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Joakim Dillner - One of the best experts on this subject based on the ideXlab platform.

  • Primary screening for Human Papillomavirus infection
    Best practice & research. Clinical obstetrics & gynaecology, 2001
    Co-Authors: Joakim Dillner
    Abstract:

    As Human penisme/topic-papillomavirus/">Papillomavirus infection is now known to be a necessary penisme/topic-risk/">risk factor for at least 95% of cervical cancers, the medical community has a responsibility to assess and evaluate how this knowledge should best be used for the prevention of cervical cancer. Organized screening strategies combining cytological screening with Human penisme/topic-papillomavirus/">Papillomavirus testing in older age groups could theoretically be more sensitive than current screening programmes in reducing the incidence of cervical cancer. If it is possible safely to extend the screening interval in Human penisme/topic-papillomavirus/">Papillomavirus-negative women, such programmes could also both be more effective and more cost-efficient. Although some modelling studies have indicated that this could indeed be the case, evidence from clinical trials evaluating the long-term protective effect of primary Human penisme/topic-papillomavirus/">Papillomavirus screening is still lacking. The key issues on the research agenda for primary Human penisme/topic-papillomavirus/">Papillomavirus screening are reviewed.

  • Conization for cervical intraepithelial neoplasia is followed by disappearance of Human Papillomavirus deoxyribonucleic acid and a decline in serum and cervical mucus antibodies against Human Papillomavirus antigens.
    American journal of obstetrics and gynecology, 1996
    Co-Authors: Kristina Elfgren, Peter Bistoletti, Lena Dillner, Jan M. M. Walboomers, Chris J.l.m. Meijer, Joakim Dillner
    Abstract:

    Abstract OBJECTIVE: Our purpose was to investigate whether conization for cervical intraepithelial neoplasia eliminates Human penisme/topic-papillomavirus/">Papillomavirus deoxyribonucleic acid and affects the levels of serum and cervical mucus antibodies against Human penisme/topic-papillomavirus/">Papillomavirus antigens. penisme/topic-study-design/">STUDY DESIGN: Analysis of paired cervical brush and serum samples taken from 23 women with cervical intraepithelial neoplasia before and 16 to 27 months after conization was performed for presence of Human penisme/topic-papillomavirus/">Papillomavirus deoxyribonucleic acid by polymerase chain reaction and for Human penisme/topic-papillomavirus/">Papillomavirus antibodies by enzyme-linked immunosorbent assay. RESULTS: Four women had recurrent cervical intraepithelial neoplasia, whereas 19 women were disease free. Eighteen of 23 women were positive for Human penisme/topic-papillomavirus/">Papillomavirus deoxyribonucleic acid before treatment. At follow-up only the 4 women with recurrent cervical intraepithelial neoplasia were positive. Serum immunoglobulin G levels and A levels and immunoglobulin A levels in cervical mucus against most of the tested Human penisme/topic-papillomavirus/">Papillomavirus antigens had declined at follow-up. CONCLUSIONS: Human penisme/topic-papillomavirus/">Papillomavirus deoxyribonucleic acid was regularly eliminated and Human penisme/topic-papillomavirus/">Papillomavirus antibody levels, especially local immunoglobulin A, declined after efficient treatment, suggesting that conization may be effective for treating the underlying Human penisme/topic-papillomavirus/">Papillomavirus infection. (AM J OBSTET GYNECOL 1996;174:937-42.)

Elizabeth A Baker - One of the best experts on this subject based on the ideXlab platform.

  • negative emotions and stigma associated with a Human Papillomavirus test result a comparison between Human Papillomavirus positive men and women
    Journal of Health Psychology, 2015
    Co-Authors: Ellen M Daley, Christopher W. Wheldon, Cheryl A Vamos, Stephanie K Kolar, Elizabeth A Baker
    Abstract:

    Human penisme/topic-papillomavirus/">Papillomavirus has largely been framed as a women’s health issue, and the psychosocial impact of Human penisme/topic-papillomavirus/">Papillomavirus among men remains unclear. In this study, we found that women infected with Human penisme/topic-papillomavirus/">Papillomavirus (n = 154) experienced a greater degree of negative emotions and stigma than Human penisme/topic-papillomavirus/">Papillomavirus–infected men (n = 190). Among women, younger age and less education were associated with greater expression of negative emotions and stigma. Conversely, being single was significantly associated with a greater degree of negative emotions and stigma beliefs among men. These findings suggest the need to re-frame messages that both men and women receive regarding Human penisme/topic-papillomavirus/">Papillomavirus.

