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Lisa Stowers - One of the best experts on this subject based on the ideXlab platform.
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piezo2 in sensory neurons and urothelial cells coordinates Urination
Nature, 2020Co-Authors: Kara L Marshall, D Saade, Nima Ghitani, Adam Coombs, Marcin Szczot, Jason Keller, Tracy Ogata, Ihab Daou, Lisa StowersAbstract:Henry Miller stated that "to relieve a full bladder is one of the great human joys". Urination is critically important in health and ailments of the lower urinary tract cause high pathological burden. Although there have been advances in understanding the central circuitry in the brain that facilitates Urination1-3, there is a lack of in-depth mechanistic insight into the process. In addition to central control, micturition reflexes that govern Urination are all initiated by peripheral mechanical stimuli such as bladder stretch and urethral flow4. The mechanotransduction molecules and cell types that function as the primary stretch and pressure detectors in the urinary tract mostly remain unknown. Here we identify expression of the mechanosensitive ion channel PIEZO2 in lower urinary tract tissues, where it is required for low-threshold bladder-stretch sensing and urethral micturition reflexes. We show that PIEZO2 acts as a sensor in both the bladder urothelium and innervating sensory neurons. Humans and mice lacking functional PIEZO2 have impaired bladder control, and humans lacking functional PIEZO2 report deficient bladder-filling sensation. This study identifies PIEZO2 as a key mechanosensor in urinary function. These findings set the foundation for future work to identify the interactions between urothelial cells and sensory neurons that control Urination.
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voluntary Urination control by brainstem neurons that relax the urethral sphincter
Nature Neuroscience, 2018Co-Authors: Jaso A Kelle, Jingyi Che, Sierra Simpso, Eric Houje Wang, Varoth Lilascharoe, Olivie George, Yung Kook Lim, Lisa StowersAbstract:Voluntary Urination ensures that waste is eliminated when safe and socially appropriate, even without a pressing urge. Uncontrolled Urination, or incontinence, is a common problem with few treatment options. Normal urine release requires a small region in the brainstem known as Barrington's nucleus (Bar), but specific neurons that relax the urethral sphincter and enable urine flow are unknown. Here we identify a small subset of Bar neurons that control the urethral sphincter in mice. These excitatory neurons express estrogen receptor 1 (BarESR1), project to sphincter-relaxing interneurons in the spinal cord and are active during natural Urination. Optogenetic stimulation of BarESR1 neurons rapidly initiates sphincter bursting and efficient voiding in anesthetized and behaving animals. Conversely, optogenetic and chemogenetic inhibition reveals their necessity in motivated Urination behavior. The identification of these cells provides an expanded model for the control of Urination and its dysfunction.
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brainstem control of urethral sphincter relaxation and scent marking behavior
bioRxiv, 2018Co-Authors: Jaso A Kelle, Jingyi Che, Sierra Simpso, Eric Houje Wang, Varoth Lilascharoe, Olivie George, Yung Kook Lim, Lisa StowersAbstract:Urination may occur either reflexively in response to a full bladder or deliberately irrespective of immediate need. Voluntary control is desired because it ensures that waste is expelled when consciously desired and socially appropriate. Urine release requires two primary components: bladder pressure and urethral relaxation. Although the bladder contracts during Urination, its slow smooth muscle is not under direct voluntary control and its contraction alone is not sufficient for voiding. The decisive action of Urination is at the urethral sphincter, where striated muscle permits fast control. This sphincter is normally constricted, but relaxes to enable urine flow. Barringtons nucleus (Bar, or pontine micturition center) in the brainstem is known to be essential for the switch from urine storage to elimination, and a subset of Bar neurons expressing corticotropin releasing hormone (BarCRH) have recently been shown to promote bladder contraction. However, Bar neurons that relax the urethral sphincter to enable Urination behavior have not been identified. Here we describe novel brainstem neurons that control the external urethral sphincter. We find that scent marking behavior in male mice depends upon a subpopulation of spatially clustered Bar neurons that express high levels of estrogen receptor 1 (BarESR1). These neurons are glutamatergic, project to urinary nuclei in the spinal cord with a bias towards sphincter-inhibiting interneurons, and their activity correlates with natural Urination. Optogenetic stimulation of BarESR1 neurons rapidly initiates sphincter bursting and efficient voiding in absence of sensory cues in anesthetized and behaving animals. Conversely, inhibiting the activity of these neurons prevents olfactory cues from promoting scent marking behavior. The identification of BarESR1 cells provides an expanded model for the supraspinal control of Urination and its dysfunction.
