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Kate M Denton - One of the best experts on this subject based on the ideXlab platform.
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blunted natriuretic response to saline loading in sheep with Hypertensive Kidney Disease following radiofrequency catheter based renal denervation
Scientific Reports, 2021Co-Authors: Reetu R Singh, Zoe Mcardle, Lindsea C Booth, Clive N May, Karen M Moritz, Markus P Schlaich, Harshil Singh, Geoffrey A Head, Kate M DentonAbstract:Renal sympathetic nerves contribute to renal excretory function during volume expansion. We hypothesized that intact renal innervation is required for excretion of a fluid/electrolyte load in Hypertensive chronic Kidney Disease (CKD) and normotensive healthy settings. Blood pressure, Kidney hemodynamic and excretory response to 180 min of isotonic saline loading (0.13 ml/kg/min) were examined in female normotensive (control) and Hypertensive CKD sheep at 2 and 11 months after sham (control-intact, CKD-intact) or radiofrequency catheter-based RDN (control-RDN, CKD-RDN) procedure. Basal blood pressure was ~ 7 to 9 mmHg lower at 2, and 11 months in CKD-RDN compared with CKD-intact sheep. Saline loading did not alter glomerular filtration rate in any group. At 2 months, in response to saline loading, total urine and sodium excretion were ~ 40 to 50% less, in control-RDN and CKD-RDN than intact groups. At 11 months, the natriuretic and diuretic response to saline loading were similar between control-intact, control-RDN and CKD-intact groups but sodium excretion was ~ 42% less in CKD-RDN compared with CKD-intact at this time-point. These findings indicate that chronic withdrawal of basal renal sympathetic activity impairs fluid/electrolyte excretion during volume expansion. Clinically, a reduced ability to excrete a saline load following RDN may contribute to disturbances in body fluid balance in Hypertensive CKD.
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increase in bioavailability of nitric oxide after renal denervation improves Kidney function in sheep with Hypertensive Kidney Disease
Hypertension, 2021Co-Authors: Reetu R Singh, Zoe Mcardle, Lindsea C Booth, Clive N May, G Head, Karen M Moritz, Markus P Schlaich, Kate M DentonAbstract:Overactivity of renal sympathetic nerves and nitric oxide (NO) deficiency occur in Hypertensive chronic Kidney Disease (CKD). In sheep with Hypertensive CKD and NO deficiency, renal denervation (RD...
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increase in bioavailability of nitric oxide after renal denervation improves Kidney function in sheep with Hypertensive Kidney Disease
Hypertension, 2021Co-Authors: Reetu R Singh, Zoe Mcardle, Lindsea C Booth, Clive N May, G Head, Karen M Moritz, Markus P Schlaich, Kate M DentonAbstract:Overactivity of renal sympathetic nerves and nitric oxide (NO) deficiency occur in Hypertensive chronic Kidney Disease (CKD). In sheep with Hypertensive CKD and NO deficiency, renal denervation (RDN) reduces blood pressure and improves Kidney function (glomerular filtration rate). We hypothesized that this improvement in glomerular filtration rate after RDN is associated with increased NO bioavailability. In this study, glomerular filtration rate response to systemic inhibition of NOS (NO synthase) was examined in healthy and CKD sheep at 2 and 30 months after a sham (intact nerves) or RDN procedure. Basal urinary total nitrate (nitrate+nitrite) excretion was examined at 2 and 30 months, and Kidney protein expression of endothelial and neuronal NOS was assessed at 30 months. Urinary nitrate+nitrite in CKD-RDN and healthy sheep was ≈50% to 70% greater than in CKD-intact. During NOS inhibition, the fall in glomerular filtration rate in CKD-RDN sheep was ≈20% greater than in CKD-intact. These effects in CKD-RDN sheep were similar to those in healthy sheep. Endothelial NOS protein expression was lower in CKD-intact sheep compared with healthy sheep and compared with CKD-RDN. In summary, RDN normalizes NO bioavailability and restores contribution of NO to renal hemodynamics in CKD. These changes may promote improvements in Kidney function and sustained blood pressure lowering after RDN in Hypertensive CKD.
