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M Chvapil - One of the best experts on this subject based on the ideXlab platform.

  • Effects on wound healing of zinc oxide in a Hydrocolloid Dressing.
    Journal of the American Academy of Dermatology, 1993
    Co-Authors: M S Agren, L Franzén, M Chvapil
    Abstract:

    Zinc oxide incorporated in gauze enhances healing of chronic wounds in humans and experimental pig wounds. The purpose of this study was to examine the effects of zinc oxide added to a Hydrocolloid Dressing on the healing of surgical wounds in domestic pigs. Forty partial-thickness wounds (2.2 x 2.2 cm and 400 microns deep) were treated with different zinc oxide concentrations, and epithelialization was evaluated morphometrically in a total of 320 histologic sections. Wound closure, bacterial growth, and inflammation were studied in eight full-thickness wounds (2.5 x 4.5 cm). The level of serum zinc was determined before and after treatment. In partial-thickness wounds, concentrations of zinc oxide at or below 1.0% (wt/wt) inhibited epithelialization, whereas no effect was observed at zinc oxide concentrations from 2% to 6%. In full-thickness wounds, zinc oxide (6%) reduced bacterial growth by about 2 log units and increased the inflammatory response in the granulation tissue, but had no effect on healing when compared with control (Hydrocolloid alone). Serum zinc levels remained unchanged throughout the treatment period. Apart from inhibiting bacterial growth, no additional beneficial effects on wound healing in nutritionally balanced pigs were found by supplementing a Hydrocolloid Dressing with zinc oxide.

  • Effects on wound healing of zinc oxide in a Hydrocolloid Dressing
    Journal of the American Academy of Dermatology, 1993
    Co-Authors: M S Agren, L Franzén, M Chvapil
    Abstract:

    Background: Zinc oxide incorporated in gauze enhances healing of chronic wounds in humans and experimental pig wounds. Objective: The purpose of this study was to examine the effects of zinc oxide added to a Hydrocolloid Dressing on the healing of surgical wounds in domestic pigs. Methods: Forty partial-thickness wounds (2.2 × 2.2 cm and 400 μm deep) were treated with different zinc oxide concentrations, and epithelialization was evaluated morphometrically in a total of 320 histologic sections. Wound closure, bacterial growth, and inflammation were studied in eight full-thickness wounds (2.5 × 4.5 cm). The level of serum zinc was determined before and after treatment. Results: In partial-thickness wounds, concentrations of zinc oxide at or below 1.0% (wt/wt) inhibited epithelialization, whereas no effect was observed at zinc oxide concentrations from 2% to 6%. In full-thickness wounds, zinc oxide (6%) reduced bacterial growth by about 2 log units and increased the inflammatory response in the granulation tissue, but had no effect on healing when compared with control (Hydrocolloid alone). Serum zinc levels remained unchanged throughout the treatment period. Conclusion: Apart from inhibiting bacterial growth, no additional beneficial effects on wound healing in nutritionally balanced pigs were found by supplementing a Hydrocolloid Dressing with zinc oxide.

Katharine Speak - One of the best experts on this subject based on the ideXlab platform.

  • Hydrocolloid Dressings for healing diabetic foot ulcers
    Cochrane Database of Systematic Reviews, 2013
    Co-Authors: Jo C Dumville, Susan Omeara, Sohan Deshpande, Katharine Speak
    Abstract:

