The Experts below are selected from a list of 54 Experts worldwide ranked by ideXlab platform
Philip Hougaard - One of the best experts on this subject based on the ideXlab platform.
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Prevalence of micro- and macroalbuminuria, arterial Hypertension, Retinopathy and large vessel disease in European type 2 (non-insulin-dependent) diabetic patients.
Diabetologia, 1991Co-Authors: Mari-anne Gall, Peter Rossing, P. Skøtt, P. Damsbo, Allan Vaag, K. Bech, A. Dejgaard, M. Lauritzen, E. Lauritzen, Philip HougaardAbstract:The prevalence of micro- and macroalbuminuria was determined in Type 2 (non-insulin-dependent) diabetic patients, less than 76 years of age, attending a diabetic clinic during 1987. All eligible patients (n=557) were asked to collect a 24-h urine sample for quantitative albumin analysis. Urine collections were obtained in 296 males and 253 females (96%). Normoalbuminuria were defined as urinary albumin excretion≤30 mg/24 h (n=323), microalbuminuria as 31–299 mg/24 h (n=151), and macroalbuminuria as ≥300 mg/ 24 h (n=75). The prevalence of macroalbuminuria was significantly higher in males (20%) than in females (6%), while the prevalence of microalbuminuria was almost identical in males (26%) and females (29%). The prevalence of arterial Hypertension increased with increased albuminuria, being 48%, 68%, and 85% in patients with normoalbuminuria, microalbuminuria, and macroalbuminuria respectively. Prevalence of proliferative Retinopathy rose with increasing albuminuria, being 2%, 5% and 12% in patients with normoalbuminuria, microalbuminuria, and macroalbuminuria respectively. Prevalence of coronary heart disease, based on Minnesota coded electrocardiograms, was more frequent in patients with macroalbuminuria (46%) compared to patients with microalbuminuria (26%) and patients with normoalbuminuria (22%). Foot ulcers were more frequent in micro- and macroalbuminuric patients, being 13% and 25%, respectively, compared to 5% in patients with normoalbuminuria. This cross-sectional study has revealed a high prevalence of microalbuminuria (27%) and macroalbuminuria (14%) in Type 2 diabetic patients. Patients with raised urinary albumin excretion are characterized by obesity, elevated haemoglobin Alc, increased frequency of arterial Hypertension, proliferative Retinopathy, coronary heart disease and foot ulcers. Thus, these findings suggest that urinary excretion of albumin should be monitored routinely in patients with Type 2 diabetes.
Mari-anne Gall - One of the best experts on this subject based on the ideXlab platform.
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Prevalence of micro- and macroalbuminuria, arterial Hypertension, Retinopathy and large vessel disease in European type 2 (non-insulin-dependent) diabetic patients.
Diabetologia, 1991Co-Authors: Mari-anne Gall, Peter Rossing, P. Skøtt, P. Damsbo, Allan Vaag, K. Bech, A. Dejgaard, M. Lauritzen, E. Lauritzen, Philip HougaardAbstract:The prevalence of micro- and macroalbuminuria was determined in Type 2 (non-insulin-dependent) diabetic patients, less than 76 years of age, attending a diabetic clinic during 1987. All eligible patients (n=557) were asked to collect a 24-h urine sample for quantitative albumin analysis. Urine collections were obtained in 296 males and 253 females (96%). Normoalbuminuria were defined as urinary albumin excretion≤30 mg/24 h (n=323), microalbuminuria as 31–299 mg/24 h (n=151), and macroalbuminuria as ≥300 mg/ 24 h (n=75). The prevalence of macroalbuminuria was significantly higher in males (20%) than in females (6%), while the prevalence of microalbuminuria was almost identical in males (26%) and females (29%). The prevalence of arterial Hypertension increased with increased albuminuria, being 48%, 68%, and 85% in patients with normoalbuminuria, microalbuminuria, and macroalbuminuria respectively. Prevalence of proliferative Retinopathy rose with increasing albuminuria, being 2%, 5% and 12% in patients with normoalbuminuria, microalbuminuria, and macroalbuminuria respectively. Prevalence of coronary heart disease, based on Minnesota coded electrocardiograms, was more frequent in patients with macroalbuminuria (46%) compared to patients with microalbuminuria (26%) and patients with normoalbuminuria (22%). Foot ulcers were more frequent in micro- and macroalbuminuric patients, being 13% and 25%, respectively, compared to 5% in patients with normoalbuminuria. This cross-sectional study has revealed a high prevalence of microalbuminuria (27%) and macroalbuminuria (14%) in Type 2 diabetic patients. Patients with raised urinary albumin excretion are characterized by obesity, elevated haemoglobin Alc, increased frequency of arterial Hypertension, proliferative Retinopathy, coronary heart disease and foot ulcers. Thus, these findings suggest that urinary excretion of albumin should be monitored routinely in patients with Type 2 diabetes.
