The Experts below are selected from a list of 210 Experts worldwide ranked by ideXlab platform
Derek M Mckay - One of the best experts on this subject based on the ideXlab platform.
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Young mice expel the tapeworm Hymenolepis diminuta and are protected from colitis by triggering a memory response with worm antigen.
American journal of physiology. Gastrointestinal and liver physiology, 2018Co-Authors: Toshio Arai, Arthur Wang, Fernando Lopes, Adam Shute, Derek M MckayAbstract:This study demonstrates that juvenile mice are protected from colitis by infection with the tapeworm Hymenolepis diminuta and that using worm antigen to trigger an immunological memory response in ...
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enteric epithelial cells support growth of Hymenolepis diminuta in vitro and trigger th2 promoting events in a species specific manner
International Journal for Parasitology, 2015Co-Authors: Fernando Lopes, Jose L Reyes, Arthur Wang, Gabriella Leung, Derek M MckayAbstract:Abstract Knowledge of the gut epithelium in modulating immune responses to cestode parasites is scant. Hymenolepis diminuta causes no damage to its rodent host and is expelled from mice. Hymenolepis diminuta (scolex + 2 cm strobila) was cultured with rat (IEC6), human (T84) or mouse (IEC4) epithelial cell lines: all promoted worm survival, but those cultured on IEC6 (rat is a permissive host) were the healthiest. In contrast, production of Th2 polarising cytokines, IL-17e, IL-33 and TSLP, was greatest in IEC4 cells, less in T84 epithelia and almost negligible in IEC6 cells. Thus, the enteric epithelium is a key determinant of the response to infection with H. diminuta and is predictive of host permissiveness.
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splenic b cells from Hymenolepis diminuta infected mice ameliorate colitis independent of t cells and via cooperation with macrophages
Journal of Immunology, 2015Co-Authors: Jose L Reyes, Arthur Wang, Maria Fernando, Rabea Graepel, Gabriella Leung, Nico Van Rooijen, Mikael Sigvardsson, Derek M MckayAbstract:Helminth parasites provoke multicellular immune responses in their hosts that can suppress concomitant disease. The gut lumen-dwelling tapeworm Hymenolepis diminuta, unlike other parasites assessed ...
Jose L Reyes - One of the best experts on this subject based on the ideXlab platform.
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macrophages treated with antigen from the tapeworm Hymenolepis diminuta condition cd25 t cells to suppress colitis
The FASEB Journal, 2019Co-Authors: Jose L Reyes, Gabriella Leung, Fernando Lopes, Adam Shute, Timothy S Jayme, Chelsea E Matisz, Regula Burkhard, Matheus B H Carneiro, Matthew L WorkentineAbstract:Macrophages play central roles in immunity as early effectors and modulating adaptive immune reponses; we implicated macrophages in the anticolitic effect of infection with the tapeworm Hymenolepis...
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enteric epithelial cells support growth of Hymenolepis diminuta in vitro and trigger th2 promoting events in a species specific manner
International Journal for Parasitology, 2015Co-Authors: Fernando Lopes, Jose L Reyes, Arthur Wang, Gabriella Leung, Derek M MckayAbstract:Abstract Knowledge of the gut epithelium in modulating immune responses to cestode parasites is scant. Hymenolepis diminuta causes no damage to its rodent host and is expelled from mice. Hymenolepis diminuta (scolex + 2 cm strobila) was cultured with rat (IEC6), human (T84) or mouse (IEC4) epithelial cell lines: all promoted worm survival, but those cultured on IEC6 (rat is a permissive host) were the healthiest. In contrast, production of Th2 polarising cytokines, IL-17e, IL-33 and TSLP, was greatest in IEC4 cells, less in T84 epithelia and almost negligible in IEC6 cells. Thus, the enteric epithelium is a key determinant of the response to infection with H. diminuta and is predictive of host permissiveness.
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splenic b cells from Hymenolepis diminuta infected mice ameliorate colitis independent of t cells and via cooperation with macrophages
Journal of Immunology, 2015Co-Authors: Jose L Reyes, Arthur Wang, Maria Fernando, Rabea Graepel, Gabriella Leung, Nico Van Rooijen, Mikael Sigvardsson, Derek M MckayAbstract:Helminth parasites provoke multicellular immune responses in their hosts that can suppress concomitant disease. The gut lumen-dwelling tapeworm Hymenolepis diminuta, unlike other parasites assessed ...
Fernando Lopes - One of the best experts on this subject based on the ideXlab platform.
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macrophages treated with antigen from the tapeworm Hymenolepis diminuta condition cd25 t cells to suppress colitis
The FASEB Journal, 2019Co-Authors: Jose L Reyes, Gabriella Leung, Fernando Lopes, Adam Shute, Timothy S Jayme, Chelsea E Matisz, Regula Burkhard, Matheus B H Carneiro, Matthew L WorkentineAbstract:Macrophages play central roles in immunity as early effectors and modulating adaptive immune reponses; we implicated macrophages in the anticolitic effect of infection with the tapeworm Hymenolepis...
