The Experts below are selected from a list of 930 Experts worldwide ranked by ideXlab platform
Shepo Shi - One of the best experts on this subject based on the ideXlab platform.
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enzymatic synthesis of 2 hydroxy 4h quinolizin 4 one scaffolds by integrating coenzyme a ligases and a type iii pks from Huperzia serrata
RSC Advances, 2020Co-Authors: Juan Wang, Ning Ding, Xiao Liu, Xiaohui Wang, Xiaoping Shi, Shepo ShiAbstract:2-Hydroxy-4H-quinolizin-4-one scaffolds were enzymatically synthesized by integrating three enzymes including phenylacetate-CoA ligase (PcPCL) from an endophytic fungus Penicillium chrysogenum MT-12, malonyl-CoA synthase (AtMatB) from Arabidopsis thaliana, and a type III polyketide synthase (HsPKS3) from Chinese club moss Huperzia serrata. The findings paved the way to produce these kinds of structurally interesting alkaloids by engineered microorganisms.
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lycopodium alkaloids from Huperzia serrata
Fitoterapia, 2019Co-Authors: Fangfang Jiang, Ning Ding, Hongyun Yang, Fangfang Jia, Yuan Luo, Juan Wang, Xiao Liu, Xiaohui Wang, Shepo ShiAbstract:Abstract Five new Lycopodium alkaloids, huperzine Y1 (1), huperzine Y2 (2), huperzine Y3 (3), (+)-huperzine Z (4a) and (−)-huperzine Z (4b) as well as ten known alkaloids (5–14) were isolated from Huperzia serrata. The structures of the new compounds were established using extensive spectroscopic (1D and 2D NMR, IR, and HRESIMS) and calculated electronic circular dichroism (ECD) methods. Compounds 4a and 4b were a pair of enantiomers successfully separated by chiral HPLC resolution. Compounds 2 and 3 indicated inhibitory activities against acetylcholinesterase with IC50 value of 57.1 ± 1.6 and 32.7 ± 1.0 μΜ, respectively. However, no compound showed inhibitory effect on butyrocholinesterase at the concentration of 100 μΜ.
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polyketides from alternaria alternata mt 47 an endophytic fungus isolated from Huperzia serrata
Fitoterapia, 2019Co-Authors: Hongyun Yang, Fangfang Jiang, Ning Ding, Fangfang Jia, Yuan Luo, Xiao Liu, Lili Wang, Zhixiang Zhu, Shepo ShiAbstract:Abstract Four new polyketides, alternatains A-D (1–4), along with 17 known compounds (5–21) were obtained from the solid substrate fermentation cultures of Alternaria alternata MT-47, an endophytic fungus isolated from the medicinal plant of Huperzia serrata. Their structures were elucidated by extensive spectroscopic and spectrometric techniques (1D and 2D NMR, IR, and HRESIMS) and calculated electronic circular dichroism (ECD) method. Compounds 4, 6, 15, and 21 exhibited inhibitory activities on ATP release of thrombin-activated platelets with IC50 values in the range of 18.2–68.8 μM.
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synthesis of unnatural 2 substituted quinolones and 1 3 diketones by a member of type iii polyketide synthases from Huperzia serrata
Organic Letters, 2016Co-Authors: Juan Wang, Xiao Liu, Xiaohui Wang, Xiaoping Shi, Yuelin Song, Kewu Zeng, Le Zhang, Shepo ShiAbstract:A curcuminoids, benzalacetone-, and quinolone-producing type III polyketide synthase (HsPKS3) from Huperzia serrata uniquely catalyzes the formation of unnatural 2-substituted quinolones and 1,3-diketones via head-to-head condensation of two completely different substrates. The broad range of substrate tolerance of HsPKS3 facilitates accessing structurally diverse 2-substituted quinolones and 1,3-diketones.
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Synthesis of Unnatural 2‑Substituted Quinolones and 1,3-Diketones by a Member of Type III Polyketide Synthases from Huperzia serrata
2016Co-Authors: Juan Wang, Xiao Liu, Xiaohui Wang, Xiaoping Shi, Yuelin Song, Kewu Zeng, Le Zhang, Shepo ShiAbstract:A curcuminoids, benzalacetone-, and quinolone-producing type III polyketide synthase (HsPKS3) from Huperzia serrata uniquely catalyzes the formation of unnatural 2-substituted quinolones and 1,3-diketones via head-to-head condensation of two completely different substrates. The broad range of substrate tolerance of HsPKS3 facilitates accessing structurally diverse 2-substituted quinolones and 1,3-diketones
Changheng Tan - One of the best experts on this subject based on the ideXlab platform.