  • Negative emotions and stigma associated with a Human Papillomavirus test result: A comparison between Human Papillomavirus–positive men and women
    Journal of health psychology, 2013
    Co-Authors: Ellen M Daley, Christopher W. Wheldon, Cheryl A Vamos, Stephanie K Kolar, Elizabeth A Baker
    Abstract:

    Human penisme/topic-papillomavirus/">Papillomavirus has largely been framed as a women's health issue, and the psychosocial impact of Human penisme/topic-papillomavirus/">Papillomavirus among men remains unclear. In this study, we found that women infected with Human penisme/topic-papillomavirus/">Papillomavirus (n = 154) experienced a greater degree of negative emotions and stigma than Human penisme/topic-papillomavirus/">Papillomavirus-infected men (n = 190). Among women, younger age and less education were associated with greater expression of negative emotions and stigma. Conversely, being single was significantly associated with a greater degree of negative emotions and stigma beliefs among men. These findings suggest the need to re-frame messages that both men and women receive regarding Human penisme/topic-papillomavirus/">Papillomavirus.

S. Gerber - One of the best experts on this subject based on the ideXlab platform.

  • Clinical follow-up of women infected with Human Papillomavirus-16, either alone or with other Human Papillomavirus types: identification of different risk groups.
    American Journal of Obstetrics and Gynecology, 2009
    Co-Authors: Olivier Cottier, Roland Sahli, Anca Mihaescu, Pierre De Grandi, Michel Boulvain, S. Gerber
    Abstract:

    Objectives Evaluation of the clinical impact of multiple infections of the cervix by Human penisme/topic-papillomavirus/">Papillomavirus, including Human penisme/topic-papillomavirus/">Papillomavirus-16, compared with single Human penisme/topic-papillomavirus/">Papillomavirus-16 infection. penisme/topic-study-design/">Study Design One hundred sixty-nine women were classified in 3 categories depending on their Human penisme/topic-papillomavirus/">Papillomavirus profile: Human penisme/topic-papillomavirus/">Papillomavirus-16 only, Human penisme/topic-papillomavirus/">Papillomavirus-16 and low-penisme/topic-risk/">risk type(s), and Human penisme/topic-papillomavirus/">Papillomavirus-16 and other high-penisme/topic-risk/">risk type(s). Cervical brush samples were analyzed for Human penisme/topic-papillomavirus/">Papillomavirus DNA by polymerase chain reaction and reverse line blot hybridization. All women were evaluated with colposcopy during 24 months or more. Management was according to the Bethesda recommendations. Results Women infected with Human penisme/topic-papillomavirus/">Papillomavirus-16 and other high-penisme/topic-risk/">risk Human penisme/topic-papillomavirus/">Papillomavirus type(s) presented more progression or no change in the grade of dysplasia, compared with women of the other groups (relative penisme/topic-risk/">risk [RR], 1.39; 95% confidence interval [CI], 1.07-1.82; P = .02 at 6 months; RR, 2.10; 95% CI, 1.46-3.02; P P = .004 at 24 months). Conclusion Coinfection of women with Human penisme/topic-papillomavirus/">Papillomavirus-16 and other high-penisme/topic-risk/">risk Human penisme/topic-papillomavirus/">Papillomavirus type(s) increases the penisme/topic-risk/">risk of unfavorable evolution.

  • Clinical follow-up of women infected with Human Papillomavirus-16, either alone or with other Human Papillomavirus types: identification of different risk groups.
    American journal of obstetrics and gynecology, 2009
    Co-Authors: Olivier Cottier, Roland Sahli, Anca Mihaescu, Pierre De Grandi, Michel Boulvain, S. Gerber
    Abstract:

    Evaluation of the clinical impact of multiple infections of the cervix by Human penisme/topic-papillomavirus/">Papillomavirus, including Human penisme/topic-papillomavirus/">Papillomavirus-16, compared with single Human penisme/topic-papillomavirus/">Papillomavirus-16 infection. One hundred sixty-nine women were classified in 3 categories depending on their Human penisme/topic-papillomavirus/">Papillomavirus profile: Human penisme/topic-papillomavirus/">Papillomavirus-16 only, Human penisme/topic-papillomavirus/">Papillomavirus-16 and low-penisme/topic-risk/">risk type(s), and Human penisme/topic-papillomavirus/">Papillomavirus-16 and other high-penisme/topic-risk/">risk type(s). Cervical brush samples were analyzed for Human penisme/topic-papillomavirus/">Papillomavirus DNA by polymerase chain reaction and reverse line blot hybridization. All women were evaluated with colposcopy during 24 months or more. Management was according to the Bethesda recommendations. Women infected with Human penisme/topic-papillomavirus/">Papillomavirus-16 and other high-penisme/topic-risk/">risk Human penisme/topic-papillomavirus/">Papillomavirus type(s) presented more progression or no change in the grade of dysplasia, compared with women of the other groups (relative penisme/topic-risk/">risk [RR], 1.39; 95% confidence interval [CI], 1.07-1.82; P = .02 at 6 months; RR, 2.10; 95% CI, 1.46-3.02; P < .001 at 12 months; RR, 1.82; 95% CI, 1.21-2.72; P = .004 at 24 months). Coinfection of women with Human penisme/topic-papillomavirus/">Papillomavirus-16 and other high-penisme/topic-risk/">risk Human penisme/topic-papillomavirus/">Papillomavirus type(s) increases the penisme/topic-risk/">risk of unfavorable evolution.

Minerva Becker - One of the best experts on this subject based on the ideXlab platform.

  • apparent diffusion coefficient histograms of Human Papillomavirus positive and Human Papillomavirus negative head and neck squamous cell carcinoma assessment of tumor heterogeneity and comparison with histopathology
    American Journal of Neuroradiology, 2017
    Co-Authors: T De Perrot, Vincent Lenoir, Domingo M Ayllon, Nicolas Dulguerov, Marc Pusztaszeri, Minerva Becker
    Abstract:

    BACKGROUND AND PURPOSE: Head and neck penisme/topic-squamous-cell/">squamous cell carcinoma associated with Human penisme/topic-papillomavirus/">Papillomavirus infection represents a distinct tumor entity. We hypothesized that diffusion phenotypes based on the histogram analysis of ADC values reflect distinct degrees of tumor heterogeneity in Human penisme/topic-papillomavirus/">Papillomavirus–positive and Human penisme/topic-papillomavirus/">Papillomavirus–negative head and neck penisme/topic-squamous-cell/">squamous cell carcinomas. MATERIALS AND METHODS: One hundred five consecutive patients (mean age, 64 years; range, 45–87 years) with primary oropharyngeal ( n = 52) and oral cavity ( n = 53) head and neck penisme/topic-squamous-cell/">squamous cell carcinoma underwent MR imaging with anatomic and diffusion-weighted sequences ( b = 0, b = 1000 s/mm 2 , monoexponential ADC calculation). The collected tumor voxels from the contoured ROIs provided histograms from which position, dispersion, and form parameters were computed. Histogram data were correlated with histopathology, p16-immunohistochemistry, and polymerase chain reaction for Human penisme/topic-papillomavirus/">Papillomavirus DNA. RESULTS: There were 21 Human penisme/topic-papillomavirus/">Papillomavirus–positive and 84 Human penisme/topic-papillomavirus/">Papillomavirus–negative head and neck penisme/topic-squamous-cell/">squamous cell carcinomas. At histopathology, Human penisme/topic-papillomavirus/">Papillomavirus–positive cancers were more often nonkeratinizing (13/21, 62%) than Human penisme/topic-papillomavirus/">Papillomavirus–negative cancers (19/84, 23%; P = .001), and their mitotic index was higher (71% versus 49%; P = .005). ROI-based mean and median ADCs were significantly lower in Human penisme/topic-papillomavirus/">Papillomavirus–positive (1014 ± 178 × 10 −6 mm 2 /s and 970 ± 187 × 10 −6 mm 2 /s, respectively) than in Human penisme/topic-papillomavirus/">Papillomavirus–negative tumors (1184 ± 168 × 10 −6 mm 2 /s and 1161 ± 175 × 10 −6 mm 2 /s, respectively; P P CONCLUSIONS: Diffusion phenotypes of Human penisme/topic-papillomavirus/">Papillomavirus–positive and Human penisme/topic-papillomavirus/">Papillomavirus–negative head and neck penisme/topic-squamous-cell/">squamous cell carcinomas show significant differences, which reflect their distinct degree of tumor heterogeneity.

