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Andy Sun - One of the best experts on this subject based on the ideXlab platform.
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higher gastric parietal cell antibody titer significantly increases the frequencies of macrocytosis serum vitamin b12 deficiency and Hyperhomocysteinemia in patients with burning mouth syndrome
Journal of Dental Sciences, 2021Co-Authors: Ying Tai Jin, Chunpin Chiang, Julia Yu Fong Chang, Andy SunAbstract:Abstract Background/purpose Our previous study found 109 gastric parietal cell antibody (GPCA)-positive burning mouth syndrome (BMS) patients (so-called GPCA+BMS patients in this study) in a group of 884 BMS patients. This study evaluated whether high-titer (GPCA titer ≥ 160) GPCA+BMS patients had greater frequencies of macrocytosis, anemia, serum iron and vitamin B12 deficiencies, and Hyperhomocysteinemia than low-titer (GPCA titer Materials and methods Complete blood count, serum iron, vitamin B12, folic acid, homocysteine, and GPCA levels in 42 high-titer GPCA+BMS patients, 67 low-titer GPCA+BMS patients, and 442 healthy control subjects were measured and compared. Results We found that 33.3%, 38.1%, 19.0%, 33.3%, 2.4%, and 57.1% of 42 high-titer GPCA+BMS patients and 10.4%, 25.4%, 14.9%, 6.0%, 1.5%, and 11.9% of 67 low-titer GPCA+BMS patients were diagnosed as having macrocytosis, blood hemoglobin, iron, vitamin B12, and folic acid deficiencies, and Hyperhomocysteinemia, respectively. Moreover, both 42 high-titer and 67 low-titer GPCA+BMS patients had significantly greater frequencies of macrocytosis, blood hemoglobin, serum iron and vitamin B12 deficiencies, and Hyperhomocysteinemia than 442 healthy control subjects (all P-values Conclusion The high-titer GPCA+BMS patients have significantly greater frequencies of macrocytosis, anemia, serum iron and vitamin B12 deficiencies, and Hyperhomocysteinemia than healthy control subjects and significantly greater frequencies of macrocytosis, serum vitamin B12 deficiency, and Hyperhomocysteinemia than low-titer GPCA+BMS patients.
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anemia hematinic deficiencies and Hyperhomocysteinemia in serum gastric parietal cell antibody positive burning mouth syndrome patients without serum thyroid autoantibodies
Journal of Dental Sciences, 2021Co-Authors: Ying Tai Jin, Chunpin Chiang, Julia Yu Fong Chang, Andy SunAbstract:Background/purpose Our previous study found that 70 of 884 burning mouth syndrome (BMS) patients have serum gastric parietal cell antibody (GPCA) positivity but without thyroglobulin antibody (TGA) and thyroid microsomal antibody (TMA) (so-called GPCA+TGA-TMA-BMS patients). This study assessed whether these 70 GPCA+TGA-TMA-BMS patients had significantly higher frequencies of macrocytosis, anemia, hematinic deficiencies, and Hyperhomocysteinemia than 553 GPCA-negative, TGA-negative, and TMA-negative BMS (GPCA-TGA-TMA-BMS) patients or 442 healthy control subjects. Materials and methods Complete blood count, serum iron, vitamin B12, folic acid, homocysteine, GPCA, TGA, and TMA levels in 70 GPCA+TGA-TMA-BMS patients, 553 GPCA-TGA-TMA-BMS patients, and 442 healthy control subjects were measured and compared. Results We found that 15.7%, 28.6%, 20.0%, 11.4%, 2.9%, and 25.7% of 70 GPCA+TGA-TMA-BMS patients and 3.8%, 17.7%, 15.9%, 3.8%, 2.7%, and 20.1% of 553 GPCA-TGA-TMA-BMS patients had macrocytosis, blood hemoglobin, iron, vitamin B12, and folic acid deficiencies, and Hyperhomocysteinemia, respectively. Moreover, both 70 GPCA+TGA-TMA-BMS patients and 553 GPCA-TGA-TMA-BMS patients had significantly greater frequencies of macrocytosis, blood hemoglobin, serum iron, vitamin B12, and folic acid deficiencies, and Hyperhomocysteinemia than 442 healthy control subjects (all P-values < 0.05). In addition, 70 GPCA+TGA-TMA-BMS patients also had greater frequencies of macrocytosis, anemia, serum vitamin B12 deficiency, and Hyperhomocysteinemia than 553 GPCA-TGA-TMA-BMS patients (all P-values < 0.05). Conclusion The GPCA + TGA-TMA-BMS patients have significantly greater frequencies of macrocytosis, anemia, serum iron, vitamin B12, and folic acid deficiencies, and Hyperhomocysteinemia than healthy control subjects and significantly greater frequencies of macrocytosis, anemia, serum vitamin B12 deficiency, and Hyperhomocysteinemia than GPCA-TGA-TMA-BMS patients.
