The Experts below are selected from a list of 30636 Experts worldwide ranked by ideXlab platform
Kejin Zhang - One of the best experts on this subject based on the ideXlab platform.
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a study on the correlation between il1rapl1 and Human Cognitive Ability
Neuroscience Letters, 2008Co-Authors: Gengsi Xi, Shumiao Zhang, Ruijuan Fu, Zijian Zheng, Kejin ZhangAbstract:This study aimed to investigate the effects of IL1RAPL1 on the Human Cognitive Ability. Four genetic marker sites, i.e., DXS1218, DXS9896, rs6526806 and rs12847959 on IL1RAPL1 were genotyped in 332 Qinba Mountain Area children. Meanwhile, a cognition test with a C-WISC scale was performed to study the relationship of genotype with cognition test scores. Results indicated that genotypes of DXS1218, DXS9896 and rs12847959 were associated with memory/concentration factor intelligence quotient (IQ) (P = 0.027, 0.042, 0.029, respectively). DXS1218 also associated with full IQ, verbal IQ, and performance IQ (P = 0.006, 0.014, 0.006, respectively). rs12847959 were related to verbal comprehension factor and perceptual organization factor IQ (P = 0.021, 0.043, respectively). Further study on rat brain revealed that Il1rapl was mainly expressed in memory/concentration-associated encephalic regions, such as hippocampus, dentate fascia, osmesis perithelium, and piriform cortex. mRNA expression levels of Il1rapl in brains of rats with different learning and memory abilities showed significant difference. Combined data suggested that IL1RAPL1 affected Human Cognitive Ability to some extent, especially the memory and concentration capAbility.
Clancy Blair - One of the best experts on this subject based on the ideXlab platform.
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how similar are fluid cognition and general intelligence a developmental neuroscience perspective on fluid cognition as an aspect of Human Cognitive Ability
Behavioral and Brain Sciences, 2006Co-Authors: Clancy BlairAbstract:This target article considers the relation of fluid Cognitive functioning to general intelligence. A neurobiological model differentiating working memory/executive function Cognitive processes of the prefrontal cortex from aspects of psychometrically defined general intelligence is presented. Work examining the rise in mean intelligence-test performance between normative cohorts, the neuropsychology and neuroscience of Cognitive function in typically and atypically developing Human populations, and stress, brain development, and corticolimbic connectivity in Human and nonHuman animal models is reviewed and found to provide evidence of mechanisms through which early experience affects the development of an aspect of cognition closely related to, but distinct from, general intelligence. Particular emphasis is placed on the role of emotion in fluid cognition and on research indicating fluid Cognitive deficits associated with early hippocampal pathology and with dysregulation of the hypothalamic-pituitary-adrenal axis stress-response system. Findings are seen to be consistent with the idea of an independent fluid Cognitive construct and to assist with the interpretation of findings from the study of early compensatory education for children facing psychosocial adversity and from behavior genetic research on intelligence. It is concluded that ongoing development of neurobiologically grounded measures of fluid Cognitive skills appropriate for young children will play a key role in understanding early mental development and the adaptive success to which it is related, particularly for young children facing social and economic disadvantage. Specifically, in the evaluation of the efficacy of compensatory education efforts such as Head Start and the readiness for school of children from diverse backgrounds, it is important to distinguish fluid cognition from psychometrically defined general intelligence.
Sakti Srivastava - One of the best experts on this subject based on the ideXlab platform.
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spatial and visual reasoning do these abilities improve in first year veterinary medical students exposed to an integrated curriculum
Journal of Veterinary Medical Education, 2017Co-Authors: Claudio J Gutierrez, Munashe Chigerwe, Jan E Ilkiw, Patricia Youngblood, Steven D Holladay, Sakti SrivastavaAbstract:Spatial visualization Ability refers to the Human Cognitive Ability to form, retrieve, and manipulate mental models of spatial nature. Visual reasoning Ability has been linked to spatial Ability. There is currently limited information about how entry-level spatial and visual reasoning abilities may predict veterinary anatomy performance or may be enhanced with progression through the veterinary anatomy content in an integrated curriculum. The present study made use of two tests that measure spatial Ability and one test that measures visual reasoning Ability in veterinary students: Guay's Visualization of Views Test, adapted version (GVVT), the Mental Rotations Test (MRT), and Raven's Advanced Progressive Matrices Test, short form (RavenT). The tests were given to the entering class of veterinary students during their orientation week and at week 32 in the veterinary medical curriculum. Mean score on the MRT significantly increased from 15.2 to 20.1, and on the RavenT significantly increased from 7.5 to 8....