  • Apparent Diffusion Coefficient Histograms of Human Papillomavirus–Positive and Human Papillomavirus–Negative Head and Neck Squamous Cell Carcinoma: Assessment of Tumor Heterogeneity and Comparison with Histopathology
    AJNR. American journal of neuroradiology, 2017
    Co-Authors: T De Perrot, Vincent Lenoir, Nicolas Dulguerov, Marc Pusztaszeri, M. Domingo Ayllón, Minerva Becker
    Abstract:

    BACKGROUND AND PURPOSE: Head and neck penisme/topic-squamous-cell/">squamous cell carcinoma associated with Human penisme/topic-papillomavirus/">Papillomavirus infection represents a distinct tumor entity. We hypothesized that diffusion phenotypes based on the histogram analysis of ADC values reflect distinct degrees of tumor heterogeneity in Human penisme/topic-papillomavirus/">Papillomavirus–positive and Human penisme/topic-papillomavirus/">Papillomavirus–negative head and neck penisme/topic-squamous-cell/">squamous cell carcinomas. MATERIALS AND METHODS: One hundred five consecutive patients (mean age, 64 years; range, 45–87 years) with primary oropharyngeal ( n = 52) and oral cavity ( n = 53) head and neck penisme/topic-squamous-cell/">squamous cell carcinoma underwent MR imaging with anatomic and diffusion-weighted sequences ( b = 0, b = 1000 s/mm 2 , monoexponential ADC calculation). The collected tumor voxels from the contoured ROIs provided histograms from which position, dispersion, and form parameters were computed. Histogram data were correlated with histopathology, p16-immunohistochemistry, and polymerase chain reaction for Human penisme/topic-papillomavirus/">Papillomavirus DNA. RESULTS: There were 21 Human penisme/topic-papillomavirus/">Papillomavirus–positive and 84 Human penisme/topic-papillomavirus/">Papillomavirus–negative head and neck penisme/topic-squamous-cell/">squamous cell carcinomas. At histopathology, Human penisme/topic-papillomavirus/">Papillomavirus–positive cancers were more often nonkeratinizing (13/21, 62%) than Human penisme/topic-papillomavirus/">Papillomavirus–negative cancers (19/84, 23%; P = .001), and their mitotic index was higher (71% versus 49%; P = .005). ROI-based mean and median ADCs were significantly lower in Human penisme/topic-papillomavirus/">Papillomavirus–positive (1014 ± 178 × 10 −6 mm 2 /s and 970 ± 187 × 10 −6 mm 2 /s, respectively) than in Human penisme/topic-papillomavirus/">Papillomavirus–negative tumors (1184 ± 168 × 10 −6 mm 2 /s and 1161 ± 175 × 10 −6 mm 2 /s, respectively; P P CONCLUSIONS: Diffusion phenotypes of Human penisme/topic-papillomavirus/">Papillomavirus–positive and Human penisme/topic-papillomavirus/">Papillomavirus–negative head and neck penisme/topic-squamous-cell/">squamous cell carcinomas show significant differences, which reflect their distinct degree of tumor heterogeneity.

Silvia Franceschi - One of the best experts on this subject based on the ideXlab platform.

  • Human Papillomavirus and cervical cancer.
    Lancet (London England), 2013
    Co-Authors: Emma J. Crosbie, Mark H. Einstein, Silvia Franceschi, Henry C Kitchener
    Abstract:

    Cervical cancer is caused by Human penisme/topic-papillomavirus/">Papillomavirus infection. Most Human penisme/topic-papillomavirus/">Papillomavirus infection is harmless and clears spontaneously but persistent infection with high-penisme/topic-risk/">risk Human penisme/topic-papillomavirus/">Papillomavirus (especially type 16) can cause cancer of the cervix, penisme/topic-vulva/">vulva, vagina, anus, penis, and oropharynx. The virus exclusively infects epithelium and produces new viral particles only in fully mature epithelial cells. Human penisme/topic-papillomavirus/">Papillomavirus disrupts normal cell-cycle control, promoting uncontrolled cell division and the accumulation of genetic damage. Two effective prophylactic vaccines composed of Human penisme/topic-papillomavirus/">Papillomavirus type 16 and 18, and Human penisme/topic-papillomavirus/">Papillomavirus type 16, 18, 6, and 11 virus-like particles have been introduced in many developed countries as a primary prevention strategy. Human penisme/topic-papillomavirus/">Papillomavirus testing is clinically valuable for secondary prevention in triaging low-grade cytology and as a test of cure after treatment. More sensitive than cytology, primary screening by Human penisme/topic-papillomavirus/">Papillomavirus testing could enable screening intervals to be extended. If these prevention strategies can be implemented in developing countries, many thousands of lives could be saved.