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anemia hematinic deficiencies and gastric parietal cell antibody positivity in burning mouth syndrome patients with or without Hyperhomocysteinemia
Journal of Dental Sciences, 2020Co-Authors: Chunpin Chiang, Meng Ling Chiang, Andy SunAbstract:Abstract Background/purpose Our previous study found that 170 of 884 burning mouth syndrome (BMS) patients have Hyperhomocysteinemia. This study assessed whether these 170 BMS patients with Hyperhomocysteinemia had significantly higher frequencies of anemia, hematinic deficiencies, and serum gastric parietal cell antibody (GPCA) positivity than 714 BMS patients without Hyperhomocysteinemia or 442 healthy control subjects. Materials and methods The blood hemoglobin (Hb) and serum iron, vitamin B12, folic acid, homocysteine, and GPCA levels in 170 BMS patients with Hyperhomocysteinemia, 714 BMS patients without Hyperhomocysteinemia, and 442 healthy control subjects were measured and compared. Results We found that 170 BMS patients with Hyperhomocysteinemia had significantly higher frequencies of macrocytosis, blood Hb and serum iron, vitamin B12, and folic acid deficiencies, and serum GPCA positivity than 442 healthy control subjects (all P-values Conclusion BMS patients with Hyperhomocysteinemia had significantly higher frequencies of macrocytosis, anemia, serum iron, vitamin B12, and folic acid deficiencies, and serum GPCA positivity than healthy control subjects or BMS patients without Hyperhomocysteinemia.
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anemia hematinic deficiencies Hyperhomocysteinemia and serum gastric parietal cell antibody positivity in 884 patients with burning mouth syndrome
Journal of the Formosan Medical Association, 2020Co-Authors: Chunpin Chiang, Julia Yu Fong Chang, Andy SunAbstract:Background/Purpose Burning mouth syndrome (BMS) is characterized by burning sensation of the oral mucosa in the absence of clinically apparent oral mucosal alterations. This study evaluated the anemia, hematinic deficiencies, Hyperhomocysteinemia, and serum gastric parietal cell antibody (GPCA) positivity in 884 BMS patients. Methods The blood hemoglobin (Hb) and serum iron, vitamin B12, folic acid, homocysteine, GPCA levels in 884 BMS patients were measured and compared with the corresponding levels in 442 age- and sex-matched healthy control subjects. Results We found that 175 (19.8%), 143 (16.2%), 42 (4.8%), 20 (2.3%), 170 (19.2%), and 109 (12.3%) BMS patients had blood Hb, serum iron, vitamin B12, and folic acid deficiencies, Hyperhomocysteinemia, and serum GPCA positivity, respectively. Moreover, 884 BMS patients had significantly higher frequencies of blood Hb and serum iron, vitamin B12, and folic acid deficiencies, Hyperhomocysteinemia, and serum GPCA positivity than 442 healthy control subjects (all P-values Conclusion BMS patients have significantly higher frequencies of blood Hb and serum iron, vitamin B12, and folic acid deficiencies, Hyperhomocysteinemia, and serum GPCA positivity than healthy control subjects.
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anemia hematinic deficiencies and gastric parietal cell antibody positivity in atrophic glossitis patients with or without Hyperhomocysteinemia
Journal of the Formosan Medical Association, 2020Co-Authors: Chunpin Chiang, Julia Yu Fong Chang, Andy SunAbstract:Background/Purpose Our previous study found that 127 of 1064 atrophic glossitis (AG) patients have Hyperhomocysteinemia. This study assessed whether the AG patients with Hyperhomocysteinemia had significantly higher frequencies of anemia, hematinic deficiencies, and serum gastric parietal cell antibody (GPCA) positivity than AG patients without Hyperhomocysteinemia or healthy control subjects. Methods The blood hemoglobin (Hb) and serum iron, vitamin B12, folic acid, homocysteine, and GPCA levels in 127 AG patients with Hyperhomocysteinemia, 937 AG patients without Hyperhomocysteinemia, and 532 healthy control subjects were measured and compared. Results We found that 127 AG patients with Hyperhomocysteinemia had significantly higher frequencies of blood Hb and serum iron, vitamin B12, and folic acid deficiencies and serum GPCA positivity than 532 healthy control subjects (all P-values Conclusion AG patients with Hyperhomocysteinemia had significantly higher frequencies of anemia, serum iron, vitamin B12, and folic acid deficiencies, and serum GPCA positivity than healthy control subjects and significantly higher frequencies of anemia, serum vitamin B12 and folic acid deficiencies, and serum GPCA positivity than AG patients without Hyperhomocysteinemia.
Chunpin Chiang - One of the best experts on this subject based on the ideXlab platform.
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higher gastric parietal cell antibody titer significantly increases the frequencies of macrocytosis serum vitamin b12 deficiency and Hyperhomocysteinemia in patients with burning mouth syndrome
Journal of Dental Sciences, 2021Co-Authors: Ying Tai Jin, Chunpin Chiang, Julia Yu Fong Chang, Andy SunAbstract:Abstract Background/purpose Our previous study found 109 gastric parietal cell antibody (GPCA)-positive burning mouth syndrome (BMS) patients (so-called GPCA+BMS patients in this study) in a group of 884 BMS patients. This study evaluated whether high-titer (GPCA titer ≥ 160) GPCA+BMS patients had greater frequencies of macrocytosis, anemia, serum iron and vitamin B12 deficiencies, and Hyperhomocysteinemia than low-titer (GPCA titer Materials and methods Complete blood count, serum iron, vitamin B12, folic acid, homocysteine, and GPCA levels in 42 high-titer GPCA+BMS patients, 67 low-titer GPCA+BMS patients, and 442 healthy control subjects were measured and compared. Results We found that 33.3%, 38.1%, 19.0%, 33.3%, 2.4%, and 57.1% of 42 high-titer GPCA+BMS patients and 10.4%, 25.4%, 14.9%, 6.0%, 1.5%, and 11.9% of 67 low-titer GPCA+BMS patients were diagnosed as having macrocytosis, blood hemoglobin, iron, vitamin B12, and folic acid deficiencies, and Hyperhomocysteinemia, respectively. Moreover, both 42 high-titer and 67 low-titer GPCA+BMS patients had significantly greater frequencies of macrocytosis, blood hemoglobin, serum iron and vitamin B12 deficiencies, and Hyperhomocysteinemia than 442 healthy control subjects (all P-values Conclusion The high-titer GPCA+BMS patients have significantly greater frequencies of macrocytosis, anemia, serum iron and vitamin B12 deficiencies, and Hyperhomocysteinemia than healthy control subjects and significantly greater frequencies of macrocytosis, serum vitamin B12 deficiency, and Hyperhomocysteinemia than low-titer GPCA+BMS patients.
