The Experts below are selected from a list of 282 Experts worldwide ranked by ideXlab platform
T E King - One of the best experts on this subject based on the ideXlab platform.
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can ct distinguish Hypersensitivity Pneumonitis from idiopathic pulmonary fibrosis
American Journal of Roentgenology, 1995Co-Authors: David A Lynch, T E King, John D Newell, P M Logan, Nestor L. MüllerAbstract:The clinical management of patients with idiopathic pulmonary fibrosis differs markedly from that of patients with Hypersensitivity Pneumonitis. However, the two diseases often cannot be differentiated on clinical grounds. The purpose of this study was to establish whether CT can be used to make the distinction.Thirty-six patients with idiopathic pulmonary fibrosis and 27 patients with Hypersensitivity Pneumonitis were studied. All diagnoses were confirmed or supported by open lung biopsy. Three of the patients with idiopathic pulmonary fibrosis had desquamative interstitial pneumonia, and the remainder had usual interstitial pneumonia. In 19 of the 27 patients with Hypersensitivity Pneumonitis, the disease was chronic (symptoms lasting more than 1 year), while eight had acute or subacute symptoms. Two radiologists, who had not previously seen any of the cases and were blinded to the diagnosis, reviewed the CT images by consensus. The extent and distribution of CT features (including ground-glass attenuat...
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Chronic Hypersensitivity Pneumonitis: use of CT in diagnosis.
AJR. American journal of roentgenology, 1992Co-Authors: D L Buschman, G Gamsu, J A Waldron, J S Klein, T E KingAbstract:In its subacute or chronic form, Hypersensitivity Pneumonitis is often difficult to distinguish clinically and physiologically from other idiopathic diffuse lung diseases. The aim of this study was to identify high-resolution CT features that allow distinction of chronic Hypersensitivity Pneumonitis from other chronic diffuse parenchymal lung diseases.Six patients with chronic Hypersensitivity Pneumonitis were examined with pulmonary function testing, bronchoalveolar lavage, lung biopsy, chest radiography, and high-resolution CT. The chest radiographs and high-resolution CT scans were reviewed independently by three observers without knowledge of the patients' clinical status. Discrepancies between the observers were resolved by consensus.The chest radiographs revealed normal lung volumes with a combination of abnormalities: a mixed alveolar/interstitial pattern in five cases, peribronchiolar thickening in three, a diffuse granular pattern in one, and a linear fibrotic pattern in one. In general, the high...
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Hypersensitivity Pneumonitis: sensitivity of high-resolution CT in a population-based study.
AJR. American journal of roentgenology, 1992Co-Authors: D A Lynch, C S Rose, D Way, T E KingAbstract:Hypersensitivity Pneumonitis refers to a group of pulmonary disorders caused by inhalation of organic or inorganic particulates by sensitized persons. The diagnosis relies on a constellation of findings: exposure to an offending antigen, characteristic signs and symptoms, abnormal chest findings on physical examination, and abnormalities on pulmonary function tests and radiographic evaluation. In population-based studies, the sensitivity of chest radiography for detection of this disease is relatively low. The aim of this study was to determine the sensitivity of high-resolution CT (HRCT) for detection of Hypersensitivity Pneumonitis diagnosed in a population of swimming-pool employees.Thirty-one symptomatic employees of a recreation center who were referred because of possible Hypersensitivity Pneumonitis were examined by using chest radiography, HRCT, and fiberoptic bronchoscopy with bronchoalveolar lavage and transbronchial biopsy. Hypersensitivity Pneumonitis was diagnosed in subjects who had two or m...
Nevin W. Wilson - One of the best experts on this subject based on the ideXlab platform.
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Basement shower Hypersensitivity Pneumonitis secondary to epicoccum nigrum
Chest, 1996Co-Authors: Mary Beth Hogan, W. Thomas Corder, Robert S. Pore, Roy Patterson, Nevin W. WilsonAbstract:Two children developed Hypersensitivity Pneumonitis after extensive exposure to an unventilated basement shower. Commercial precipitin panels were negative. After home inspection, individual mold species were isolated from the household and extracted. Precipitating antibodies to Epicoccum nigrum were found in both children. Resolution of the Hypersensitivity Pneumonitis occurred with avoidance and glucocorticosteroid therapy. E nigrum is a newly identified etiologie agent for Hypersensitivity Pneumonitis found in a mold-contaminated home.
