The Experts below are selected from a list of 315 Experts worldwide ranked by ideXlab platform
Prabha D Nair - One of the best experts on this subject based on the ideXlab platform.
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a simple and effective method for making multipotent multilineage scaffolds with Hydrophilic Nature without any postmodification treatment
Colloids and Surfaces B: Biointerfaces, 2016Co-Authors: Dhanesh Vaikkath, Rakhi Anitha, Babitha Sumathy, Prabha D NairAbstract:Abstract A number of biodegradable and bioresorbable materials, as well as scaffold designs, have been experimentally and/or clinically studied for tissue engineering of diverse tissue types. Cell-material responses are strongly dependent on the properties of the scaffold material. In this study, scaffolds based on polycaprolactone (PCL) and PCL blended with a triblock copolymer, Polycaprolactone–polytetrahydrofuran–polycaprolactone (PCL–PTHF–PCL) at different ratios were fabricated by electrospinning. Blending and electrospinning of the triblock copolymer with PCL generated a super Hydrophilic scaffold, the mechanical and biological properties of which varied with the concentration of the triblock copolymer. The Hydrophilicity of the electrospun scaffolds was determined by measurement of water–air contact angle. Cellular response to the electrospun scaffolds was studied by seeding two types of cells, L929 fibroblast cell line and rat mesenchymal stem cells (RMSC). We observed that the super Hydrophilicity of the material did not prevent cell adhesion, while the cell proliferation was low or negligible for scaffolds containing higher amount of PCL–PTHF–PCL. Chondrogenic differentiation of RMSC was found to be better on the PCL blend containing 10% (w/v) of PCL–PTHF–PCL than the bare PCL. Our studies indicate that the cellular response is dependent on the biomaterial composition and highlight the importance of tailoring the scaffold properties for applications in tissue engineering and regenerative medicine.
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A simple and effective method for making multipotent/multilineage scaffolds with Hydrophilic Nature without any postmodification/treatment
Colloids and Surfaces B: Biointerfaces, 2015Co-Authors: Dhanesh Vaikkath, Rakhi Anitha, Babitha Sumathy, Prabha D NairAbstract:Abstract A number of biodegradable and bioresorbable materials, as well as scaffold designs, have been experimentally and/or clinically studied for tissue engineering of diverse tissue types. Cell-material responses are strongly dependent on the properties of the scaffold material. In this study, scaffolds based on polycaprolactone (PCL) and PCL blended with a triblock copolymer, Polycaprolactone–polytetrahydrofuran–polycaprolactone (PCL–PTHF–PCL) at different ratios were fabricated by electrospinning. Blending and electrospinning of the triblock copolymer with PCL generated a super Hydrophilic scaffold, the mechanical and biological properties of which varied with the concentration of the triblock copolymer. The Hydrophilicity of the electrospun scaffolds was determined by measurement of water–air contact angle. Cellular response to the electrospun scaffolds was studied by seeding two types of cells, L929 fibroblast cell line and rat mesenchymal stem cells (RMSC). We observed that the super Hydrophilicity of the material did not prevent cell adhesion, while the cell proliferation was low or negligible for scaffolds containing higher amount of PCL–PTHF–PCL. Chondrogenic differentiation of RMSC was found to be better on the PCL blend containing 10% (w/v) of PCL–PTHF–PCL than the bare PCL. Our studies indicate that the cellular response is dependent on the biomaterial composition and highlight the importance of tailoring the scaffold properties for applications in tissue engineering and regenerative medicine.
Girish M Joshi - One of the best experts on this subject based on the ideXlab platform.
