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Annelore Altendorf-hofmann - One of the best experts on this subject based on the ideXlab platform.
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Head and neck Cancer in Germany: a site-specific analysis of survival of the Thuringian Cancer registration database
Journal of Cancer Research and Clinical Oncology, 2010Co-Authors: Orlando Guntinas-lichius, Peter Lochner, Thomas Wendt, Stefan Schultze-mosgau, Jens Buentzel, Andreas Mueller, Dirk Eßer, Annelore Altendorf-hofmannAbstract:Objective To describe epidemiology and prognosis of head and neck Cancer in Germany. Methods We analyzed the Thuringian Cancer registry database from 1996 to 2005. 3,821 cases with primary head and neck Cancer were evaluated for patient’s characteristics, tumor stage, incidence, treatment, and trends in overall survival. Results During the period 1996–2005, the incidence of oropharynx, Hypopharynx, larynx, and salivary gland Cancer increased significantly for males, and of oral cavity and Hypopharynx Cancer for females. There was a significant trend using more multimodal therapy combining surgery, radiotherapy, and chemotherapy, and to use less radiotherapy as a single modality. The median follow-up time of patients alive was 42 months. The 5-year overall survival rate (OS) for all patients was 47.8%. The site-specific 5-year OS for lip, oral cavity, nasopharynx, oropharynx, Hypopharynx, larynx, salivary gland, and nose/paranasal sinus Cancer was 75.7, 42.6, 43.5, 45.9, 27.2, 57.3, 61.0, and 34.9%, respectively. The multivariate analysis showed that male gender, age ≥60 years, therapy without surgery, higher T classification, N classification, and M classification were independent significant negative risk factors for OS ( p
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Head and neck Cancer in Germany: a site-specific analysis of survival of the Thuringian Cancer registration database
Journal of Cancer Research and Clinical Oncology, 2009Co-Authors: Orlando Guntinas-lichius, Thomas G. Wendt, Peter Lochner, Stefan Schultze-mosgau, Jens Buentzel, Andreas Mueller, Dirk Eßer, Annelore Altendorf-hofmannAbstract:To describe epidemiology and prognosis of head and neck Cancer in Germany. We analyzed the Thuringian Cancer registry database from 1996 to 2005. 3,821 cases with primary head and neck Cancer were evaluated for patient’s characteristics, tumor stage, incidence, treatment, and trends in overall survival. During the period 1996–2005, the incidence of oropharynx, Hypopharynx, larynx, and salivary gland Cancer increased significantly for males, and of oral cavity and Hypopharynx Cancer for females. There was a significant trend using more multimodal therapy combining surgery, radiotherapy, and chemotherapy, and to use less radiotherapy as a single modality. The median follow-up time of patients alive was 42 months. The 5-year overall survival rate (OS) for all patients was 47.8%. The site-specific 5-year OS for lip, oral cavity, nasopharynx, oropharynx, Hypopharynx, larynx, salivary gland, and nose/paranasal sinus Cancer was 75.7, 42.6, 43.5, 45.9, 27.2, 57.3, 61.0, and 34.9%, respectively. The multivariate analysis showed that male gender, age ≥60 years, therapy without surgery, higher T classification, N classification, and M classification were independent significant negative risk factors for OS (p
Orlando Guntinas-lichius - One of the best experts on this subject based on the ideXlab platform.
