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Peter R Holt - One of the best experts on this subject based on the ideXlab platform.

  • Eosinophil-induced chronic active hepatitis in the idiopathic Hypereosinophilic Syndrome.
    Hepatology, 1991
    Co-Authors: Anthony Foong, John V. Scholes, Gail M Kephart, Gerald J. Gleich, Peter R Holt
    Abstract:

    A 19-yr-old man had features of chronic hepatitis with piecemeal necrosis as the sole clinical feature of the idiopathic Hypereosinophilic Syndrome. Liver biopsy specimens demonstrated the presence of activated eosinophils and, by immunohistochemical staining, major basic protein in areas of hepatic cell damage. The case demonstrates the clinical presentation of the idiopathic Hypereosinophilic Syndrome as chronic hepatitis and the association between eosinophil infiltration and degranulation with the presence of hepatocyte necrosis. (HEPATOLOGY 1991;13:1090–1094.)

Barbara H. Bjornson - One of the best experts on this subject based on the ideXlab platform.

Patricia H Davis - One of the best experts on this subject based on the ideXlab platform.

  • cerebral arteriolar thromboembolism in idiopathic Hypereosinophilic Syndrome
    JAMA Neurology, 2009
    Co-Authors: Mikayel Grigoryan, Scott D Geisler, Erik K St Louis, Gary L Baumbach, Patricia H Davis
    Abstract:

    Objective To describe imaging findings as well as postmortem brain and cardiac pathology in a patient with fulminant idiopathic Hypereosinophilic Syndrome. Design Case report. Setting University hospital. Patient A 48-year-old right-handed man with hypereosinophilia, rapidly progressive encephalopathy, and focal neurological deficits who died 22 days after presentation. Main Outcome Measures Physical examination, radiologic, and neuropathologic examination results. Results Imaging of the brain revealed bihemispheric ischemic changes in and beyond the watershed distributions. Pathology review demonstrated mural cardiac thrombus that likely caused cardioembolism as well as diffuse microangiopathy despite resolution of the hypereosinophilia. Conclusions Timely recognition of idiopathic Hypereosinophilic Syndrome may enable aggressive treatment prior to widespread cardioembolism and degranulation that result in devastating cerebrovascular complications.

Ann M. Dvorak - One of the best experts on this subject based on the ideXlab platform.

  • The Idiopathic Hypereosinophilic Syndrome
    Archives of dermatology, 1996
    Co-Authors: Peter F. Weller, Ann M. Dvorak
    Abstract:

    THE IDIOPATHIC Hypereosinophilic Syndrome represents a leukoproliferative process likely caused by a number of disorders, all of which are marked by sustained overproduction of eosinophils. 1 In addition to the hallmark eosinophilia, this Syndrome is distinctive because of its predilection for damaging specific organs, including the heart. The consequent endomyocardial fibrosis is not restricted to the idiopathic Hypereosinophilic Syndrome; identical cardiac damage may develop with eosinophilias secondary to other diseases with identifiable causes. Notably, not all patients with hypereosinophilia develop the organ damage characteristic of the Hypereosinophilic Syndrome. No specific tests are diagnostic of the Hypereosinophilic Syndrome; rather, the Syndrome is defined by the combination of unexplained prolonged eosinophilia and evidence of organ involvement. DEFINITION OF THE Syndrome From analyses of eosinophilic patients referred to the National Institutes of Health and other reported cases of Hypereosinophilic Syndrome, Chusid and colleagues 2 in 1975 identified the three defining features of the

J.d. Durrer - One of the best experts on this subject based on the ideXlab platform.