  • Human Papillomavirus vaccines in HIV-positive men and women.
    Current opinion in oncology, 2007
    Co-Authors: Hugo De Vuyst, Silvia Franceschi
    Abstract:

    PURPOSE OF REVIEW Individuals with HIV are at greater penisme/topic-risk/">risk of Human penisme/topic-papillomavirus/">Papillomavirus-related cancers. This report will assess the potential and limitations of vaccines against Human penisme/topic-papillomavirus/">Papillomavirus in HIV-positive individuals. RECENT FINDINGS A worldwide meta-analysis of published data established the under-representation of HPV16, and increased prevalence of multiple-type Human penisme/topic-papillomavirus/">Papillomavirus infections in HIV-positive women. Associations between HIV-related immunodepression, the progression of Human penisme/topic-papillomavirus/">Papillomavirus infection to cervical lesions, and an increased penisme/topic-risk/">risk of cervical cancer in women with HIV have also been shown. An increased incidence of Human penisme/topic-papillomavirus/">Papillomavirus infection in anal and penisme/topic-vulva/">vulvar/vaginal neoplasia has been reported in individuals with HIV. A prophylactic vaccine against HPV6, 11, 16 and 18 has been licensed, and one against HPV16 and 18 is under evaluation. Both have shown efficacy against persistent infection, as well as related Human penisme/topic-papillomavirus/">Papillomavirus cervical lesions for up to 5 years. Preliminary results have also been reported on therapeutic vaccines, notably for the treatment of cervical intraepithelial neoplasia grades 2 and 3. SUMMARY The safety and efficacy of Human penisme/topic-papillomavirus/">Papillomavirus vaccines in individuals with HIV need to be assessed to prevent cervical cancer in current and future generations. Screening for Human penisme/topic-papillomavirus/">Papillomavirus-related cancer among HIV patients should be undertaken.

  • Prevalence and determinants of Human Papillomavirus genital infection in men.
    British journal of cancer, 2002
    Co-Authors: Silvia Franceschi, Xavier Castellsagué, L. Dal Maso, Jennifer S. Smith, M Plummer, C Ngelangel, S Chichareon, José Eluf-neto, Keerti V. Shah, P J F Snijders
    Abstract:

    Four-hundred-forty-five husbands of women with invasive cervical carcinoma, 165 of women with in situ cervical cancer, and 717 of control women (age range 19–82 years) were interviewed and a sample of exfoliated cells from the penis obtained in seven case–control studies conducted by the International Agency for Research on Cancer. The characteristics of Human penisme/topic-papillomavirus/">Papillomavirus-positive and Human penisme/topic-papillomavirus/">Papillomavirus-negative husbands were compared using odds ratios and 95% confidence intervals. Thirteen per cent of the husbands of control women, 18% of the husbands of women with invasive cervical carcinoma, and 21% of the husbands of in situ cervical carcinoma women were positive for penile Human penisme/topic-papillomavirus/">Papillomavirus DNA. Human penisme/topic-papillomavirus/">Papillomavirus 16 was detected in 45 husbands, Human penisme/topic-papillomavirus/">Papillomavirus 18, 31 or 33 in 19, and Human penisme/topic-papillomavirus/">Papillomavirus 6/11 in 6, but the majority of Human penisme/topic-papillomavirus/">Papillomavirus infection (158) was with other or unspecified Human penisme/topic-papillomavirus/">Papillomavirus types. The same Human penisme/topic-papillomavirus/">Papillomavirus type was seldom identified in both husband and wife. The strongest variation in penile Human penisme/topic-papillomavirus/">Papillomavirus infection was by country, with percentages among the husbands of control women ranging between 3% in Spain and 39% in Brazil. Having had over 50 lifetime sexual partners, compared with only one, was associated with an odds ratio of 2.3. British Journal of Cancer (2002) 86, 705–711. DOI: 10.1038/sj/bjc/6600194 www.bjcancer.com © 2002 Cancer Research UK