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abstract 045 attenuated natriuretic response to saline loading in sheep with Hypertensive Kidney Disease following radiofrequency catheter based renal denervation
Hypertension, 2019Co-Authors: Kate M Denton, Lindsea C Booth, Clive N May, Karen M Moritz, Markus P Schlaich, Harshil Singh, Geoffrey A Head, Zoe Mccardle, Reetu R SinghAbstract:In the present study, we examined the chronic effect of renal denervation (RDN) on the blood pressure (BP) and renal function in response to a slow-infused isotonic saline load. Normotensive (contr...
Reetu R Singh - One of the best experts on this subject based on the ideXlab platform.
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blunted natriuretic response to saline loading in sheep with Hypertensive Kidney Disease following radiofrequency catheter based renal denervation
Scientific Reports, 2021Co-Authors: Reetu R Singh, Zoe Mcardle, Lindsea C Booth, Clive N May, Karen M Moritz, Markus P Schlaich, Harshil Singh, Geoffrey A Head, Kate M DentonAbstract:Renal sympathetic nerves contribute to renal excretory function during volume expansion. We hypothesized that intact renal innervation is required for excretion of a fluid/electrolyte load in Hypertensive chronic Kidney Disease (CKD) and normotensive healthy settings. Blood pressure, Kidney hemodynamic and excretory response to 180 min of isotonic saline loading (0.13 ml/kg/min) were examined in female normotensive (control) and Hypertensive CKD sheep at 2 and 11 months after sham (control-intact, CKD-intact) or radiofrequency catheter-based RDN (control-RDN, CKD-RDN) procedure. Basal blood pressure was ~ 7 to 9 mmHg lower at 2, and 11 months in CKD-RDN compared with CKD-intact sheep. Saline loading did not alter glomerular filtration rate in any group. At 2 months, in response to saline loading, total urine and sodium excretion were ~ 40 to 50% less, in control-RDN and CKD-RDN than intact groups. At 11 months, the natriuretic and diuretic response to saline loading were similar between control-intact, control-RDN and CKD-intact groups but sodium excretion was ~ 42% less in CKD-RDN compared with CKD-intact at this time-point. These findings indicate that chronic withdrawal of basal renal sympathetic activity impairs fluid/electrolyte excretion during volume expansion. Clinically, a reduced ability to excrete a saline load following RDN may contribute to disturbances in body fluid balance in Hypertensive CKD.
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increase in bioavailability of nitric oxide after renal denervation improves Kidney function in sheep with Hypertensive Kidney Disease
Hypertension, 2021Co-Authors: Reetu R Singh, Zoe Mcardle, Lindsea C Booth, Clive N May, G Head, Karen M Moritz, Markus P Schlaich, Kate M DentonAbstract:Overactivity of renal sympathetic nerves and nitric oxide (NO) deficiency occur in Hypertensive chronic Kidney Disease (CKD). In sheep with Hypertensive CKD and NO deficiency, renal denervation (RD...