    BACKGROUND: Foot ulcers in people with diabetes are a prevalent and serious global health issue. Wound Dressings are regarded as important components of ulcer treatment, with clinicians and patients having many different types to choose from including Hydrocolloid Dressings. There is a range of different Hydrocolloids available including fibrous-Hydrocolloid and Hydrocolloid (matrix) Dressings. A clear and current overview of current evidence is required to facilitate decision-making regarding Dressing use. OBJECTIVES: To compare the effects of Hydrocolloid wound Dressings with no Dressing or alternative Dressings on the healing of foot ulcers in people with diabetes. SEARCH METHODS: We searched The Cochrane Wounds Group Specialised Register (searched 4 January 2012); The Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library 2011, Issue 4); Ovid MEDLINE (1950 to December Week 3 2011); Ovid MEDLINE (In-Process & Other Non-Indexed Citations, January 03, 2012); Ovid EMBASE (1980 to 2011 Week 52); and EBSCO CINAHL (1982 to 30 December 2011). There were no restrictions based on language or date of publication. SELECTION CRITERIA: Published or unpublished randomised controlled trials (RCTs) that have compared the effects on ulcer healing of Hydrocolloid with alternative wound Dressings or no Dressing in the treatment of foot ulcers in people with diabetes. DATA COLLECTION AND ANALYSIS: Two review authors independently performed study selection, risk of bias assessment and data extraction. MAIN RESULTS: We included four studies (511 participants) in the review: these compared Hydrocolloids with basic wound contact Dressings, foam Dressings and alginate Dressings. Meta-analysis of two studies indicated no statistically significant difference in ulcer healing between fibrous-Hydrocolloids and basic wound contact Dressings: risk ratio 1.01 (95% CI 0.74 to 1.38). One of these studies found that a basic wound contact Dressing was more cost-effective than a fibrous-Hydrocolloid Dressing. One study compared a Hydrocolloid-matrix Dressing with a foam Dressing and found no statistically significant difference in the number of ulcers healed. There was no statistically significant difference in healing between an antimicrobial (silver) fibrous-Hydrocolloid Dressing and standard alginate Dressing; or an antimicrobial Dressing (iodine-impregnated) and a standard fibrous Hydrocolloid Dressing. AUTHORS' CONCLUSIONS: Currently there is no research evidence to suggest that any type of Hydrocolloid wound Dressing is more effective in healing diabetic foot ulcers than other types of Dressing. Decision makers may wish to consider aspects such as Dressing cost and the wound management properties offered by each Dressing type e.g. exudate management.

  • The Cochrane Library - Hydrocolloid Dressings for healing diabetic foot ulcers
    Cochrane Database of Systematic Reviews, 2013
    Co-Authors: Susan O’meara, Sohan Deshpande, Jo C Dumville, Katharine Speak
    Abstract:

    BACKGROUND: Foot ulcers in people with diabetes are a prevalent and serious global health issue. Wound Dressings are regarded as important components of ulcer treatment, with clinicians and patients having many different types to choose from including Hydrocolloid Dressings. There is a range of different Hydrocolloids available including fibrous-Hydrocolloid and Hydrocolloid (matrix) Dressings. A clear and current overview of current evidence is required to facilitate decision-making regarding Dressing use. OBJECTIVES: To compare the effects of Hydrocolloid wound Dressings with no Dressing or alternative Dressings on the healing of foot ulcers in people with diabetes. SEARCH METHODS: We searched The Cochrane Wounds Group Specialised Register (searched 4 January 2012); The Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library 2011, Issue 4); Ovid MEDLINE (1950 to December Week 3 2011); Ovid MEDLINE (In-Process & Other Non-Indexed Citations, January 03, 2012); Ovid EMBASE (1980 to 2011 Week 52); and EBSCO CINAHL (1982 to 30 December 2011). There were no restrictions based on language or date of publication. SELECTION CRITERIA: Published or unpublished randomised controlled trials (RCTs) that have compared the effects on ulcer healing of Hydrocolloid with alternative wound Dressings or no Dressing in the treatment of foot ulcers in people with diabetes. DATA COLLECTION AND ANALYSIS: Two review authors independently performed study selection, risk of bias assessment and data extraction. MAIN RESULTS: We included four studies (511 participants) in the review: these compared Hydrocolloids with basic wound contact Dressings, foam Dressings and alginate Dressings. Meta-analysis of two studies indicated no statistically significant difference in ulcer healing between fibrous-Hydrocolloids and basic wound contact Dressings: risk ratio 1.01 (95% CI 0.74 to 1.38). One of these studies found that a basic wound contact Dressing was more cost-effective than a fibrous-Hydrocolloid Dressing. One study compared a Hydrocolloid-matrix Dressing with a foam Dressing and found no statistically significant difference in the number of ulcers healed. There was no statistically significant difference in healing between an antimicrobial (silver) fibrous-Hydrocolloid Dressing and standard alginate Dressing; or an antimicrobial Dressing (iodine-impregnated) and a standard fibrous Hydrocolloid Dressing. AUTHORS' CONCLUSIONS: Currently there is no research evidence to suggest that any type of Hydrocolloid wound Dressing is more effective in healing diabetic foot ulcers than other types of Dressing. Decision makers may wish to consider aspects such as Dressing cost and the wound management properties offered by each Dressing type e.g. exudate management.

