod into symmetrical pellets. The pellets were then spheronized in a traditional spheronizer at an elevated temperature. Thermal properties of the pellet formulation components and the Hot-Melt extrudate were studied to determine suitability of the formulation for HME. Pellets were examined using scanning electron microscopy to determine the effect of spheronization time on surface morphology. The rate of release of theophylline from the Hot-Melt extruded spherical pellets was characterized using USP 24 Apparatus 2 dissolution testing after initial pellet production and after 1 year storage in sealed HDPE containers at 25 degrees C/60% RH.
Sampada B Upadhye - One of the best experts on this subject based on the ideXlab platform.
-
Pharmaceutical applications of Hot-Melt extrusion: part I.
Drug development and industrial pharmacy, 2020Co-Authors: Michael M. Crowley, Sunil Kumar Battu, Sampada B Upadhye, Sridhar Thumma, Michael A. Repka, James W Mcginity, Feng Zhang, Charles MartinAbstract:Interest in Hot-Melt extrusion techniques for pharmaceutical applications is growing rapidly with well over 100 papers published in the pharmaceutical scientific literature in the last 12 years. Hot-Melt extrusion (HME) has been a widely applied technique in the plastics industry and has been demonstrated recently to be a viable method to prepare several types of dosage forms and drug delivery systems. Hot-Melt extruded dosage forms are complex mixtures of active medicaments, functional excipients, and processing aids. HME also offers several advantages over traditional pharmaceutical processing techniques including the absence of solvents, few processing steps, continuous operation, and the possibility of the formation of solid dispersions and improved bioavailability. This article, Part I, reviews the pharmaceutical applications of Hot-Melt extrusion, including equipment, principles of operation, and process technology. The raw materials processed using this technique are also detailed and the physicochemical properties of the resultant dosage forms are described. Part II of this review will focus on various applications of HME in drug delivery such as granules, pellets, immediate and modified release tablets, transmucosal and transdermal systems, and implants.
-
Applications of Hot-Melt extrusion for drug delivery
Expert Opinion on Drug Delivery, 2008Co-Authors: Michael A. Repka, Sunil Kumar Battu, Ramesh Srirangam, Soumyajit Majumdar, Sampada B UpadhyeAbstract:In today's pharmaceutical arena, it is estimated that more than 40% of new chemical entities produced during drug discovery efforts exhibit poor solubility characteristics. However, over the last decade Hot-Melt extrusion (HME) has emerged as a powerful processing technology for drug delivery and has opened the door to a host of molecules previously considered unviable as drugs. HME is considered to be an efficient technique in developing solid molecular dispersions and has been demonstrated to provide sustained, modified and targeted drug delivery resulting in improved bioavailability. This article reviews the range of HME applications for pharmaceutical dosage forms, such as tablets, capsules, films and implants for drug delivery through oral, transdermal, transmucosal, transungual, as well as other routes of administration. Interest in HME as a pharmaceutical process continues to grow and the potential of automation and reduction of capital investment and labor costs have made this technique worthy of consideration as a drug delivery solution.
-
Pharmaceutical applications of Hot-Melt extrusion: Part II
Drug Development and Industrial Pharmacy, 2007Co-Authors: Michael A. Repka, Michael M. Crowley, Sunil Kumar Battu, Sampada B Upadhye, Sridhar Thumma, Charles Martin, Feng Zhang, James W McginityAbstract:The advent of high through-put screening in the drug discovery process has resulted in compounds with high lipophilicity and poor solubility. Increasing the solubility of such compounds poses a major challenge to formulation scientists. Various approaches have been adopted to address this including preparation of solid dispersions and solid solutions. Hot-Melt extrusion is an efficient technology for producing solid molecular dispersions with considerable advantages over solvent-based processes such as spray drying and co-precipitation. Hot-Melt extrusion has been demonstrated to provide sustained, modified, and targeted drug delivery. Improvements in bioavailability utilizing the Hot-Melt extrusion technique demonstrate the value of the technology as a potential drug delivery processing tool. The interest in Hot-Melt extrusion technology for pharmaceutical applications is evident from the increasing number of patents and publications in the scientific literature. Part II of this article reviews the myriad of Hot-Melt extrusion applications for pharmaceutical dosage forms including granules, pellets, tablets, implants, transmucosal, and transdermal systems.