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increase in bioavailability of nitric oxide after renal denervation improves Kidney function in sheep with Hypertensive Kidney Disease
Hypertension, 2021Co-Authors: Reetu R Singh, Zoe Mcardle, Lindsea C Booth, Clive N May, G Head, Karen M Moritz, Markus P Schlaich, Kate M DentonAbstract:Overactivity of renal sympathetic nerves and nitric oxide (NO) deficiency occur in Hypertensive chronic Kidney Disease (CKD). In sheep with Hypertensive CKD and NO deficiency, renal denervation (RDN) reduces blood pressure and improves Kidney function (glomerular filtration rate). We hypothesized that this improvement in glomerular filtration rate after RDN is associated with increased NO bioavailability. In this study, glomerular filtration rate response to systemic inhibition of NOS (NO synthase) was examined in healthy and CKD sheep at 2 and 30 months after a sham (intact nerves) or RDN procedure. Basal urinary total nitrate (nitrate+nitrite) excretion was examined at 2 and 30 months, and Kidney protein expression of endothelial and neuronal NOS was assessed at 30 months. Urinary nitrate+nitrite in CKD-RDN and healthy sheep was ≈50% to 70% greater than in CKD-intact. During NOS inhibition, the fall in glomerular filtration rate in CKD-RDN sheep was ≈20% greater than in CKD-intact. These effects in CKD-RDN sheep were similar to those in healthy sheep. Endothelial NOS protein expression was lower in CKD-intact sheep compared with healthy sheep and compared with CKD-RDN. In summary, RDN normalizes NO bioavailability and restores contribution of NO to renal hemodynamics in CKD. These changes may promote improvements in Kidney function and sustained blood pressure lowering after RDN in Hypertensive CKD.
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abstract 045 attenuated natriuretic response to saline loading in sheep with Hypertensive Kidney Disease following radiofrequency catheter based renal denervation
Hypertension, 2019Co-Authors: Kate M Denton, Lindsea C Booth, Clive N May, Karen M Moritz, Markus P Schlaich, Harshil Singh, Geoffrey A Head, Zoe Mccardle, Reetu R SinghAbstract:In the present study, we examined the chronic effect of renal denervation (RDN) on the blood pressure (BP) and renal function in response to a slow-infused isotonic saline load. Normotensive (contr...
Markus P Schlaich - One of the best experts on this subject based on the ideXlab platform.
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blunted natriuretic response to saline loading in sheep with Hypertensive Kidney Disease following radiofrequency catheter based renal denervation
Scientific Reports, 2021Co-Authors: Reetu R Singh, Zoe Mcardle, Lindsea C Booth, Clive N May, Karen M Moritz, Markus P Schlaich, Harshil Singh, Geoffrey A Head, Kate M DentonAbstract:Renal sympathetic nerves contribute to renal excretory function during volume expansion. We hypothesized that intact renal innervation is required for excretion of a fluid/electrolyte load in Hypertensive chronic Kidney Disease (CKD) and normotensive healthy settings. Blood pressure, Kidney hemodynamic and excretory response to 180 min of isotonic saline loading (0.13 ml/kg/min) were examined in female normotensive (control) and Hypertensive CKD sheep at 2 and 11 months after sham (control-intact, CKD-intact) or radiofrequency catheter-based RDN (control-RDN, CKD-RDN) procedure. Basal blood pressure was ~ 7 to 9 mmHg lower at 2, and 11 months in CKD-RDN compared with CKD-intact sheep. Saline loading did not alter glomerular filtration rate in any group. At 2 months, in response to saline loading, total urine and sodium excretion were ~ 40 to 50% less, in control-RDN and CKD-RDN than intact groups. At 11 months, the natriuretic and diuretic response to saline loading were similar between control-intact, control-RDN and CKD-intact groups but sodium excretion was ~ 42% less in CKD-RDN compared with CKD-intact at this time-point. These findings indicate that chronic withdrawal of basal renal sympathetic activity impairs fluid/electrolyte excretion during volume expansion. Clinically, a reduced ability to excrete a saline load following RDN may contribute to disturbances in body fluid balance in Hypertensive CKD.
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increase in bioavailability of nitric oxide after renal denervation improves Kidney function in sheep with Hypertensive Kidney Disease
Hypertension, 2021Co-Authors: Reetu R Singh, Zoe Mcardle, Lindsea C Booth, Clive N May, G Head, Karen M Moritz, Markus P Schlaich, Kate M DentonAbstract:Overactivity of renal sympathetic nerves and nitric oxide (NO) deficiency occur in Hypertensive chronic Kidney Disease (CKD). In sheep with Hypertensive CKD and NO deficiency, renal denervation (RD...
