The Experts below are selected from a list of 3111 Experts worldwide ranked by ideXlab platform
Lei Shao - One of the best experts on this subject based on the ideXlab platform.
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the relationship between subfoveal choroidal thickness and Hypertensive Retinopathy
Scientific Reports, 2021Co-Authors: Lei Shao, Ling Xiao Zhou, Wen Bin WeiAbstract:The Beijing Eye Study 2011 is a population-based cross-sectional study in Northern China, which enrolled 3468 participants whose age were more than 50 years. A detailed ophthalmic examination was performed including spectral-domain optical coherence tomography with enhanced depth imaging for measurement of SFCT and fundus photography. Blood pressure, fundus photographs and choroidal OCT-images were available for 3237 (93.3%) subjects, with 1953 (56.3 ± 0.8%) of the study population fulfilled the diagnosis of hypertension and 1089 subjects having Hypertensive Retinopathy. For the Hypertensive cases, the SFCT in patients with Hypertensive Retinopathy (286.48 ± 105.23 µm) was significantly thicker than subjects without Hypertensive Retinopathy (187.04 ± 78.80 µm, P < 0.001). SFCT was significantly associated with the stage of Hypertensive Retinopathy (P < 0.001), but not significantly associated with diastolic blood pressure (P = 0.94), history (P = 0.95) and years (P = 0.91) of hypertension. In conclusion, hypertension as systemic disease was not significantly affect the subfoveal choroidal thickness, but as ocular disease, Hypertensive Retinopathy was significantly related to changes of choroidal thickness. Lesions of choroid during chronic hypertension may play an important role in development of Hypertensive Retinopathy.
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The relationship between Subfoveal Choroidal Thickness and Hypertensive Retinopathy.
Scientific reports, 2021Co-Authors: Lei Shao, Ling Xiao Zhou, Wen Bin WeiAbstract:The Beijing Eye Study 2011 is a population-based cross-sectional study in Northern China, which enrolled 3468 participants whose age were more than 50 years. A detailed ophthalmic examination was performed including spectral-domain optical coherence tomography with enhanced depth imaging for measurement of SFCT and fundus photography. Blood pressure, fundus photographs and choroidal OCT-images were available for 3237 (93.3%) subjects, with 1953 (56.3 ± 0.8%) of the study population fulfilled the diagnosis of hypertension and 1089 subjects having Hypertensive Retinopathy. For the Hypertensive cases, the SFCT in patients with Hypertensive Retinopathy (286.48 ± 105.23 µm) was significantly thicker than subjects without Hypertensive Retinopathy (187.04 ± 78.80 µm, P
Wen Bin Wei - One of the best experts on this subject based on the ideXlab platform.
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the relationship between subfoveal choroidal thickness and Hypertensive Retinopathy
Scientific Reports, 2021Co-Authors: Lei Shao, Ling Xiao Zhou, Wen Bin WeiAbstract:The Beijing Eye Study 2011 is a population-based cross-sectional study in Northern China, which enrolled 3468 participants whose age were more than 50 years. A detailed ophthalmic examination was performed including spectral-domain optical coherence tomography with enhanced depth imaging for measurement of SFCT and fundus photography. Blood pressure, fundus photographs and choroidal OCT-images were available for 3237 (93.3%) subjects, with 1953 (56.3 ± 0.8%) of the study population fulfilled the diagnosis of hypertension and 1089 subjects having Hypertensive Retinopathy. For the Hypertensive cases, the SFCT in patients with Hypertensive Retinopathy (286.48 ± 105.23 µm) was significantly thicker than subjects without Hypertensive Retinopathy (187.04 ± 78.80 µm, P < 0.001). SFCT was significantly associated with the stage of Hypertensive Retinopathy (P < 0.001), but not significantly associated with diastolic blood pressure (P = 0.94), history (P = 0.95) and years (P = 0.91) of hypertension. In conclusion, hypertension as systemic disease was not significantly affect the subfoveal choroidal thickness, but as ocular disease, Hypertensive Retinopathy was significantly related to changes of choroidal thickness. Lesions of choroid during chronic hypertension may play an important role in development of Hypertensive Retinopathy.