-
Hot-Melt Extrusion technique: A Review
ISRN pharmaceutics, 2007Co-Authors: Jörg Breitenbach, Zhang Feng Crowley, Michael M., Joshua S Boateng, Sunil Kumar Battu, Sampada B Upadhye, Martin J. Snowden, Dennis Douroumis, Mohammed Maniruzzaman, Michael A. Repka, Sridhar ThummaAbstract:Hot-Melt extrusion is one of the most widely applied processing technology in the plastic, rubber and food industry. Today this technology has found its place in the array of pharmaceutical manufacturing operations. Melt extrusion process are currently applied in the pharmaceutical field for the manufacture of a variety of dosage forms and formulations such as granules, pellets, tablets, suppositories, implants, stents, transdermal systems and ophthalmic inserts. This review article in detail describes the mel extrusion equipment and process. Industrial application of this process along with specific areas on pharmaceutical industry is ilustrated. This article concludes with the overview of published examples of the melt extrusion process.
-
Pharmaceutical Applications of Hot-Melt Extrusion: Part I
Drug Development and Industrial Pharmacy, 2007Co-Authors: Michael M. Crowley, Sunil Kumar Battu, Sampada B Upadhye, Sridhar Thumma, Michael A. Repka, James W Mcginity, Feng Zhang, Charles R. MartinAbstract:Interest in Hot-Melt extrusion techniques for pharmaceutical applications is growing rapidly with well over 100 papers published in the pharmaceutical scientific literature in the last 12 years. Hot-Melt extrusion (HME) has been a widely applied technique in the plastics industry and has been demonstrated recently to be a viable method to prepare several types of dosage forms and drug delivery systems. Hot-Melt extruded dosage forms are complex mixtures of active medicaments, functional excipients, and processing aids. HME also offers several advantages over traditional pharmaceutical processing techniques including the absence of solvents, few processing steps, continuous operation, and the possibility of the formation of solid dispersions and improved bioavailability. This article, Part I, reviews the pharmaceutical applications of Hot-Melt extrusion, including equipment, principles of operation, and process technology. The raw materials processed using this technique are also detailed and the physicoch...
Sridhar Thumma - One of the best experts on this subject based on the ideXlab platform.
-
Pharmaceutical applications of Hot-Melt extrusion: part I.
Drug development and industrial pharmacy, 2020Co-Authors: Michael M. Crowley, Sunil Kumar Battu, Sampada B Upadhye, Sridhar Thumma, Michael A. Repka, James W Mcginity, Feng Zhang, Charles MartinAbstract:Interest in Hot-Melt extrusion techniques for pharmaceutical applications is growing rapidly with well over 100 papers published in the pharmaceutical scientific literature in the last 12 years. Hot-Melt extrusion (HME) has been a widely applied technique in the plastics industry and has been demonstrated recently to be a viable method to prepare several types of dosage forms and drug delivery systems. Hot-Melt extruded dosage forms are complex mixtures of active medicaments, functional excipients, and processing aids. HME also offers several advantages over traditional pharmaceutical processing techniques including the absence of solvents, few processing steps, continuous operation, and the possibility of the formation of solid dispersions and improved bioavailability. This article, Part I, reviews the pharmaceutical applications of Hot-Melt extrusion, including equipment, principles of operation, and process technology. The raw materials processed using this technique are also detailed and the physicochemical properties of the resultant dosage forms are described. Part II of this review will focus on various applications of HME in drug delivery such as granules, pellets, immediate and modified release tablets, transmucosal and transdermal systems, and implants.