Jaso A Kelle - One of the best experts on this subject based on the ideXlab platform.
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voluntary Urination control by brainstem neurons that relax the urethral sphincter
Nature Neuroscience, 2018Co-Authors: Jaso A Kelle, Jingyi Che, Sierra Simpso, Eric Houje Wang, Varoth Lilascharoe, Olivie George, Yung Kook Lim, Lisa StowersAbstract:Voluntary Urination ensures that waste is eliminated when safe and socially appropriate, even without a pressing urge. Uncontrolled Urination, or incontinence, is a common problem with few treatment options. Normal urine release requires a small region in the brainstem known as Barrington's nucleus (Bar), but specific neurons that relax the urethral sphincter and enable urine flow are unknown. Here we identify a small subset of Bar neurons that control the urethral sphincter in mice. These excitatory neurons express estrogen receptor 1 (BarESR1), project to sphincter-relaxing interneurons in the spinal cord and are active during natural Urination. Optogenetic stimulation of BarESR1 neurons rapidly initiates sphincter bursting and efficient voiding in anesthetized and behaving animals. Conversely, optogenetic and chemogenetic inhibition reveals their necessity in motivated Urination behavior. The identification of these cells provides an expanded model for the control of Urination and its dysfunction.
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brainstem control of urethral sphincter relaxation and scent marking behavior
bioRxiv, 2018Co-Authors: Jaso A Kelle, Jingyi Che, Sierra Simpso, Eric Houje Wang, Varoth Lilascharoe, Olivie George, Yung Kook Lim, Lisa StowersAbstract:Urination may occur either reflexively in response to a full bladder or deliberately irrespective of immediate need. Voluntary control is desired because it ensures that waste is expelled when consciously desired and socially appropriate. Urine release requires two primary components: bladder pressure and urethral relaxation. Although the bladder contracts during Urination, its slow smooth muscle is not under direct voluntary control and its contraction alone is not sufficient for voiding. The decisive action of Urination is at the urethral sphincter, where striated muscle permits fast control. This sphincter is normally constricted, but relaxes to enable urine flow. Barringtons nucleus (Bar, or pontine micturition center) in the brainstem is known to be essential for the switch from urine storage to elimination, and a subset of Bar neurons expressing corticotropin releasing hormone (BarCRH) have recently been shown to promote bladder contraction. However, Bar neurons that relax the urethral sphincter to enable Urination behavior have not been identified. Here we describe novel brainstem neurons that control the external urethral sphincter. We find that scent marking behavior in male mice depends upon a subpopulation of spatially clustered Bar neurons that express high levels of estrogen receptor 1 (BarESR1). These neurons are glutamatergic, project to urinary nuclei in the spinal cord with a bias towards sphincter-inhibiting interneurons, and their activity correlates with natural Urination. Optogenetic stimulation of BarESR1 neurons rapidly initiates sphincter bursting and efficient voiding in absence of sensory cues in anesthetized and behaving animals. Conversely, inhibiting the activity of these neurons prevents olfactory cues from promoting scent marking behavior. The identification of BarESR1 cells provides an expanded model for the supraspinal control of Urination and its dysfunction.
K. Nakashima - One of the best experts on this subject based on the ideXlab platform.
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Development of an Urination Assist System - A Bladder Compressing System with a Link-Work Mechanism
2007 IEEE International Conference on Mechatronics, 2007Co-Authors: K. Kiguchi, Y. Sakamoto, K. Nakashima, J. UozumiAbstract:In this paper, we propose a compact Urination assist system that is implantable in a patient who has difficulty in Urination caused by the decline of bladder muscular power, disconnection of the nerve to a bladder, etc. in order to assist the Urination. The proposed system assists the Urination by directly pushing the bladder of the patient using a link-work mechanism. SMA springs and Peltier elements are used to activate the proposed system. The effectiveness of the proposed system is evaluated by experiment.
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A study on implantable Urination assist systems - development of a bladder compression system
The 26th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, 2004Co-Authors: K. Kiguchi, Y. Sakamoto, J. Uozumi, K. NakashimaAbstract:We propose an Urination assist system implantable in a patient who has difficulty in Urination caused by the neuropathic bladder in order to assist the Urination. The proposed system assists the Urination by directly pushing the bladder of the patient using shape memory alloys (SMA). Peltier elements are used to control the temperature in the system. The effectiveness of the proposed system is evaluated by experiment with a bladder model.
Takeo Nakayama - One of the best experts on this subject based on the ideXlab platform.
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Night-time frequency of Urination as a manifestation of sleep-disordered breathing: the Nagahama study.