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Head and neck Cancer in Germany: a site-specific analysis of survival of the Thuringian Cancer registration database
Journal of Cancer Research and Clinical Oncology, 2010Co-Authors: Orlando Guntinas-lichius, Peter Lochner, Thomas Wendt, Stefan Schultze-mosgau, Jens Buentzel, Andreas Mueller, Dirk Eßer, Annelore Altendorf-hofmannAbstract:Objective To describe epidemiology and prognosis of head and neck Cancer in Germany. Methods We analyzed the Thuringian Cancer registry database from 1996 to 2005. 3,821 cases with primary head and neck Cancer were evaluated for patient’s characteristics, tumor stage, incidence, treatment, and trends in overall survival. Results During the period 1996–2005, the incidence of oropharynx, Hypopharynx, larynx, and salivary gland Cancer increased significantly for males, and of oral cavity and Hypopharynx Cancer for females. There was a significant trend using more multimodal therapy combining surgery, radiotherapy, and chemotherapy, and to use less radiotherapy as a single modality. The median follow-up time of patients alive was 42 months. The 5-year overall survival rate (OS) for all patients was 47.8%. The site-specific 5-year OS for lip, oral cavity, nasopharynx, oropharynx, Hypopharynx, larynx, salivary gland, and nose/paranasal sinus Cancer was 75.7, 42.6, 43.5, 45.9, 27.2, 57.3, 61.0, and 34.9%, respectively. The multivariate analysis showed that male gender, age ≥60 years, therapy without surgery, higher T classification, N classification, and M classification were independent significant negative risk factors for OS ( p
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Head and neck Cancer in Germany: a site-specific analysis of survival of the Thuringian Cancer registration database
Journal of Cancer Research and Clinical Oncology, 2009Co-Authors: Orlando Guntinas-lichius, Thomas G. Wendt, Peter Lochner, Stefan Schultze-mosgau, Jens Buentzel, Andreas Mueller, Dirk Eßer, Annelore Altendorf-hofmannAbstract:To describe epidemiology and prognosis of head and neck Cancer in Germany. We analyzed the Thuringian Cancer registry database from 1996 to 2005. 3,821 cases with primary head and neck Cancer were evaluated for patient’s characteristics, tumor stage, incidence, treatment, and trends in overall survival. During the period 1996–2005, the incidence of oropharynx, Hypopharynx, larynx, and salivary gland Cancer increased significantly for males, and of oral cavity and Hypopharynx Cancer for females. There was a significant trend using more multimodal therapy combining surgery, radiotherapy, and chemotherapy, and to use less radiotherapy as a single modality. The median follow-up time of patients alive was 42 months. The 5-year overall survival rate (OS) for all patients was 47.8%. The site-specific 5-year OS for lip, oral cavity, nasopharynx, oropharynx, Hypopharynx, larynx, salivary gland, and nose/paranasal sinus Cancer was 75.7, 42.6, 43.5, 45.9, 27.2, 57.3, 61.0, and 34.9%, respectively. The multivariate analysis showed that male gender, age ≥60 years, therapy without surgery, higher T classification, N classification, and M classification were independent significant negative risk factors for OS (p
Steven E. Schild - One of the best experts on this subject based on the ideXlab platform.
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radiochemotherapy versus surgery plus radio chemo therapy for stage t3 t4 larynx and Hypopharynx Cancer results of a matched pair analysis
European Journal of Cancer, 2011Co-Authors: Dirk Rades, Ursula Schroeder, Amira Bajrovic, Steven E. SchildAbstract:Abstract The standard treatment for non-metastatic T3/T4 larynx and Hypopharynx Cancer varies. This study compared definitive radiochemotherapy to surgery followed by radio(chemo)therapy. Forty-four patients treated with radiochemotherapy were matched to 88 patients receiving surgery plus radio(chemo)therapy. Groups were matched 1:2 for eight factors including age, gender, performance status, tumour site, histologic grade, T-/N-category and AJCC stage. Groups were compared for loco-regional control, metastases-free survival, overall survival and toxicity. Two-year loco-regional control rates were 75% after surgery plus radio(chemotherapy) and 66% after radiochemotherapy ( p = 0.39). Metastases-free survival rates were 76% and 77%, respectively ( p = 0.76). Overall survival rates were 67% and 63%, respectively ( p = 0.95). During follow up, 60% and 9% of the patients, respectively, received a total laryngectomy ( p = 0.004). Grade ⩾3 oral mucositis and haematologic toxicity rates were higher with radiochemotherapy. Other toxicities were similar. Outcomes of radiochemotherapy appeared similar to those of surgery plus radio(chemo)therapy. The larynx preservation rate was higher after radiochemotherapy.
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Radiochemotherapy versus surgery plus radio(chemo)therapy for stage T3/T4 larynx and Hypopharynx Cancer - results of a matched-pair analysis.
European journal of cancer (Oxford England : 1990), 2011Co-Authors: Dirk Rades, Ursula Schroeder, Amira Bajrovic, Steven E. SchildAbstract:Abstract The standard treatment for non-metastatic T3/T4 larynx and Hypopharynx Cancer varies. This study compared definitive radiochemotherapy to surgery followed by radio(chemo)therapy. Forty-four patients treated with radiochemotherapy were matched to 88 patients receiving surgery plus radio(chemo)therapy. Groups were matched 1:2 for eight factors including age, gender, performance status, tumour site, histologic grade, T-/N-category and AJCC stage. Groups were compared for loco-regional control, metastases-free survival, overall survival and toxicity. Two-year loco-regional control rates were 75% after surgery plus radio(chemotherapy) and 66% after radiochemotherapy ( p = 0.39). Metastases-free survival rates were 76% and 77%, respectively ( p = 0.76). Overall survival rates were 67% and 63%, respectively ( p = 0.95). During follow up, 60% and 9% of the patients, respectively, received a total laryngectomy ( p = 0.004). Grade ⩾3 oral mucositis and haematologic toxicity rates were higher with radiochemotherapy. Other toxicities were similar. Outcomes of radiochemotherapy appeared similar to those of surgery plus radio(chemo)therapy. The larynx preservation rate was higher after radiochemotherapy.