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anemia hematinic deficiencies and Hyperhomocysteinemia in serum gastric parietal cell antibody positive burning mouth syndrome patients without serum thyroid autoantibodies
Journal of Dental Sciences, 2021Co-Authors: Ying Tai Jin, Chunpin Chiang, Julia Yu Fong Chang, Andy SunAbstract:Background/purpose Our previous study found that 70 of 884 burning mouth syndrome (BMS) patients have serum gastric parietal cell antibody (GPCA) positivity but without thyroglobulin antibody (TGA) and thyroid microsomal antibody (TMA) (so-called GPCA+TGA-TMA-BMS patients). This study assessed whether these 70 GPCA+TGA-TMA-BMS patients had significantly higher frequencies of macrocytosis, anemia, hematinic deficiencies, and Hyperhomocysteinemia than 553 GPCA-negative, TGA-negative, and TMA-negative BMS (GPCA-TGA-TMA-BMS) patients or 442 healthy control subjects. Materials and methods Complete blood count, serum iron, vitamin B12, folic acid, homocysteine, GPCA, TGA, and TMA levels in 70 GPCA+TGA-TMA-BMS patients, 553 GPCA-TGA-TMA-BMS patients, and 442 healthy control subjects were measured and compared. Results We found that 15.7%, 28.6%, 20.0%, 11.4%, 2.9%, and 25.7% of 70 GPCA+TGA-TMA-BMS patients and 3.8%, 17.7%, 15.9%, 3.8%, 2.7%, and 20.1% of 553 GPCA-TGA-TMA-BMS patients had macrocytosis, blood hemoglobin, iron, vitamin B12, and folic acid deficiencies, and Hyperhomocysteinemia, respectively. Moreover, both 70 GPCA+TGA-TMA-BMS patients and 553 GPCA-TGA-TMA-BMS patients had significantly greater frequencies of macrocytosis, blood hemoglobin, serum iron, vitamin B12, and folic acid deficiencies, and Hyperhomocysteinemia than 442 healthy control subjects (all P-values < 0.05). In addition, 70 GPCA+TGA-TMA-BMS patients also had greater frequencies of macrocytosis, anemia, serum vitamin B12 deficiency, and Hyperhomocysteinemia than 553 GPCA-TGA-TMA-BMS patients (all P-values < 0.05). Conclusion The GPCA + TGA-TMA-BMS patients have significantly greater frequencies of macrocytosis, anemia, serum iron, vitamin B12, and folic acid deficiencies, and Hyperhomocysteinemia than healthy control subjects and significantly greater frequencies of macrocytosis, anemia, serum vitamin B12 deficiency, and Hyperhomocysteinemia than GPCA-TGA-TMA-BMS patients.
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anemia hematinic deficiencies and gastric parietal cell antibody positivity in burning mouth syndrome patients with or without Hyperhomocysteinemia
Journal of Dental Sciences, 2020Co-Authors: Chunpin Chiang, Meng Ling Chiang, Andy SunAbstract:Abstract Background/purpose Our previous study found that 170 of 884 burning mouth syndrome (BMS) patients have Hyperhomocysteinemia. This study assessed whether these 170 BMS patients with Hyperhomocysteinemia had significantly higher frequencies of anemia, hematinic deficiencies, and serum gastric parietal cell antibody (GPCA) positivity than 714 BMS patients without Hyperhomocysteinemia or 442 healthy control subjects. Materials and methods The blood hemoglobin (Hb) and serum iron, vitamin B12, folic acid, homocysteine, and GPCA levels in 170 BMS patients with Hyperhomocysteinemia, 714 BMS patients without Hyperhomocysteinemia, and 442 healthy control subjects were measured and compared. Results We found that 170 BMS patients with Hyperhomocysteinemia had significantly higher frequencies of macrocytosis, blood Hb and serum iron, vitamin B12, and folic acid deficiencies, and serum GPCA positivity than 442 healthy control subjects (all P-values Conclusion BMS patients with Hyperhomocysteinemia had significantly higher frequencies of macrocytosis, anemia, serum iron, vitamin B12, and folic acid deficiencies, and serum GPCA positivity than healthy control subjects or BMS patients without Hyperhomocysteinemia.
