Synaptic Plasticity

14,000,000 Leading Edge Experts on the ideXlab platform

Scan Science and Technology

Contact Leading Edge Experts & Companies

Scan Science and Technology

Contact Leading Edge Experts & Companies

The Experts below are selected from a list of 81897 Experts worldwide ranked by ideXlab platform

Graham L Collingridge - One of the best experts on this subject based on the ideXlab platform.

  • Synaptic Plasticity in the hippocampal slice preparation.
    Current protocols in neuroscience, 2011
    Co-Authors: Zuner A Bortolotto, Mascia Amici, William W Anderson, John T R Isaac, Graham L Collingridge
    Abstract:

    Synaptic Plasticity is the process by which the brain alters the strength of its Synaptic connections, a fundamental function of the brain that enables individuals to learn from experience. The study of Synaptic Plasticity often involves the application of standard in vitro electrophysiological techniques to hippocampal slice preparations. This unit discusses many of the special considerations that are applicable for the optimal study of Synaptic Plasticity in this system. Most of these principles also apply to the study of Synaptic Plasticity in other brain slice preparations.

  • Current Protocols in Neuroscience - Synaptic Plasticity in the hippocampal slice preparation
    Current protocols in protein science, 2011
    Co-Authors: Zuner A Bortolotto, Mascia Amici, William W Anderson, John T R Isaac, Graham L Collingridge
    Abstract:

    Synaptic Plasticity is the process by which the brain alters the strength of its Synaptic connections, a fundamental function of the brain that enables individuals to learn from experience. The study of Synaptic Plasticity often involves the application of standard in vitro electrophysiological techniques to hippocampal slice preparations. This unit discusses many of the special considerations that are applicable for the optimal study of Synaptic Plasticity in this system. Most of these principles also apply to the study of Synaptic Plasticity in other brain slice preparations.

  • Neuronal calcium sensors and Synaptic Plasticity.
    Biochemical Society Transactions, 2009
    Co-Authors: Mascia Amici, Graham L Collingridge, Andrew J Doherty, David E. Jane, Kwangwook Cho, Sheila L. Dargan
    Abstract:

    Calcium entry plays a major role in the induction of several forms of Synaptic Plasticity in different areas of the central nervous system. The spatiotemporal aspects of these calcium signals can determine the type of Synaptic Plasticity induced, e.g. LTP (long-term potentiation) or LTD (long-term depression). A vast amount of research has been conducted to identify the molecular and cellular signalling pathways underlying LTP and LTD, but many components remain to be identified. Calcium sensor proteins are thought to play an essential role in regulating the initial part of Synaptic Plasticity signalling pathways. However, there is still a significant gap in knowledge, and it is only recently that evidence for the importance of members of the NCS (neuronal calcium sensor) protein family has started to emerge. The present minireview aims to bring together evidence supporting a role for NCS proteins in Plasticity, focusing on emerging roles of NCS-1 and hippocalcin.

  • Ca2+stores and hippocampal Synaptic Plasticity
    Seminars in Neuroscience, 1996
    Co-Authors: Bruno G. Frenguelli, Aj Irving, Graham L Collingridge
    Abstract:

    Abstract For many years the importance of internal calcium stores (ICSs) in excitation–contraction coupling and endocrine function has been well recognized. With the discovery of ICSs in the CNS, evidence has accumulated regarding their role in neuronal function, and in particular, Synaptic Plasticity. In this review we focus on the involvement of ICSs in Synaptic Plasticity in the hippocampus.

Yukiko Goda - One of the best experts on this subject based on the ideXlab platform.

  • unraveling mechanisms of homeostatic Synaptic Plasticity
    Neuron, 2010
    Co-Authors: Karine Pozo, Yukiko Goda
    Abstract:

    Homeostatic Synaptic Plasticity is a negative feedback mechanism that neurons use to offset excessive excitation or inhibition by adjusting their Synaptic strengths. Recent findings reveal a complex web of signaling processes involved in this compensatory form of Synaptic strength regulation, and in contrast to the popular view of homeostatic Plasticity as a slow, global phenomenon, neurons may also rapidly tune the efficacy of individual synapses on demand. Here we review our current understanding of cellular and molecular mechanisms of homeostatic Synaptic Plasticity.

Karine Pozo - One of the best experts on this subject based on the ideXlab platform.

