The Experts below are selected from a list of 27357 Experts worldwide ranked by ideXlab platform
Sara Marangoni - One of the best experts on this subject based on the ideXlab platform.
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recovery from confabulation after normotensive Hydrocephalus shunting
Cortex, 2016Co-Authors: Gianfranco Dalla Barba, Marta Brazzarola, Claudia Barbera, Sara MarangoniAbstract:Confabulation, the production of statements and actions that are unintentionally incongruous to the subject's history, background, present and future situation, is observed in several conditions affecting the nervous system, but it has never been described in normotensive Hydrocephalus. In this article we report on a patient with normotensive Hydrocephalus who suffered from an amnesic-confabulatory syndrome. After Hydrocephalus shunting, both amnesia and confabulation cleared up abruptly. We discuss this finding in terms of a possible disconnection of the hippocampus, due to transitory white matter damage, which may have recovered after Hydrocephalus shunting.
G Linnell - One of the best experts on this subject based on the ideXlab platform.
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Communicating Hydrocephalus after Gamma Knife Radiosurgery for Vestibular Schwannoma: An MR Imaging Study
2016Co-Authors: Keith A Cauley, B Ratkovits, S P Braff, G LinnellAbstract:SUMMARY: Vestibular schwannomas are common, and gamma knife radiosurgery is a treatment option of symptomatic tumors. Hydrocephalus may be a complication of gamma knife treatment of vestibular schwannoma, though the cause-and-effect relationship can be debated because tumors can cause Hydrocephalus without treatment. We present an MR imaging study of an unusual case of communicating Hydrocephalus after gamma knife radiosurgery of a vestibular schwannoma in which the timeline of events strongly suggests that gamma knife played a contributory role in the develop-ment of Hydrocephalus. We discuss risk factors for the development of Hydrocephalus after radiation therapy and the role of MR CSF cine-flow study in the evaluation of treatment options for hydroceph-alus in this setting. Hydrocephalus is an uncommon and controversial compli-cation of gamma knife radiosurgery for vestibular schwan-nomas.WereportacompleteMRimagingstudy includingpretreat-ment and posttreatment imaging and MR CSF cine-flow study of such a case. The findings are consistent with a communicating hy-drocephalus secondary to tumornecrosis, likelyacceleratedorwors-ened by gammaknife treatment
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communicating Hydrocephalus after gamma knife radiosurgery for vestibular schwannoma an mr imaging study
American Journal of Neuroradiology, 2009Co-Authors: Keith A Cauley, B Ratkovits, S P Braff, G LinnellAbstract:Vestibular schwannomas are common, and gamma knife radiosurgery is a treatment option of symptomatic tumors. Hydrocephalus may be a complication of gamma knife treatment of vestibular schwannoma, though the cause-and-effect relationship can be debated because tumors can cause Hydrocephalus without treatment. We present an MR imaging study of an unusual case of communicating Hydrocephalus after gamma knife radiosurgery of a vestibular schwannoma in which the timeline of events strongly suggests that gamma knife played a contributory role in the development of Hydrocephalus. We discuss risk factors for the development of Hydrocephalus after radiation therapy and the role of MR CSF cine-flow study in the evaluation of treatment options for Hydrocephalus in this setting.
Richard F. Keep - One of the best experts on this subject based on the ideXlab platform.
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effects of minocycline on epiplexus macrophage activation choroid plexus injury and Hydrocephalus development in spontaneous hypertensive rats
Journal of Cerebral Blood Flow and Metabolism, 2019Co-Authors: Xiaodi Hao, Ya Hua, Richard F. KeepAbstract:Hydrocephalus has been reported to occur in spontaneous hypertensive rats (SHRs). The purposes of this study were (1) to use T2 magnetic resonance imaging to examine time of onset, (2) to elucidate potential underlying mechanisms and (3) to determine whether minocycline could prevent Hydrocephalus development. Ventriculomegaly was evaluated by T2 imaging in SHRs and Wistar-Kyoto rats from weeks 4 to 7 after birth. Brain histology and transmission electron microscopy were used to assess the periventricular and choroid plexus damage. SHRs were also treated with either vehicle or minocycline. We found that Hydrocephalus was observed in SHRs but not in Wistar-Kyoto rats. It occurred at seven weeks of age but was not present at four and five weeks. The Hydrocephalus was associated with epiplexus cell (macrophage) activation, choroid plexus cell death and damage to the ventricle wall. Treatment with minocycline from week 5 attenuated Hydrocephalus development and pathological changes in choroid plexus and ventricular wall at week 7. The current study found that spontaneous Hydrocephalus arises at ∼7 weeks in male SHRs. The early development of Hydrocephalus (persistent ventricular dilatation) may result from epiplexus cell activation, choroid plexus cell death and periventricular damage, which can be ameliorated by treatment with minocycline.