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anemia hematinic deficiencies Hyperhomocysteinemia and serum gastric parietal cell antibody positivity in 884 patients with burning mouth syndrome
Journal of the Formosan Medical Association, 2020Co-Authors: Chunpin Chiang, Julia Yu Fong Chang, Andy SunAbstract:Background/Purpose Burning mouth syndrome (BMS) is characterized by burning sensation of the oral mucosa in the absence of clinically apparent oral mucosal alterations. This study evaluated the anemia, hematinic deficiencies, Hyperhomocysteinemia, and serum gastric parietal cell antibody (GPCA) positivity in 884 BMS patients. Methods The blood hemoglobin (Hb) and serum iron, vitamin B12, folic acid, homocysteine, GPCA levels in 884 BMS patients were measured and compared with the corresponding levels in 442 age- and sex-matched healthy control subjects. Results We found that 175 (19.8%), 143 (16.2%), 42 (4.8%), 20 (2.3%), 170 (19.2%), and 109 (12.3%) BMS patients had blood Hb, serum iron, vitamin B12, and folic acid deficiencies, Hyperhomocysteinemia, and serum GPCA positivity, respectively. Moreover, 884 BMS patients had significantly higher frequencies of blood Hb and serum iron, vitamin B12, and folic acid deficiencies, Hyperhomocysteinemia, and serum GPCA positivity than 442 healthy control subjects (all P-values Conclusion BMS patients have significantly higher frequencies of blood Hb and serum iron, vitamin B12, and folic acid deficiencies, Hyperhomocysteinemia, and serum GPCA positivity than healthy control subjects.
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anemia hematinic deficiencies and gastric parietal cell antibody positivity in atrophic glossitis patients with or without Hyperhomocysteinemia
Journal of the Formosan Medical Association, 2020Co-Authors: Chunpin Chiang, Julia Yu Fong Chang, Andy SunAbstract:Background/Purpose Our previous study found that 127 of 1064 atrophic glossitis (AG) patients have Hyperhomocysteinemia. This study assessed whether the AG patients with Hyperhomocysteinemia had significantly higher frequencies of anemia, hematinic deficiencies, and serum gastric parietal cell antibody (GPCA) positivity than AG patients without Hyperhomocysteinemia or healthy control subjects. Methods The blood hemoglobin (Hb) and serum iron, vitamin B12, folic acid, homocysteine, and GPCA levels in 127 AG patients with Hyperhomocysteinemia, 937 AG patients without Hyperhomocysteinemia, and 532 healthy control subjects were measured and compared. Results We found that 127 AG patients with Hyperhomocysteinemia had significantly higher frequencies of blood Hb and serum iron, vitamin B12, and folic acid deficiencies and serum GPCA positivity than 532 healthy control subjects (all P-values Conclusion AG patients with Hyperhomocysteinemia had significantly higher frequencies of anemia, serum iron, vitamin B12, and folic acid deficiencies, and serum GPCA positivity than healthy control subjects and significantly higher frequencies of anemia, serum vitamin B12 and folic acid deficiencies, and serum GPCA positivity than AG patients without Hyperhomocysteinemia.
Julia Yu Fong Chang - One of the best experts on this subject based on the ideXlab platform.
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higher gastric parietal cell antibody titer significantly increases the frequencies of macrocytosis serum vitamin b12 deficiency and Hyperhomocysteinemia in patients with burning mouth syndrome
Journal of Dental Sciences, 2021Co-Authors: Ying Tai Jin, Chunpin Chiang, Julia Yu Fong Chang, Andy SunAbstract:Abstract Background/purpose Our previous study found 109 gastric parietal cell antibody (GPCA)-positive burning mouth syndrome (BMS) patients (so-called GPCA+BMS patients in this study) in a group of 884 BMS patients. This study evaluated whether high-titer (GPCA titer ≥ 160) GPCA+BMS patients had greater frequencies of macrocytosis, anemia, serum iron and vitamin B12 deficiencies, and Hyperhomocysteinemia than low-titer (GPCA titer Materials and methods Complete blood count, serum iron, vitamin B12, folic acid, homocysteine, and GPCA levels in 42 high-titer GPCA+BMS patients, 67 low-titer GPCA+BMS patients, and 442 healthy control subjects were measured and compared. Results We found that 33.3%, 38.1%, 19.0%, 33.3%, 2.4%, and 57.1% of 42 high-titer GPCA+BMS patients and 10.4%, 25.4%, 14.9%, 6.0%, 1.5%, and 11.9% of 67 low-titer GPCA+BMS patients were diagnosed as having macrocytosis, blood hemoglobin, iron, vitamin B12, and folic acid deficiencies, and Hyperhomocysteinemia, respectively. Moreover, both 42 high-titer and 67 low-titer GPCA+BMS patients had significantly greater frequencies of macrocytosis, blood hemoglobin, serum iron and vitamin B12 deficiencies, and Hyperhomocysteinemia than 442 healthy control subjects (all P-values Conclusion The high-titer GPCA+BMS patients have significantly greater frequencies of macrocytosis, anemia, serum iron and vitamin B12 deficiencies, and Hyperhomocysteinemia than healthy control subjects and significantly greater frequencies of macrocytosis, serum vitamin B12 deficiency, and Hyperhomocysteinemia than low-titer GPCA+BMS patients.