  • The Cochrane Library - Hydrocolloid Dressings for healing diabetic foot ulcers
    Cochrane Database of Systematic Reviews, 2013
    Co-Authors: Jo C Dumville, Susan O’meara, Sohan Deshpande, Katharine Speak
    Abstract:

    Background Foot ulcers in people with diabetes are a prevalent and serious global health issue. Wound Dressings are regarded as important components of ulcer treatment, with clinicians and patients having many different types to choose from including Hydrocolloid Dressings. There is a range of different Hydrocolloids available including fibrous-Hydrocolloid and Hydrocolloid (matrix) Dressings. A clear and current overview of current evidence is required to facilitate decision-making regarding Dressing use. Objectives To compare the effects of Hydrocolloid wound Dressings with no Dressing or alternative Dressings on the healing of foot ulcers in people with diabetes. Search methods For this first update, in April 2013, we searched the following databases the Cochrane Wounds Group Specialised Register; The Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library); Ovid MEDLINE; Ovid MEDLINE (In-Process & Other Non-Indexed Citations); Ovid EMBASE; and EBSCO CINAHL. There were no restrictions based on language or date of publication. Selection criteria Published or unpublished randomised controlled trials (RCTs) that have compared the effects on ulcer healing of Hydrocolloid with alternative wound treatments in the treatment of foot ulcers in people with diabetes. Data collection and analysis Two review authors independently performed study selection, risk of bias assessment and data extraction. Main results We included five studies (535 participants) in the review: these compared Hydrocolloids with basic wound contact Dressings, foam Dressings, alginate Dressings and a topical treatment. Meta-analysis of two studies indicated no statistically significant difference in ulcer healing between fibrous-Hydrocolloids and basic wound contact Dressings: risk ratio 1.01 (95% CI 0.74 to 1.38). One of these studies found that a basic wound contact Dressing was more cost-effective than a fibrous-Hydrocolloid Dressing. One study compared a Hydrocolloid-matrix Dressing with a foam Dressing and found no statistically significant difference in the number of ulcers healed. There was no statistically significant difference in healing between an antimicrobial (silver) fibrous-Hydrocolloid Dressing and standard alginate Dressing; an antimicrobial Dressing (iodine-impregnated) and a standard fibrous Hydrocolloid Dressing or a standard fibrous Hydrocolloid Dressing and a topical cream containing plant extracts. Authors' conclusions Currently there is no research evidence to suggest that any type of Hydrocolloid wound Dressing is more effective in healing diabetic foot ulcers than other types of Dressing or a topical cream containing plant extracts. Decision makers may wish to consider aspects such as Dressing cost and the wound management properties offered by each Dressing type e.g. exudate management.

