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H Matsuda - One of the best experts on this subject based on the ideXlab platform.

  • Urinary excretion of Human Growth Hormone in children with short stature: correlation with pituitary secretion of Human Growth Hormone.
    The Journal of pediatrics, 1992
    Co-Authors: K Kida, M Hayashi, Y Kaino, Y Goto, M Ikeuchi, H Matsuda
    Abstract:

    Thirty-five children with short-stature underwent insulin-loading and sleep tests for assessment of secretion of Human Growth Hormone. Correlations between the levels of Human Growth Hormone in the serum and urine during the tests were examined to elucidate the clinical significance of urinary Human Growth Hormone levels in short children. The concentration and total amount of Human Growth Hormone in the urine correlated significantly with the peak concentration of serum Human Growth Hormone (r = 0.81, p less than 0.001 and r = 0.80, p less than 0.001, respectively) and the integrated concentration of Human Growth Hormone (r = 0.85, p less than 0.001 and r = 0.85, p less than 0.001, respectively) in the insulin-loading test. The concentration and total amount of Human Growth Hormone in the morning urine also correlated significantly with the peak concentration of serum Human Growth Hormone (r = 0.80, p less than 0.001 and r = 0.70, p less than 0.001, respectively) and the integrated concentration of serum Human Growth Hormone (r = 0.80, p less than 0.001 and r = 0.72, p less than 0.001, respectively) in the sleep test. The concentration or total amount of Human Growth Hormone in the urine differed significantly among children with Human Growth Hormone deficiency, those with nonendocrine short stature, and those with normal stature (p less than 0.05). These data suggest that measurement of Human Growth Hormone in the urine may be used to assess secretion of Human Growth Hormone, serving as a screening test for Human Growth Hormone deficiency in children.

  • Urinary excretion of Human Growth Hormone in children with short stature: Correlation with pituitary secretion of Human Growth Hormone
    The Journal of Pediatrics, 1992
    Co-Authors: K Kida, M Hayashi, Y Kaino, Y Goto, M Ikeuchi, H Matsuda
    Abstract:

    Thirty-five children with short-stature underwent insulin-loading and sleep tests for assessment of secretion of Human Growth Hormone. Correlations between the levels of Human Growth Hormone in the serum and urine during the tests were examined to elucidate the clinical significance of urinary Human Growth Hormone levels in short children. The concentration and total amount of Human Growth Hormone in the urine correlated significantly with the peak concentration of serum Human Growth Hormone ( r =0.81, p r =0.80, p r =0.85, p r =0.85, p r =0.80, p p r =0.80, p r =0.72, p p

K Kida - One of the best experts on this subject based on the ideXlab platform.

  • Urinary excretion of Human Growth Hormone in children with short stature: correlation with pituitary secretion of Human Growth Hormone.
    The Journal of pediatrics, 1992
    Co-Authors: K Kida, M Hayashi, Y Kaino, Y Goto, M Ikeuchi, H Matsuda
    Abstract:

    Thirty-five children with short-stature underwent insulin-loading and sleep tests for assessment of secretion of Human Growth Hormone. Correlations between the levels of Human Growth Hormone in the serum and urine during the tests were examined to elucidate the clinical significance of urinary Human Growth Hormone levels in short children. The concentration and total amount of Human Growth Hormone in the urine correlated significantly with the peak concentration of serum Human Growth Hormone (r = 0.81, p less than 0.001 and r = 0.80, p less than 0.001, respectively) and the integrated concentration of Human Growth Hormone (r = 0.85, p less than 0.001 and r = 0.85, p less than 0.001, respectively) in the insulin-loading test. The concentration and total amount of Human Growth Hormone in the morning urine also correlated significantly with the peak concentration of serum Human Growth Hormone (r = 0.80, p less than 0.001 and r = 0.70, p less than 0.001, respectively) and the integrated concentration of serum Human Growth Hormone (r = 0.80, p less than 0.001 and r = 0.72, p less than 0.001, respectively) in the sleep test. The concentration or total amount of Human Growth Hormone in the urine differed significantly among children with Human Growth Hormone deficiency, those with nonendocrine short stature, and those with normal stature (p less than 0.05). These data suggest that measurement of Human Growth Hormone in the urine may be used to assess secretion of Human Growth Hormone, serving as a screening test for Human Growth Hormone deficiency in children.