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anemia hematinic deficiencies and Hyperhomocysteinemia in serum gastric parietal cell antibody positive burning mouth syndrome patients without serum thyroid autoantibodies
Journal of Dental Sciences, 2021Co-Authors: Ying Tai Jin, Chunpin Chiang, Julia Yu Fong Chang, Andy SunAbstract:Background/purpose Our previous study found that 70 of 884 burning mouth syndrome (BMS) patients have serum gastric parietal cell antibody (GPCA) positivity but without thyroglobulin antibody (TGA) and thyroid microsomal antibody (TMA) (so-called GPCA+TGA-TMA-BMS patients). This study assessed whether these 70 GPCA+TGA-TMA-BMS patients had significantly higher frequencies of macrocytosis, anemia, hematinic deficiencies, and Hyperhomocysteinemia than 553 GPCA-negative, TGA-negative, and TMA-negative BMS (GPCA-TGA-TMA-BMS) patients or 442 healthy control subjects. Materials and methods Complete blood count, serum iron, vitamin B12, folic acid, homocysteine, GPCA, TGA, and TMA levels in 70 GPCA+TGA-TMA-BMS patients, 553 GPCA-TGA-TMA-BMS patients, and 442 healthy control subjects were measured and compared. Results We found that 15.7%, 28.6%, 20.0%, 11.4%, 2.9%, and 25.7% of 70 GPCA+TGA-TMA-BMS patients and 3.8%, 17.7%, 15.9%, 3.8%, 2.7%, and 20.1% of 553 GPCA-TGA-TMA-BMS patients had macrocytosis, blood hemoglobin, iron, vitamin B12, and folic acid deficiencies, and Hyperhomocysteinemia, respectively. Moreover, both 70 GPCA+TGA-TMA-BMS patients and 553 GPCA-TGA-TMA-BMS patients had significantly greater frequencies of macrocytosis, blood hemoglobin, serum iron, vitamin B12, and folic acid deficiencies, and Hyperhomocysteinemia than 442 healthy control subjects (all P-values < 0.05). In addition, 70 GPCA+TGA-TMA-BMS patients also had greater frequencies of macrocytosis, anemia, serum vitamin B12 deficiency, and Hyperhomocysteinemia than 553 GPCA-TGA-TMA-BMS patients (all P-values < 0.05). Conclusion The GPCA + TGA-TMA-BMS patients have significantly greater frequencies of macrocytosis, anemia, serum iron, vitamin B12, and folic acid deficiencies, and Hyperhomocysteinemia than healthy control subjects and significantly greater frequencies of macrocytosis, anemia, serum vitamin B12 deficiency, and Hyperhomocysteinemia than GPCA-TGA-TMA-BMS patients.
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anemia hematinic deficiencies Hyperhomocysteinemia and serum gastric parietal cell antibody positivity in 884 patients with burning mouth syndrome
Journal of the Formosan Medical Association, 2020Co-Authors: Chunpin Chiang, Julia Yu Fong Chang, Andy SunAbstract:Background/Purpose Burning mouth syndrome (BMS) is characterized by burning sensation of the oral mucosa in the absence of clinically apparent oral mucosal alterations. This study evaluated the anemia, hematinic deficiencies, Hyperhomocysteinemia, and serum gastric parietal cell antibody (GPCA) positivity in 884 BMS patients. Methods The blood hemoglobin (Hb) and serum iron, vitamin B12, folic acid, homocysteine, GPCA levels in 884 BMS patients were measured and compared with the corresponding levels in 442 age- and sex-matched healthy control subjects. Results We found that 175 (19.8%), 143 (16.2%), 42 (4.8%), 20 (2.3%), 170 (19.2%), and 109 (12.3%) BMS patients had blood Hb, serum iron, vitamin B12, and folic acid deficiencies, Hyperhomocysteinemia, and serum GPCA positivity, respectively. Moreover, 884 BMS patients had significantly higher frequencies of blood Hb and serum iron, vitamin B12, and folic acid deficiencies, Hyperhomocysteinemia, and serum GPCA positivity than 442 healthy control subjects (all P-values Conclusion BMS patients have significantly higher frequencies of blood Hb and serum iron, vitamin B12, and folic acid deficiencies, Hyperhomocysteinemia, and serum GPCA positivity than healthy control subjects.
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anemia hematinic deficiencies and gastric parietal cell antibody positivity in atrophic glossitis patients with or without Hyperhomocysteinemia
Journal of the Formosan Medical Association, 2020Co-Authors: Chunpin Chiang, Julia Yu Fong Chang, Andy SunAbstract:Background/Purpose Our previous study found that 127 of 1064 atrophic glossitis (AG) patients have Hyperhomocysteinemia. This study assessed whether the AG patients with Hyperhomocysteinemia had significantly higher frequencies of anemia, hematinic deficiencies, and serum gastric parietal cell antibody (GPCA) positivity than AG patients without Hyperhomocysteinemia or healthy control subjects. Methods The blood hemoglobin (Hb) and serum iron, vitamin B12, folic acid, homocysteine, and GPCA levels in 127 AG patients with Hyperhomocysteinemia, 937 AG patients without Hyperhomocysteinemia, and 532 healthy control subjects were measured and compared. Results We found that 127 AG patients with Hyperhomocysteinemia had significantly higher frequencies of blood Hb and serum iron, vitamin B12, and folic acid deficiencies and serum GPCA positivity than 532 healthy control subjects (all P-values Conclusion AG patients with Hyperhomocysteinemia had significantly higher frequencies of anemia, serum iron, vitamin B12, and folic acid deficiencies, and serum GPCA positivity than healthy control subjects and significantly higher frequencies of anemia, serum vitamin B12 and folic acid deficiencies, and serum GPCA positivity than AG patients without Hyperhomocysteinemia.
