The Experts below are selected from a list of 909 Experts worldwide ranked by ideXlab platform

Vincenzo Leuzzi - One of the best experts on this subject based on the ideXlab platform.

  • Teaching Video NeuroImages: Clinical course of infantile ascending hereditary spastic paralysis
    Neurology, 2014
    Co-Authors: Mario Mastrangelo, Pia Bernasconi, Paola De Liso, Caterina Caputi, Sara Bertino, Vincenzo Leuzzi
    Abstract:

    A 15-year-old boy presented with a history of an early-onset spastic paraparesis that progressed toward a severe quadriparesis (video on the Neurology ® Web site at [www.neurology.org][1]), hypokinesia and bradykinesia, dysphagia, dysarthria, and Hypomimia. Delayed motor evoked potentials and corticobulbar tract signal abnormality on brain MRI (figure) suggested corticospinal tract involvement. Cognitive functioning was preserved (Leiter-R IQ 86). ALS2 gene sequencing detected a homozygous c.2992C>T (p.R998X) substitution in exon 18 and confirmed the diagnosis of infantile ascending hereditary spastic paralysis (IAHSP).1 [1]: http://www.neurology.org/

Andrew J Lees - One of the best experts on this subject based on the ideXlab platform.

  • concomitant progressive supranuclear palsy and chronic traumatic encephalopathy in a boxer
    Acta neuropathologica communications, 2014
    Co-Authors: Helen Ling, Eleanna Kara, Tamas Revesz, Andrew J Lees, Gordon T Plant, Davide Martino
    Abstract:

    We report the case of a 75-year-old ex-professional boxer who developed diplopia and eye movement abnormalities in his 60’s followed by memory impairment, low mood and recurrent falls. Examination shortly before death revealed Hypomimia, dysarthria, vertical supranuclear gaze palsy and impaired postural reflexes. Pathological examination demonstrated 4-repeat tau neuronal and glial lesions, including tufted astrocytes, consistent with a diagnosis of progressive supranuclear palsy. In addition, neurofibrillary tangles composed of mixed 3-repeat and 4-repeat tau and astrocytic tangles in a distribution highly suggestive of chronic traumatic encephalopathy were observed together with limbic TDP-43 pathology. Possible mechanisms for the co-occurrence of these two tau pathologies are discussed.

  • Parkinsonism due to Kernohan notch: Clinical, structural, and functional imaging correlates
    Neurology, 2004
    Co-Authors: Andrew Evans, Sveto Gacinovic, Durval C. Costa, Andrew J Lees
    Abstract:

    A man aged 27 years fell backward down stairs, striking his head and losing consciousness. In the emergency department, he had a Glasgow Coma Score of 3, and his pupils were fixed and dilated. There was no significant hypoxia after the injury. CT showed left parieto-occipital fracture and underlying subdural hematoma with minimal midline shift. He underwent left hemicraniectomy and evacuation of subdural and epidural hematoma and required 2 weeks of postoperative respiratory support in an intensive care unit. As he regained voluntary movement, he had persistent slowing of left-sided movements and left hand tremor in the following months. Cerebral MRI 9 months after the injury confirmed left frontoparietal post-traumatic change and a lesion in the right cerebral peduncle involving the midbrain and region of the right substantia nigra (figure). One year after the injury, he had decreased left arm swing with walking, asymmetric facial Hypomimia, marked rigidity of the left arm and leg, but no significant pyramidal signs. He could …

David B. Vodušek - One of the best experts on this subject based on the ideXlab platform.

  • Management of sexual dysfunction in Parkinson's disease.
    Therapeutic advances in neurological disorders, 2011
    Co-Authors: Gila Bronner, David B. Vodušek
    Abstract:

    Nonmotor symptoms, among them sexual dysfunction, are common and underrecognized in patients with Parkinson disease; they play a major role in the deterioration of quality of life of patients and their partners. Loss of desire and dissatisfaction with their sexual life is encountered in both genders. Hypersexuality (HS), erectile dysfunction and problems with ejaculation are found in male patients, and loss of lubrication and involuntary urination during sex are found in female patients. Tremor, Hypomimia, muscle rigidity, bradykinesia, ‘clumsiness’ in fine motor control, dyskinesias, hypersalivation and sweating may interfere with sexual function. Optimal dopaminergic treatment should facilitate sexual encounters of the couple. Appropriate counselling diminishes some of the problems (reluctance to engage in sex, problems with ejaculation, lubrication and urinary incontinence). Treatment of erectile dysfunction with sildenafil and apomorphine is evidence based. HS or compulsive sexual behaviour are side effects of dopaminergic therapy, particularly by dopaminergic agonists, and should be treated primarily by diminishing their dose. Neurologists should actively investigate sexual dysfunction in their Parkinsonian patients and offer treatment, optimally within a multidisciplinary team, where a dedicated professional would deal with sexual counselling.

Davide Martino - One of the best experts on this subject based on the ideXlab platform.

  • concomitant progressive supranuclear palsy and chronic traumatic encephalopathy in a boxer
    Acta neuropathologica communications, 2014
    Co-Authors: Helen Ling, Eleanna Kara, Tamas Revesz, Andrew J Lees, Gordon T Plant, Davide Martino
    Abstract:

    We report the case of a 75-year-old ex-professional boxer who developed diplopia and eye movement abnormalities in his 60’s followed by memory impairment, low mood and recurrent falls. Examination shortly before death revealed Hypomimia, dysarthria, vertical supranuclear gaze palsy and impaired postural reflexes. Pathological examination demonstrated 4-repeat tau neuronal and glial lesions, including tufted astrocytes, consistent with a diagnosis of progressive supranuclear palsy. In addition, neurofibrillary tangles composed of mixed 3-repeat and 4-repeat tau and astrocytic tangles in a distribution highly suggestive of chronic traumatic encephalopathy were observed together with limbic TDP-43 pathology. Possible mechanisms for the co-occurrence of these two tau pathologies are discussed.

Mario Mastrangelo - One of the best experts on this subject based on the ideXlab platform.

  • Teaching Video NeuroImages: Clinical course of infantile ascending hereditary spastic paralysis
    Neurology, 2014
    Co-Authors: Mario Mastrangelo, Pia Bernasconi, Paola De Liso, Caterina Caputi, Sara Bertino, Vincenzo Leuzzi
    Abstract:

    A 15-year-old boy presented with a history of an early-onset spastic paraparesis that progressed toward a severe quadriparesis (video on the Neurology ® Web site at [www.neurology.org][1]), hypokinesia and bradykinesia, dysphagia, dysarthria, and Hypomimia. Delayed motor evoked potentials and corticobulbar tract signal abnormality on brain MRI (figure) suggested corticospinal tract involvement. Cognitive functioning was preserved (Leiter-R IQ 86). ALS2 gene sequencing detected a homozygous c.2992C>T (p.R998X) substitution in exon 18 and confirmed the diagnosis of infantile ascending hereditary spastic paralysis (IAHSP).1 [1]: http://www.neurology.org/