The Experts below are selected from a list of 44184 Experts worldwide ranked by ideXlab platform
Walter Giger - One of the best experts on this subject based on the ideXlab platform.
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occurrence and sorption behavior of sulfonamides macrolides and trimethoprim in activated sludge treatment
Environmental Science & Technology, 2005Co-Authors: Anke Gobel, Angela Thomsen, Christa S Mcardell, And Adriano Joss, Walter GigerAbstract:The occurrence of sulfonamide and macrolide antimicrobials, as well as trimethoprim, was investigated in conventional activated sludge treatment. Average daily loads in untreated wastewater correlated well with those estimated from annual consumption data and pharmacokinetic behavior. Considerable variations were found during a day, and seasonal differences seem to occur for the macrolides, probably caused by a higher consumption of these substances in winter. The most predominant macrolide and sulfonamide antimicrobials were clarithromycin and sulfamethoxazole, respectively. In the case of sulfamethoxazole, the main Human Metabolite, N4-acetylsulfamethoxazole, was included as an analyte, accounting for up to 86% of the total load in untreated wastewater. The results obtained illustrate the importance of considering retransformable substances, for example Human Metabolites, when investigating the behavior and fate of pharmaceuticals. Average concentrations of sulfapyridine, sulfamethoxazole, trimethoprim,...
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trace determination of macrolide and sulfonamide antimicrobials a Human sulfonamide Metabolite and trimethoprim in wastewater using liquid chromatography coupled to electrospray tandem mass spectrometry
Analytical Chemistry, 2004Co-Authors: Anke Gobel, Christa S Mcardell, Marc J F Suter, Walter GigerAbstract:An analytical method has been developed and validated for the simultaneous trace determination of four macrolide antibiotics, six sulfonamides, the Human Metabolite N4-acetylsulfamethoxazole, and trimethoprim in wastewater. The method was validated for tertiary, secondary, andunlike in previously published methodsalso for primary effluents of municipal wastewater treatment plants. This wide range of application is necessary to thoroughly investigate the occurrence and fate of chemicals in wastewater treatment. Wastewater samples were enriched by solid-phase extraction, followed by reversed-phase liquid chromatography coupled to tandem mass spectrometry using positive electrospray ionization. Recoveries from all sample matrixes were generally above 80%, and the combined measurement uncertainty varied between 2 and 18%. Concentrations measured in tertiary effluents ranged between 10 ng/L for roxithromycin and 423 ng/L for sulfamethoxazole. Corresponding levels in primary effluents varied from 22 to 1450 ng/...
Min Song - One of the best experts on this subject based on the ideXlab platform.
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removal of sulfonamide antibiotics and Human Metabolite by biochar and biochar h2o2 in synthetic urine
Water Research, 2018Co-Authors: Peizhe Sun, Tan Meng, Ruochun Zhang, Min Song, Jing RenAbstract:Source-separated urine has been increasingly regarded as a promising alternative waste-stream for effectively removing pharmaceuticals and Human Metabolites. This study investigated the removal of sulfonamide antibiotics, one category among the most frequently detected antibiotics in the environment, by biochar and biochar/H2O2 in synthetic urine matrix. The adsorption and degradation of four parent sulfonamide antibiotics, including sulfamethoxazole, sulfadiazine, sulfamethazine, sulfadimethoxine, and one Human Metabolite, N4-acetyl-sulfamethoxazole (together referred as SAs) were investigated. Biochar derived from cotton straw was applied as adsorbent for SAs and catalyst for H2O2. Results showed that the adsorption of SAs was inhibited in urine compared with that in phosphate buffer solution. Bicarbonate in urine placed major influence. Langmuir isotherm model well described the adsorption process in both buffer and urine matrices. Adsorption and desorption rates were estimated by a kinetic model, which well fitted the removal of SAs from aqueous phase at various biochar doses. The adsorption of SAs on biochar was due to multiple forces, in which van der Waals forces and hydrophobicity played major roles in distinguishing the sorption behavior of different SAs. To destruct the SAs, H2O2 was added with biochar. Except for N4-acetyl-sulfamethoxazole, all the parent SAs can be degraded in urine matrix. Carbonate radical, produced from the activation of peroxymonocarbonate by biochar, was proposed to be the major contributing reactive species in biochar/H2O2 system in urine matrix.
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Removal of sulfonamide antibiotics and Human Metabolite by biochar and biochar/H2O2 in synthetic urine.
