The Experts below are selected from a list of 3 Experts worldwide ranked by ideXlab platform
Judd M. Aiken - One of the best experts on this subject based on the ideXlab platform.
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Early-onset calorie restriction conserves fiber number in aging Rat skeletal muscle
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2004Co-Authors: Susan H. Mckiernan, Entela Bua, Jennifer Mcgorray, Judd M. AikenAbstract:SPECIFIC AIMSSarcopenia is the age-related loss of muscle mass and function. It is a complicated multifactorial process with no clear etiology. Muscle mass loss with age has a significant impact on the physiological and social well-being of the aged. Calorie restriction (CR) has been shown to retard many of the deleterious effects of aging in rodent and nonhuman primate models. We hypothesize that CR would significantly affect progressive muscle mass loss with age. The specific aims of this work were to examine the effects of aging on skeletal muscle in a long-lived Hybrid Rat Strain by analysis of muscle weight, muscle fiber number, and muscle fiber atrophy using three different muscles and to determine the influence of early-onset CR on that process in young, intermediate aged, and very aged animals.PRINCIPAL FINDINGS1. Significant sarcopenic changes occurred in the skeletal muscle of the Hybrid Rat between 21 and 36 months of age. Calorie restriction retarded muscle mass loss but did not prevent itThe ...
Susan H. Mckiernan - One of the best experts on this subject based on the ideXlab platform.
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Early-onset calorie restriction conserves fiber number in aging Rat skeletal muscle
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2004Co-Authors: Susan H. Mckiernan, Entela Bua, Jennifer Mcgorray, Judd M. AikenAbstract:SPECIFIC AIMSSarcopenia is the age-related loss of muscle mass and function. It is a complicated multifactorial process with no clear etiology. Muscle mass loss with age has a significant impact on the physiological and social well-being of the aged. Calorie restriction (CR) has been shown to retard many of the deleterious effects of aging in rodent and nonhuman primate models. We hypothesize that CR would significantly affect progressive muscle mass loss with age. The specific aims of this work were to examine the effects of aging on skeletal muscle in a long-lived Hybrid Rat Strain by analysis of muscle weight, muscle fiber number, and muscle fiber atrophy using three different muscles and to determine the influence of early-onset CR on that process in young, intermediate aged, and very aged animals.PRINCIPAL FINDINGS1. Significant sarcopenic changes occurred in the skeletal muscle of the Hybrid Rat between 21 and 36 months of age. Calorie restriction retarded muscle mass loss but did not prevent itThe ...
Entela Bua - One of the best experts on this subject based on the ideXlab platform.
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Early-onset calorie restriction conserves fiber number in aging Rat skeletal muscle
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2004Co-Authors: Susan H. Mckiernan, Entela Bua, Jennifer Mcgorray, Judd M. AikenAbstract:SPECIFIC AIMSSarcopenia is the age-related loss of muscle mass and function. It is a complicated multifactorial process with no clear etiology. Muscle mass loss with age has a significant impact on the physiological and social well-being of the aged. Calorie restriction (CR) has been shown to retard many of the deleterious effects of aging in rodent and nonhuman primate models. We hypothesize that CR would significantly affect progressive muscle mass loss with age. The specific aims of this work were to examine the effects of aging on skeletal muscle in a long-lived Hybrid Rat Strain by analysis of muscle weight, muscle fiber number, and muscle fiber atrophy using three different muscles and to determine the influence of early-onset CR on that process in young, intermediate aged, and very aged animals.PRINCIPAL FINDINGS1. Significant sarcopenic changes occurred in the skeletal muscle of the Hybrid Rat between 21 and 36 months of age. Calorie restriction retarded muscle mass loss but did not prevent itThe ...
Jennifer Mcgorray - One of the best experts on this subject based on the ideXlab platform.
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Early-onset calorie restriction conserves fiber number in aging Rat skeletal muscle
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2004Co-Authors: Susan H. Mckiernan, Entela Bua, Jennifer Mcgorray, Judd M. AikenAbstract:SPECIFIC AIMSSarcopenia is the age-related loss of muscle mass and function. It is a complicated multifactorial process with no clear etiology. Muscle mass loss with age has a significant impact on the physiological and social well-being of the aged. Calorie restriction (CR) has been shown to retard many of the deleterious effects of aging in rodent and nonhuman primate models. We hypothesize that CR would significantly affect progressive muscle mass loss with age. The specific aims of this work were to examine the effects of aging on skeletal muscle in a long-lived Hybrid Rat Strain by analysis of muscle weight, muscle fiber number, and muscle fiber atrophy using three different muscles and to determine the influence of early-onset CR on that process in young, intermediate aged, and very aged animals.PRINCIPAL FINDINGS1. Significant sarcopenic changes occurred in the skeletal muscle of the Hybrid Rat between 21 and 36 months of age. Calorie restriction retarded muscle mass loss but did not prevent itThe ...