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lycopodium alkaloids from Huperzia serrata
Journal of Asian Natural Products Research, 2010Co-Authors: Yanfang Yang, Changheng Tan, Junjie Tan, Shanhao Jiang, Kai Xiao, Dayuan ZhuAbstract:A new lycopodane-type Lycopodium alkaloid, 6α-hydroxy-5,15-oxide-lycopodane (1), and seven known alkaloids were isolated from the whole plants of Huperzia serrata. Their structures were elucidated by means of spectroscopic methods. 12-Deoxyhuperzine O (2) was reported as a naturally occurring alkaloid for the first time, and showed an antagonist effect on the N-methyl-d-aspartate receptor with an IC50 value of 0.92 μM.
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triterpenoid constituents of Huperzia miyoshiana
Chinese Journal of Chemistry, 2010Co-Authors: Xiaotian Tong, Changheng Tan, Shanhao Jiang, Hui Zhou, Dayuan ZhuAbstract:Thirteen triterpenoids, including three new ones, miyoshianols A (1), B (2) and C (3), were isolated from Huperzia miyoshiana. The structures of these new compounds were established as 3-O-dihydroferuloyltohogenol (1), 16-oxo-3β, 21β-dihydroxy-serrat-14-en-24-ferulate (2) and 16-oxo-3α, 21β-dihydroxyserrat-14-en-24-ferulate (3), respectively, on the basis of their spectroscopic analysis.
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two new n oxide lycopodium alkaloids from Huperzia serrata
Natural Product Research, 2009Co-Authors: Hengbin Wang, Changheng Tan, Junjie Tan, Shanhao Jiang, Yilei Chen, Dayuan ZhuAbstract:Two new Lycopodium alkaloids, N-oxidehuperzine E (1) and N-oxidehuperzine F (2), along with two known alkaloids, huperzines E (3) and F (4), were isolated from Huperzia serrata (Thunb.) Trev. Their structures were elucidated by spectroscopic and chemical transformations.
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huperzine a from Huperzia species an ethnopharmacolgical review
Journal of Ethnopharmacology, 2007Co-Authors: Changheng Tan, Dayuan Zhu, David R Gang, Peigen XiaoAbstract:Huperzine A (HupA), isolated originally from a traditional Chinese medicine Qiang Ceng Ta, whole plant of Huperzia serrata (Thunb. ex Murray) Trev., a member of the Huperziaceae family, has attracted intense attention since its marked anticholinesterase activity was discovered by Chinese scientists. Several members of the Huperziaceae (Huperzia and Phlegmariurus species) have been used as medicines in China for contusions, strains, swellings, schizophrenia, myasthenia gravis and organophosphate poisoning. HupA has been marketed in China as a new drug for Alzheimer's disease (AD) treatment and its derivative ZT-1 is being developed as anti-AD new drug candidate both in China and in Europe. A review of the chemistry, bioactivities, toxicology, clinical trials and natural resources of HupA source plants is presented.
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lycopodium alkaloids from Huperzia serrata
ChemInform, 2007Co-Authors: Hengbin Wang, Changheng Tan, Junjie Tan, Mingyao Gao, Shanhao Jiang, Dayuan ZhuAbstract:Three new Lycopodium alkaloids, 2-chlorohuperzine E (1), huperzines E′ (2), and F′ (3), along with two known compounds, huperzines E and F, were isolated from Huperzia serrata (Thunb.) Trev. Their structures were elucidated by spectroscopic methods.
Dayuan Zhu - One of the best experts on this subject based on the ideXlab platform.
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lycopodium alkaloids from Huperzia serrata
Journal of Asian Natural Products Research, 2010Co-Authors: Yanfang Yang, Changheng Tan, Junjie Tan, Shanhao Jiang, Kai Xiao, Dayuan ZhuAbstract:A new lycopodane-type Lycopodium alkaloid, 6α-hydroxy-5,15-oxide-lycopodane (1), and seven known alkaloids were isolated from the whole plants of Huperzia serrata. Their structures were elucidated by means of spectroscopic methods. 12-Deoxyhuperzine O (2) was reported as a naturally occurring alkaloid for the first time, and showed an antagonist effect on the N-methyl-d-aspartate receptor with an IC50 value of 0.92 μM.
