The Experts below are selected from a list of 9243 Experts worldwide ranked by ideXlab platform
Kunihiro Sumoto - One of the best experts on this subject based on the ideXlab platform.
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synthesis of new 5 substituted Hydantoins and symmetrical twin drug type Hydantoin derivatives
ChemInform, 2014Co-Authors: Fumiko Fujisaki, Enko Fukami, Fumio Miake, Nobuhiro Kashige, Ayumi Naito, Kunihiro SumotoAbstract:New 5-substituted Hydantoins (III) and (IV) and symmetrical twin-drug type Hydantoin derivatives (VII) are synthesized.
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Synthesis of New 5‐Substituted Hydantoins and Symmetrical Twin‐Drug Type Hydantoin Derivatives.
ChemInform, 2014Co-Authors: Fumiko Fujisaki, Enko Fukami, Fumio Miake, Nobuhiro Kashige, Ayumi Naito, Kunihiro SumotoAbstract:New 5-substituted Hydantoins (III) and (IV) and symmetrical twin-drug type Hydantoin derivatives (VII) are synthesized.
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synthesis of new 5 substituted Hydantoins and symmetrical twin drug type Hydantoin derivatives
Chemical & Pharmaceutical Bulletin, 2014Co-Authors: Fumiko Fujisaki, Enko Fukami, Fumio Miake, Nobuhiro Kashige, Ayumi Naito, Kunihiro SumotoAbstract:: In connection with our studies on Hydantoin derivatives, a conventional regioselective chemical transformation of 5-methylene Hydantoins 4a-c to 5-aminomethyl-substituted Hydantoins 5-10 or to 5-amino-5-methyl-disubstituted Hydantoins 11-14 is described. Synthesis of bivalent twin-drug type Hydantoin derivatives 19-24 and the binding property of a bivalent symmetrical Hydantoin derivative 24b to sulfated glycosaminoglycans are also described.
Fumiko Fujisaki - One of the best experts on this subject based on the ideXlab platform.
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synthesis of new 5 substituted Hydantoins and symmetrical twin drug type Hydantoin derivatives
ChemInform, 2014Co-Authors: Fumiko Fujisaki, Enko Fukami, Fumio Miake, Nobuhiro Kashige, Ayumi Naito, Kunihiro SumotoAbstract:New 5-substituted Hydantoins (III) and (IV) and symmetrical twin-drug type Hydantoin derivatives (VII) are synthesized.
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Synthesis of New 5‐Substituted Hydantoins and Symmetrical Twin‐Drug Type Hydantoin Derivatives.
ChemInform, 2014Co-Authors: Fumiko Fujisaki, Enko Fukami, Fumio Miake, Nobuhiro Kashige, Ayumi Naito, Kunihiro SumotoAbstract:New 5-substituted Hydantoins (III) and (IV) and symmetrical twin-drug type Hydantoin derivatives (VII) are synthesized.
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synthesis of new 5 substituted Hydantoins and symmetrical twin drug type Hydantoin derivatives
Chemical & Pharmaceutical Bulletin, 2014Co-Authors: Fumiko Fujisaki, Enko Fukami, Fumio Miake, Nobuhiro Kashige, Ayumi Naito, Kunihiro SumotoAbstract:: In connection with our studies on Hydantoin derivatives, a conventional regioselective chemical transformation of 5-methylene Hydantoins 4a-c to 5-aminomethyl-substituted Hydantoins 5-10 or to 5-amino-5-methyl-disubstituted Hydantoins 11-14 is described. Synthesis of bivalent twin-drug type Hydantoin derivatives 19-24 and the binding property of a bivalent symmetrical Hydantoin derivative 24b to sulfated glycosaminoglycans are also described.
Michal Szostak - One of the best experts on this subject based on the ideXlab platform.
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twisted n acyl Hydantoins rotationally inverted urea imides of relevance in n c o cross coupling
Journal of Organic Chemistry, 2018Co-Authors: Roman Szostak, Roger A. Lalancette, Michal SzostakAbstract:We report a combined structural and computational study on the properties of twisted acyclic Hydantoins. These compounds feature cyclic urea-imide moiety that is widely found in bioactive compounds and is structurally related to the classic bridged Hydantoins proposed by Smissman more than 50 years ago. We demonstrate that C to N-substitution of the imide moiety in the succinimide ring to give Hydantoin results in one of the most distorted acyclic amide bonds reported to date. The energetic properties of twisted acyclic Hydantoins with respect to structures, resonance energies, barriers to rotation, and proton affinities are discussed. The energetic and structural properties of twisted acyclic Hydantoins described provide a benchmark to facilitate the development of twisted amides based on the biorelevant cyclic urea-imide scaffold.