  • Hydrocolloid Dressings for healing diabetic foot ulcers.
    The Cochrane database of systematic reviews, 2012
    Co-Authors: Jo C Dumville, Sohan Deshpande, Susan O'meara, Katharine Speak
    Abstract:

    Foot ulcers in people with diabetes are a prevalent and serious global health issue. Wound Dressings are regarded as important components of ulcer treatment, with clinicians and patients having many different types to choose from including Hydrocolloid Dressings. There is a range of different Hydrocolloids available including fibrous-Hydrocolloid and Hydrocolloid (matrix) Dressings. A clear and current overview of current evidence is required to facilitate decision-making regarding Dressing use. To compare the effects of Hydrocolloid wound Dressings with no Dressing or alternative Dressings on the healing of foot ulcers in people with diabetes. We searched The Cochrane Wounds Group Specialised Register (searched 4 January 2012); The Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library 2011, Issue 4); Ovid MEDLINE (1950 to December Week 3 2011); Ovid MEDLINE (In-Process & Other Non-Indexed Citations, January 03, 2012); Ovid EMBASE (1980 to 2011 Week 52); and EBSCO CINAHL (1982 to 30 December 2011). There were no restrictions based on language or date of publication. Published or unpublished randomised controlled trials (RCTs) that have compared the effects on ulcer healing of Hydrocolloid with alternative wound Dressings or no Dressing in the treatment of foot ulcers in people with diabetes. Two review authors independently performed study selection, risk of bias assessment and data extraction. We included four studies (511 participants) in the review: these compared Hydrocolloids with basic wound contact Dressings, foam Dressings and alginate Dressings. Meta-analysis of two studies indicated no statistically significant difference in ulcer healing between fibrous-Hydrocolloids and basic wound contact Dressings: risk ratio 1.01 (95% CI 0.74 to 1.38). One of these studies found that a basic wound contact Dressing was more cost-effective than a fibrous-Hydrocolloid Dressing. One study compared a Hydrocolloid-matrix Dressing with a foam Dressing and found no statistically significant difference in the number of ulcers healed. There was no statistically significant difference in healing between an antimicrobial (silver) fibrous-Hydrocolloid Dressing and standard alginate Dressing; or an antimicrobial Dressing (iodine-impregnated) and a standard fibrous Hydrocolloid Dressing. Currently there is no research evidence to suggest that any type of Hydrocolloid wound Dressing is more effective in healing diabetic foot ulcers than other types of Dressing. Decision makers may wish to consider aspects such as Dressing cost and the wound management properties offered by each Dressing type e.g. exudate management.

M S Agren - One of the best experts on this subject based on the ideXlab platform.

  • Effects on wound healing of zinc oxide in a Hydrocolloid Dressing.
    Journal of the American Academy of Dermatology, 1993
    Co-Authors: M S Agren, L Franzén, M Chvapil
    Abstract:

    Zinc oxide incorporated in gauze enhances healing of chronic wounds in humans and experimental pig wounds. The purpose of this study was to examine the effects of zinc oxide added to a Hydrocolloid Dressing on the healing of surgical wounds in domestic pigs. Forty partial-thickness wounds (2.2 x 2.2 cm and 400 microns deep) were treated with different zinc oxide concentrations, and epithelialization was evaluated morphometrically in a total of 320 histologic sections. Wound closure, bacterial growth, and inflammation were studied in eight full-thickness wounds (2.5 x 4.5 cm). The level of serum zinc was determined before and after treatment. In partial-thickness wounds, concentrations of zinc oxide at or below 1.0% (wt/wt) inhibited epithelialization, whereas no effect was observed at zinc oxide concentrations from 2% to 6%. In full-thickness wounds, zinc oxide (6%) reduced bacterial growth by about 2 log units and increased the inflammatory response in the granulation tissue, but had no effect on healing when compared with control (Hydrocolloid alone). Serum zinc levels remained unchanged throughout the treatment period. Apart from inhibiting bacterial growth, no additional beneficial effects on wound healing in nutritionally balanced pigs were found by supplementing a Hydrocolloid Dressing with zinc oxide.