Ling Xiao Zhou - One of the best experts on this subject based on the ideXlab platform.
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the relationship between subfoveal choroidal thickness and Hypertensive Retinopathy
Scientific Reports, 2021Co-Authors: Lei Shao, Ling Xiao Zhou, Wen Bin WeiAbstract:The Beijing Eye Study 2011 is a population-based cross-sectional study in Northern China, which enrolled 3468 participants whose age were more than 50 years. A detailed ophthalmic examination was performed including spectral-domain optical coherence tomography with enhanced depth imaging for measurement of SFCT and fundus photography. Blood pressure, fundus photographs and choroidal OCT-images were available for 3237 (93.3%) subjects, with 1953 (56.3 ± 0.8%) of the study population fulfilled the diagnosis of hypertension and 1089 subjects having Hypertensive Retinopathy. For the Hypertensive cases, the SFCT in patients with Hypertensive Retinopathy (286.48 ± 105.23 µm) was significantly thicker than subjects without Hypertensive Retinopathy (187.04 ± 78.80 µm, P < 0.001). SFCT was significantly associated with the stage of Hypertensive Retinopathy (P < 0.001), but not significantly associated with diastolic blood pressure (P = 0.94), history (P = 0.95) and years (P = 0.91) of hypertension. In conclusion, hypertension as systemic disease was not significantly affect the subfoveal choroidal thickness, but as ocular disease, Hypertensive Retinopathy was significantly related to changes of choroidal thickness. Lesions of choroid during chronic hypertension may play an important role in development of Hypertensive Retinopathy.
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The relationship between Subfoveal Choroidal Thickness and Hypertensive Retinopathy.
Scientific reports, 2021Co-Authors: Lei Shao, Ling Xiao Zhou, Wen Bin WeiAbstract:The Beijing Eye Study 2011 is a population-based cross-sectional study in Northern China, which enrolled 3468 participants whose age were more than 50 years. A detailed ophthalmic examination was performed including spectral-domain optical coherence tomography with enhanced depth imaging for measurement of SFCT and fundus photography. Blood pressure, fundus photographs and choroidal OCT-images were available for 3237 (93.3%) subjects, with 1953 (56.3 ± 0.8%) of the study population fulfilled the diagnosis of hypertension and 1089 subjects having Hypertensive Retinopathy. For the Hypertensive cases, the SFCT in patients with Hypertensive Retinopathy (286.48 ± 105.23 µm) was significantly thicker than subjects without Hypertensive Retinopathy (187.04 ± 78.80 µm, P
Wen Bin Wei - One of the best experts on this subject based on the ideXlab platform.
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The relationship between Subfoveal Choroidal Thickness and Hypertensive Retinopathy.
Scientific reports, 2021Co-Authors: Lei Shao, Ling Xiao Zhou, Wen Bin WeiAbstract:The Beijing Eye Study 2011 is a population-based cross-sectional study in Northern China, which enrolled 3468 participants whose age were more than 50 years. A detailed ophthalmic examination was performed including spectral-domain optical coherence tomography with enhanced depth imaging for measurement of SFCT and fundus photography. Blood pressure, fundus photographs and choroidal OCT-images were available for 3237 (93.3%) subjects, with 1953 (56.3 ± 0.8%) of the study population fulfilled the diagnosis of hypertension and 1089 subjects having Hypertensive Retinopathy. For the Hypertensive cases, the SFCT in patients with Hypertensive Retinopathy (286.48 ± 105.23 µm) was significantly thicker than subjects without Hypertensive Retinopathy (187.04 ± 78.80 µm, P
Tien Yin Wong - One of the best experts on this subject based on the ideXlab platform.