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Twisted N‑Acyl-Hydantoins: Rotationally Inverted Urea-Imides of Relevance in N–C(O) Cross-coupling
2018Co-Authors: Roman Szostak, Roger A. Lalancette, Chengwei Liu, Michal SzostakAbstract:We report a combined structural and computational study on the properties of twisted acyclic Hydantoins. These compounds feature cyclic urea-imide moiety that is widely found in bioactive compounds and is structurally related to the classic bridged Hydantoins proposed by Smissman more than 50 years ago. We demonstrate that C to N-substitution of the imide moiety in the succinimide ring to give Hydantoin results in one of the most distorted acyclic amide bonds reported to date. The energetic properties of twisted acyclic Hydantoins with respect to structures, resonance energies, barriers to rotation, and proton affinities are discussed. The energetic and structural properties of twisted acyclic Hydantoins described provide a benchmark to facilitate the development of twisted amides based on the biorelevant cyclic urea-imide scaffold
Enko Fukami - One of the best experts on this subject based on the ideXlab platform.
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synthesis of new 5 substituted Hydantoins and symmetrical twin drug type Hydantoin derivatives
ChemInform, 2014Co-Authors: Fumiko Fujisaki, Enko Fukami, Fumio Miake, Nobuhiro Kashige, Ayumi Naito, Kunihiro SumotoAbstract:New 5-substituted Hydantoins (III) and (IV) and symmetrical twin-drug type Hydantoin derivatives (VII) are synthesized.
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Synthesis of New 5‐Substituted Hydantoins and Symmetrical Twin‐Drug Type Hydantoin Derivatives.
ChemInform, 2014Co-Authors: Fumiko Fujisaki, Enko Fukami, Fumio Miake, Nobuhiro Kashige, Ayumi Naito, Kunihiro SumotoAbstract:New 5-substituted Hydantoins (III) and (IV) and symmetrical twin-drug type Hydantoin derivatives (VII) are synthesized.
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synthesis of new 5 substituted Hydantoins and symmetrical twin drug type Hydantoin derivatives
Chemical & Pharmaceutical Bulletin, 2014Co-Authors: Fumiko Fujisaki, Enko Fukami, Fumio Miake, Nobuhiro Kashige, Ayumi Naito, Kunihiro SumotoAbstract:: In connection with our studies on Hydantoin derivatives, a conventional regioselective chemical transformation of 5-methylene Hydantoins 4a-c to 5-aminomethyl-substituted Hydantoins 5-10 or to 5-amino-5-methyl-disubstituted Hydantoins 11-14 is described. Synthesis of bivalent twin-drug type Hydantoin derivatives 19-24 and the binding property of a bivalent symmetrical Hydantoin derivative 24b to sulfated glycosaminoglycans are also described.
Fumio Miake - One of the best experts on this subject based on the ideXlab platform.
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synthesis of new 5 substituted Hydantoins and symmetrical twin drug type Hydantoin derivatives
ChemInform, 2014Co-Authors: Fumiko Fujisaki, Enko Fukami, Fumio Miake, Nobuhiro Kashige, Ayumi Naito, Kunihiro SumotoAbstract:New 5-substituted Hydantoins (III) and (IV) and symmetrical twin-drug type Hydantoin derivatives (VII) are synthesized.
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Synthesis of New 5‐Substituted Hydantoins and Symmetrical Twin‐Drug Type Hydantoin Derivatives.
ChemInform, 2014Co-Authors: Fumiko Fujisaki, Enko Fukami, Fumio Miake, Nobuhiro Kashige, Ayumi Naito, Kunihiro SumotoAbstract:New 5-substituted Hydantoins (III) and (IV) and symmetrical twin-drug type Hydantoin derivatives (VII) are synthesized.
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synthesis of new 5 substituted Hydantoins and symmetrical twin drug type Hydantoin derivatives
Chemical & Pharmaceutical Bulletin, 2014Co-Authors: Fumiko Fujisaki, Enko Fukami, Fumio Miake, Nobuhiro Kashige, Ayumi Naito, Kunihiro SumotoAbstract:: In connection with our studies on Hydantoin derivatives, a conventional regioselective chemical transformation of 5-methylene Hydantoins 4a-c to 5-aminomethyl-substituted Hydantoins 5-10 or to 5-amino-5-methyl-disubstituted Hydantoins 11-14 is described. Synthesis of bivalent twin-drug type Hydantoin derivatives 19-24 and the binding property of a bivalent symmetrical Hydantoin derivative 24b to sulfated glycosaminoglycans are also described.