  • Effects on wound healing of zinc oxide in a Hydrocolloid Dressing
    Journal of the American Academy of Dermatology, 1993
    Co-Authors: M S Agren, L Franzén, M Chvapil
    Abstract:

    Background: Zinc oxide incorporated in gauze enhances healing of chronic wounds in humans and experimental pig wounds. Objective: The purpose of this study was to examine the effects of zinc oxide added to a Hydrocolloid Dressing on the healing of surgical wounds in domestic pigs. Methods: Forty partial-thickness wounds (2.2 × 2.2 cm and 400 μm deep) were treated with different zinc oxide concentrations, and epithelialization was evaluated morphometrically in a total of 320 histologic sections. Wound closure, bacterial growth, and inflammation were studied in eight full-thickness wounds (2.5 × 4.5 cm). The level of serum zinc was determined before and after treatment. Results: In partial-thickness wounds, concentrations of zinc oxide at or below 1.0% (wt/wt) inhibited epithelialization, whereas no effect was observed at zinc oxide concentrations from 2% to 6%. In full-thickness wounds, zinc oxide (6%) reduced bacterial growth by about 2 log units and increased the inflammatory response in the granulation tissue, but had no effect on healing when compared with control (Hydrocolloid alone). Serum zinc levels remained unchanged throughout the treatment period. Conclusion: Apart from inhibiting bacterial growth, no additional beneficial effects on wound healing in nutritionally balanced pigs were found by supplementing a Hydrocolloid Dressing with zinc oxide.

Jo C Dumville - One of the best experts on this subject based on the ideXlab platform.

  • Hydrocolloid Dressings for healing diabetic foot ulcers
    Cochrane Database of Systematic Reviews, 2013
    Co-Authors: Jo C Dumville, Susan Omeara, Sohan Deshpande, Katharine Speak
    Abstract:

    BACKGROUND: Foot ulcers in people with diabetes are a prevalent and serious global health issue. Wound Dressings are regarded as important components of ulcer treatment, with clinicians and patients having many different types to choose from including Hydrocolloid Dressings. There is a range of different Hydrocolloids available including fibrous-Hydrocolloid and Hydrocolloid (matrix) Dressings. A clear and current overview of current evidence is required to facilitate decision-making regarding Dressing use. OBJECTIVES: To compare the effects of Hydrocolloid wound Dressings with no Dressing or alternative Dressings on the healing of foot ulcers in people with diabetes. SEARCH METHODS: We searched The Cochrane Wounds Group Specialised Register (searched 4 January 2012); The Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library 2011, Issue 4); Ovid MEDLINE (1950 to December Week 3 2011); Ovid MEDLINE (In-Process & Other Non-Indexed Citations, January 03, 2012); Ovid EMBASE (1980 to 2011 Week 52); and EBSCO CINAHL (1982 to 30 December 2011). There were no restrictions based on language or date of publication. SELECTION CRITERIA: Published or unpublished randomised controlled trials (RCTs) that have compared the effects on ulcer healing of Hydrocolloid with alternative wound Dressings or no Dressing in the treatment of foot ulcers in people with diabetes. DATA COLLECTION AND ANALYSIS: Two review authors independently performed study selection, risk of bias assessment and data extraction. MAIN RESULTS: We included four studies (511 participants) in the review: these compared Hydrocolloids with basic wound contact Dressings, foam Dressings and alginate Dressings. Meta-analysis of two studies indicated no statistically significant difference in ulcer healing between fibrous-Hydrocolloids and basic wound contact Dressings: risk ratio 1.01 (95% CI 0.74 to 1.38). One of these studies found that a basic wound contact Dressing was more cost-effective than a fibrous-Hydrocolloid Dressing. One study compared a Hydrocolloid-matrix Dressing with a foam Dressing and found no statistically significant difference in the number of ulcers healed. There was no statistically significant difference in healing between an antimicrobial (silver) fibrous-Hydrocolloid Dressing and standard alginate Dressing; or an antimicrobial Dressing (iodine-impregnated) and a standard fibrous Hydrocolloid Dressing. AUTHORS' CONCLUSIONS: Currently there is no research evidence to suggest that any type of Hydrocolloid wound Dressing is more effective in healing diabetic foot ulcers than other types of Dressing. Decision makers may wish to consider aspects such as Dressing cost and the wound management properties offered by each Dressing type e.g. exudate management.