Marshall R. Posner - One of the best experts on this subject based on the ideXlab platform.
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sequential therapy for the locally advanced larynx and Hypopharynx Cancer subgroup in tax 324 survival surgery and organ preservation
Annals of Oncology, 2009Co-Authors: Marshall R. Posner, C. M. Norris, Lori J. Wirth, Dong M Shin, Kevin J Cullen, Eric Winquist, Cesar R Blajman, E A Mickiewicz, Gary Frenette, L F PlinarAbstract:Abstract Background Locally advanced laryngeal and hypopharyngeal Cancers (LHC) represent a group of Cancers for which surgery, laryngectomy-free survival (LFS), overall survival (OS), and progression-free survival (PFS) are clinically meaningful end points. Patients and methods These outcomes were analyzed in the subgroup of assessable LHC patients enrolled in TAX 324, a phase III trial of sequential therapy comparing docetaxel plus cisplatin and fluorouracil (TPF) against cisplatin and fluorouracil (PF), followed by chemoradiotherapy. Results Among 501 patients enrolled in TAX 324, 166 had LHC (TPF, n = 90; PF, n = 76). Patient characteristics were similar between subgroups. Median OS for TPF was 59 months [95% confidence interval (CI): 31–not reached] versus 24 months (95% CI: 13–42) for PF [hazard ratio (HR) for death: 0.62; 95% CI: 0.41–0.94; P = 0.024]. Median PFS for TPF was 21 months (95% CI: 12–59) versus 11 months (95% CI: 8–14) for PF (HR: 0.66; 95% CI: 0.45–0.97; P = 0.032). Among operable patients (TPF, n = 67; PF, n = 56), LFS was significantly greater with TPF (HR: 0.59; 95% CI: 0.37–0.95; P = 0.030). Three-year LFS with TPF was 52% versus 32% for PF. Fewer TPF patients had surgery (22% versus 42%; P = 0.030). Conclusions In locally advanced LHC, sequential therapy with induction TPF significantly improved survival and PFS versus PF. Among operable patients, TPF also significantly improved LFS and PFS. These results support the use of sequential TPF followed by carboplatin chemoradiotherapy as a treatment option for organ preservation or to improve survival in locally advanced LHC.
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Sequential therapy for locally advanced larynx and Hypopharynx Cancer: Subgroup analysis from the TAX 324 Study
Journal of Clinical Oncology, 2008Co-Authors: Marshall R. Posner, C. M. Norris, Roy B. Tishler, Lori J. Wirth, Robert I. HaddadAbstract:6031 Background: The Phase III Tax 324 trial compared sequential therapy (ST) with induction docetaxel, cisplatin and 5-fluorouracil (TPF) to cisplatin and 5-fluorouracil (PF) with both followed by chemoradiotherapy (CRT) with weekly carboplatin. Locally advanced larynx (LX) and Hypopharynx (HPX) Cancers represent an important subgroup in which laryngectomy free survival (LFS), as well as overall survival (OS), and progression free survival (PFS), are cardinal endpoints. Methods: All patients (pts) with LX or HPX Cancer enrolled in TAX 324 were identified. Data were extracted from Case Report Forms and analyzed as described. LFS was defined as pts with operable disease and alive with no primary site surgery. Details of treatment and overall safety have been previously reported (Posner et al, NEJM, 2007). Results: Of 501 evaluable pts, 89 and 77 had LX or HPX Cancer, respectively. Of these 166, 90 were randomized to TPF and 76 to PF. There were no significant differences between the two arms with regard to...
Franco Berrino - One of the best experts on this subject based on the ideXlab platform.