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disparity in hydrophobic to Hydrophilic Nature of polymer blend modified by k2ti6o13 as a function of air plasma treatment
Progress in Organic Coatings, 2017Co-Authors: E Dhanumalayan, Ajinkya M Trimukhe, Rajendra R Deshmukh, Girish M JoshiAbstract:Abstract Polymer blends of Poly (vinylidenefluoride) (PVDF)/Poly (methyl methacrylate) (PMMA) were modified by Potassium hexa-titanate oxide (K 2 Ti 6 O 13 ) in weight fraction ratio. The blends were further exposed to air plasma treatment. The alteration of surface morphology due to plasma treatment was analyzed using polarizing optical, scanning electron and atomic force microscopic techniques. The confirmation of chemical composition and elemental analysis of untreated and treated blends were done using Fourier transform infrared spectrum (FTIR) and energy dispersion spectroscopy (EDS). Theoretical methods of calculating contact angle (θ°), surface energy (γ SE ), and roughness average (R a ) were disclosed to evaluate the experimental data. The microscopic observations clearly demonstrated the synergic effect induced by plasma treatment which improved the surface energy and formation of micro texture. Surface energy was estimated from contact angle data, which demonstrate the significant disparity in hydrophobic to Hydrophilic Nature. It is well known that the air plasma treatment incorporates polar functional groups onto the surface, which is responsible for the decrease in contact angle. Further, the increase in surface roughness as seen from AFM is also responsible for the decrease in contact angle and Hydrophilic Nature. The optimization of barrier properties of polymer blends using plasma treatment can be useful in the development of liquid attracting layer applications.
Dhanesh Vaikkath - One of the best experts on this subject based on the ideXlab platform.
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a simple and effective method for making multipotent multilineage scaffolds with Hydrophilic Nature without any postmodification treatment
Colloids and Surfaces B: Biointerfaces, 2016Co-Authors: Dhanesh Vaikkath, Rakhi Anitha, Babitha Sumathy, Prabha D NairAbstract:Abstract A number of biodegradable and bioresorbable materials, as well as scaffold designs, have been experimentally and/or clinically studied for tissue engineering of diverse tissue types. Cell-material responses are strongly dependent on the properties of the scaffold material. In this study, scaffolds based on polycaprolactone (PCL) and PCL blended with a triblock copolymer, Polycaprolactone–polytetrahydrofuran–polycaprolactone (PCL–PTHF–PCL) at different ratios were fabricated by electrospinning. Blending and electrospinning of the triblock copolymer with PCL generated a super Hydrophilic scaffold, the mechanical and biological properties of which varied with the concentration of the triblock copolymer. The Hydrophilicity of the electrospun scaffolds was determined by measurement of water–air contact angle. Cellular response to the electrospun scaffolds was studied by seeding two types of cells, L929 fibroblast cell line and rat mesenchymal stem cells (RMSC). We observed that the super Hydrophilicity of the material did not prevent cell adhesion, while the cell proliferation was low or negligible for scaffolds containing higher amount of PCL–PTHF–PCL. Chondrogenic differentiation of RMSC was found to be better on the PCL blend containing 10% (w/v) of PCL–PTHF–PCL than the bare PCL. Our studies indicate that the cellular response is dependent on the biomaterial composition and highlight the importance of tailoring the scaffold properties for applications in tissue engineering and regenerative medicine.