  • The Cochrane Library - Hydrocolloid Dressings for healing diabetic foot ulcers
    Cochrane Database of Systematic Reviews, 2013
    Co-Authors: Susan O’meara, Sohan Deshpande, Jo C Dumville, Katharine Speak
    Abstract:

    BACKGROUND: Foot ulcers in people with diabetes are a prevalent and serious global health issue. Wound Dressings are regarded as important components of ulcer treatment, with clinicians and patients having many different types to choose from including Hydrocolloid Dressings. There is a range of different Hydrocolloids available including fibrous-Hydrocolloid and Hydrocolloid (matrix) Dressings. A clear and current overview of current evidence is required to facilitate decision-making regarding Dressing use. OBJECTIVES: To compare the effects of Hydrocolloid wound Dressings with no Dressing or alternative Dressings on the healing of foot ulcers in people with diabetes. SEARCH METHODS: We searched The Cochrane Wounds Group Specialised Register (searched 4 January 2012); The Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library 2011, Issue 4); Ovid MEDLINE (1950 to December Week 3 2011); Ovid MEDLINE (In-Process & Other Non-Indexed Citations, January 03, 2012); Ovid EMBASE (1980 to 2011 Week 52); and EBSCO CINAHL (1982 to 30 December 2011). There were no restrictions based on language or date of publication. SELECTION CRITERIA: Published or unpublished randomised controlled trials (RCTs) that have compared the effects on ulcer healing of Hydrocolloid with alternative wound Dressings or no Dressing in the treatment of foot ulcers in people with diabetes. DATA COLLECTION AND ANALYSIS: Two review authors independently performed study selection, risk of bias assessment and data extraction. MAIN RESULTS: We included four studies (511 participants) in the review: these compared Hydrocolloids with basic wound contact Dressings, foam Dressings and alginate Dressings. Meta-analysis of two studies indicated no statistically significant difference in ulcer healing between fibrous-Hydrocolloids and basic wound contact Dressings: risk ratio 1.01 (95% CI 0.74 to 1.38). One of these studies found that a basic wound contact Dressing was more cost-effective than a fibrous-Hydrocolloid Dressing. One study compared a Hydrocolloid-matrix Dressing with a foam Dressing and found no statistically significant difference in the number of ulcers healed. There was no statistically significant difference in healing between an antimicrobial (silver) fibrous-Hydrocolloid Dressing and standard alginate Dressing; or an antimicrobial Dressing (iodine-impregnated) and a standard fibrous Hydrocolloid Dressing. AUTHORS' CONCLUSIONS: Currently there is no research evidence to suggest that any type of Hydrocolloid wound Dressing is more effective in healing diabetic foot ulcers than other types of Dressing. Decision makers may wish to consider aspects such as Dressing cost and the wound management properties offered by each Dressing type e.g. exudate management.