  • unraveling mechanisms of homeostatic Synaptic Plasticity
    Neuron, 2010
    Co-Authors: Karine Pozo, Yukiko Goda
    Abstract:

    Homeostatic Synaptic Plasticity is a negative feedback mechanism that neurons use to offset excessive excitation or inhibition by adjusting their Synaptic strengths. Recent findings reveal a complex web of signaling processes involved in this compensatory form of Synaptic strength regulation, and in contrast to the popular view of homeostatic Plasticity as a slow, global phenomenon, neurons may also rapidly tune the efficacy of individual synapses on demand. Here we review our current understanding of cellular and molecular mechanisms of homeostatic Synaptic Plasticity.

Mascia Amici - One of the best experts on this subject based on the ideXlab platform.

  • Synaptic Plasticity in the hippocampal slice preparation.
    Current protocols in neuroscience, 2011
    Co-Authors: Zuner A Bortolotto, Mascia Amici, William W Anderson, John T R Isaac, Graham L Collingridge
    Abstract:

    Synaptic Plasticity is the process by which the brain alters the strength of its Synaptic connections, a fundamental function of the brain that enables individuals to learn from experience. The study of Synaptic Plasticity often involves the application of standard in vitro electrophysiological techniques to hippocampal slice preparations. This unit discusses many of the special considerations that are applicable for the optimal study of Synaptic Plasticity in this system. Most of these principles also apply to the study of Synaptic Plasticity in other brain slice preparations.

  • Current Protocols in Neuroscience - Synaptic Plasticity in the hippocampal slice preparation
    Current protocols in protein science, 2011
    Co-Authors: Zuner A Bortolotto, Mascia Amici, William W Anderson, John T R Isaac, Graham L Collingridge
    Abstract:

    Synaptic Plasticity is the process by which the brain alters the strength of its Synaptic connections, a fundamental function of the brain that enables individuals to learn from experience. The study of Synaptic Plasticity often involves the application of standard in vitro electrophysiological techniques to hippocampal slice preparations. This unit discusses many of the special considerations that are applicable for the optimal study of Synaptic Plasticity in this system. Most of these principles also apply to the study of Synaptic Plasticity in other brain slice preparations.

  • Neuronal calcium sensors and Synaptic Plasticity.
    Biochemical Society Transactions, 2009
    Co-Authors: Mascia Amici, Graham L Collingridge, Andrew J Doherty, David E. Jane, Kwangwook Cho, Sheila L. Dargan
    Abstract:

    Calcium entry plays a major role in the induction of several forms of Synaptic Plasticity in different areas of the central nervous system. The spatiotemporal aspects of these calcium signals can determine the type of Synaptic Plasticity induced, e.g. LTP (long-term potentiation) or LTD (long-term depression). A vast amount of research has been conducted to identify the molecular and cellular signalling pathways underlying LTP and LTD, but many components remain to be identified. Calcium sensor proteins are thought to play an essential role in regulating the initial part of Synaptic Plasticity signalling pathways. However, there is still a significant gap in knowledge, and it is only recently that evidence for the importance of members of the NCS (neuronal calcium sensor) protein family has started to emerge. The present minireview aims to bring together evidence supporting a role for NCS proteins in Plasticity, focusing on emerging roles of NCS-1 and hippocalcin.

Zuner A Bortolotto - One of the best experts on this subject based on the ideXlab platform.

  • Synaptic Plasticity in the hippocampal slice preparation.
    Current protocols in neuroscience, 2011
    Co-Authors: Zuner A Bortolotto, Mascia Amici, William W Anderson, John T R Isaac, Graham L Collingridge
    Abstract:

    Synaptic Plasticity is the process by which the brain alters the strength of its Synaptic connections, a fundamental function of the brain that enables individuals to learn from experience. The study of Synaptic Plasticity often involves the application of standard in vitro electrophysiological techniques to hippocampal slice preparations. This unit discusses many of the special considerations that are applicable for the optimal study of Synaptic Plasticity in this system. Most of these principles also apply to the study of Synaptic Plasticity in other brain slice preparations.

  • Current Protocols in Neuroscience - Synaptic Plasticity in the hippocampal slice preparation
    Current protocols in protein science, 2011
    Co-Authors: Zuner A Bortolotto, Mascia Amici, William W Anderson, John T R Isaac, Graham L Collingridge
    Abstract:

    Synaptic Plasticity is the process by which the brain alters the strength of its Synaptic connections, a fundamental function of the brain that enables individuals to learn from experience. The study of Synaptic Plasticity often involves the application of standard in vitro electrophysiological techniques to hippocampal slice preparations. This unit discusses many of the special considerations that are applicable for the optimal study of Synaptic Plasticity in this system. Most of these principles also apply to the study of Synaptic Plasticity in other brain slice preparations.