The Experts below are selected from a list of 123291 Experts worldwide ranked by ideXlab platform
T. Maindron - One of the best experts on this subject based on the ideXlab platform.
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Inkjet deposition of a hole-transporting small molecule to realize a Hybrid Solution-evaporation green top-emitting OLED
Organic Electronics, 2017Co-Authors: S. Olivier, E. Ishow, S. Meunier Della-gatta, T. MaindronAbstract:The QUPD molecule has been deposited by inkjet printing as a hole-transport layer in top-emitting green OLEDs. A systematic study of the QUPD-based ink formulation has been done and different solvent mixtures have been investigated, in order to find the best composition (QUPD in toluene/IPA/anisole, 8/1/1 v/v/v) leading to the best film forming properties. Spin-coated PEDOT-PSS has been used as hole injecting layer. Subsequent layers have been deposited by vacuum sublimation. The resulting Hybrid, Solution-sublimation, OLEDs have been encapsulated by atomic layer deposition using Al2O3 material. In order to overcome the issue related to the thickness control of the organic layers deposited from Solution, second order cavity length OLEDs have been fabricated by modifying the n-doped electron transport layer thickness. In that case, the relative OLED efficiency variation (10.5%) due to the thickness variation is far less compared to first order cavity length (34%) allowing a better reproducibility of the OLED fabrication. In the end, high efficiency (18 lm/W) green OLEDs of two different sizes, 0.44 cm(2) and 4 cm(2), have been fabricated, using an inkjet printed QUPD layer as hole transporting layer. (C) 2017 Elsevier B.V. All rights reserved.
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Inkjet deposition of a hole-transporting small molecule to realize a Hybrid Solution-evaporation green top-emitting OLED
Organic Electronics, 2017Co-Authors: S. Olivier, E. Ishow, S. Meunier Della-gatta, T. MaindronAbstract:Abstract The QUPD molecule has been deposited by inkjet printing as a hole-transport layer in top-emitting green OLEDs. A systematic study of the QUPD-based ink formulation has been done and different solvent mixtures have been investigated, in order to find the best composition (QUPD in toluene/IPA/anisole, 8/1/1 v/v/v) leading to the best film forming properties. Spin-coated PEDOT-PSS has been used as hole injecting layer. Subsequent layers have been deposited by vacuum sublimation. The resulting Hybrid, Solution-sublimation, OLEDs have been encapsulated by atomic layer deposition using Al 2 O 3 material. In order to overcome the issue related to the thickness control of the organic layers deposited from Solution, second order cavity length OLEDs have been fabricated by modifying the n-doped electron transport layer thickness. In that case, the relative OLED efficiency variation (10.5%) due to the thickness variation is far less compared to first order cavity length (34%) allowing a better reproducibility of the OLED fabrication. In the end, high efficiency (18 lm/W) green OLEDs of two different sizes, 0.44 cm 2 and 4 cm 2 , have been fabricated, using an inkjet printed QUPD layer as hole transporting layer.
Gianluigi Veglia - One of the best experts on this subject based on the ideXlab platform.
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structural topology of phospholamban pentamer in lipid bilayers by a Hybrid Solution and solid state nmr method
Proceedings of the National Academy of Sciences of the United States of America, 2011Co-Authors: Raffaello Verardi, Nathaniel J. Traaseth, Naomi M Walsh, Gianluigi VegliaAbstract:Phospholamban (PLN) is a type II membrane protein that inhibits the sarcoplasmic reticulum Ca2+-ATPase (SERCA), thereby regulating calcium homeostasis in cardiac muscle. In membranes, PLN forms pentamers that have been proposed to function either as a storage for active monomers or as ion channels. Here, we report the T-state structure of pentameric PLN solved by a Hybrid Solution and solid-state NMR method. In lipid bilayers, PLN adopts a pinwheel topology with a narrow hydrophobic pore, which excludes ion transport. In the T state, the cytoplasmic amphipathic helices (domains Ia) are absorbed into the lipid bilayer with the transmembrane domains arranged in a left-handed coiled-coil configuration, crossing the bilayer with a tilt angle of approximately 11° with respect to the membrane normal. The tilt angle difference between the monomer and pentamer is approximately 13°, showing that intramembrane helix–helix association forces dominate over the hydrophobic mismatch, driving the overall topology of the transmembrane assembly. Our data reveal that both topology and function of PLN are shaped by the interactions with lipids, which fine-tune the regulation of SERCA.
