Hyperalimentation

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Fredrik H Nystrom - One of the best experts on this subject based on the ideXlab platform.

  • transient increase in hdl cholesterol during weight gain by Hyperalimentation in healthy subjects
    Obesity, 2011
    Co-Authors: Torbjorn Lindstrom, Stergios Kechagias, Martin Carlsson, Fredrik H Nystrom
    Abstract:

    Determination of lipid levels is fundamental in cardiovascular risk assessment. We studied the short-term effects of fast food-based Hyperalimentation on lipid levels in healthy subjects. Twelve healthy men and six healthy women with a mean age of 26 ± 6.6 years and an aged-matched control group were recruited for this prospective interventional study. Subjects in the intervention group aimed for a body weight increase of 5–15% by doubling the baseline caloric intake by eating at least two fast food-based meals a day in combination with adoption of a sedentary lifestyle for 4 weeks. This protocol induced a weight gain from 67.6 ± 9.1 kg to 74.0 ± 11 kg (P < 0.001). A numerical increase in the levels of high-density lipoprotein (HDL)-cholesterol occurred in all subjects during the study and this was apparent already at the first week in 16/18 subjects (mean increase at week 1: +22.0 ± 16%, range from −7 to +50%), whereas the highest level of HDL during the study as compared with baseline values varied from +6% to +58% (mean +31.6 ± 15%). The intake of saturated fat in the early phase of the trial related positively with the HDL-cholesterol-increase in the second week (r = 0.53, P = 0.028). Although the levels of insulin doubled at week 2, the increase in low-density lipoprotein (LDL)-cholesterol was only +12 ± 17%, and there was no statistically significant changes in fasting serum triglycerides. We conclude that Hyperalimentation can induce a fast but transient increase in HDL-cholesterol that is of clinical interest when estimating cardiovascular risk based on serum lipid levels.

  • men develop more intraabdominal obesity and signs of the metabolic syndrome after Hyperalimentation than women
    Metabolism-clinical and Experimental, 2009
    Co-Authors: Styrbjorn Erlingsson, Sebastian Herard, Olof Dahlqvist Leinhard, Torbjorb Lindstrom, Toste Lanne, Magnus Borga, Fredrik H Nystrom
    Abstract:

    We prospectively studied the effects of fast food-based Hyperalimentation on insulin sensitivity and components of the metabolic syndrome and analyzed this with respect to sex. Twelve nonobese men ...

  • quantification of abdominal fat accumulation during Hyperalimentation using mri
    ISMRM Annual Meeting (ISMRM'09) Honolulu Hawaii USA 18-24 April 2009, 2009
    Co-Authors: Olof Dahlqvist Leinhard, Peter Lundberg, Fredrik H Nystrom, Andreas Johansson, Joakim Rydell, Johan Kihlberg, Orjan Smedby, Magnus Borga
    Abstract:

    There is an increasing demand for imaging methods that can be used for automatic, accurate and quantitative determination of the amounts of abdominal fat. Such methods are important as they will allow the evaluation of some of the risk factors underlying the ’metabolic syndrome’. The metabolic syndrome is becoming common in large parts of the world, and it appears that a dominant risk factor for developing this syndrome is abdominal obesity. Subjects that are afflicted with the metabolic syndrome are exposed to a high risk for developing a large range of diseases such as type 2 diabetes, cardiac failure, and stroke. The aim of this work

  • fast food based hyper alimentation can induce rapid and profound elevation of serum alanine aminotransferase in healthy subjects
    Gut, 2008
    Co-Authors: Stergios Kechagias, Asa Ernersson, Olof Leinhard Dahlqvist, Peter Lundberg, Torbjorn Lindstrom, Fredrik H Nystrom
    Abstract:

    Objective: To study the effect of fast-food-based Hyperalimentation on liver enzymes and hepatic triglyceride content (HTGC). Design: Prospective interventional study with parallel control group.

Duk Soo Bae - One of the best experts on this subject based on the ideXlab platform.

Pureun Narae Kang - One of the best experts on this subject based on the ideXlab platform.

C Morgan - One of the best experts on this subject based on the ideXlab platform.