  • The Cochrane Library - Hydrocolloid Dressings for healing diabetic foot ulcers
    Cochrane Database of Systematic Reviews, 2013
    Co-Authors: Jo C Dumville, Susan O’meara, Sohan Deshpande, Katharine Speak
    Abstract:

    Background Foot ulcers in people with diabetes are a prevalent and serious global health issue. Wound Dressings are regarded as important components of ulcer treatment, with clinicians and patients having many different types to choose from including Hydrocolloid Dressings. There is a range of different Hydrocolloids available including fibrous-Hydrocolloid and Hydrocolloid (matrix) Dressings. A clear and current overview of current evidence is required to facilitate decision-making regarding Dressing use. Objectives To compare the effects of Hydrocolloid wound Dressings with no Dressing or alternative Dressings on the healing of foot ulcers in people with diabetes. Search methods For this first update, in April 2013, we searched the following databases the Cochrane Wounds Group Specialised Register; The Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library); Ovid MEDLINE; Ovid MEDLINE (In-Process & Other Non-Indexed Citations); Ovid EMBASE; and EBSCO CINAHL. There were no restrictions based on language or date of publication. Selection criteria Published or unpublished randomised controlled trials (RCTs) that have compared the effects on ulcer healing of Hydrocolloid with alternative wound treatments in the treatment of foot ulcers in people with diabetes. Data collection and analysis Two review authors independently performed study selection, risk of bias assessment and data extraction. Main results We included five studies (535 participants) in the review: these compared Hydrocolloids with basic wound contact Dressings, foam Dressings, alginate Dressings and a topical treatment. Meta-analysis of two studies indicated no statistically significant difference in ulcer healing between fibrous-Hydrocolloids and basic wound contact Dressings: risk ratio 1.01 (95% CI 0.74 to 1.38). One of these studies found that a basic wound contact Dressing was more cost-effective than a fibrous-Hydrocolloid Dressing. One study compared a Hydrocolloid-matrix Dressing with a foam Dressing and found no statistically significant difference in the number of ulcers healed. There was no statistically significant difference in healing between an antimicrobial (silver) fibrous-Hydrocolloid Dressing and standard alginate Dressing; an antimicrobial Dressing (iodine-impregnated) and a standard fibrous Hydrocolloid Dressing or a standard fibrous Hydrocolloid Dressing and a topical cream containing plant extracts. Authors' conclusions Currently there is no research evidence to suggest that any type of Hydrocolloid wound Dressing is more effective in healing diabetic foot ulcers than other types of Dressing or a topical cream containing plant extracts. Decision makers may wish to consider aspects such as Dressing cost and the wound management properties offered by each Dressing type e.g. exudate management.

  • Hydrocolloid Dressings for healing diabetic foot ulcers.
    The Cochrane database of systematic reviews, 2012
    Co-Authors: Jo C Dumville, Sohan Deshpande, Susan O'meara, Katharine Speak
    Abstract:

    Foot ulcers in people with diabetes are a prevalent and serious global health issue. Wound Dressings are regarded as important components of ulcer treatment, with clinicians and patients having many different types to choose from including Hydrocolloid Dressings. There is a range of different Hydrocolloids available including fibrous-Hydrocolloid and Hydrocolloid (matrix) Dressings. A clear and current overview of current evidence is required to facilitate decision-making regarding Dressing use. To compare the effects of Hydrocolloid wound Dressings with no Dressing or alternative Dressings on the healing of foot ulcers in people with diabetes. We searched The Cochrane Wounds Group Specialised Register (searched 4 January 2012); The Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library 2011, Issue 4); Ovid MEDLINE (1950 to December Week 3 2011); Ovid MEDLINE (In-Process & Other Non-Indexed Citations, January 03, 2012); Ovid EMBASE (1980 to 2011 Week 52); and EBSCO CINAHL (1982 to 30 December 2011). There were no restrictions based on language or date of publication. Published or unpublished randomised controlled trials (RCTs) that have compared the effects on ulcer healing of Hydrocolloid with alternative wound Dressings or no Dressing in the treatment of foot ulcers in people with diabetes. Two review authors independently performed study selection, risk of bias assessment and data extraction. We included four studies (511 participants) in the review: these compared Hydrocolloids with basic wound contact Dressings, foam Dressings and alginate Dressings. Meta-analysis of two studies indicated no statistically significant difference in ulcer healing between fibrous-Hydrocolloids and basic wound contact Dressings: risk ratio 1.01 (95% CI 0.74 to 1.38). One of these studies found that a basic wound contact Dressing was more cost-effective than a fibrous-Hydrocolloid Dressing. One study compared a Hydrocolloid-matrix Dressing with a foam Dressing and found no statistically significant difference in the number of ulcers healed. There was no statistically significant difference in healing between an antimicrobial (silver) fibrous-Hydrocolloid Dressing and standard alginate Dressing; or an antimicrobial Dressing (iodine-impregnated) and a standard fibrous Hydrocolloid Dressing. Currently there is no research evidence to suggest that any type of Hydrocolloid wound Dressing is more effective in healing diabetic foot ulcers than other types of Dressing. Decision makers may wish to consider aspects such as Dressing cost and the wound management properties offered by each Dressing type e.g. exudate management.

