The Experts below are selected from a list of 267 Experts worldwide ranked by ideXlab platform
Elizabeth A Veal - One of the best experts on this subject based on the ideXlab platform.
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Hydrogen Peroxide as a signaling molecule
Antioxidants & Redox Signaling, 2011Co-Authors: Elizabeth A VealAbstract:Abstract Increases in Hydrogen Peroxide can initiate protective responses to limit or repair oxidative damage. However, Hydrogen Peroxide signals also fine-tune responses to growth factors and cytokines to control cell division, differentiation, and migration. Here we discuss some of the mechanisms by which Hydrogen Peroxide is sensed and utilized as a signaling molecule to regulate diverse biological processes. We also discuss how the localization and levels of Hydrogen Peroxide, antioxidants, and the cellular metal composition together influence the nature of the response. Antioxid. Redox Signal. 15, 147–151.
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Hydrogen Peroxide sensing and signaling
Molecular Cell, 2007Co-Authors: Elizabeth A Veal, Brian A MorganAbstract:It is well established that oxidative stress is an important cause of cell damage associated with the initiation and progression of many diseases. Consequently, all air-living organisms contain antioxidant enzymes that limit oxidative stress by detoxifying reactive oxygen species, including Hydrogen Peroxide. However, in eukaryotes, Hydrogen Peroxide also has important roles as a signaling molecule in the regulation of a variety of biological processes. Here, we will discuss the molecular mechanisms by which Hydrogen Peroxide is sensed and the increasing evidence that antioxidant enzymes play multiple, key roles as sensors and regulators of signal transduction in response to Hydrogen Peroxide.
Kenneth D Karlin - One of the best experts on this subject based on the ideXlab platform.
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Hydrogen Peroxide as a sustainable energy carrier electrocatalytic production of Hydrogen Peroxide and the fuel cell
Electrochimica Acta, 2012Co-Authors: Kenneth D Karlin, Yusuke Yamada, Shunichi FukuzumiAbstract:This review describes homogeneous and heterogeneous catalytic reduction of dioxygen with metal complexes focusing on the catalytic two-electron reduction of dioxygen to produce Hydrogen Peroxide. Whether two-electron reduction of dioxygen to produce Hydrogen Peroxide or four-electron O2-reduction to produce water occurs depends on the types of metals and ligands that are utilized. Those factors controlling the two processes are discussed in terms of metal–oxygen intermediates involved in the catalysis. Metal complexes acting as catalysts for selective two-electron reduction of oxygen can be utilized as metal complex-modified electrodes in the electrocatalytic reduction to produce Hydrogen Peroxide. Hydrogen Peroxide thus produced can be used as a fuel in a Hydrogen Peroxide fuel cell. A Hydrogen Peroxide fuel cell can be operated with a one-compartment structure without a membrane, which is certainly more promising for the development of low-cost fuel cells as compared with two compartment Hydrogen fuel cells that require membranes. Hydrogen Peroxide is regarded as an environmentally benign energy carrier because it can be produced by the electrocatalytic two-electron reduction of O2, which is abundant in air, using solar cells; the Hydrogen Peroxide thus produced could then be readily stored and then used as needed to generate electricity through the use of Hydrogen Peroxide fuel cells.
Shunichi Fukuzumi - One of the best experts on this subject based on the ideXlab platform.
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Thermal and Photocatalytic Production of Hydrogen Peroxide and its Use in Hydrogen Peroxide Fuel Cells
Australian Journal of Chemistry, 2014Co-Authors: Shunichi Fukuzumi, Yusuke YamadaAbstract:This mini review describes our recent developments on the thermal and photocatalytic production of Hydrogen Peroxide and its use in Hydrogen Peroxide fuel cells. Selective two-electron reduction of dioxygen to Hydrogen Peroxide by one-electron reductants has been made possible by using appropriate metal complexes with an acid. Protonation of the ligands of the complexes facilitates the reduction of O2. The photocatalytic two-electron reduction of dioxygen to Hydrogen Peroxide also occurs using organic photocatalysts and oxalic acid as an electron source in buffer solutions. The control of the water content and pH of a reaction solution is significant for improving the catalytic activity and durability. A Hydrogen Peroxide fuel cell can be operated with a one-compartment structure without a membrane, which is certainly more promising for the development of low-cost fuel cells as compared with two compartment Hydrogen fuel cells that require membranes. Utilisation of iron complexes as cathode materials are reviewed.
