The Experts below are selected from a list of 2055 Experts worldwide ranked by ideXlab platform
Ross A Widenhoefer - One of the best experts on this subject based on the ideXlab platform.
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tandem gold silver catalyzed cycloaddition Hydroarylation of 7 aryl 1 6 enynes to form 6 6 diarylbicyclo 3 2 0 heptanes
ChemInform, 2015Co-Authors: Bradley D Robertson, Rachel E M Brooner, Ross A WidenhoeferAbstract:The tandem cycloaddition/Hydroarylation of title compounds (I), (IV), and (V) with electron-rich arenes in the presence of a Au/Ag catalytic system is reported.
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tandem gold silver catalyzed cycloaddition Hydroarylation of 7 aryl 1 6 enynes to form 6 6 diarylbicyclo 3 2 0 heptanes
Chemistry: A European Journal, 2015Co-Authors: Bradley D Robertson, Rachel E M Brooner, Ross A WidenhoeferAbstract:: Mixtures of [{PCy2(o-biphenyl)}AuCl] and AgSbF6 catalyze the tandem cycloaddition/Hydroarylation of 7-aryl-1,6-enynes with electron-rich arenes to form 6,6-diarylbicyclo[3.2.0]heptanes in good yield under mild conditions. Experimental observations point to a mechanism involving gold-catalyzed cycloaddition followed by silver-catalyzed Hydroarylation of a bicyclo[3.2.0]hept-1(7)-ene intermediate.
Hiroaki Ohno - One of the best experts on this subject based on the ideXlab platform.
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formal 4 2 reaction between 1 3 diynes and pyrroles gold i catalyzed indole synthesis by double Hydroarylation
ChemInform, 2015Co-Authors: Yuka Matsuda, Saori Naoe, Shinya Oishi, Nobutaka Fujii, Hiroaki OhnoAbstract:The novel protocol combines a Hydroarylation of 1,3-diynes with pyrroles with a subsequent intramolecular Hydroarylation to furnish 4,7-disubstituted indoles under mild conditions.
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formal 4 2 reaction between 1 3 diynes and pyrroles gold i catalyzed indole synthesis by double Hydroarylation
Chemistry: A European Journal, 2015Co-Authors: Yuka Matsuda, Saori Naoe, Shinya Oishi, Nobutaka Fujii, Hiroaki OhnoAbstract:Indole synthesis by a gold(I)-catalyzed intermolecular formal [4+2] reaction between 1,3-diynes and pyrroles has been developed. This reaction involves the Hydroarylation of 1,3-diynes with pyrroles followed by an intramolecular Hydroarylation to give the 4,7-disubstituted indoles. This reaction can also be applied to the synthesis of carbazoles when indoles are used as the nucleophiles instead of pyrroles.
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gold i catalyzed polycyclizations of polyenyne type anilines based on hydroamination and consecutive Hydroarylation cascade
ChemInform, 2012Co-Authors: Kimio Hirano, Shinya Oishi, Nobutaka Fujii, Yusuke Inaba, Kiyosei Takasu, Yoshiji Takemoto, Hiroaki OhnoAbstract:A hydroamination–double Hydroarylation cascade using aniline derivatives bearing a trienyne moiety as the substrate was efficiently promoted by a gold(I) catalyst to produce benzo[a]naphtho[2,1-c]carbazole derivatives in good yields. This reaction is applicable to various substituted trienyne-type anilines, including 2,3-diethynylthiophene derivatives. The reaction of anilines bearing a tetraenyne and pentaenyne moiety allows direct construction of highly fused carbazoles by tetra- and pentacyclization, respectively, through hydroamination and consecutive Hydroarylation without producing any theoretical waste products from the substrates.
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gold catalyzed Hydroarylation of allenes a highly regioselective carbon carbon bond formation producing six membered rings
Organic Letters, 2007Co-Authors: Toshiaki Watanabe, Shinya Oishi, Nobutaka Fujii, Hiroaki OhnoAbstract:Gold-catalyzed intramolecular Hydroarylation of allenic anilines and phenols offers an efficient route to dihydroquinoline and chromene derivatives under mild reaction conditions. The Hydroarylation takes place at the terminal or central allenic carbon depending on the substrate structure, leading to a highly selective formation of six-membered rings.
Bradley D Robertson - One of the best experts on this subject based on the ideXlab platform.
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tandem gold silver catalyzed cycloaddition Hydroarylation of 7 aryl 1 6 enynes to form 6 6 diarylbicyclo 3 2 0 heptanes
ChemInform, 2015Co-Authors: Bradley D Robertson, Rachel E M Brooner, Ross A WidenhoeferAbstract:The tandem cycloaddition/Hydroarylation of title compounds (I), (IV), and (V) with electron-rich arenes in the presence of a Au/Ag catalytic system is reported.
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tandem gold silver catalyzed cycloaddition Hydroarylation of 7 aryl 1 6 enynes to form 6 6 diarylbicyclo 3 2 0 heptanes
Chemistry: A European Journal, 2015Co-Authors: Bradley D Robertson, Rachel E M Brooner, Ross A WidenhoeferAbstract:: Mixtures of [{PCy2(o-biphenyl)}AuCl] and AgSbF6 catalyze the tandem cycloaddition/Hydroarylation of 7-aryl-1,6-enynes with electron-rich arenes to form 6,6-diarylbicyclo[3.2.0]heptanes in good yield under mild conditions. Experimental observations point to a mechanism involving gold-catalyzed cycloaddition followed by silver-catalyzed Hydroarylation of a bicyclo[3.2.0]hept-1(7)-ene intermediate.