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Hybrid Solution and Solid-State NMR Analysis of SERCA/Phospholamban Interactions in lipid membranes: From Structural Dynamics to Function
Biophysical Journal, 2009Co-Authors: Gianluigi Veglia, Nathaniel J. Traaseth, Raffaello Verardi, Lei ShiAbstract:Phospholamban (PLN) is a sarcoplasmic reticulum (SR) integral membrane protein that regulates calcium translocation in cardiac muscle. Upon interaction with SERCA (the SR calcium ATPase). PLN decreases the rate of calcium uptake, reducing the apparent affinity of the enzyme for Ca2+ ions. This process is reversed by adrenergic stimulation of protein kinase A, which phosphorylates PLN at Ser16, re-starting the muscle contraction cycle. Here, we present the Hybrid Solution and solid-state NMR structural analysis of PLN in its pentameric (storage), monomeric (active), and SERCA-bound forms in lipid membranes. This knowledge about the structural dynamics PLN under these different stages is used to steer the extent of PLN control on SERCA activity. These findings lay the groundwork for the rational design of PLN loss-of-function mutants to be used in gene therapy.
S. Olivier - One of the best experts on this subject based on the ideXlab platform.
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Inkjet deposition of a hole-transporting small molecule to realize a Hybrid Solution-evaporation green top-emitting OLED
Organic Electronics, 2017Co-Authors: S. Olivier, E. Ishow, S. Meunier Della-gatta, T. MaindronAbstract:The QUPD molecule has been deposited by inkjet printing as a hole-transport layer in top-emitting green OLEDs. A systematic study of the QUPD-based ink formulation has been done and different solvent mixtures have been investigated, in order to find the best composition (QUPD in toluene/IPA/anisole, 8/1/1 v/v/v) leading to the best film forming properties. Spin-coated PEDOT-PSS has been used as hole injecting layer. Subsequent layers have been deposited by vacuum sublimation. The resulting Hybrid, Solution-sublimation, OLEDs have been encapsulated by atomic layer deposition using Al2O3 material. In order to overcome the issue related to the thickness control of the organic layers deposited from Solution, second order cavity length OLEDs have been fabricated by modifying the n-doped electron transport layer thickness. In that case, the relative OLED efficiency variation (10.5%) due to the thickness variation is far less compared to first order cavity length (34%) allowing a better reproducibility of the OLED fabrication. In the end, high efficiency (18 lm/W) green OLEDs of two different sizes, 0.44 cm(2) and 4 cm(2), have been fabricated, using an inkjet printed QUPD layer as hole transporting layer. (C) 2017 Elsevier B.V. All rights reserved.
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Inkjet deposition of a hole-transporting small molecule to realize a Hybrid Solution-evaporation green top-emitting OLED
Organic Electronics, 2017Co-Authors: S. Olivier, E. Ishow, S. Meunier Della-gatta, T. MaindronAbstract:Abstract The QUPD molecule has been deposited by inkjet printing as a hole-transport layer in top-emitting green OLEDs. A systematic study of the QUPD-based ink formulation has been done and different solvent mixtures have been investigated, in order to find the best composition (QUPD in toluene/IPA/anisole, 8/1/1 v/v/v) leading to the best film forming properties. Spin-coated PEDOT-PSS has been used as hole injecting layer. Subsequent layers have been deposited by vacuum sublimation. The resulting Hybrid, Solution-sublimation, OLEDs have been encapsulated by atomic layer deposition using Al 2 O 3 material. In order to overcome the issue related to the thickness control of the organic layers deposited from Solution, second order cavity length OLEDs have been fabricated by modifying the n-doped electron transport layer thickness. In that case, the relative OLED efficiency variation (10.5%) due to the thickness variation is far less compared to first order cavity length (34%) allowing a better reproducibility of the OLED fabrication. In the end, high efficiency (18 lm/W) green OLEDs of two different sizes, 0.44 cm 2 and 4 cm 2 , have been fabricated, using an inkjet printed QUPD layer as hole transporting layer.
Raffaello Verardi - One of the best experts on this subject based on the ideXlab platform.
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structural topology of phospholamban pentamer in lipid bilayers by a Hybrid Solution and solid state nmr method
Proceedings of the National Academy of Sciences of the United States of America, 2011Co-Authors: Raffaello Verardi, Nathaniel J. Traaseth, Naomi M Walsh, Gianluigi VegliaAbstract:Phospholamban (PLN) is a type II membrane protein that inhibits the sarcoplasmic reticulum Ca2+-ATPase (SERCA), thereby regulating calcium homeostasis in cardiac muscle. In membranes, PLN forms pentamers that have been proposed to function either as a storage for active monomers or as ion channels. Here, we report the T-state structure of pentameric PLN solved by a Hybrid Solution and solid-state NMR method. In lipid bilayers, PLN adopts a pinwheel topology with a narrow hydrophobic pore, which excludes ion transport. In the T state, the cytoplasmic amphipathic helices (domains Ia) are absorbed into the lipid bilayer with the transmembrane domains arranged in a left-handed coiled-coil configuration, crossing the bilayer with a tilt angle of approximately 11° with respect to the membrane normal. The tilt angle difference between the monomer and pentamer is approximately 13°, showing that intramembrane helix–helix association forces dominate over the hydrophobic mismatch, driving the overall topology of the transmembrane assembly. Our data reveal that both topology and function of PLN are shaped by the interactions with lipids, which fine-tune the regulation of SERCA.