-
Pharmaceutical applications of Hot-Melt extrusion: Part II
Drug Development and Industrial Pharmacy, 2007Co-Authors: Michael A. Repka, Michael M. Crowley, Sunil Kumar Battu, Sampada B Upadhye, Sridhar Thumma, Charles Martin, Feng Zhang, James W McginityAbstract:The advent of high through-put screening in the drug discovery process has resulted in compounds with high lipophilicity and poor solubility. Increasing the solubility of such compounds poses a major challenge to formulation scientists. Various approaches have been adopted to address this including preparation of solid dispersions and solid solutions. Hot-Melt extrusion is an efficient technology for producing solid molecular dispersions with considerable advantages over solvent-based processes such as spray drying and co-precipitation. Hot-Melt extrusion has been demonstrated to provide sustained, modified, and targeted drug delivery. Improvements in bioavailability utilizing the Hot-Melt extrusion technique demonstrate the value of the technology as a potential drug delivery processing tool. The interest in Hot-Melt extrusion technology for pharmaceutical applications is evident from the increasing number of patents and publications in the scientific literature. Part II of this article reviews the myriad of Hot-Melt extrusion applications for pharmaceutical dosage forms including granules, pellets, tablets, implants, transmucosal, and transdermal systems.
-
Hot-Melt Extrusion technique: A Review
ISRN pharmaceutics, 2007Co-Authors: Jörg Breitenbach, Zhang Feng Crowley, Michael M., Joshua S Boateng, Sunil Kumar Battu, Sampada B Upadhye, Martin J. Snowden, Dennis Douroumis, Mohammed Maniruzzaman, Michael A. Repka, Sridhar ThummaAbstract:Hot-Melt extrusion is one of the most widely applied processing technology in the plastic, rubber and food industry. Today this technology has found its place in the array of pharmaceutical manufacturing operations. Melt extrusion process are currently applied in the pharmaceutical field for the manufacture of a variety of dosage forms and formulations such as granules, pellets, tablets, suppositories, implants, stents, transdermal systems and ophthalmic inserts. This review article in detail describes the mel extrusion equipment and process. Industrial application of this process along with specific areas on pharmaceutical industry is ilustrated. This article concludes with the overview of published examples of the melt extrusion process.
-
Pharmaceutical Applications of Hot-Melt Extrusion: Part I
Drug Development and Industrial Pharmacy, 2007Co-Authors: Michael M. Crowley, Sunil Kumar Battu, Sampada B Upadhye, Sridhar Thumma, Michael A. Repka, James W Mcginity, Feng Zhang, Charles R. MartinAbstract:Interest in Hot-Melt extrusion techniques for pharmaceutical applications is growing rapidly with well over 100 papers published in the pharmaceutical scientific literature in the last 12 years. Hot-Melt extrusion (HME) has been a widely applied technique in the plastics industry and has been demonstrated recently to be a viable method to prepare several types of dosage forms and drug delivery systems. Hot-Melt extruded dosage forms are complex mixtures of active medicaments, functional excipients, and processing aids. HME also offers several advantages over traditional pharmaceutical processing techniques including the absence of solvents, few processing steps, continuous operation, and the possibility of the formation of solid dispersions and improved bioavailability. This article, Part I, reviews the pharmaceutical applications of Hot-Melt extrusion, including equipment, principles of operation, and process technology. The raw materials processed using this technique are also detailed and the physicoch...
Sunil Kumar Battu - One of the best experts on this subject based on the ideXlab platform.
-
Pharmaceutical applications of Hot-Melt extrusion: part I.
Drug development and industrial pharmacy, 2020Co-Authors: Michael M. Crowley, Sunil Kumar Battu, Sampada B Upadhye, Sridhar Thumma, Michael A. Repka, James W Mcginity, Feng Zhang, Charles MartinAbstract:Interest in Hot-Melt extrusion techniques for pharmaceutical applications is growing rapidly with well over 100 papers published in the pharmaceutical scientific literature in the last 12 years. Hot-Melt extrusion (HME) has been a widely applied technique in the plastics industry and has been demonstrated recently to be a viable method to prepare several types of dosage forms and drug delivery systems. Hot-Melt extruded dosage forms are complex mixtures of active medicaments, functional excipients, and processing aids. HME also offers several advantages over traditional pharmaceutical processing techniques including the absence of solvents, few processing steps, continuous operation, and the possibility of the formation of solid dispersions and improved bioavailability. This article, Part I, reviews the pharmaceutical applications of Hot-Melt extrusion, including equipment, principles of operation, and process technology. The raw materials processed using this technique are also detailed and the physicochemical properties of the resultant dosage forms are described. Part II of this review will focus on various applications of HME in drug delivery such as granules, pellets, immediate and modified release tablets, transmucosal and transdermal systems, and implants.