Gojko Lalic - One of the best experts on this subject based on the ideXlab platform.
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nickel catalyzed anti markovnikov Hydroarylation of alkenes
Chemical Science, 2019Co-Authors: Julia Nguyen, Andrea Chong, Gojko LalicAbstract:We have developed a nickel-catalyzed Hydroarylation of alkenes using aryl halides as coupling partners. Excellent anti-Markovnikov selectivity is achieved with aryl-substituted alkenes and enol ethers. We also show that Hydroarylation occurs with alkyl substituted alkenes to yield linear products. Preliminary examination of the reaction mechanism suggests irreversible hydrometallation as the selectivity determining step of the Hydroarylation.
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diastereodivergent reductive cross coupling of alkynes through tandem catalysis z and e selective Hydroarylation of terminal alkynes
Journal of the American Chemical Society, 2018Co-Authors: Megan K Armstrong, Madison B Goodstein, Gojko LalicAbstract:A diastereodivergent Hydroarylation of terminal alkynes is accomplished using tandem catalysis. The Hydroarylation allows highly selective synthesis of both E and Z diastereoisomers of aryl alkenes, from the same set of starting materials, using the same combination of palladium and copper catalysts. The selectivity is controlled by simple changes in the stoichiometry of the alcohol additive. The Hydroarylation has excellent substrate scope and can be accomplished in the presence of various classes of compounds, including esters, nitriles, alkyl halides, epoxides, carbamates, acetals, ethers, silyl ethers, and thioethers. The Z-selective Hydroarylation is accomplished using a new approach based on tandem Sonogashira coupling and catalytic semireduction. The E-selective Hydroarylation involves an additional catalytic isomerization of the Z-alkene. Our explorations of the reaction mechanism explain the role of individual reaction components and how the subtle changes in the reaction conditions influence the rates of specific steps of the Hydroarylation. Our studies also show that, although the Z- and E-selective Hydroarylation reactions are mechanistically closely related, the roles of the palladium and copper catalysts in the two reactions are different.
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Diastereodivergent Reductive Cross Coupling of Alkynes through Tandem Catalysis: Z- and E‑Selective Hydroarylation of Terminal Alkynes
2018Co-Authors: Megan K. Armstrong, Madison B Goodstein, Gojko LalicAbstract:A diastereodivergent Hydroarylation of terminal alkynes is accomplished using tandem catalysis. The Hydroarylation allows highly selective synthesis of both E and Z diastereoisomers of aryl alkenes, from the same set of starting materials, using the same combination of palladium and copper catalysts. The selectivity is controlled by simple changes in the stoichiometry of the alcohol additive. The Hydroarylation has excellent substrate scope and can be accomplished in the presence of various classes of compounds, including esters, nitriles, alkyl halides, epoxides, carbamates, acetals, ethers, silyl ethers, and thioethers. The Z-selective Hydroarylation is accomplished using a new approach based on tandem Sonogashira coupling and catalytic semireduction. The E-selective Hydroarylation involves an additional catalytic isomerization of the Z-alkene. Our explorations of the reaction mechanism explain the role of individual reaction components and how the subtle changes in the reaction conditions influence the rates of specific steps of the Hydroarylation. Our studies also show that, although the Z- and E-selective Hydroarylation reactions are mechanistically closely related, the roles of the palladium and copper catalysts in the two reactions are different
Erik V. Van Der Eycken - One of the best experts on this subject based on the ideXlab platform.
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catalyst controlled exo endo selectivity in a post ugi intramolecular Hydroarylation synthesis of pyrrolopyridinones pyrroloazepinones and benzothienopyridines
ChemInform, 2015Co-Authors: Amit Kumar, Sunil K. Sharma, Virinder S. Parmar, Erik V. Van Der EyckenAbstract:Abstract A facile catalyst-controlled regioselective post-Ugi intramolecular Hydroarylation process was established, which delivers an expedient access to biologically significant heterocycles such as pyrrolopyridinones, pyrroloazepinones, and benzothienopyridines.
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regioselective synthesis of diversely substituted diazoninones through a post ugi gold catalyzed intramolecular Hydroarylation process
European Journal of Organic Chemistry, 2014Co-Authors: Dipak D. Vachhani, Amit Kumar, Sunil K. Sharma, Virinder S. Parmar, Erik V. Van Der EyckenAbstract:A highly efficient approach for the regioselective construction of fused nine-membered rings (diazoninone framework) was developed by employing sequential Ugi and gold-catalyzed intramolecular Hydroarylation reactions. The scope of this intramolecular cyclization has been demonstrated.
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Gold(I)-Catalyzed Post-Ugi Hydroarylation: An Approach to Pyrrolopyridines and Azepinoindoles.
ChemInform, 2013Co-Authors: Amit Kumar, Dipak D. Vachhani, Sachin G. Modha, Sunil K. Sharma, Virinder S. Parmar, Erik V. Van Der EyckenAbstract:An efficient intramolecular Hydroarylation reaction to the corresponding title heterocycles under mild reaction conditions is developed.
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a concise route to indoloazocines via a sequential ugi gold catalyzed intramolecular Hydroarylation
ChemInform, 2012Co-Authors: Sachin G. Modha, Dipak D. Vachhani, Jeroen Jacobs, Luc Van Meervelt, Erik V. Van Der EyckenAbstract:A diversity oriented approach for the synthesis of indoloazocines is reported employing an Ugi reaction followed by a gold-catalyzed intramolecular Hydroarylation.