  • Urinary excretion of Human Growth Hormone in children with short stature: Correlation with pituitary secretion of Human Growth Hormone
    The Journal of Pediatrics, 1992
    Co-Authors: K Kida, M Hayashi, Y Kaino, Y Goto, M Ikeuchi, H Matsuda
    Abstract:

    Thirty-five children with short-stature underwent insulin-loading and sleep tests for assessment of secretion of Human Growth Hormone. Correlations between the levels of Human Growth Hormone in the serum and urine during the tests were examined to elucidate the clinical significance of urinary Human Growth Hormone levels in short children. The concentration and total amount of Human Growth Hormone in the urine correlated significantly with the peak concentration of serum Human Growth Hormone ( r =0.81, p r =0.80, p r =0.85, p r =0.85, p r =0.80, p p r =0.80, p r =0.72, p p

Pang Q - One of the best experts on this subject based on the ideXlab platform.

  • Pharmacokinetic analysis of lactosaminated Human Growth Hormone and Human Growth Hormone
    Hua xi yi ke da xue xue bao = Journal of West China University of Medical Sciences = Huaxi yike daxue xuebao, 2000
    Co-Authors: Li Y, Guan C, Zhang H, Li T, Chen Z, Pang Q
    Abstract:

    This study was undertaken to explore and compare the pharmacokinetic features of lactosaminated Human Growth Hormone(hGH-L) and Human Growth Hormone (hGH). Radioimmunoassay (RIA) technique was used. After mice were intravenously injected with hGH-L, their blood and liver samples were collected and handled. The blood drug concentration and liver drug concentration were determined using RIA technique. Then the pharmacokinetic parameters were obtained by analysing the curves of blood drug concentration-time and liver drug concentration-time. hGH was determinated with the same methods. The results showed that the area under curve (AUC) of blood drug concentration-time curve of hGH-L was 32,686.90, the mean remain time (MRT) of hGH-L in blood was 21.37 minutes, but the AUC of blood drug concentration-time curve of hGH was 36,913.08 and the MRT of hGH in blood was 24.98 minutes. Therefore, in blood, the uptake of hGH-L was less than that of hGH, the removal of hGH-L was faster than the removal of hGH. In liver, for hGH-L, the half-time of distribution (t1/2 alpha) was 1.84 minutes, the half-time of removal(t1/2 beta) was 11.09 minutes, the AUC of liver drug concentration-time curve was 17,621.9; for hGH, the t1/2 alpha was 2.11 minutes, the t1/2 beta was 75.65 minutes, the AUC of liver drug concentration-time curve was 12,148.2. Therefore, in liver, the uptake of hGH-L was more than that of hGH, the distribution and removal of hGH-L were faster than those of hGH. Therefore, the pharmacokinetic features of hGH-L was better than the feature of hGH.

  • Comparative study on livertaxis of lactosaminated Human Growth Hormone and galactosyl-Human Growth Hormone
    Hua xi yi ke da xue xue bao = Journal of West China University of Medical Sciences = Huaxi yike daxue xuebao, 1999
    Co-Authors: Li Y, Guan C, Zhang H, Li L, Yang X, Chen C, Li T, Pang Q
    Abstract:

    This study was conducted to compare the livertaxis of lactosaminated Human Growth Hormone (hGH-L) with that of galactosyl Human Growth Hormone (hGH-Gal), using radioactive tracer technique. hGH-L and hGH-Gal were first prepared. After hGH-L, hGH-Gal and hGH were labelled with 131I or 125I, the data on biodistribution in mice, imaging in rabbits and chicken were obtained. hGH-L and hGH-Gal had remarkable livertaxis and their percentages for uptake in liver were 68.83%-74.65% and 68.18%-74% respectively, which were about two times as high as that of hGH. All of the hepatic bindings were receptor-mediated. But, the synthesizing of hGH-L was more easy-to-do, more mild in reaction conditions, and more economical of raw material as compared with the synthesizing of hGH-Gal. Therefore, hGH-L is a more potential receptor-mediated hepatic targeting secreting somatomedian drug for treating dwarfism.

M Hayashi - One of the best experts on this subject based on the ideXlab platform.