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increase in bioavailability of nitric oxide after renal denervation improves Kidney function in sheep with Hypertensive Kidney Disease
Hypertension, 2021Co-Authors: Reetu R Singh, Zoe Mcardle, Lindsea C Booth, Clive N May, G Head, Karen M Moritz, Markus P Schlaich, Kate M DentonAbstract:Overactivity of renal sympathetic nerves and nitric oxide (NO) deficiency occur in Hypertensive chronic Kidney Disease (CKD). In sheep with Hypertensive CKD and NO deficiency, renal denervation (RDN) reduces blood pressure and improves Kidney function (glomerular filtration rate). We hypothesized that this improvement in glomerular filtration rate after RDN is associated with increased NO bioavailability. In this study, glomerular filtration rate response to systemic inhibition of NOS (NO synthase) was examined in healthy and CKD sheep at 2 and 30 months after a sham (intact nerves) or RDN procedure. Basal urinary total nitrate (nitrate+nitrite) excretion was examined at 2 and 30 months, and Kidney protein expression of endothelial and neuronal NOS was assessed at 30 months. Urinary nitrate+nitrite in CKD-RDN and healthy sheep was ≈50% to 70% greater than in CKD-intact. During NOS inhibition, the fall in glomerular filtration rate in CKD-RDN sheep was ≈20% greater than in CKD-intact. These effects in CKD-RDN sheep were similar to those in healthy sheep. Endothelial NOS protein expression was lower in CKD-intact sheep compared with healthy sheep and compared with CKD-RDN. In summary, RDN normalizes NO bioavailability and restores contribution of NO to renal hemodynamics in CKD. These changes may promote improvements in Kidney function and sustained blood pressure lowering after RDN in Hypertensive CKD.
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abstract 045 attenuated natriuretic response to saline loading in sheep with Hypertensive Kidney Disease following radiofrequency catheter based renal denervation
Hypertension, 2019Co-Authors: Kate M Denton, Lindsea C Booth, Clive N May, Karen M Moritz, Markus P Schlaich, Harshil Singh, Geoffrey A Head, Zoe Mccardle, Reetu R SinghAbstract:In the present study, we examined the chronic effect of renal denervation (RDN) on the blood pressure (BP) and renal function in response to a slow-infused isotonic saline load. Normotensive (contr...
Lindsea C Booth - One of the best experts on this subject based on the ideXlab platform.
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blunted natriuretic response to saline loading in sheep with Hypertensive Kidney Disease following radiofrequency catheter based renal denervation
Scientific Reports, 2021Co-Authors: Reetu R Singh, Zoe Mcardle, Lindsea C Booth, Clive N May, Karen M Moritz, Markus P Schlaich, Harshil Singh, Geoffrey A Head, Kate M DentonAbstract:Renal sympathetic nerves contribute to renal excretory function during volume expansion. We hypothesized that intact renal innervation is required for excretion of a fluid/electrolyte load in Hypertensive chronic Kidney Disease (CKD) and normotensive healthy settings. Blood pressure, Kidney hemodynamic and excretory response to 180 min of isotonic saline loading (0.13 ml/kg/min) were examined in female normotensive (control) and Hypertensive CKD sheep at 2 and 11 months after sham (control-intact, CKD-intact) or radiofrequency catheter-based RDN (control-RDN, CKD-RDN) procedure. Basal blood pressure was ~ 7 to 9 mmHg lower at 2, and 11 months in CKD-RDN compared with CKD-intact sheep. Saline loading did not alter glomerular filtration rate in any group. At 2 months, in response to saline loading, total urine and sodium excretion were ~ 40 to 50% less, in control-RDN and CKD-RDN than intact groups. At 11 months, the natriuretic and diuretic response to saline loading were similar between control-intact, control-RDN and CKD-intact groups but sodium excretion was ~ 42% less in CKD-RDN compared with CKD-intact at this time-point. These findings indicate that chronic withdrawal of basal renal sympathetic activity impairs fluid/electrolyte excretion during volume expansion. Clinically, a reduced ability to excrete a saline load following RDN may contribute to disturbances in body fluid balance in Hypertensive CKD.