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A simple and effective method for making multipotent/multilineage scaffolds with Hydrophilic Nature without any postmodification/treatment
Colloids and Surfaces B: Biointerfaces, 2015Co-Authors: Dhanesh Vaikkath, Rakhi Anitha, Babitha Sumathy, Prabha D NairAbstract:Abstract A number of biodegradable and bioresorbable materials, as well as scaffold designs, have been experimentally and/or clinically studied for tissue engineering of diverse tissue types. Cell-material responses are strongly dependent on the properties of the scaffold material. In this study, scaffolds based on polycaprolactone (PCL) and PCL blended with a triblock copolymer, Polycaprolactone–polytetrahydrofuran–polycaprolactone (PCL–PTHF–PCL) at different ratios were fabricated by electrospinning. Blending and electrospinning of the triblock copolymer with PCL generated a super Hydrophilic scaffold, the mechanical and biological properties of which varied with the concentration of the triblock copolymer. The Hydrophilicity of the electrospun scaffolds was determined by measurement of water–air contact angle. Cellular response to the electrospun scaffolds was studied by seeding two types of cells, L929 fibroblast cell line and rat mesenchymal stem cells (RMSC). We observed that the super Hydrophilicity of the material did not prevent cell adhesion, while the cell proliferation was low or negligible for scaffolds containing higher amount of PCL–PTHF–PCL. Chondrogenic differentiation of RMSC was found to be better on the PCL blend containing 10% (w/v) of PCL–PTHF–PCL than the bare PCL. Our studies indicate that the cellular response is dependent on the biomaterial composition and highlight the importance of tailoring the scaffold properties for applications in tissue engineering and regenerative medicine.
Turng Lihsheng - One of the best experts on this subject based on the ideXlab platform.
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influence of the hydrophobic Hydrophilic Nature of biomedical polymers and nanocomposites on in vitro biological development
Macromolecular Materials and Engineering, 2017Co-Authors: Elena Torres, Anna Valleslluch, Vicent Fombuena, Brett N Napiwocki, Turng LihshengAbstract:In this work, cell viability, proliferation, and morphology are studied on two pairs of polymers used in the biomedical field that have similar chemical Natures but differ in hydrophobicity. On the one hand, hydrophobic polyester poly(e-caprolactone), is modified by blending with poly(lactic acid). On the other hand, the Hydrophilic acrylate poly(2-hydroxyethyl methacrylate) (PHEMA), is copolymerized with ethyl methacrylate (EMA) at a ratio of 50/50 wt.% P(HEMA-co-EMA). These two polymers are used as neat resins or combined with hydroxyapatite (HA) nanoparticles and halloysite nanotubes (HNTs) to enhance cell attachment and mechanical properties. Cell proliferation is greater on moderately hydrophobic materials at the initial stage, with cells showing a round shape and aggregating in clusters. However, over longer culture periods, cell proliferation is more advanced on more Hydrophilic surfaces, where cells spread out with a flatter shape. Improvement of cell viability is observed with the addition of HA and HNTs.
E Dhanumalayan - One of the best experts on this subject based on the ideXlab platform.
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disparity in hydrophobic to Hydrophilic Nature of polymer blend modified by k2ti6o13 as a function of air plasma treatment
Progress in Organic Coatings, 2017Co-Authors: E Dhanumalayan, Ajinkya M Trimukhe, Rajendra R Deshmukh, Girish M JoshiAbstract:Abstract Polymer blends of Poly (vinylidenefluoride) (PVDF)/Poly (methyl methacrylate) (PMMA) were modified by Potassium hexa-titanate oxide (K 2 Ti 6 O 13 ) in weight fraction ratio. The blends were further exposed to air plasma treatment. The alteration of surface morphology due to plasma treatment was analyzed using polarizing optical, scanning electron and atomic force microscopic techniques. The confirmation of chemical composition and elemental analysis of untreated and treated blends were done using Fourier transform infrared spectrum (FTIR) and energy dispersion spectroscopy (EDS). Theoretical methods of calculating contact angle (θ°), surface energy (γ SE ), and roughness average (R a ) were disclosed to evaluate the experimental data. The microscopic observations clearly demonstrated the synergic effect induced by plasma treatment which improved the surface energy and formation of micro texture. Surface energy was estimated from contact angle data, which demonstrate the significant disparity in hydrophobic to Hydrophilic Nature. It is well known that the air plasma treatment incorporates polar functional groups onto the surface, which is responsible for the decrease in contact angle. Further, the increase in surface roughness as seen from AFM is also responsible for the decrease in contact angle and Hydrophilic Nature. The optimization of barrier properties of polymer blends using plasma treatment can be useful in the development of liquid attracting layer applications.