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does serum gastric parietal cell antibody titer have influence on anemia and vitamin b12 deficiency in atrophic glossitis patients
Journal of the Formosan Medical Association, 2020Co-Authors: Chunpin Chiang, Julia Yu Fong Chang, Andy SunAbstract:Background/Purpose Our previous study found 284 gastric parietal cell antibody (GPCA)-positive atrophic glossitis (AG) patients (so-called GPCA + AG patients in this study) in a group of 1064 AG patients. This study evaluated whether high-titer (GPCA titer ≥ 160) GPCA + AG patients had greater frequencies of anemia, vitamin B12 deficiency, macrocytosis, and Hyperhomocysteinemia than low-titer (GPCA titer + AG patients. Methods Complete blood count, serum iron, vitamin B12, folic acid, homocysteine, and GPCA levels in 117 high-titer GPCA + AG patients, 167 low-titer GPCA + AG patients, and 532 healthy control subjects were measured and compared. Results We found that 12.0%, 29.1%, 23.1%, 16.2%, 1.7%, and 23.1% of 117 high-titer GPCA + AG patients and 5.4%, 17.4%, 17.4%, 7.2%, 1.2%, and 14.4% of 167 low-titer GPCA + AG patients were diagnosed as having macrocytosis, blood hemoglobin, iron, vitamin B12, and folic acid deficiencies, and Hyperhomocysteinemia, respectively. Moreover, both 117 high-titer and 167 low-titer GPCA + AG patients had significantly greater frequencies of macrocytosis, blood hemoglobin, serum iron and vitamin B12 deficiencies, and Hyperhomocysteinemia than 532 healthy control subjects (all P -values + AG patients also had greater frequencies of anemia ( P = 0.029, statistically significant), serum vitamin B12 deficiency ( P = 0.027, statistically significant), macrocytosis ( P = 0.075, marginal significance), and Hyperhomocysteinemia ( P = 0.085, marginal significance) than 167 low-titer GPCA + AG patients. Conclusion For GPCA + AG patients, high-titer GPCA + AG patients have greater frequencies of anemia, serum vitamin B12 deficiency, macrocytosis, and Hyperhomocysteinemia than low-titer GPCA + AG patients.
Hieronim Jakubowski - One of the best experts on this subject based on the ideXlab platform.
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the pathophysiological hypothesis of homocysteine thiolactone mediated vascular disease
Journal of Physiology and Pharmacology, 2008Co-Authors: Hieronim JakubowskiAbstract:Accumulating evidence suggests that homocysteine (Hcy) metabolite, the thioester Hcy-thiolactone, plays an important role in atherothrombosis. Hcy-thiolactone is a product of an error-editing reaction in protein biosynthesis which forms when Hcy is mistakenly selected by methionyl-tRN A synthetase. The thioester chemistry of Hcy-thiolactone underlies its ability to from isopeptide bonds with protein lysine residues, which impairs or alters protein’s function. Protein targets for the modification by Hcy-thiolactone include fibrinogen, low-density lipoprotein, highdensity lipoprotein, albumin, hemoglobin, and ferritin. Pathophysiological consequences of protein N-homocysteinylation include protein and cell damage, activation of an adaptive immune response and synthesis of auto-antibodies against N-Hcy-proteins, and enhanced thrombosis caused by N-Hcy-fibrinogen. Recent development of highly sensitive chemical and immunohistochemical assays has allowed verification of the hypothesis that the Hcy-thiolactone pathway contributes to pathophysiolo gy of the vascular system, in particular of the prediction that conditions predisposing to atherosclerosis, such as genetic or dietary Hyperhomocysteinemia, lead to elevation of Hcy-thiolacto ne and N-Hcy-protein. This prediction has been confirmed in vivo both in humans and in mice. For example, plasma Hcy-thiolactone was found to be elevated 59-72-fold in human patients with Hyperhomocysteinemia secondary to mutations in methylenetetrahydrofolate reductase (MTHFR) or cystathionine b-synthase (CBS) genes. Plasma N-Hcy-protein levels are elevated 24-30-fold in MTHFR- or CBSdeficiency, both in human patients and in mice. Plasma and urinary Hcy-thiolactone and plasma N-Hcy-protein levels are also elevated up to 30-fold in mice fed a hyperhomocysteinemic (1.5% methionine) diet. Furthermore, plasma levels of prothromobogenic N-Hcy-fibrinogen were elevated in human CBS deficiency, which explains increased atherothrombosis observed in CBS-deficient patients. We also observed increased immunohistochemical staining for N-Hcy-protein in aortic lesions from ApoE-deficient mice with Hyperhomocysteinemia induced by a high methionine diet, relative to the mice fed a normal chow diet. We conclude that genetic or dietary Hyperhomocysteinemia significantly elevates proatherothrombotic metabolites Hcy-thiolactone and N-Hcy-proteins in humans and mice.