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increase in bioavailability of nitric oxide after renal denervation improves Kidney function in sheep with Hypertensive Kidney Disease
Hypertension, 2021Co-Authors: Reetu R Singh, Zoe Mcardle, Lindsea C Booth, Clive N May, G Head, Karen M Moritz, Markus P Schlaich, Kate M DentonAbstract:Overactivity of renal sympathetic nerves and nitric oxide (NO) deficiency occur in Hypertensive chronic Kidney Disease (CKD). In sheep with Hypertensive CKD and NO deficiency, renal denervation (RD...
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increase in bioavailability of nitric oxide after renal denervation improves Kidney function in sheep with Hypertensive Kidney Disease
Hypertension, 2021Co-Authors: Reetu R Singh, Zoe Mcardle, Lindsea C Booth, Clive N May, G Head, Karen M Moritz, Markus P Schlaich, Kate M DentonAbstract:Overactivity of renal sympathetic nerves and nitric oxide (NO) deficiency occur in Hypertensive chronic Kidney Disease (CKD). In sheep with Hypertensive CKD and NO deficiency, renal denervation (RDN) reduces blood pressure and improves Kidney function (glomerular filtration rate). We hypothesized that this improvement in glomerular filtration rate after RDN is associated with increased NO bioavailability. In this study, glomerular filtration rate response to systemic inhibition of NOS (NO synthase) was examined in healthy and CKD sheep at 2 and 30 months after a sham (intact nerves) or RDN procedure. Basal urinary total nitrate (nitrate+nitrite) excretion was examined at 2 and 30 months, and Kidney protein expression of endothelial and neuronal NOS was assessed at 30 months. Urinary nitrate+nitrite in CKD-RDN and healthy sheep was ≈50% to 70% greater than in CKD-intact. During NOS inhibition, the fall in glomerular filtration rate in CKD-RDN sheep was ≈20% greater than in CKD-intact. These effects in CKD-RDN sheep were similar to those in healthy sheep. Endothelial NOS protein expression was lower in CKD-intact sheep compared with healthy sheep and compared with CKD-RDN. In summary, RDN normalizes NO bioavailability and restores contribution of NO to renal hemodynamics in CKD. These changes may promote improvements in Kidney function and sustained blood pressure lowering after RDN in Hypertensive CKD.
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abstract 045 attenuated natriuretic response to saline loading in sheep with Hypertensive Kidney Disease following radiofrequency catheter based renal denervation
Hypertension, 2019Co-Authors: Kate M Denton, Lindsea C Booth, Clive N May, Karen M Moritz, Markus P Schlaich, Harshil Singh, Geoffrey A Head, Zoe Mccardle, Reetu R SinghAbstract:In the present study, we examined the chronic effect of renal denervation (RDN) on the blood pressure (BP) and renal function in response to a slow-infused isotonic saline load. Normotensive (contr...
Clive N May - One of the best experts on this subject based on the ideXlab platform.