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Hybrid Solution and Solid-State NMR Analysis of SERCA/Phospholamban Interactions in lipid membranes: From Structural Dynamics to Function
Biophysical Journal, 2009Co-Authors: Gianluigi Veglia, Nathaniel J. Traaseth, Raffaello Verardi, Lei ShiAbstract:Phospholamban (PLN) is a sarcoplasmic reticulum (SR) integral membrane protein that regulates calcium translocation in cardiac muscle. Upon interaction with SERCA (the SR calcium ATPase). PLN decreases the rate of calcium uptake, reducing the apparent affinity of the enzyme for Ca2+ ions. This process is reversed by adrenergic stimulation of protein kinase A, which phosphorylates PLN at Ser16, re-starting the muscle contraction cycle. Here, we present the Hybrid Solution and solid-state NMR structural analysis of PLN in its pentameric (storage), monomeric (active), and SERCA-bound forms in lipid membranes. This knowledge about the structural dynamics PLN under these different stages is used to steer the extent of PLN control on SERCA activity. These findings lay the groundwork for the rational design of PLN loss-of-function mutants to be used in gene therapy.
E. Ishow - One of the best experts on this subject based on the ideXlab platform.
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Inkjet deposition of a hole-transporting small molecule to realize a Hybrid Solution-evaporation green top-emitting OLED
Organic Electronics, 2017Co-Authors: S. Olivier, E. Ishow, S. Meunier Della-gatta, T. MaindronAbstract:The QUPD molecule has been deposited by inkjet printing as a hole-transport layer in top-emitting green OLEDs. A systematic study of the QUPD-based ink formulation has been done and different solvent mixtures have been investigated, in order to find the best composition (QUPD in toluene/IPA/anisole, 8/1/1 v/v/v) leading to the best film forming properties. Spin-coated PEDOT-PSS has been used as hole injecting layer. Subsequent layers have been deposited by vacuum sublimation. The resulting Hybrid, Solution-sublimation, OLEDs have been encapsulated by atomic layer deposition using Al2O3 material. In order to overcome the issue related to the thickness control of the organic layers deposited from Solution, second order cavity length OLEDs have been fabricated by modifying the n-doped electron transport layer thickness. In that case, the relative OLED efficiency variation (10.5%) due to the thickness variation is far less compared to first order cavity length (34%) allowing a better reproducibility of the OLED fabrication. In the end, high efficiency (18 lm/W) green OLEDs of two different sizes, 0.44 cm(2) and 4 cm(2), have been fabricated, using an inkjet printed QUPD layer as hole transporting layer. (C) 2017 Elsevier B.V. All rights reserved.
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Inkjet deposition of a hole-transporting small molecule to realize a Hybrid Solution-evaporation green top-emitting OLED
Organic Electronics, 2017Co-Authors: S. Olivier, E. Ishow, S. Meunier Della-gatta, T. MaindronAbstract:Abstract The QUPD molecule has been deposited by inkjet printing as a hole-transport layer in top-emitting green OLEDs. A systematic study of the QUPD-based ink formulation has been done and different solvent mixtures have been investigated, in order to find the best composition (QUPD in toluene/IPA/anisole, 8/1/1 v/v/v) leading to the best film forming properties. Spin-coated PEDOT-PSS has been used as hole injecting layer. Subsequent layers have been deposited by vacuum sublimation. The resulting Hybrid, Solution-sublimation, OLEDs have been encapsulated by atomic layer deposition using Al 2 O 3 material. In order to overcome the issue related to the thickness control of the organic layers deposited from Solution, second order cavity length OLEDs have been fabricated by modifying the n-doped electron transport layer thickness. In that case, the relative OLED efficiency variation (10.5%) due to the thickness variation is far less compared to first order cavity length (34%) allowing a better reproducibility of the OLED fabrication. In the end, high efficiency (18 lm/W) green OLEDs of two different sizes, 0.44 cm 2 and 4 cm 2 , have been fabricated, using an inkjet printed QUPD layer as hole transporting layer.