Sleep Medicine, 2020Co-Authors: Satoshi Hamada, Yasuharu Tabara, Kimihiko Murase, Takeshi Matsumoto, Kazuya Setoh, Tomoko Wakamura, Takahisa Kawaguchi, Shinji Kosugi, Takeo Nakayama, Toyohiro HiraiAbstract:Abstract Aims Sleep-disordered breathing (SDB) is a well-known risk factor for cardiovascular outcomes. Studies of patients with SDB have identified frequent night-time Urination as a manifestation related to SDB. We aimed to clarify whether night-time frequency of Urination is independently associated with SDB in a general population. We also investigated whether night-time frequency of Urination can help presumptive diagnose SDB. Methods Study participants consisted of 7,151 community residents. Oxygen saturation during sleep was measured for four nights using a pulse oximeter. SDB was defined as ≥15 events per hour in which oxygen desaturation exceeded or equal to 3% during an actigraphy-determined sleep period. Night-time frequency of Urination was recorded for 1 week using a sleep diary. Results Significant positive correlations were evident between night-time frequency of Urination and SDB (none, 5.8%; once/night, 14.1%; twice/night, 20.1%; thrice/night, 28.7%; >thrice/night, 44.1%, P thrice/night = 3.73, P Conclusion Night-time frequency of Urination was associated with SDB. Our findings suggest that the Urination frequency should be considered a manifestation of SDB even in a general population.
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lifestyle habits associated with nocturnal Urination frequency the nagahama study
Neurourology and Urodynamics, 2019Co-Authors: Yasuharu Tabara, Kimihiko Murase, Takeshi Matsumoto, Kazuya Setoh, Takahisa Kawaguchi, Shinji Kosugi, Toyohiro Hirai, Shunsuke Nagashima, Satoshi Funada, Takeo NakayamaAbstract:BACKGROUND Nocturia is a risk factor for poor quality of life and increased mortality. This study was aimed to clarifying dietary habits, eating behaviors, and sleep characteristics associated with nocturia to identify modifiable lifestyle factors for nocturia. METHODS This cross-sectional study included 5683 community residents (64.5 ± 7.7 years old). The frequency of nocturnal Urination was recorded for 1 week using a sleep diary. The frequency of food intake, unfavorable eating behaviors, and sleep characteristics that may have influence on salt intake and wasting were obtained using a structured questionnaire. RESULTS The frequency of nocturnal Urination was increased with age (β = .312, P < .001). Other basic factors associated with the frequency were the male sex (β = .090), hypertension (β = .038), sleep apnea (β = .030), B-type natriuretic peptide level (β = .089), and spot urine sodium excretion (β = -.058). Dietary factors independently associated with nocturnal Urination frequency were coffee (≥1 time/day: β = -.059, P < .001) and green vegetable consumption (≥1 time/week: β = -.042, P = .001), whereas habitual intake of dairy products, miso soup, and alcohol were not associated with Urination frequency. Later bedtime was inversely associated with nocturnal Urination frequency independent of sleep duration (before 23:00: β = -.096; before 24:00: β = -.225; after midnight: β = -.240; all P < .001). CONCLUSION Coffee and green vegetable consumption and later bedtime but not sleep duration are lifestyle factors associated with nocturnal Urination frequency.
K. Kiguchi - One of the best experts on this subject based on the ideXlab platform.
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Development of an Urination Assist System - A Bladder Compressing System with a Link-Work Mechanism
2007 IEEE International Conference on Mechatronics, 2007Co-Authors: K. Kiguchi, Y. Sakamoto, K. Nakashima, J. UozumiAbstract:In this paper, we propose a compact Urination assist system that is implantable in a patient who has difficulty in Urination caused by the decline of bladder muscular power, disconnection of the nerve to a bladder, etc. in order to assist the Urination. The proposed system assists the Urination by directly pushing the bladder of the patient using a link-work mechanism. SMA springs and Peltier elements are used to activate the proposed system. The effectiveness of the proposed system is evaluated by experiment.
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A study on implantable Urination assist systems - development of a bladder compression system
The 26th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, 2004Co-Authors: K. Kiguchi, Y. Sakamoto, J. Uozumi, K. NakashimaAbstract:We propose an Urination assist system implantable in a patient who has difficulty in Urination caused by the neuropathic bladder in order to assist the Urination. The proposed system assists the Urination by directly pushing the bladder of the patient using shape memory alloys (SMA). Peltier elements are used to control the temperature in the system. The effectiveness of the proposed system is evaluated by experiment with a bladder model.