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Basement shower Hypersensitivity Pneumonitis secondary to Epicoccum nigrum
Chest, 1996Co-Authors: Mary Beth Hogan, W. Thomas Corder, Robert S. Pore, Roy Patterson, Nevin W. WilsonAbstract:Two children developed Hypersensitivity Pneumonitis after extensive exposure to an unventilated basement shower. Commercial precipitin panels were negative. After home inspection, individual mold species were isolated from the household and extracted. Precipitating antibodies to Epicoccum nigrum were found in both children. Resolution of the Hypersensitivity Pneumonitis occurred with avoidance and glucocorticosteroid therapy. E nigrum is a newly identified etiologic agent for Hypersensitivity Pneumonitis found in a mold-contaminated home.
X Baur - One of the best experts on this subject based on the ideXlab platform.
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Hypersensitivity Pneumonitis extrinsic allergic alveolitis induced by isocyanates
The Journal of Allergy and Clinical Immunology, 1995Co-Authors: X BaurAbstract:Abstract Background: Chemical-induced Hypersensitivity Pneumonitis has been so far rarely described. The purpose of this study was to find out whether Hypersensitivity Pneumonitis is a common disorder in isocyanate workers. Methods: Company physicians' case histories of 1780 isocyanate workers were evaluated. In 16 subjects suspected of having isocyanate-induced Hypersensitivity Pneumonitis, chest x-ray films were made; levels of IgE and IgG antibodies to isocyanate–human serum albumin were estimated; conjugates and isocyanate challenge tests, bronchoalveolar lavage fluid analyses, and/or lung histologic investigations were performed. Results: Each of the 14 study patients who had Hypersensitivity Pneumonitis had work-related dyspnea and fever occurring several hours after the start of work with isocyanates. Typical clinical findings were the reduction of lung diffusing capacity ( n = 10), reticular or nodular lung patterns in the x-ray film ( n = 9), and serum IgG antibodies specific to isocyanate–human serum albumin conjugates ( n = 10). Restrictive ventilation patterns in the inhalation challenge tests ( n = 5), lymphocytic and/or neutrophilic alveolitis seen in bronchoalveolar lavage fluid analyses ( n = 7), and lymphohistocytic patterns mostly associated with mild fibrosis in lung histology ( n = 5) confirmed the diagnosis. Conclusion: Occupational exposure to isocyanate vapors and aerosols induces typical Hypersensitivity Pneumonitis in at least 1% of the isocyanate workers with symptoms. Diphenylmethan diisocyanate was found to be the main cause of this disorder. (J ALLERGY CLIN IMMUNOL 1995;95:1004-10.)
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Hypersensitivity Pneumonitis (extrinsic allergic alveolitis) induced by isocyanates.
The Journal of allergy and clinical immunology, 1995Co-Authors: X BaurAbstract:Chemical-induced Hypersensitivity Pneumonitis has been so far rarely described. The purpose of this study was to find out whether Hypersensitivity Pneumonitis is a common disorder in isocyanate workers. Company physicians' case histories of 1780 isocyanate workers were evaluated. In 16 subjects suspected of having isocyanate-induced Hypersensitivity Pneumonitis, chest x-ray films were made; levels of IgE and IgG antibodies to isocyanate-human serum albumin were estimated; conjugates and isocyanate challenge tests, bronchoalveolar lavage fluid analyses, and/or lung histologic investigations were performed. Each of the 14 study patients who had Hypersensitivity Pneumonitis had work-related dyspnea and fever occurring several hours after the start of work with isocyanates. Typical clinical findings were the reduction of lung diffusing capacity (n = 10), reticular or nodular lung patterns in the x-ray film (n = 9), and serum IgG antibodies specific to isocyanate-human serum albumin conjugates (n = 10). Restrictive ventilation patterns in the inhalation challenge tests (n = 5), lymphocytic and/or neutrophilic alveolitis seen in bronchoalveolar lavage fluid analyses (n = 7), and lymphohistiocytic patterns mostly associated with mild fibrosis in lung histology (n = 5) confirmed the diagnosis. Occupational exposure to isocyanate vapors and aerosols induces typical Hypersensitivity Pneumonitis in at least 1% of the isocyanate workers with symptoms. Diphenylmethane diisocyanate was found to be the main cause of this disorder.
