The Experts below are selected from a list of 81 Experts worldwide ranked by ideXlab platform

Jose Gutierrez - One of the best experts on this subject based on the ideXlab platform.

  • Infectious agents associated with schizophrenia: a meta-analysis.
    Schizophrenia research, 2011
    Co-Authors: Isabel Arias, Antonio Sorlozano, Enrique Villegas, Juan De Dios Luna, Kathryn Mckenney, Jorge Cervilla, Blanca Gutierrez, Jose Gutierrez
    Abstract:

    Schizophrenia is a highly disabling and limiting disorder for patients and the possibility that infections by some microorganisms may be associated to its development may allow prevention and recovery. In the current study we have done a meta-analysis of studies that have assessed the possible association between detection of different infectious agents and schizophrenia. We report results that support the idea that there is a statistically significant association between schizophrenia and infection by Human Herpesvirus 2 (OR=1.34; CI 95%: 1.09-1.70; p=0.05), Borna Disease Virus (OR=2.03; CI 95%: 1.35-3.06; p

  • Infectious agents associated with schizophrenia: a meta-analysis.
    Schizophrenia Research, 2011
    Co-Authors: Isabel Arias, Antonio Sorlozano, Enrique Villegas, Juan De Dios Luna, Kathryn Mckenney, Jorge Cervilla, Blanca Gutierrez, Jose Gutierrez
    Abstract:

    Abstract Schizophrenia is a highly disabling and limiting disorder for patients and the possibility that infections by some microorganisms may be associated to its development may allow prevention and recovery. In the current study we have done a meta-analysis of studies that have assessed the possible association between detection of different infectious agents and schizophrenia. We report results that support the idea that there is a statistically significant association between schizophrenia and infection by Human Herpesvirus 2 (OR = 1.34; CI 95%: 1.09–1.70; p  = 0.05), Borna Disease Virus (OR = 2.03; CI 95%: 1.35–3.06; p p Chlamydophila pneumoniae (OR = 6.34; CI 95%: 2.83–14.19; p Chlamydophila psittaci (OR = 29.05; CI 95%: 8.91–94.70; p Toxoplasma gondii (OR = 2.70; CI 95%: 1.34–4.42; p  = 0.005). The implications of these findings are discussed and further research options are also explicated.

Johan Neyts - One of the best experts on this subject based on the ideXlab platform.

  • Assessing the Efficacy of Cidofovir against Herpesvirus-Induced Genital Lesions in Goats Using Different Therapeutic Regimens
    Antimicrobial agents and chemotherapy, 2008
    Co-Authors: Maria Tempesta, Michele Camero, Anna Lucia Bellacicco, Elvira Tarsitano, Giuseppe Crescenzo, Vito Martella, Nicola Decaro, Johan Neyts, Canio Buonavoglia
    Abstract:

    Caprine Herpesvirus 1 (CpHV-1) infection in goats induces genital vesicular-ulcerative lesions that strictly resemble those produced by Human Herpesvirus 2 in Humans. In previous studies, the potent inhibition of CpHV-1 by cidofovir was demonstrated. Cidofovir antiherpetic activity was evaluated in goats infected experimentally by the vaginal route with CpHV-1 and then treated locally at different times after infection. The administration of 1% cidofovir cream onto vaginal mucosa was able to prevent the onset of genital lesions and to decrease significantly the titers of the virus shed by the infected animals, notably in the groups treated shortly after infection (24 and 48 h). The efficacy of cidofovir against caprine Herpesvirus infection was higher when the treatment was started shortly after infection than when lesions were already present and advanced. Herpesvirus genital infection of goats is a useful animal model to study the activity of antiviral drugs against Human Herpesvirus infections.

  • Potent inhibition of genital Herpesvirus infection in goats by cidofovir.
    Antiviral therapy, 2007
    Co-Authors: Maria Tempesta, Michele Camero, Anna Lucia Bellacicco, Elvira Tarsitano, Giuseppe Crescenzo, Julien Thiry, Vito Martella, Nicola Decaro, Gabriella Elia, Johan Neyts
    Abstract:

    Background: Like Human Herpesvirus 2 (HHV-2) in Humans, infection by caprine Herpesvirus 1 in goats is associated with genital lesions, and this provides a unique model to study the efficacy and effects of anti-herpetic drugs. Methods: The antiviral activity of cidofovir was assessed in goats infected experimentally, using various therapeutic protocols. Results: Topic administration of cidofovir 1% cream prevented the onset of virus-induced genital lesions and drastically reduced virus shedding. Conclusion: Cidofovir appears to be a very efficient drug for the prevention of genital lesions caused by an alphaHerpesvirus.

Isabel Arias - One of the best experts on this subject based on the ideXlab platform.

  • Infectious agents associated with schizophrenia: a meta-analysis.
    Schizophrenia research, 2011
    Co-Authors: Isabel Arias, Antonio Sorlozano, Enrique Villegas, Juan De Dios Luna, Kathryn Mckenney, Jorge Cervilla, Blanca Gutierrez, Jose Gutierrez
    Abstract:

    Schizophrenia is a highly disabling and limiting disorder for patients and the possibility that infections by some microorganisms may be associated to its development may allow prevention and recovery. In the current study we have done a meta-analysis of studies that have assessed the possible association between detection of different infectious agents and schizophrenia. We report results that support the idea that there is a statistically significant association between schizophrenia and infection by Human Herpesvirus 2 (OR=1.34; CI 95%: 1.09-1.70; p=0.05), Borna Disease Virus (OR=2.03; CI 95%: 1.35-3.06; p