  • g69 p Hyperalimentation using current uk parenteral amino acid formulations does not prevent low plasma arginine levels in very preterm infants
    Archives of Disease in Childhood, 2014
    Co-Authors: C Morgan, Maw Tan, P Mcgowan, L Burgess, Kelly Mayes
    Abstract:

    Background Arginine deficiency is well recognised in very preterm infants (VPI) receiving parenteral nutrition (PN) and is associated with major morbidity. Current UK PN amino acid (AA) formulations are AA-P (arginine 8.4 g/100 gAA) and AA-V (arginine 6.2 g/100 gAA). Human milk contains 4 g/100 gAA arginine. We hypothesised that Hyperalimentation in PN-dependent VPI would prevent arginine deficiency irrespective of AA formulation. Aim To compare the plasma arginine levels in VPI (reference range; RR:54–78 micromol/l) randomised to receive control PN (CPN) or Hyperalimentation PN (HPN) regimens in two randomised controlled trials (RCT). Methods Both studies were single centre RCT with HPN containing 30% more protein/energy than CPN. RCT1 (AA-P) and RCT2 (AA-V) recruited infants 35% nutrients from PN. Results Plasma AA levels were obtained at median (IQR) postnatal age 9 (8–10) days in both RCT1 and RCT2. Both studies achieved significantly higher actual daily protein and arginine intakes (Table 1) in HPN compared to CPN infants (p Conclusion These study data demonstrate Hyperalimentation does not prevent low plasma arginine levels in VPI. The proportion of arginine in current UK neonatal PN AA formulations is too low.

  • effect of Hyperalimentation and insulin treated hyperglycemia on tyrosine levels in very preterm infants receiving parenteral nutrition
    Journal of Parenteral and Enteral Nutrition, 2014
    Co-Authors: Kelly Mayes, Maw Tan, C Morgan
    Abstract:

    Background: Hyperalimentation describes the increase in glucose, amino acids (AAs), and lipid intake designed to overcome postnatal growth failure in preterm infants. Preterm infants are dependent on phenylalanine metabolism to maintain tyrosine levels because of tyrosine concentration limits in parenteral nutrition (PN). We hypothesized that Hyperalimentation would increase individual AA levels when compared with the control group but avoid high phenylalanine/tyrosine levels. Aim: To compare the plasma AA profiles on days 8–10 of life in preterm infants receiving a Hyperalimentation vs a control regimen. Methods: Infants <29 weeks’ gestation were randomized to receive Hyperalimentation (30% more PN macronutrients) or a control regimen. Data were collected to measure macronutrient (including protein) intake and PN intolerance, including hyperglycemia, insulin use, urea, and AA profile. Plasma profiles of 23 individual AA levels were measured on days 8–10 using ion exchange chromatography. Results: One hun...

  • Hyperalimentation results in paradoxical fall in tyrosine levels in very preterm infants receiving parenteral nutrition
    Archives of Disease in Childhood, 2012
    Co-Authors: Kelly Mayes, Maw Tan, C Morgan
    Abstract:

    Background Hyperalimentation describes the increase in glucose, amino acid and lipid intake designed to overcome postnatal growth failure in preterm infants. Preterm infants are dependent on phenylalanine metabolism to maintain tyrosine levels because of tyrosine concentration limits in parenteral nutrition (PN). Phenylalanine hydroxylase activity is increased by increasing phenylalanine intake (preterm infants), steroids and diabetes (animal models). The latter is reversed by insulin administration. Hyperalimentation increases hyperglycaemia requiring insulin treatment1. Aim To compare the plasma amino acid profiles in preterm infants receiving a Hyperalimentation versus a control PN regimen. Methods Infants Results 142 infants were randomised with 118 amino acid profiles obtained on day 8-10. There were no differences in birthweight or gestation between groups. Of the 22 individual plasma amino acid levels, 14 showed a rise (p 0.05) when comparing Hyperalimentation (n=57) with controls (n=61). Median (IQR) phenylalanine levels increased from 72 (63-79) mmol/l to 80 (65-89) mmol/l (p=0.03). Only tyrosine levels fell (p Conclusion Hyperalimentation results in a paradoxical fall in plasma tyrosine levels associated with an increase in insulin-treated hyperglycaemia. We propose that insulin administration inhibits phenylalanine hydroxylase activity preventing the PN dependent preterm infant maintaining adequate tyrosine levels.

Byounggie Kim - One of the best experts on this subject based on the ideXlab platform.