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spatial and visual reasoning do these abilities improve in first year veterinary medical students exposed to an integrated curriculum
Journal of Veterinary Medical Education, 2017Co-Authors: Juan Claudio Gutierrez, Munashe Chigerwe, Jan E Ilkiw, Patricia Youngblood, Steven D Holladay, Sakti SrivastavaAbstract:Spatial visualization Ability refers to the Human Cognitive Ability to form, retrieve, and manipulate mental models of spatial nature. Visual reasoning Ability has been linked to spatial Ability. There is currently limited information about how entry-level spatial and visual reasoning abilities may predict veterinary anatomy performance or may be enhanced with progression through the veterinary anatomy content in an integrated curriculum. The present study made use of two tests that measure spatial Ability and one test that measures visual reasoning Ability in veterinary students: Guay's Visualization of Views Test, adapted version (GVVT), the Mental Rotations Test (MRT), and Raven's Advanced Progressive Matrices Test, short form (RavenT). The tests were given to the entering class of veterinary students during their orientation week and at week 32 in the veterinary medical curriculum. Mean score on the MRT significantly increased from 15.2 to 20.1, and on the RavenT significantly increased from 7.5 to 8.8. When females only were evaluated, results were similar to the total class outcome; however, all three tests showed significant increases in mean scores. A positive correlation between the pre- and post-test scores was found for all three tests. The present results should be considered preliminary at best for associating anatomic learning in an integrated curriculum with spatial and visual reasoning abilities. Other components of the curriculum, for instance histology or physiology, could also influence the improved spatial visualization and visual reasoning test scores at week 32.
Zijian Zheng - One of the best experts on this subject based on the ideXlab platform.
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a study on the correlation between il1rapl1 and Human Cognitive Ability
Neuroscience Letters, 2008Co-Authors: Gengsi Xi, Shumiao Zhang, Ruijuan Fu, Zijian Zheng, Kejin ZhangAbstract:This study aimed to investigate the effects of IL1RAPL1 on the Human Cognitive Ability. Four genetic marker sites, i.e., DXS1218, DXS9896, rs6526806 and rs12847959 on IL1RAPL1 were genotyped in 332 Qinba Mountain Area children. Meanwhile, a cognition test with a C-WISC scale was performed to study the relationship of genotype with cognition test scores. Results indicated that genotypes of DXS1218, DXS9896 and rs12847959 were associated with memory/concentration factor intelligence quotient (IQ) (P = 0.027, 0.042, 0.029, respectively). DXS1218 also associated with full IQ, verbal IQ, and performance IQ (P = 0.006, 0.014, 0.006, respectively). rs12847959 were related to verbal comprehension factor and perceptual organization factor IQ (P = 0.021, 0.043, respectively). Further study on rat brain revealed that Il1rapl was mainly expressed in memory/concentration-associated encephalic regions, such as hippocampus, dentate fascia, osmesis perithelium, and piriform cortex. mRNA expression levels of Il1rapl in brains of rats with different learning and memory abilities showed significant difference. Combined data suggested that IL1RAPL1 affected Human Cognitive Ability to some extent, especially the memory and concentration capAbility.
Galina Apostolova - One of the best experts on this subject based on the ideXlab platform.
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genes encoding satb2 interacting proteins in adult cerebral cortex contribute to Human Cognitive Ability
PLOS Genetics, 2019Co-Authors: Isabella Cera, Laura Whitton, Derek W Morris, Gary Donohoe, Georg Dechant, Galina ApostolovaAbstract:During CNS development, the nuclear protein SATB2 is expressed in superficial cortical layers and determines projection neuron identity. In the adult CNS, SATB2 is expressed in pyramidal neurons of all cortical layers and is a regulator of synaptic plasticity and long-term memory. Common variation in SATB2 locus confers risk of schizophrenia, whereas rare, de novo structural and single nucleotide variants cause severe intellectual disAbility and absent or limited speech. To characterize differences in SATB2 molecular function in developing vs adult neocortex, we isolated SATB2 protein interactomes at the two ontogenetic stages and identified multiple novel SATB2 interactors. SATB2 interactomes are highly enriched for proteins that stabilize de novo chromatin loops. The comparison between the neonatal and adult SATB2 protein complexes indicates a developmental shift in SATB2 molecular function, from transcriptional repression towards organization of chromosomal superstructure. Accordingly, gene sets regulated by SATB2 in the neocortex of neonatal and adult mice show limited overlap. Genes encoding SATB2 protein interactors were grouped for gene set analysis of Human GWAS data. Common variants associated with Human Cognitive Ability are enriched within the genes encoding adult but not neonatal SATB2 interactors. Our data support a shift in the function of SATB2 in cortex over lifetime and indicate that regulation of spatial chromatin architecture by the SATB2 interactome contributes to Cognitive function in the general population.