-
Pharmaceutical applications of Hot-Melt extrusion: Part II
Drug Development and Industrial Pharmacy, 2007Co-Authors: Michael A. Repka, Michael M. Crowley, Sunil Kumar Battu, Sampada B Upadhye, Sridhar Thumma, Charles Martin, Feng Zhang, James W McginityAbstract:The advent of high through-put screening in the drug discovery process has resulted in compounds with high lipophilicity and poor solubility. Increasing the solubility of such compounds poses a major challenge to formulation scientists. Various approaches have been adopted to address this including preparation of solid dispersions and solid solutions. Hot-Melt extrusion is an efficient technology for producing solid molecular dispersions with considerable advantages over solvent-based processes such as spray drying and co-precipitation. Hot-Melt extrusion has been demonstrated to provide sustained, modified, and targeted drug delivery. Improvements in bioavailability utilizing the Hot-Melt extrusion technique demonstrate the value of the technology as a potential drug delivery processing tool. The interest in Hot-Melt extrusion technology for pharmaceutical applications is evident from the increasing number of patents and publications in the scientific literature. Part II of this article reviews the myriad of Hot-Melt extrusion applications for pharmaceutical dosage forms including granules, pellets, tablets, implants, transmucosal, and transdermal systems.
-
Hot-Melt Extrusion technique: A Review
ISRN pharmaceutics, 2007Co-Authors: Jörg Breitenbach, Zhang Feng Crowley, Michael M., Joshua S Boateng, Sunil Kumar Battu, Sampada B Upadhye, Martin J. Snowden, Dennis Douroumis, Mohammed Maniruzzaman, Michael A. Repka, Sridhar ThummaAbstract:Hot-Melt extrusion is one of the most widely applied processing technology in the plastic, rubber and food industry. Today this technology has found its place in the array of pharmaceutical manufacturing operations. Melt extrusion process are currently applied in the pharmaceutical field for the manufacture of a variety of dosage forms and formulations such as granules, pellets, tablets, suppositories, implants, stents, transdermal systems and ophthalmic inserts. This review article in detail describes the mel extrusion equipment and process. Industrial application of this process along with specific areas on pharmaceutical industry is ilustrated. This article concludes with the overview of published examples of the melt extrusion process.
-
Pharmaceutical Applications of Hot-Melt Extrusion: Part I
Drug Development and Industrial Pharmacy, 2007Co-Authors: Michael M. Crowley, Sunil Kumar Battu, Sampada B Upadhye, Sridhar Thumma, Michael A. Repka, James W Mcginity, Feng Zhang, Charles R. MartinAbstract:Interest in Hot-Melt extrusion techniques for pharmaceutical applications is growing rapidly with well over 100 papers published in the pharmaceutical scientific literature in the last 12 years. Hot-Melt extrusion (HME) has been a widely applied technique in the plastics industry and has been demonstrated recently to be a viable method to prepare several types of dosage forms and drug delivery systems. Hot-Melt extruded dosage forms are complex mixtures of active medicaments, functional excipients, and processing aids. HME also offers several advantages over traditional pharmaceutical processing techniques including the absence of solvents, few processing steps, continuous operation, and the possibility of the formation of solid dispersions and improved bioavailability. This article, Part I, reviews the pharmaceutical applications of Hot-Melt extrusion, including equipment, principles of operation, and process technology. The raw materials processed using this technique are also detailed and the physicoch...