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the pathophysiological hypothesis of homocysteine thiolactone mediated vascular disease
Journal of Physiology and Pharmacology, 2008Co-Authors: Hieronim JakubowskiAbstract:Accumulating evidence suggests that homocysteine (Hcy) metabolite, the thioester Hcy-thiolactone, plays an important role in atherothrombosis. Hcy-thiolactone is a product of an error-editing reaction in protein biosynthesis which forms when Hcy is mistakenly selected by methionyl-tRNA synthetase. The thioester chemistry of Hcy-thiolactone underlies its ability to from isopeptide bonds with protein lysine residues, which impairs or alters protein's function. Protein targets for the modification by Hcy-thiolactone include fibrinogen, low-density lipoprotein, high-density lipoprotein, albumin, hemoglobin, and ferritin. Pathophysiological consequences of protein N-homocysteinylation include protein and cell damage, activation of an adaptive immune response and synthesis of auto-antibodies against N-Hcy-proteins, and enhanced thrombosis caused by N-Hcy-fibrinogen. Recent development of highly sensitive chemical and immunohistochemical assays has allowed verification of the hypothesis that the Hcy-thiolactone pathway contributes to pathophysiology of the vascular system, in particular of the prediction that conditions predisposing to atherosclerosis, such as genetic or dietary Hyperhomocysteinemia, lead to elevation of Hcy-thiolactone and N-Hcy-protein. This prediction has been confirmed in vivo both in humans and in mice. For example, plasma Hcy-thiolactone was found to be elevated 59-72-fold in human patients with Hyperhomocysteinemia secondary to mutations in methylenetetrahydrofolate reductase (MTHFR) or cystathionine beta-synthase (CBS) genes. Plasma N-Hcy-protein levels are elevated 24-30-fold in MTHFR- or CBS-deficiency, both in human patients and in mice. Plasma and urinary Hcy-thiolactone and plasma N-Hcy-protein levels are also elevated up to 30-fold in mice fed a hyperhomocysteinemic (1.5% methionine) diet. Furthermore, plasma levels of prothromobogenic N-Hcy-fibrinogen were elevated in human CBS deficiency, which explains increased atherothrombosis observed in CBS-deficient patients. We also observed increased immunohistochemical staining for N-Hcy-protein in aortic lesions from ApoE-deficient mice with Hyperhomocysteinemia induced by a high methionine diet, relative to the mice fed a normal chow diet. We conclude that genetic or dietary Hyperhomocysteinemia significantly elevates proatherothrombotic metabolites Hcy-thiolactone and N-Hcy-proteins in humans and mice.
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the molecular basis of homocysteine thiolactone mediated vascular disease
Clinical Chemistry and Laboratory Medicine, 2007Co-Authors: Hieronim JakubowskiAbstract:Accumulating evidence suggests that a metabolite of homocysteine (Hcy), the thioester Hcy-thiolactone, plays an important role in atherogenesis and thrombosis. Hcy-thiolactone levels are elevated in hyperhomocysteinemic humans and mice. The thioester chemistry of Hcy-thiolactone underlies its ability to form isopeptide bonds with protein lysine residues, which impairs or alters the protein's function. Protein targets for the modification by Hcy-thiolactone in human blood include fibrinogen, low-density lipoprotein, and high-density lipoprotein. Protein N-homocysteinylation leads to pathophysiological responses, including increased susceptibility to thrombogenesis caused by N-Hcy-fibrinogen, and an autoimmune response elicited by N-Hcy-proteins. Chronic activation of these responses in Hyperhomocysteinemia over many years could lead to vascular disease. This article reviews recent evidence supporting the hypothesis that Hcy-thiolactone contributes to pathophysiological effects of Hcy on the vascular system.
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mutations in methylenetetrahydrofolate reductase or cystathionine β syntase gene or a high methionine diet increase homocysteine thiolactone levels in humans and mice
The FASEB Journal, 2007Co-Authors: Grazyna Chwatko, Kevin A Strauss, Diana M Shih, Godfried H.j. Boers, Hieronim JakubowskiAbstract:Genetic disorders of homocysteine (Hcy) metabolism or a high-methionine diet lead to elevations of plasma Hcy levels. In humans, severe genetic Hyperhomocysteinemia results in premature death from vascular complications whereas dietary Hyperhomocysteinemia is often used to induce atherosclerosis in animal models. Hcy is mistakenly selected in place of methionine by methionyl-tRNA synthetase during protein biosynthesis, which results in the formation of Hcy-thiolactone and initiates a pathophysiological pathway that has been implicated in human vascular disease. However, whether genetic deficiencies in Hcy metabolism or a high-methionine diet affect Hcy-thiolactone levels in mammals has been unknown. Here we show that plasma Hcy-thiolactone is elevated 59-fold and 72-fold in human patients with Hyperhomocysteinemia secondary to mutations in methylenetetrahydrofolate reductase and cystathionine β-synthase genes, respectively. We also show that mice, like humans, eliminate Hcy-thiolactone by urinary excretio...