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triterpenoid constituents of Huperzia miyoshiana
Chinese Journal of Chemistry, 2010Co-Authors: Xiaotian Tong, Changheng Tan, Shanhao Jiang, Hui Zhou, Dayuan ZhuAbstract:Thirteen triterpenoids, including three new ones, miyoshianols A (1), B (2) and C (3), were isolated from Huperzia miyoshiana. The structures of these new compounds were established as 3-O-dihydroferuloyltohogenol (1), 16-oxo-3β, 21β-dihydroxy-serrat-14-en-24-ferulate (2) and 16-oxo-3α, 21β-dihydroxyserrat-14-en-24-ferulate (3), respectively, on the basis of their spectroscopic analysis.
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two new n oxide lycopodium alkaloids from Huperzia serrata
Natural Product Research, 2009Co-Authors: Hengbin Wang, Changheng Tan, Junjie Tan, Shanhao Jiang, Yilei Chen, Dayuan ZhuAbstract:Two new Lycopodium alkaloids, N-oxidehuperzine E (1) and N-oxidehuperzine F (2), along with two known alkaloids, huperzines E (3) and F (4), were isolated from Huperzia serrata (Thunb.) Trev. Their structures were elucidated by spectroscopic and chemical transformations.
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two new nitrone alkaloids from Huperzia serrata
Helvetica Chimica Acta, 2008Co-Authors: Wenyun Gao, Shanhao Jiang, Dayuan ZhuAbstract:Two new nitrone alkaloids were isolated from the whole plant of Huperzia serrata (Thunb.) Trev. They are both phlegmarine-type lycopodium alkaloids with a nitrone moiety. Their structures were elucidated on the basis of spectral evidences, and their configurations were established on the basis of optical rotation, CD, and NOESY-NMR data.
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huperzine a from Huperzia species an ethnopharmacolgical review
Journal of Ethnopharmacology, 2007Co-Authors: Changheng Tan, Dayuan Zhu, David R Gang, Peigen XiaoAbstract:Huperzine A (HupA), isolated originally from a traditional Chinese medicine Qiang Ceng Ta, whole plant of Huperzia serrata (Thunb. ex Murray) Trev., a member of the Huperziaceae family, has attracted intense attention since its marked anticholinesterase activity was discovered by Chinese scientists. Several members of the Huperziaceae (Huperzia and Phlegmariurus species) have been used as medicines in China for contusions, strains, swellings, schizophrenia, myasthenia gravis and organophosphate poisoning. HupA has been marketed in China as a new drug for Alzheimer's disease (AD) treatment and its derivative ZT-1 is being developed as anti-AD new drug candidate both in China and in Europe. A review of the chemistry, bioactivities, toxicology, clinical trials and natural resources of HupA source plants is presented.
Nopporn Thasana - One of the best experts on this subject based on the ideXlab platform.
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squarrosine a and pyrrolhuperzine a new lycopodium alkaloids from thai and philippine Huperzia squarrosa
Planta Medica, 2016Co-Authors: Thanasan Nilsu, Sakornrat Thorroad, Somsak Ruchirawat, Nopporn ThasanaAbstract:Two new Lycopodium alkaloids, squarrosine A (1) and pyrrolhuperzine A (2), were isolated from the Thai and Philippine plant Huperzia squarrosa. (R)-2-Piperidineacetic acid (5) was a known alkaloid, but has now been isolated for the first time from a natural source. Their structures were elucidated using extensive spectroscopic analyses and, for pyrrolhuperzine A (2), confirmation by chemical transformation. The new compounds exhibited moderate acetylcholinesterase inhibitory activities.
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three new lycopodium alkaloids from Huperzia carinata and Huperzia squarrosa
Tetrahedron, 2014Co-Authors: Sakornrat Thorroad, Prateep Worawittayanont, Nisachon Khunnawutmanotham, Nitirat Chimnoi, Apiwan Jumruksa, Somsak Ruchirawat, Nopporn ThasanaAbstract:Abstract Eleven Lycopodium alkaloids with lycodine-type, lycopodine-type, and fawcettimine-related skeletons were isolated from the whole plants of Huperzia carinata (Desv. Ex. Poir.) Trevis and Huperzia squarrosa (G. Forst) Trevis (Huperziaceae). Among them, 8,15-dihydrohuperzine A (2), lycocarinatine A (3), and lycoposerramine U N-oxide (11) are new compounds. The structures of these new alkaloids were elucidated on the basis of 2D NMR correlations. Some of these isolated alkaloids were assayed for acetylcholinesterase (AChE) inhibitory activity.