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Hypertensive Retinopathy and Risk of Stroke
Hypertension (Dallas Tex. : 1979), 2013Co-Authors: Yi Ting Ong, Tien Yin Wong, Ronald Klein, Barbara E. K. Klein, Paul Mitchell, A. Richey Sharrett, David J. Couper, M. Kamran IkramAbstract:Although assessment of Hypertensive Retinopathy signs has been recommended for determining end-organ damage and stratifying vascular risk in persons with hypertension, its value remains unclear. In this study, we examine whether Hypertensive Retinopathy predicts the long-term risk of stroke in those with hypertension. A total of 2907 participants with hypertension aged 50 to 73 years at the 1993 to 1995 examination, who had gradable retinal photographs, no history of diabetes mellitus, stroke, and coronary heart disease at baseline and data on incident stroke, were included from the Atherosclerosis Risk in Communities (ARIC) Study. Retinal photographs were assessed for Hypertensive Retinopathy signs and classified as none, mild, and moderate/severe. Incident events of any stroke, cerebral infarction, and hemorrhagic stroke were identified and validated. After a mean follow-up period of 13.0 years, 165 persons developed incident stroke (146 cerebral infarctions and 15 hemorrhagic strokes). After adjusting for age, sex, blood pressure, and other risk factors, persons with moderate Hypertensive Retinopathy were more likely to have stroke (moderate versus no Retinopathy: multivariable hazard ratios, 2.37 [95% confidence interval, 1.39-4.02]). In participants with hypertension on medication with good control of blood pressure, Hypertensive Retinopathy was related to an increased risk of cerebral infarction (mild Retinopathy: hazard ratio, 1.96 [95% confidence interval, 1.09-3.55]; and moderate Retinopathy: hazard ratio, 2.98 [95% confidence interval, 1.01-8.83]). Hypertensive Retinopathy predicts the long-term risk of stroke, independent of blood pressure, even in treated patients with hypertension with good hypertension control. Retinal photographic assessment of Hypertensive Retinopathy signs may be useful for assessment of stroke risk.
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Fred Hollows lecture: Hypertensive Retinopathy - a journey from fundoscopy to digital imaging.
Clinical & experimental ophthalmology, 2006Co-Authors: Tien Yin WongAbstract:Hypertensive Retinopathy refers to a spectrum of retinal microvascular signs that develop in response to elevated blood pressure. These signs are broadly divided into localized signs (focal retinal arteriolar narrowing, arteriovenous nicking, retinal haemorrhages, cotton wool spots, hard exudates and microaneurysms) and diffuse signs (generalized retinal arteriolar narrowing, arterial wall opacification and optic disc oedema). Although their association with systemic morbidity was recognized more than a century ago, the prognostic significance of Hypertensive Retinopathy has not received much attention. In large part, this is because clinical assessment of Hypertensive Retinopathy signs with the direct fundoscopy has proven imprecise. Data from large population-based studies in the past decade, using retinal photographic methods to define Hypertensive Retinopathy signs, have provided new insights into the epidemiology, systemic associations and clinical significance of Hypertensive Retinopathy. These studies show that Hypertensive Retinopathy signs are common (up to 14% of adults aged 40 years and older, even in those without clinical diabetes or hypertension) and are strongly associated with blood pressure. Various Retinopathy signs predict the risk of stroke, congestive heart failure and cardiovascular mortality, independent of blood pressure and other risk factors. These data suggest that patients with Hypertensive Retinopathy signs may benefit from a careful cardiovascular evaluation, and appropriate risk reduction therapy if indicated. Future advances in digital retinal imaging technology will allow researchers and clinicians to better chart and monitor the vascular effects of hypertension.
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Hypertensive Retinopathy signs as risk indicators of cardiovascular morbidity and mortality.
British medical bulletin, 2005Co-Authors: Tien Yin Wong, Rachel McintoshAbstract:Hypertensive Retinopathy has long been regarded as a risk indicator for systemic morbidity and mortality. New population-based studies show that Hypertensive Retinopathy signs are strongly associated with blood pressure, but inconsistently associated with cholesterol and other risk factors of atherosclerosis. Mild Hypertensive Retinopathy signs, such as generalized and focal retinal arteriolar narrowing and arteriovenous nicking, are weakly associated with systemic vascular diseases. Moderate Hypertensive Retinopathy signs, such as isolated microaneurysms, haemorrhages and cotton-wool spots, are strongly associated with subclinical cerebrovascular disease and predict incident clinical stroke, congestive heart failure and cardiovascular mortality, independent of blood pressure and other traditional risk factors. These data support the concept that an assessment of retinal vascular changes may provide further information for vascular risk stratification in persons with hypertension.