Water Research, 2018Co-Authors: Yaxiu Li, Tan Meng, Ruochun Zhang, Min SongAbstract:Abstract Source-separated urine has been increasingly regarded as a promising alternative waste-stream for effectively removing pharmaceuticals and Human Metabolites. This study investigated the removal of sulfonamide antibiotics, one category among the most frequently detected antibiotics in the environment, by biochar and biochar/H2O2 in synthetic urine matrix. The adsorption and degradation of four parent sulfonamide antibiotics, including sulfamethoxazole, sulfadiazine, sulfamethazine, sulfadimethoxine, and one Human Metabolite, N4-acetyl-sulfamethoxazole (together referred as SAs) were investigated. Biochar derived from cotton straw was applied as adsorbent for SAs and catalyst for H2O2. Results showed that the adsorption of SAs was inhibited in urine compared with that in phosphate buffer solution. Bicarbonate in urine placed major influence. Langmuir isotherm model well described the adsorption process in both buffer and urine matrices. Adsorption and desorption rates were estimated by a kinetic model, which well fitted the removal of SAs from aqueous phase at various biochar doses. The adsorption of SAs on biochar was due to multiple forces, in which van der Waals forces and hydrophobicity played major roles in distinguishing the sorption behavior of different SAs. To destruct the SAs, H2O2 was added with biochar. Except for N4-acetyl-sulfamethoxazole, all the parent SAs can be degraded in urine matrix. Carbonate radical, produced from the activation of peroxymonocarbonate by biochar, was proposed to be the major contributing reactive species in biochar/H2O2 system in urine matrix.
Doheon Lee - One of the best experts on this subject based on the ideXlab platform.
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A systematic approach to identify therapeutic effects of natural products based on Human Metabolite information
BMC Bioinformatics, 2018Co-Authors: Kyungrin Noh, Sunyong Yoo, Doheon LeeAbstract:Background Natural products have been widely investigated in the drug development field. Their traditional use cases as medicinal agents and their resemblance of our endogenous compounds show the possibility of new drug development. Many researchers have focused on identifying therapeutic effects of natural products, yet the resemblance of natural products and Human Metabolites has been rarely touched. Methods We propose a novel method which predicts therapeutic effects of natural products based on their similarity with Human Metabolites. In this study, we compare the structure, target and phenotype similarities between natural products and Human Metabolites to capture molecular and phenotypic properties of both compounds. With the generated similarity features, we train support vector machine model to identify similar natural product and Human Metabolite pairs. The known functions of Human Metabolites are then mapped to the paired natural products to predict their therapeutic effects. Results With our selected three feature sets, structure, target and phenotype similarities, our trained model successfully paired similar natural products and Human Metabolites. When applied to the natural product derived drugs, we could successfully identify their indications with high specificity and sensitivity. We further validated the found therapeutic effects of natural products with the literature evidence. Conclusions These results suggest that our model can match natural products to similar Human Metabolites and provide possible therapeutic effects of natural products. By utilizing the similar Human Metabolite information, we expect to find new indications of natural products which could not be covered by previous in silico methods.
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A systematic approach to identify therapeutic effects of natural products based on Human Metabolite information
BMC Bioinformatics, 2018Co-Authors: Kyungrin Noh, Sunyong Yoo, Doheon LeeAbstract:Natural products have been widely investigated in the drug development field. Their traditional use cases as medicinal agents and their resemblance of our endogenous compounds show the possibility of new drug development. Many researchers have focused on identifying therapeutic effects of natural products, yet the resemblance of natural products and Human Metabolites has been rarely touched. We propose a novel method which predicts therapeutic effects of natural products based on their similarity with Human Metabolites. In this study, we compare the structure, target and phenotype similarities between natural products and Human Metabolites to capture molecular and phenotypic properties of both compounds. With the generated similarity features, we train support vector machine model to identify similar natural product and Human Metabolite pairs. The known functions of Human Metabolites are then mapped to the paired natural products to predict their therapeutic effects. With our selected three feature sets, structure, target and phenotype similarities, our trained model successfully paired similar natural products and Human Metabolites. When applied to the natural product derived drugs, we could successfully identify their indications with high specificity and sensitivity. We further validated the found therapeutic effects of natural products with the literature evidence. These results suggest that our model can match natural products to similar Human Metabolites and provide possible therapeutic effects of natural products. By utilizing the similar Human Metabolite information, we expect to find new indications of natural products which could not be covered by previous in silico methods.