L Franzén - One of the best experts on this subject based on the ideXlab platform.

  • Effects on wound healing of zinc oxide in a Hydrocolloid Dressing.
    Journal of the American Academy of Dermatology, 1993
    Co-Authors: M S Agren, L Franzén, M Chvapil
    Abstract:

    Zinc oxide incorporated in gauze enhances healing of chronic wounds in humans and experimental pig wounds. The purpose of this study was to examine the effects of zinc oxide added to a Hydrocolloid Dressing on the healing of surgical wounds in domestic pigs. Forty partial-thickness wounds (2.2 x 2.2 cm and 400 microns deep) were treated with different zinc oxide concentrations, and epithelialization was evaluated morphometrically in a total of 320 histologic sections. Wound closure, bacterial growth, and inflammation were studied in eight full-thickness wounds (2.5 x 4.5 cm). The level of serum zinc was determined before and after treatment. In partial-thickness wounds, concentrations of zinc oxide at or below 1.0% (wt/wt) inhibited epithelialization, whereas no effect was observed at zinc oxide concentrations from 2% to 6%. In full-thickness wounds, zinc oxide (6%) reduced bacterial growth by about 2 log units and increased the inflammatory response in the granulation tissue, but had no effect on healing when compared with control (Hydrocolloid alone). Serum zinc levels remained unchanged throughout the treatment period. Apart from inhibiting bacterial growth, no additional beneficial effects on wound healing in nutritionally balanced pigs were found by supplementing a Hydrocolloid Dressing with zinc oxide.

  • Effects on wound healing of zinc oxide in a Hydrocolloid Dressing
    Journal of the American Academy of Dermatology, 1993
    Co-Authors: M S Agren, L Franzén, M Chvapil
    Abstract:

    Background: Zinc oxide incorporated in gauze enhances healing of chronic wounds in humans and experimental pig wounds. Objective: The purpose of this study was to examine the effects of zinc oxide added to a Hydrocolloid Dressing on the healing of surgical wounds in domestic pigs. Methods: Forty partial-thickness wounds (2.2 × 2.2 cm and 400 μm deep) were treated with different zinc oxide concentrations, and epithelialization was evaluated morphometrically in a total of 320 histologic sections. Wound closure, bacterial growth, and inflammation were studied in eight full-thickness wounds (2.5 × 4.5 cm). The level of serum zinc was determined before and after treatment. Results: In partial-thickness wounds, concentrations of zinc oxide at or below 1.0% (wt/wt) inhibited epithelialization, whereas no effect was observed at zinc oxide concentrations from 2% to 6%. In full-thickness wounds, zinc oxide (6%) reduced bacterial growth by about 2 log units and increased the inflammatory response in the granulation tissue, but had no effect on healing when compared with control (Hydrocolloid alone). Serum zinc levels remained unchanged throughout the treatment period. Conclusion: Apart from inhibiting bacterial growth, no additional beneficial effects on wound healing in nutritionally balanced pigs were found by supplementing a Hydrocolloid Dressing with zinc oxide.