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hematinic deficiencies Hyperhomocysteinemia and gastric parietal cell antibody positivity in atrophic glossitis patients with macrocytosis
Journal of the Formosan Medical Association, 2019Co-Authors: Chunpin Chiang, Yuhsueh Wu, Julia Yu Fong Chang, Yang Che WuAbstract:Background/Purpose Macrocytosis is defined as having the mean corpuscular volume (MCV) ≧ 100 fL. This study evaluated whether 41 atrophic glossitis (AG) patients with macrocytosis had significantly higher frequencies of anemia, hematinic deficiencies, Hyperhomocysteinemia, and serum gastric parietal cell antibody (GPCA) positivity than 532 healthy control subjects or 1064 AG patients. Methods Complete blood count, serum iron, vitamin B12, folic acid, homocysteine, and GPCA levels in 41 AG patients with macrocytosis, 1064 AG patients, and 532 healthy control subjects were measured and compared. Results We found that 73.2%, 22.0%, 73.2%, 4.9%, 80.5%, and 56.1% of 41 AG patients with macrocytosis were diagnosed as having blood hemoglobin, iron, vitamin B12, and folic acid deficiencies, Hyperhomocysteinemia, and serum GPCA positivity, respectively. Moreover, 41 AG patients with macrocytosis had significantly higher frequencies of blood hemoglobin and serum vitamin B12 deficiencies, Hyperhomocysteinemia, and serum GPCA positivity than 532 healthy control subjects or 1064 AG patients (all P -values P -values Conclusion There are significantly higher frequencies of anemia and serum iron, vitamin B12, and folic acid deficiencies, Hyperhomocysteinemia, and serum GPCA positivity in AG patients with macrocytosis than in healthy control subjects. AG patients with macrocytosis also have significantly higher frequencies of blood hemoglobin and serum vitamin B12 deficiencies, Hyperhomocysteinemia, and serum GPCA positivity than AG patients.
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anemia hematinic deficiencies and Hyperhomocysteinemia in gastric parietal cell antibody positive and negative atrophic glossitis patients
Journal of the Formosan Medical Association, 2019Co-Authors: Chunpin Chiang, Yuhsueh Wu, Julia Yu Fong Chang, Yang Che WuAbstract:Background/Purpose Approximately 27% of atrophic glossitis (AG) patients have the serum gastric parietal cell antibody (GPCA) positivity. This study assessed whether the serum GPCA or AG itself was a significant factor causing anemia, hematinic deficiencies, and Hyperhomocysteinemia in GPCA-positive AG (GPCA+AG) and GPCA-negative AG (GPCA−AG) patients. Methods The mean corpuscular volume (MCV) and mean blood hemoglobin (Hb), iron, vitamin B12, folic acid, and homocysteine levels were measured and compared between any two of three groups of 284 GPCA+AG, 780 GPCA−AG patients, and 532 healthy control subjects. Results Both 284 GPCA+AG and 780 GPCA−AG patients had significantly higher frequencies of microcytosis, macrocytosis, blood Hb, iron, vitamin B12, and folic acid deficiencies, and Hyperhomocysteinemia than 532 healthy control subjects. Moreover, 284 GPCA+AG patients had significantly higher frequencies of macrocytosis, vitamin B12 deficiency, and Hyperhomocysteinemia than 780 GPCA−AG patients. Sixty-three (22.2%) of 284 GPCA+AG patients and 139 (17.8%) of 780 GPCA−AG patients had anemia. The normocytic anemia (42.9%), pernicious anemia (34.9%), and iron deficiency anemia (15.9%) were the three most common types of anemia in the 63 anemic GPCA+AG patients. Moreover, the normocytic anemia (64.8%), iron deficiency anemia (14.4%), and thalassemia trait-induced anemia (13.7%) were the three most common types of anemia in 139 anemic GPCA−AG patients. Conclusion The disease of AG itself is a significant factor causing anemia, hematinic deficiencies, and Hyperhomocysteinemia in both GPCA+AG and GPCA−AG patients. The serum GPCA also plays a significant role in causing macrocytosis, vitamin B12 deficiency, and Hyperhomocysteinemia in GPCA+AG patients.
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significantly higher frequencies of anemia hematinic deficiencies Hyperhomocysteinemia and serum gastric parietal cell antibody positivity in atrophic glossitis patients
Journal of the Formosan Medical Association, 2018Co-Authors: Chunpin Chiang, Yang Che Wu, Yuhsueh Wu, Julia Yu Fong ChangAbstract:Background/Purpose Atrophic glossitis (AG) patients are prone to have anemia, hematinic deficiencies, Hyperhomocysteinemia, and serum gastric parietal cell antibody (GPCA) positivity. This study evaluated whether 1064 AG patients had significantly higher frequencies of anemia, hematinic deficiencies, Hyperhomocysteinemia, and serum GPCA positivity than 532 healthy control subjects. Methods The complete blood count, serum iron, vitamin B12, folic acid, homocysteine, and serum GPCA levels in 1064 AG patients and 532 age- and sex-matched healthy control subjects were measured and compared. Results We found that 7.4%, 3.9%, 19.0%, 16.9%, 5.3%, 2.3%, 11.9%, and 26.7% of 1064 AG patients were diagnosed as having microcytosis, macrocytosis, hemoglobin, iron, vitamin B12, and folic acid deficiencies, Hyperhomocysteinemia, and serum GPCA positivity, respectively. Moreover, 1064 AG patients had significantly higher frequencies of microcytosis, macrocytosis, hemoglobin, iron, vitamin B12, and folic acid deficiencies, Hyperhomocysteinemia, and serum GPCA positivity than 532 healthy control subjects (all P-values Conclusion There are significantly higher frequencies of anemia, serum iron, vitamin B12, and folic acid deficiencies, Hyperhomocysteinemia, and serum GPCA positivity in AG patients than in healthy control subjects. The normocytic anemia and iron deficiency anemia are the two most common types of anemia in our 1064 AG patients.