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Hydrogen Peroxide as a sustainable energy carrier electrocatalytic production of Hydrogen Peroxide and the fuel cell
Electrochimica Acta, 2012Co-Authors: Kenneth D Karlin, Yusuke Yamada, Shunichi FukuzumiAbstract:This review describes homogeneous and heterogeneous catalytic reduction of dioxygen with metal complexes focusing on the catalytic two-electron reduction of dioxygen to produce Hydrogen Peroxide. Whether two-electron reduction of dioxygen to produce Hydrogen Peroxide or four-electron O2-reduction to produce water occurs depends on the types of metals and ligands that are utilized. Those factors controlling the two processes are discussed in terms of metal–oxygen intermediates involved in the catalysis. Metal complexes acting as catalysts for selective two-electron reduction of oxygen can be utilized as metal complex-modified electrodes in the electrocatalytic reduction to produce Hydrogen Peroxide. Hydrogen Peroxide thus produced can be used as a fuel in a Hydrogen Peroxide fuel cell. A Hydrogen Peroxide fuel cell can be operated with a one-compartment structure without a membrane, which is certainly more promising for the development of low-cost fuel cells as compared with two compartment Hydrogen fuel cells that require membranes. Hydrogen Peroxide is regarded as an environmentally benign energy carrier because it can be produced by the electrocatalytic two-electron reduction of O2, which is abundant in air, using solar cells; the Hydrogen Peroxide thus produced could then be readily stored and then used as needed to generate electricity through the use of Hydrogen Peroxide fuel cells.
Shrey Kohli - One of the best experts on this subject based on the ideXlab platform.
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Hydrogen Peroxide sensing and signaling
Free Radicals in Human Health and Disease, 2015Co-Authors: Vibha Rani, Tanuja Yadav, Umesh Chand Singh Yadav, Shivangi Mishra, Shrey KohliAbstract:It is well established that oxidative stress is an important cause of cell damage associated with the initiation and progression of many diseases. Consequently, all air-living organisms contain antioxidant enzymes that limit oxidative stress by detoxifying reactive oxygen species, including Hydrogen Peroxide. However, in eukaryotes, Hydrogen Peroxide also has important roles as a signaling molecule in the regulation of a variety of biological processes. Here, we will discuss the molecular mechanisms by which Hydrogen Peroxide is sensed and the increasing evidence that antioxidant enzymes play multiple, key roles as sensors and regulators of signal transduction in response to Hydrogen Peroxide. © 2007 Elsevier Inc. All rights reserved.
Brian A Morgan - One of the best experts on this subject based on the ideXlab platform.
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Hydrogen Peroxide sensing and signaling
Molecular Cell, 2007Co-Authors: Elizabeth A Veal, Brian A MorganAbstract:It is well established that oxidative stress is an important cause of cell damage associated with the initiation and progression of many diseases. Consequently, all air-living organisms contain antioxidant enzymes that limit oxidative stress by detoxifying reactive oxygen species, including Hydrogen Peroxide. However, in eukaryotes, Hydrogen Peroxide also has important roles as a signaling molecule in the regulation of a variety of biological processes. Here, we will discuss the molecular mechanisms by which Hydrogen Peroxide is sensed and the increasing evidence that antioxidant enzymes play multiple, key roles as sensors and regulators of signal transduction in response to Hydrogen Peroxide.