  • Urinary excretion of Human Growth Hormone in children with short stature: correlation with pituitary secretion of Human Growth Hormone.
    The Journal of pediatrics, 1992
    Co-Authors: K Kida, M Hayashi, Y Kaino, Y Goto, M Ikeuchi, H Matsuda
    Abstract:

    Thirty-five children with short-stature underwent insulin-loading and sleep tests for assessment of secretion of Human Growth Hormone. Correlations between the levels of Human Growth Hormone in the serum and urine during the tests were examined to elucidate the clinical significance of urinary Human Growth Hormone levels in short children. The concentration and total amount of Human Growth Hormone in the urine correlated significantly with the peak concentration of serum Human Growth Hormone (r = 0.81, p less than 0.001 and r = 0.80, p less than 0.001, respectively) and the integrated concentration of Human Growth Hormone (r = 0.85, p less than 0.001 and r = 0.85, p less than 0.001, respectively) in the insulin-loading test. The concentration and total amount of Human Growth Hormone in the morning urine also correlated significantly with the peak concentration of serum Human Growth Hormone (r = 0.80, p less than 0.001 and r = 0.70, p less than 0.001, respectively) and the integrated concentration of serum Human Growth Hormone (r = 0.80, p less than 0.001 and r = 0.72, p less than 0.001, respectively) in the sleep test. The concentration or total amount of Human Growth Hormone in the urine differed significantly among children with Human Growth Hormone deficiency, those with nonendocrine short stature, and those with normal stature (p less than 0.05). These data suggest that measurement of Human Growth Hormone in the urine may be used to assess secretion of Human Growth Hormone, serving as a screening test for Human Growth Hormone deficiency in children.

  • Urinary excretion of Human Growth Hormone in children with short stature: Correlation with pituitary secretion of Human Growth Hormone
    The Journal of Pediatrics, 1992
    Co-Authors: K Kida, M Hayashi, Y Kaino, Y Goto, M Ikeuchi, H Matsuda
    Abstract:

    Thirty-five children with short-stature underwent insulin-loading and sleep tests for assessment of secretion of Human Growth Hormone. Correlations between the levels of Human Growth Hormone in the serum and urine during the tests were examined to elucidate the clinical significance of urinary Human Growth Hormone levels in short children. The concentration and total amount of Human Growth Hormone in the urine correlated significantly with the peak concentration of serum Human Growth Hormone ( r =0.81, p r =0.80, p r =0.85, p r =0.85, p r =0.80, p p r =0.80, p r =0.72, p p

Y Kaino - One of the best experts on this subject based on the ideXlab platform.

  • Urinary excretion of Human Growth Hormone in children with short stature: correlation with pituitary secretion of Human Growth Hormone.
    The Journal of pediatrics, 1992
    Co-Authors: K Kida, M Hayashi, Y Kaino, Y Goto, M Ikeuchi, H Matsuda
    Abstract:

    Thirty-five children with short-stature underwent insulin-loading and sleep tests for assessment of secretion of Human Growth Hormone. Correlations between the levels of Human Growth Hormone in the serum and urine during the tests were examined to elucidate the clinical significance of urinary Human Growth Hormone levels in short children. The concentration and total amount of Human Growth Hormone in the urine correlated significantly with the peak concentration of serum Human Growth Hormone (r = 0.81, p less than 0.001 and r = 0.80, p less than 0.001, respectively) and the integrated concentration of Human Growth Hormone (r = 0.85, p less than 0.001 and r = 0.85, p less than 0.001, respectively) in the insulin-loading test. The concentration and total amount of Human Growth Hormone in the morning urine also correlated significantly with the peak concentration of serum Human Growth Hormone (r = 0.80, p less than 0.001 and r = 0.70, p less than 0.001, respectively) and the integrated concentration of serum Human Growth Hormone (r = 0.80, p less than 0.001 and r = 0.72, p less than 0.001, respectively) in the sleep test. The concentration or total amount of Human Growth Hormone in the urine differed significantly among children with Human Growth Hormone deficiency, those with nonendocrine short stature, and those with normal stature (p less than 0.05). These data suggest that measurement of Human Growth Hormone in the urine may be used to assess secretion of Human Growth Hormone, serving as a screening test for Human Growth Hormone deficiency in children.

  • Urinary excretion of Human Growth Hormone in children with short stature: Correlation with pituitary secretion of Human Growth Hormone
    The Journal of Pediatrics, 1992
    Co-Authors: K Kida, M Hayashi, Y Kaino, Y Goto, M Ikeuchi, H Matsuda
    Abstract:

    Thirty-five children with short-stature underwent insulin-loading and sleep tests for assessment of secretion of Human Growth Hormone. Correlations between the levels of Human Growth Hormone in the serum and urine during the tests were examined to elucidate the clinical significance of urinary Human Growth Hormone levels in short children. The concentration and total amount of Human Growth Hormone in the urine correlated significantly with the peak concentration of serum Human Growth Hormone ( r =0.81, p r =0.80, p r =0.85, p r =0.85, p r =0.80, p p r =0.80, p r =0.72, p p