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blunted natriuretic response to saline loading in sheep with Hypertensive Kidney Disease following radiofrequency catheter based renal denervation
Scientific Reports, 2021Co-Authors: Reetu R Singh, Zoe Mcardle, Lindsea C Booth, Clive N May, Karen M Moritz, Markus P Schlaich, Harshil Singh, Geoffrey A Head, Kate M DentonAbstract:Renal sympathetic nerves contribute to renal excretory function during volume expansion. We hypothesized that intact renal innervation is required for excretion of a fluid/electrolyte load in Hypertensive chronic Kidney Disease (CKD) and normotensive healthy settings. Blood pressure, Kidney hemodynamic and excretory response to 180 min of isotonic saline loading (0.13 ml/kg/min) were examined in female normotensive (control) and Hypertensive CKD sheep at 2 and 11 months after sham (control-intact, CKD-intact) or radiofrequency catheter-based RDN (control-RDN, CKD-RDN) procedure. Basal blood pressure was ~ 7 to 9 mmHg lower at 2, and 11 months in CKD-RDN compared with CKD-intact sheep. Saline loading did not alter glomerular filtration rate in any group. At 2 months, in response to saline loading, total urine and sodium excretion were ~ 40 to 50% less, in control-RDN and CKD-RDN than intact groups. At 11 months, the natriuretic and diuretic response to saline loading were similar between control-intact, control-RDN and CKD-intact groups but sodium excretion was ~ 42% less in CKD-RDN compared with CKD-intact at this time-point. These findings indicate that chronic withdrawal of basal renal sympathetic activity impairs fluid/electrolyte excretion during volume expansion. Clinically, a reduced ability to excrete a saline load following RDN may contribute to disturbances in body fluid balance in Hypertensive CKD.
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increase in bioavailability of nitric oxide after renal denervation improves Kidney function in sheep with Hypertensive Kidney Disease
Hypertension, 2021Co-Authors: Reetu R Singh, Zoe Mcardle, Lindsea C Booth, Clive N May, G Head, Karen M Moritz, Markus P Schlaich, Kate M DentonAbstract:Overactivity of renal sympathetic nerves and nitric oxide (NO) deficiency occur in Hypertensive chronic Kidney Disease (CKD). In sheep with Hypertensive CKD and NO deficiency, renal denervation (RD...
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increase in bioavailability of nitric oxide after renal denervation improves Kidney function in sheep with Hypertensive Kidney Disease
Hypertension, 2021Co-Authors: Reetu R Singh, Zoe Mcardle, Lindsea C Booth, Clive N May, G Head, Karen M Moritz, Markus P Schlaich, Kate M DentonAbstract:Overactivity of renal sympathetic nerves and nitric oxide (NO) deficiency occur in Hypertensive chronic Kidney Disease (CKD). In sheep with Hypertensive CKD and NO deficiency, renal denervation (RDN) reduces blood pressure and improves Kidney function (glomerular filtration rate). We hypothesized that this improvement in glomerular filtration rate after RDN is associated with increased NO bioavailability. In this study, glomerular filtration rate response to systemic inhibition of NOS (NO synthase) was examined in healthy and CKD sheep at 2 and 30 months after a sham (intact nerves) or RDN procedure. Basal urinary total nitrate (nitrate+nitrite) excretion was examined at 2 and 30 months, and Kidney protein expression of endothelial and neuronal NOS was assessed at 30 months. Urinary nitrate+nitrite in CKD-RDN and healthy sheep was ≈50% to 70% greater than in CKD-intact. During NOS inhibition, the fall in glomerular filtration rate in CKD-RDN sheep was ≈20% greater than in CKD-intact. These effects in CKD-RDN sheep were similar to those in healthy sheep. Endothelial NOS protein expression was lower in CKD-intact sheep compared with healthy sheep and compared with CKD-RDN. In summary, RDN normalizes NO bioavailability and restores contribution of NO to renal hemodynamics in CKD. These changes may promote improvements in Kidney function and sustained blood pressure lowering after RDN in Hypertensive CKD.
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abstract 045 attenuated natriuretic response to saline loading in sheep with Hypertensive Kidney Disease following radiofrequency catheter based renal denervation
Hypertension, 2019Co-Authors: Kate M Denton, Lindsea C Booth, Clive N May, Karen M Moritz, Markus P Schlaich, Harshil Singh, Geoffrey A Head, Zoe Mccardle, Reetu R SinghAbstract:In the present study, we examined the chronic effect of renal denervation (RDN) on the blood pressure (BP) and renal function in response to a slow-infused isotonic saline load. Normotensive (contr...