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Young mice expel the tapeworm Hymenolepis diminuta and are protected from colitis by triggering a memory response with worm antigen.
American journal of physiology. Gastrointestinal and liver physiology, 2018Co-Authors: Toshio Arai, Arthur Wang, Fernando Lopes, Adam Shute, Derek M MckayAbstract:This study demonstrates that juvenile mice are protected from colitis by infection with the tapeworm Hymenolepis diminuta and that using worm antigen to trigger an immunological memory response in ...
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enteric epithelial cells support growth of Hymenolepis diminuta in vitro and trigger th2 promoting events in a species specific manner
International Journal for Parasitology, 2015Co-Authors: Fernando Lopes, Jose L Reyes, Arthur Wang, Gabriella Leung, Derek M MckayAbstract:Abstract Knowledge of the gut epithelium in modulating immune responses to cestode parasites is scant. Hymenolepis diminuta causes no damage to its rodent host and is expelled from mice. Hymenolepis diminuta (scolex + 2 cm strobila) was cultured with rat (IEC6), human (T84) or mouse (IEC4) epithelial cell lines: all promoted worm survival, but those cultured on IEC6 (rat is a permissive host) were the healthiest. In contrast, production of Th2 polarising cytokines, IL-17e, IL-33 and TSLP, was greatest in IEC4 cells, less in T84 epithelia and almost negligible in IEC6 cells. Thus, the enteric epithelium is a key determinant of the response to infection with H. diminuta and is predictive of host permissiveness.
Damanbha Lyngdoh - One of the best experts on this subject based on the ideXlab platform.
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Differential diagnosis and molecular characterization of Hymenolepis nana and Hymenolepis diminuta (Cestoda: Cyclophyllidea: Hymenolepididae) based on nuclear rDNA ITS2 gene marker
Parasitology Research, 2016Co-Authors: Sunil Sharma, Damanbha LyngdohAbstract:Given the widespread distribution and medical implication of members of the genus Hymenolepis , specific identification of the aetiological agent becomes imperative. For precise diagnosis of the species, molecular techniques such as PCR and RFLP of the nuclear ribosomal internal transcribed spacer 2 (rDNA-ITS2) gene marker were carried out. The results showed distinct restriction patterns for both Hymenolepis nana and Hymenolepis diminuta when digested with either of the enzymes RsaI, HaeIII or HhaI. The annotated rDNA-ITS2 sequences from the two species revealed differences in the length; the folded secondary structure also depicted clear demarcation between the two species with variations in length of the helices, pyrimidine-pyrimidine mismatches and sites where motifs occur. In phylogenetic analysis of the evolutionary relationship between the two species as well as with other members of the family Hymenolepididae, the species causing human hymenolepiasis were found to be distantly related as they diverged independently from the ancestral lineage.
Arthur Wang - One of the best experts on this subject based on the ideXlab platform.
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Young mice expel the tapeworm Hymenolepis diminuta and are protected from colitis by triggering a memory response with worm antigen.
American journal of physiology. Gastrointestinal and liver physiology, 2018Co-Authors: Toshio Arai, Arthur Wang, Fernando Lopes, Adam Shute, Derek M MckayAbstract:This study demonstrates that juvenile mice are protected from colitis by infection with the tapeworm Hymenolepis diminuta and that using worm antigen to trigger an immunological memory response in ...
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enteric epithelial cells support growth of Hymenolepis diminuta in vitro and trigger th2 promoting events in a species specific manner
International Journal for Parasitology, 2015Co-Authors: Fernando Lopes, Jose L Reyes, Arthur Wang, Gabriella Leung, Derek M MckayAbstract:Abstract Knowledge of the gut epithelium in modulating immune responses to cestode parasites is scant. Hymenolepis diminuta causes no damage to its rodent host and is expelled from mice. Hymenolepis diminuta (scolex + 2 cm strobila) was cultured with rat (IEC6), human (T84) or mouse (IEC4) epithelial cell lines: all promoted worm survival, but those cultured on IEC6 (rat is a permissive host) were the healthiest. In contrast, production of Th2 polarising cytokines, IL-17e, IL-33 and TSLP, was greatest in IEC4 cells, less in T84 epithelia and almost negligible in IEC6 cells. Thus, the enteric epithelium is a key determinant of the response to infection with H. diminuta and is predictive of host permissiveness.
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splenic b cells from Hymenolepis diminuta infected mice ameliorate colitis independent of t cells and via cooperation with macrophages
Journal of Immunology, 2015Co-Authors: Jose L Reyes, Arthur Wang, Maria Fernando, Rabea Graepel, Gabriella Leung, Nico Van Rooijen, Mikael Sigvardsson, Derek M MckayAbstract:Helminth parasites provoke multicellular immune responses in their hosts that can suppress concomitant disease. The gut lumen-dwelling tapeworm Hymenolepis diminuta, unlike other parasites assessed ...