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Racial Differences in the Prevalence of Hypertensive Retinopathy
Hypertension (Dallas Tex. : 1979), 2003Co-Authors: Tien Yin Wong, Ronald Klein, Barbara E. K. Klein, David J. Couper, Bruce B. Duncan, F. Javier Nieto, Larry D. Hubbard, A. Richey SharrettAbstract:Few population-based data support the hypothesis that Hypertensive Retinopathy is more common in African Americans than in whites. We examined racial differences in the prevalence of and risk factors for Hypertensive Retinopathy in a population-based sample of 1860 African Americans and 7874 white persons, aged 49 to 73 years, without diabetes. Retinal photographs were taken of one randomly selected eye and evaluated for the presence of Retinopathy (flame and blot-shaped retinal hemorrhages, microaneurysms, and soft exudates) according to standardized protocols by graders masked to participant characteristics. The prevalence of Retinopathy was 2 times higher in African Americans than in whites (7.7% versus 4.1%, age- and gender-adjusted odds ratio [OR] 2.03, 95% confidence intervals [CI] 1.65, 2.49). After controlling for 6-year mean arterial blood pressure, use of antiHypertensive medications and left ventricular hypertrophy by ECG criteria, the excess prevalence of Retinopathy in African Americans was reduced by 40% (adjusted OR 1.61, 95% CI 1.26, 2.06). Further adjustment for other vascular risk factors, common carotid artery intima-media thickness, and serum creatinine levels reduced the excess prevalence in African Americans by another 13% (adjusted OR 1.48, 95% CI 1.08, 2.03). We conclude that Hypertensive Retinopathy is twice as frequent in African Americans compared with whites without diabetes and that the excess prevalence of Retinopathy in African Americans is associated with blood pressure and severity of hypertension.
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Hypertensive Retinopathy and incident coronary heart disease in high risk men
British Journal of Ophthalmology, 2002Co-Authors: Bruce Bartholow Duncan, Tien Yin Wong, H A Tyroler, C E Davis, Flavio Danni FuchsAbstract:Background/aim: Although routine ophthalmoscopy is recommended in the evaluation of people with hypertension, the prognostic significance of Retinopathy is unknown. The purpose of this study is to determine if Hypertensive Retinopathy predicts coronary heart disease (CHD). Methods: A prospective cohort study involving 560 Hypertensive, hyperlipidaemic, middle aged men enrolled in the Lipid Research Clinic’s Coronary Primary Prevention Trial. Signs of Hypertensive Retinopathy (generalised and focal arteriolar narrowing, arteriovenous nicking, widened arteriolar light reflex, retinal haemorrhage and exudates, microaneurysms, and disc swelling) were evaluated by direct funduscopy during a baseline examination by study physicians. Incident CHD events were ascertained from hospital records, necropsy reports, and death certificates, and reviewed by a masked panel of cardiologists. Results: There were 51 definite CHD events (definite CHD deaths or myocardial infarctions) during a median follow up of 7.8 years. After adjusting for age, blood pressure, electrocardiographic manifestations of left ventricular hypertrophy, cholesterol levels and treatment, glucose and creatinine levels, and smoking status in proportional hazards analysis, the presence of Hypertensive Retinopathy predicted a doubling of the risk of definite CHD events (relative risk 2.1; 95% confidence interval (CI) 1.0 to 4.2 ). The presence of either generalised or focal arteriolar narrowing predicted almost a tripling of the risk (relative risk 2.9; 95% CI 1.3 to 6.2). Associations were similar for stage 1 hypertension (systolic and diastolic blood pressures of 140–159 and 90–99 mm Hg, respectively) and for other CHD end points. Conclusion: Hypertensive Retinopathy predicts CHD in high risk men, independent of blood pressure and CHD risk factors. The data support the concept that retinal microvascular changes are markers of blood pressure damage and may be useful in risk stratification and in the tailoring of hypertension treatment decisions.