  • Infectious agents associated with schizophrenia: a meta-analysis.
    Schizophrenia Research, 2011
    Co-Authors: Isabel Arias, Antonio Sorlozano, Enrique Villegas, Juan De Dios Luna, Kathryn Mckenney, Jorge Cervilla, Blanca Gutierrez, Jose Gutierrez
    Abstract:

    Abstract Schizophrenia is a highly disabling and limiting disorder for patients and the possibility that infections by some microorganisms may be associated to its development may allow prevention and recovery. In the current study we have done a meta-analysis of studies that have assessed the possible association between detection of different infectious agents and schizophrenia. We report results that support the idea that there is a statistically significant association between schizophrenia and infection by Human Herpesvirus 2 (OR = 1.34; CI 95%: 1.09–1.70; p  = 0.05), Borna Disease Virus (OR = 2.03; CI 95%: 1.35–3.06; p p Chlamydophila pneumoniae (OR = 6.34; CI 95%: 2.83–14.19; p Chlamydophila psittaci (OR = 29.05; CI 95%: 8.91–94.70; p Toxoplasma gondii (OR = 2.70; CI 95%: 1.34–4.42; p  = 0.005). The implications of these findings are discussed and further research options are also explicated.

Maria Tempesta - One of the best experts on this subject based on the ideXlab platform.

  • Assessing the Efficacy of Cidofovir against Herpesvirus-Induced Genital Lesions in Goats Using Different Therapeutic Regimens
    Antimicrobial agents and chemotherapy, 2008
    Co-Authors: Maria Tempesta, Michele Camero, Anna Lucia Bellacicco, Elvira Tarsitano, Giuseppe Crescenzo, Vito Martella, Nicola Decaro, Johan Neyts, Canio Buonavoglia
    Abstract:

    Caprine Herpesvirus 1 (CpHV-1) infection in goats induces genital vesicular-ulcerative lesions that strictly resemble those produced by Human Herpesvirus 2 in Humans. In previous studies, the potent inhibition of CpHV-1 by cidofovir was demonstrated. Cidofovir antiherpetic activity was evaluated in goats infected experimentally by the vaginal route with CpHV-1 and then treated locally at different times after infection. The administration of 1% cidofovir cream onto vaginal mucosa was able to prevent the onset of genital lesions and to decrease significantly the titers of the virus shed by the infected animals, notably in the groups treated shortly after infection (24 and 48 h). The efficacy of cidofovir against caprine Herpesvirus infection was higher when the treatment was started shortly after infection than when lesions were already present and advanced. Herpesvirus genital infection of goats is a useful animal model to study the activity of antiviral drugs against Human Herpesvirus infections.

  • Potent inhibition of genital Herpesvirus infection in goats by cidofovir.
    Antiviral therapy, 2007
    Co-Authors: Maria Tempesta, Michele Camero, Anna Lucia Bellacicco, Elvira Tarsitano, Giuseppe Crescenzo, Julien Thiry, Vito Martella, Nicola Decaro, Gabriella Elia, Johan Neyts
    Abstract:

    Background: Like Human Herpesvirus 2 (HHV-2) in Humans, infection by caprine Herpesvirus 1 in goats is associated with genital lesions, and this provides a unique model to study the efficacy and effects of anti-herpetic drugs. Methods: The antiviral activity of cidofovir was assessed in goats infected experimentally, using various therapeutic protocols. Results: Topic administration of cidofovir 1% cream prevented the onset of virus-induced genital lesions and drastically reduced virus shedding. Conclusion: Cidofovir appears to be a very efficient drug for the prevention of genital lesions caused by an alphaHerpesvirus.

Antonio Sorlozano - One of the best experts on this subject based on the ideXlab platform.

  • Infectious agents associated with schizophrenia: a meta-analysis.
    Schizophrenia research, 2011
    Co-Authors: Isabel Arias, Antonio Sorlozano, Enrique Villegas, Juan De Dios Luna, Kathryn Mckenney, Jorge Cervilla, Blanca Gutierrez, Jose Gutierrez
    Abstract:

    Schizophrenia is a highly disabling and limiting disorder for patients and the possibility that infections by some microorganisms may be associated to its development may allow prevention and recovery. In the current study we have done a meta-analysis of studies that have assessed the possible association between detection of different infectious agents and schizophrenia. We report results that support the idea that there is a statistically significant association between schizophrenia and infection by Human Herpesvirus 2 (OR=1.34; CI 95%: 1.09-1.70; p=0.05), Borna Disease Virus (OR=2.03; CI 95%: 1.35-3.06; p

  • Infectious agents associated with schizophrenia: a meta-analysis.
    Schizophrenia Research, 2011
    Co-Authors: Isabel Arias, Antonio Sorlozano, Enrique Villegas, Juan De Dios Luna, Kathryn Mckenney, Jorge Cervilla, Blanca Gutierrez, Jose Gutierrez
    Abstract:

    Abstract Schizophrenia is a highly disabling and limiting disorder for patients and the possibility that infections by some microorganisms may be associated to its development may allow prevention and recovery. In the current study we have done a meta-analysis of studies that have assessed the possible association between detection of different infectious agents and schizophrenia. We report results that support the idea that there is a statistically significant association between schizophrenia and infection by Human Herpesvirus 2 (OR = 1.34; CI 95%: 1.09–1.70; p  = 0.05), Borna Disease Virus (OR = 2.03; CI 95%: 1.35–3.06; p p Chlamydophila pneumoniae (OR = 6.34; CI 95%: 2.83–14.19; p Chlamydophila psittaci (OR = 29.05; CI 95%: 8.91–94.70; p Toxoplasma gondii (OR = 2.70; CI 95%: 1.34–4.42; p  = 0.005). The implications of these findings are discussed and further research options are also explicated.