Xiao Liu - One of the best experts on this subject based on the ideXlab platform.
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enzymatic synthesis of 2 hydroxy 4h quinolizin 4 one scaffolds by integrating coenzyme a ligases and a type iii pks from Huperzia serrata
RSC Advances, 2020Co-Authors: Juan Wang, Ning Ding, Xiao Liu, Xiaohui Wang, Xiaoping Shi, Shepo ShiAbstract:2-Hydroxy-4H-quinolizin-4-one scaffolds were enzymatically synthesized by integrating three enzymes including phenylacetate-CoA ligase (PcPCL) from an endophytic fungus Penicillium chrysogenum MT-12, malonyl-CoA synthase (AtMatB) from Arabidopsis thaliana, and a type III polyketide synthase (HsPKS3) from Chinese club moss Huperzia serrata. The findings paved the way to produce these kinds of structurally interesting alkaloids by engineered microorganisms.
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lycopodium alkaloids from Huperzia serrata
Fitoterapia, 2019Co-Authors: Fangfang Jiang, Ning Ding, Hongyun Yang, Fangfang Jia, Yuan Luo, Juan Wang, Xiao Liu, Xiaohui Wang, Shepo ShiAbstract:Abstract Five new Lycopodium alkaloids, huperzine Y1 (1), huperzine Y2 (2), huperzine Y3 (3), (+)-huperzine Z (4a) and (−)-huperzine Z (4b) as well as ten known alkaloids (5–14) were isolated from Huperzia serrata. The structures of the new compounds were established using extensive spectroscopic (1D and 2D NMR, IR, and HRESIMS) and calculated electronic circular dichroism (ECD) methods. Compounds 4a and 4b were a pair of enantiomers successfully separated by chiral HPLC resolution. Compounds 2 and 3 indicated inhibitory activities against acetylcholinesterase with IC50 value of 57.1 ± 1.6 and 32.7 ± 1.0 μΜ, respectively. However, no compound showed inhibitory effect on butyrocholinesterase at the concentration of 100 μΜ.
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polyketides from alternaria alternata mt 47 an endophytic fungus isolated from Huperzia serrata
Fitoterapia, 2019Co-Authors: Hongyun Yang, Fangfang Jiang, Ning Ding, Fangfang Jia, Yuan Luo, Xiao Liu, Lili Wang, Zhixiang Zhu, Shepo ShiAbstract:Abstract Four new polyketides, alternatains A-D (1–4), along with 17 known compounds (5–21) were obtained from the solid substrate fermentation cultures of Alternaria alternata MT-47, an endophytic fungus isolated from the medicinal plant of Huperzia serrata. Their structures were elucidated by extensive spectroscopic and spectrometric techniques (1D and 2D NMR, IR, and HRESIMS) and calculated electronic circular dichroism (ECD) method. Compounds 4, 6, 15, and 21 exhibited inhibitory activities on ATP release of thrombin-activated platelets with IC50 values in the range of 18.2–68.8 μM.
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synthesis of unnatural 2 substituted quinolones and 1 3 diketones by a member of type iii polyketide synthases from Huperzia serrata
Organic Letters, 2016Co-Authors: Juan Wang, Xiao Liu, Xiaohui Wang, Xiaoping Shi, Yuelin Song, Kewu Zeng, Le Zhang, Shepo ShiAbstract:A curcuminoids, benzalacetone-, and quinolone-producing type III polyketide synthase (HsPKS3) from Huperzia serrata uniquely catalyzes the formation of unnatural 2-substituted quinolones and 1,3-diketones via head-to-head condensation of two completely different substrates. The broad range of substrate tolerance of HsPKS3 facilitates accessing structurally diverse 2-substituted quinolones and 1,3-diketones.
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Synthesis of Unnatural 2‑Substituted Quinolones and 1,3-Diketones by a Member of Type III Polyketide Synthases from Huperzia serrata
2016Co-Authors: Juan Wang, Xiao Liu, Xiaohui Wang, Xiaoping Shi, Yuelin Song, Kewu Zeng, Le Zhang, Shepo ShiAbstract:A curcuminoids, benzalacetone-, and quinolone-producing type III polyketide synthase (HsPKS3) from Huperzia serrata uniquely catalyzes the formation of unnatural 2-substituted quinolones and 1,3-diketones via head-to-head condensation of two completely different substrates. The broad range of substrate tolerance of HsPKS3 facilitates accessing structurally diverse 2-substituted quinolones and 1,3-diketones