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Deferoxamine Attenuates Acute Hydrocephalus After Traumatic Brain Injury in Rats
Translational Stroke Research, 2014Co-Authors: Jinbing Zhao, Zhi Chen, Guohua Xi, Richard F. KeepAbstract:Acute post-traumatic ventricular dilation and Hydrocephalus are relatively frequent consequences of traumatic brain injury (TBI). Several recent studies have indicated that high iron levels in brain may relate to Hydrocephalus development after intracranial hemorrhage. However, the role of iron in the development of post-traumatic Hydrocephalus is still unclear. This study was to determine whether or not iron has a role in Hydrocephalus development after TBI. TBI was induced by lateral fluid-percussion in male Sprague–Dawley rats. Some rats had intraventricular injection of iron. Acute Hydrocephalus was measured by magnetic resonance T2-weighted imaging and brain hemorrhage was determined by T2* gradient–echo sequence imaging and brain hemoglobin levels. The effect of deferoxamine on TBI-induced Hydrocephalus was examined. TBI resulted in acute Hydrocephalus at 24 h (lateral ventricle volume: 24.1 ± 3.0 vs. 9.9 ± 0.2 mm^3 in sham group). Intraventricular injection of iron also caused Hydrocephalus (25.7 ± 3.4 vs. 9.0 ± 0.6 mm^3 in saline group). Deferoxamine treatment attenuated TBI-induced Hydrocephalus and heme oxygenase-1 upregulation. In conclusion, iron may contribute to acute Hydrocephalus after TBI.
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Mechanisms of Hydrocephalus After Neonatal and Adult Intraventricular Hemorrhage
Translational Stroke Research, 2012Co-Authors: Jennifer Strahle, Richard F. Keep, Hugh J. L. Garton, Cormac O. Maher, Karin M. Muraszko, Guohua XiAbstract:Intraventricular hemorrhage (IVH) is a cause of significant morbidity and mortality and is an independent predictor of a worse outcome in intracerebral hemorrhage (ICH) and germinal matrix hemorrhage (GMH). IVH may result in both injuries to the brain as well as Hydrocephalus. This paper reviews evidence on the mechanisms and potential treatments for IVH-induced Hydrocephalus. One frequently cited theory to explain Hydrocephalus after IVH involves obliteration of the arachnoid villi by microthrombi with subsequent inflammation and fibrosis causing CSF outflow obstruction. Although there is some evidence to support this theory, there may be other mechanisms involved, which contribute to the development of Hydrocephalus. It is also unclear whether the causes of acute and chronic Hydrocephalus after hemorrhage occur via different mechanisms: mechanical obstruction by blood in the former and inflammation and fibrosis in the latter. Management of IVH and strategies for prevention of brain injury and Hydrocephalus are areas requiring further study. A better understanding of the pathogenesis of Hydrocephalus after IVH may lead to improved strategies to prevent and treat post-hemorrhagic Hydrocephalus.
Gianfranco Dalla Barba - One of the best experts on this subject based on the ideXlab platform.
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recovery from confabulation after normotensive Hydrocephalus shunting
Cortex, 2016Co-Authors: Gianfranco Dalla Barba, Marta Brazzarola, Claudia Barbera, Sara MarangoniAbstract:Confabulation, the production of statements and actions that are unintentionally incongruous to the subject's history, background, present and future situation, is observed in several conditions affecting the nervous system, but it has never been described in normotensive Hydrocephalus. In this article we report on a patient with normotensive Hydrocephalus who suffered from an amnesic-confabulatory syndrome. After Hydrocephalus shunting, both amnesia and confabulation cleared up abruptly. We discuss this finding in terms of a possible disconnection of the hippocampus, due to transitory white matter damage, which may have recovered after Hydrocephalus shunting.
Keith A Cauley - One of the best experts on this subject based on the ideXlab platform.
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Communicating Hydrocephalus after Gamma Knife Radiosurgery for Vestibular Schwannoma: An MR Imaging Study
2016Co-Authors: Keith A Cauley, B Ratkovits, S P Braff, G LinnellAbstract:SUMMARY: Vestibular schwannomas are common, and gamma knife radiosurgery is a treatment option of symptomatic tumors. Hydrocephalus may be a complication of gamma knife treatment of vestibular schwannoma, though the cause-and-effect relationship can be debated because tumors can cause Hydrocephalus without treatment. We present an MR imaging study of an unusual case of communicating Hydrocephalus after gamma knife radiosurgery of a vestibular schwannoma in which the timeline of events strongly suggests that gamma knife played a contributory role in the develop-ment of Hydrocephalus. We discuss risk factors for the development of Hydrocephalus after radiation therapy and the role of MR CSF cine-flow study in the evaluation of treatment options for hydroceph-alus in this setting. Hydrocephalus is an uncommon and controversial compli-cation of gamma knife radiosurgery for vestibular schwan-nomas.WereportacompleteMRimagingstudy includingpretreat-ment and posttreatment imaging and MR CSF cine-flow study of such a case. The findings are consistent with a communicating hy-drocephalus secondary to tumornecrosis, likelyacceleratedorwors-ened by gammaknife treatment
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communicating Hydrocephalus after gamma knife radiosurgery for vestibular schwannoma an mr imaging study
American Journal of Neuroradiology, 2009Co-Authors: Keith A Cauley, B Ratkovits, S P Braff, G LinnellAbstract:Vestibular schwannomas are common, and gamma knife radiosurgery is a treatment option of symptomatic tumors. Hydrocephalus may be a complication of gamma knife treatment of vestibular schwannoma, though the cause-and-effect relationship can be debated because tumors can cause Hydrocephalus without treatment. We present an MR imaging study of an unusual case of communicating Hydrocephalus after gamma knife radiosurgery of a vestibular schwannoma in which the timeline of events strongly suggests that gamma knife played a contributory role in the development of Hydrocephalus. We discuss risk factors for the development of Hydrocephalus after radiation therapy and the role of MR CSF cine-flow study in the evaluation of treatment options for Hydrocephalus in this setting.