Anke Gobel - One of the best experts on this subject based on the ideXlab platform.
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occurrence and sorption behavior of sulfonamides macrolides and trimethoprim in activated sludge treatment
Environmental Science & Technology, 2005Co-Authors: Anke Gobel, Angela Thomsen, Christa S Mcardell, And Adriano Joss, Walter GigerAbstract:The occurrence of sulfonamide and macrolide antimicrobials, as well as trimethoprim, was investigated in conventional activated sludge treatment. Average daily loads in untreated wastewater correlated well with those estimated from annual consumption data and pharmacokinetic behavior. Considerable variations were found during a day, and seasonal differences seem to occur for the macrolides, probably caused by a higher consumption of these substances in winter. The most predominant macrolide and sulfonamide antimicrobials were clarithromycin and sulfamethoxazole, respectively. In the case of sulfamethoxazole, the main Human Metabolite, N4-acetylsulfamethoxazole, was included as an analyte, accounting for up to 86% of the total load in untreated wastewater. The results obtained illustrate the importance of considering retransformable substances, for example Human Metabolites, when investigating the behavior and fate of pharmaceuticals. Average concentrations of sulfapyridine, sulfamethoxazole, trimethoprim,...
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trace determination of macrolide and sulfonamide antimicrobials a Human sulfonamide Metabolite and trimethoprim in wastewater using liquid chromatography coupled to electrospray tandem mass spectrometry
Analytical Chemistry, 2004Co-Authors: Anke Gobel, Christa S Mcardell, Marc J F Suter, Walter GigerAbstract:An analytical method has been developed and validated for the simultaneous trace determination of four macrolide antibiotics, six sulfonamides, the Human Metabolite N4-acetylsulfamethoxazole, and trimethoprim in wastewater. The method was validated for tertiary, secondary, andunlike in previously published methodsalso for primary effluents of municipal wastewater treatment plants. This wide range of application is necessary to thoroughly investigate the occurrence and fate of chemicals in wastewater treatment. Wastewater samples were enriched by solid-phase extraction, followed by reversed-phase liquid chromatography coupled to tandem mass spectrometry using positive electrospray ionization. Recoveries from all sample matrixes were generally above 80%, and the combined measurement uncertainty varied between 2 and 18%. Concentrations measured in tertiary effluents ranged between 10 ng/L for roxithromycin and 423 ng/L for sulfamethoxazole. Corresponding levels in primary effluents varied from 22 to 1450 ng/...
Jing Ren - One of the best experts on this subject based on the ideXlab platform.
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removal of sulfonamide antibiotics and Human Metabolite by biochar and biochar h2o2 in synthetic urine
Water Research, 2018Co-Authors: Peizhe Sun, Tan Meng, Ruochun Zhang, Min Song, Jing RenAbstract:Source-separated urine has been increasingly regarded as a promising alternative waste-stream for effectively removing pharmaceuticals and Human Metabolites. This study investigated the removal of sulfonamide antibiotics, one category among the most frequently detected antibiotics in the environment, by biochar and biochar/H2O2 in synthetic urine matrix. The adsorption and degradation of four parent sulfonamide antibiotics, including sulfamethoxazole, sulfadiazine, sulfamethazine, sulfadimethoxine, and one Human Metabolite, N4-acetyl-sulfamethoxazole (together referred as SAs) were investigated. Biochar derived from cotton straw was applied as adsorbent for SAs and catalyst for H2O2. Results showed that the adsorption of SAs was inhibited in urine compared with that in phosphate buffer solution. Bicarbonate in urine placed major influence. Langmuir isotherm model well described the adsorption process in both buffer and urine matrices. Adsorption and desorption rates were estimated by a kinetic model, which well fitted the removal of SAs from aqueous phase at various biochar doses. The adsorption of SAs on biochar was due to multiple forces, in which van der Waals forces and hydrophobicity played major roles in distinguishing the sorption behavior of different SAs. To destruct the SAs, H2O2 was added with biochar. Except for N4-acetyl-sulfamethoxazole, all the parent SAs can be degraded in urine matrix. Carbonate radical, produced from the activation of peroxymonocarbonate by biochar, was proposed to be the major contributing reactive species in biochar/H2O2 system in urine matrix.