Mary Beth Hogan - One of the best experts on this subject based on the ideXlab platform.
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Basement shower Hypersensitivity Pneumonitis secondary to epicoccum nigrum
Chest, 1996Co-Authors: Mary Beth Hogan, W. Thomas Corder, Robert S. Pore, Roy Patterson, Nevin W. WilsonAbstract:Two children developed Hypersensitivity Pneumonitis after extensive exposure to an unventilated basement shower. Commercial precipitin panels were negative. After home inspection, individual mold species were isolated from the household and extracted. Precipitating antibodies to Epicoccum nigrum were found in both children. Resolution of the Hypersensitivity Pneumonitis occurred with avoidance and glucocorticosteroid therapy. E nigrum is a newly identified etiologie agent for Hypersensitivity Pneumonitis found in a mold-contaminated home.
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Basement shower Hypersensitivity Pneumonitis secondary to Epicoccum nigrum
Chest, 1996Co-Authors: Mary Beth Hogan, W. Thomas Corder, Robert S. Pore, Roy Patterson, Nevin W. WilsonAbstract:Two children developed Hypersensitivity Pneumonitis after extensive exposure to an unventilated basement shower. Commercial precipitin panels were negative. After home inspection, individual mold species were isolated from the household and extracted. Precipitating antibodies to Epicoccum nigrum were found in both children. Resolution of the Hypersensitivity Pneumonitis occurred with avoidance and glucocorticosteroid therapy. E nigrum is a newly identified etiologic agent for Hypersensitivity Pneumonitis found in a mold-contaminated home.
Roy Patterson - One of the best experts on this subject based on the ideXlab platform.
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Basement shower Hypersensitivity Pneumonitis secondary to epicoccum nigrum
Chest, 1996Co-Authors: Mary Beth Hogan, W. Thomas Corder, Robert S. Pore, Roy Patterson, Nevin W. WilsonAbstract:Two children developed Hypersensitivity Pneumonitis after extensive exposure to an unventilated basement shower. Commercial precipitin panels were negative. After home inspection, individual mold species were isolated from the household and extracted. Precipitating antibodies to Epicoccum nigrum were found in both children. Resolution of the Hypersensitivity Pneumonitis occurred with avoidance and glucocorticosteroid therapy. E nigrum is a newly identified etiologie agent for Hypersensitivity Pneumonitis found in a mold-contaminated home.
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Basement shower Hypersensitivity Pneumonitis secondary to Epicoccum nigrum
Chest, 1996Co-Authors: Mary Beth Hogan, W. Thomas Corder, Robert S. Pore, Roy Patterson, Nevin W. WilsonAbstract:Two children developed Hypersensitivity Pneumonitis after extensive exposure to an unventilated basement shower. Commercial precipitin panels were negative. After home inspection, individual mold species were isolated from the household and extracted. Precipitating antibodies to Epicoccum nigrum were found in both children. Resolution of the Hypersensitivity Pneumonitis occurred with avoidance and glucocorticosteroid therapy. E nigrum is a newly identified etiologic agent for Hypersensitivity Pneumonitis found in a mold-contaminated home.
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Hypersensitivity Pneumonitis in a raptor handler and a wild bird fancier.
Annals of allergy asthma & immunology : official publication of the American College of Allergy Asthma & Immunology, 1995Co-Authors: A C Choy, Roy Patterson, A H Ray, M RobertsAbstract:Background : Hypersensitivity Pneumonitis has been associated with a variety of antigens in various settings. We have recently encountered one case of Hypersensitivity Pneumonitis from owl droppings and another case from a wild Moluccan cockatoo. Objective : It is important to alert physicians to the possibility of Hypersensitivity Pneumonitis when dealing with wildlife workers and wild bird fanciers. Method : A report of two cases with progress and response to therapy. Results : Clinical and serologic information are of value in the diagnosis of Hypersensitivity Pneumonitis due to birds and avoidance is the optimal approach. Conclusion : There are many raptor handlers and wild bird fanciers across the United States and the world. Given the incidence of Hypersensitivity Pneumonitis in pigeon breeders, this may herald a new variant of allergic disease among wildlife workers and wild bird fanciers.