Jacob Twiss - One of the best experts on this subject based on the ideXlab platform.
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infants with chronic neonatal lung disease recommendations for the use of home oxygen therapy
The Medical Journal of Australia, 2008Co-Authors: Dominic A Fitzgerald, John R Massie, Gillian M Nixon, Adam Jaffe, Andrew Wilson, Louis I Landau, Jacob TwissAbstract:Chronic neonatal lung disease (CNLD) is defined as a supplemental oxygen requirement beyond 36 weeks' postmenstrual age, with more severely affected infants requiring oxygen beyond a full-term-equivalent age. Low-flow supplemental oxygen facilitates discharge from hospital of infants with CNLD who develop hypoxia in air. There is a lack of data on the most appropriate minimum mean target oxygen saturation (Spo(2)) level. Reflecting a variety of clinical practices and infant comorbidities (frequency of oxygen desaturation, presence of pulmonary Hypertension, Retinopathy of prematurity, and adequacy of growth), the minimum mean target range for Spo(2) during overnight oximetry should be 93%-95%. The effect of supplemental oxygen on carbon dioxide retention should be considered before deciding on an oxygen flow. Most infants with CNLD are not ready for discharge until their supplemental oxygen requirement is < or = 0.5 litres per minute delivered through a nasal cannula. The safety of short-term disconnection from supplemental oxygen should be assessed before discharge. Assessment of oxygenation during sleep with continuous overnight oximetry or polysomnography is recommended when weaning infants from supplemental oxygen. Discontinuation of oxygen therapy is based on clinical assessments and documentation of adequate oxygenation in room air. There is limited objective evidence on which to base recommendations.
Hitesh Thakur - One of the best experts on this subject based on the ideXlab platform.
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detection of Hypertension Retinopathy and diabetes using machine learning
Social Science Research Network, 2020Co-Authors: Richard Joseph, Sony Chauhan, Karishma Chichria, Tanishq Bhatia, Hitesh ThakurAbstract:Medical conditions can be identified with only photographs of the eye which is called fundus images using computer automated processes. The task of distinguishing blood vessels by simply observing retinal images has proven to be challenging without the aid of technology. Various morphological features such as retinal veins, arteries, diameter, branching angle and length have diagnostic features. The tiny blood vessels can deteriorate and leak fluid into and under the retina which causes swelling of the retina. Hypertension Retinopathy has vascular damage caused by Hypertension. Funduscopic examination shows cotton-wool spots, arteriolar construction, vascular wall changes, arteriovenous nicking, flame shaped hemorrhages, optic disc edema and yellow hard exudates.
Gillian M Nixon - One of the best experts on this subject based on the ideXlab platform.
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infants with chronic neonatal lung disease recommendations for the use of home oxygen therapy
The Medical Journal of Australia, 2008Co-Authors: Dominic A Fitzgerald, John R Massie, Gillian M Nixon, Adam Jaffe, Andrew Wilson, Louis I Landau, Jacob TwissAbstract:Chronic neonatal lung disease (CNLD) is defined as a supplemental oxygen requirement beyond 36 weeks' postmenstrual age, with more severely affected infants requiring oxygen beyond a full-term-equivalent age. Low-flow supplemental oxygen facilitates discharge from hospital of infants with CNLD who develop hypoxia in air. There is a lack of data on the most appropriate minimum mean target oxygen saturation (Spo(2)) level. Reflecting a variety of clinical practices and infant comorbidities (frequency of oxygen desaturation, presence of pulmonary Hypertension, Retinopathy of prematurity, and adequacy of growth), the minimum mean target range for Spo(2) during overnight oximetry should be 93%-95%. The effect of supplemental oxygen on carbon dioxide retention should be considered before deciding on an oxygen flow. Most infants with CNLD are not ready for discharge until their supplemental oxygen requirement is < or = 0.5 litres per minute delivered through a nasal cannula. The safety of short-term disconnection from supplemental oxygen should be assessed before discharge. Assessment of oxygenation during sleep with continuous overnight oximetry or polysomnography is recommended when weaning infants from supplemental oxygen. Discontinuation of oxygen therapy is based on clinical assessments and documentation of adequate oxygenation in room air. There is limited objective evidence on which to base recommendations.