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Occupation and larynx and Hypopharynx Cancer: an international case–control study in France, Italy, Spain, and Switzerland
Cancer Causes & Control, 2003Co-Authors: Paolo Boffetta, Lorenzo Richiardi, Franco Berrino, Jacques Estéve, Paola Pisani, Paolo Crosignani, Luc Raymond, Lourdes Zubiri, Angel Del Moral, Willy LehmannAbstract:Objective : To estimate risks for laryngeal/hypopharyngeal Cancer associated with occupational titles and industrial activities. Methods : A multicentre population-based case-control study was conducted in the early 1980s in six southern European areas. Analyses included 1010 male cases and 2176 controls. Odds ratios (ORs) (adjusted for age, study area, tobacco consumption, and alcohol consumption) were estimated for 156 occupations and 70 industrial activities. Results : An excess risk has been confirmed for categories of construction workers, potters (OR: 5.91, 95% confidence intervals 1.46-24.0), butchers (2.53, 1.22–5.22), barbers (2.33, 1.00–5.40), laborers not otherwise specified (1.52, 1.12–2.06), as well as for men who had been employed in railway transport (1.52, 0.97–2.39), shipbuilding (2.05, 0.89–4.94), and hotels (2.06, 0.89–4.75). An association was also found for shoe finishers (3.23, 0.75–13.9), loggers (2.07, 0.87–4.90), and some groups of metal workers. ORs for loggers, butchers, railway transport workers, laborers, and reinforced concreters increased with duration of employment. The suggestion of a risk for machine operators among woodworkers (3.10, 0.92–10.5) conflicts with previous findings. No significant excess of risk was found for categories previously reported to be associated with laryngeal and hypopharyngeal Cancer, such as drivers, mechanics, welders, machinists, and painters. Conclusions : The present study provides additional evidence to the hypothesis of a risk of Cancer of the larynx/Hypopharynx for workers engaged in jobs in the construction, metal, textile, ceramic, and food industries and in railway transport. Loggers were also found at risk; a previously unreported finding.
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occupation and larynx and Hypopharynx Cancer an international case control study in france italy spain and switzerland
Cancer Causes & Control, 2003Co-Authors: Paolo Boffetta, Lorenzo Richiardi, Franco Berrino, Jacques Estéve, Paola Pisani, Paolo Crosignani, Luc Raymond, Lourdes ZubiriAbstract:Objective: To estimate risks for laryngeal/hypopharyngeal Cancer associated with occupational titles and industrial activities. Methods: A multicentre population-based case-control study was conducted in the early 1980s in six southern European areas. Analyses included 1010 male cases and 2176 controls. Odds ratios (ORs) (adjusted for age, study area, tobacco consumption, and alcohol consumption) were estimated for 156 occupations and 70 industrial activities. Results: An excess risk has been confirmed for categories of construction workers, potters (OR: 5.91, 95% confidence intervals 1.46-24.0), butchers (2.53, 1.22-5.22), barbers (2.33, 1.00-5.40), laborers not otherwise specified (1.52, 1.12-2.06), as well as for men who had been employed in railway transport (1.52, 0.97-2.39), shipbuilding (2.05, 0.89-4.94), and hotels (2.06, 0.89-4.75). An association was also found for shoe finishers (3.23, 0.75-13.9), loggers (2.07, 0.87-4.90), and some groups of metal workers. ORs for loggers, butchers, railway transport workers, laborers, and reinforced concreters increased with duration of employment. The suggestion of a risk for machine operators among woodworkers (3.10, 0.92-10.5) conflicts with previous findings. No significant excess of risk was found for categories previously reported to be associated with laryngeal and hypopharyngeal Cancer, such as drivers, mechanics, welders, machinists, and painters. Conclusions: The present study provides additional evidence to the hypothesis of a risk of Cancer of the larynx/ Hypopharynx for workers engaged in jobs in the construction, metal, textile, ceramic, and food industries and in railway transport. Loggers were also found at risk; a previously unreported finding.
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occupation and larynx and Hypopharynx Cancer a job exposure matrix approach in an international case control study in france italy spain and switzerland
Cancer Causes & Control, 2003Co-Authors: Franco Berrino, Paolo Boffetta, Lorenzo Richiardi, Paola Pisani, Lourdes Zubiri, J Esteve, L Raymond, Isabella Belletti, Loredana Troschel, Nieves AscunceAbstract:Objective: To investigate the effect of exposure to occupational agents on the risk of hypopharyngeal/laryngeal Cancer. Methods: Case-control study conducted during 1979–1982 in six centres in South Europe. An occupational history and information on exposure to non-occupational factors were collected for 1010 male cases of hypopharyngeal/laryngeal Cancer as well as for 2176 population controls. The exposure to 10 occupational agents was assessed through a job-exposure matrix. As occupational histories had been collected since 1945 major analyses were restricted to subjects aged less than 55 years (315 cases and 819 controls). Results: Significant elevated risks adjusted for non-occupational variables (smoking, alcohol consumption and diet) and other occupational exposures were consistently found for organic solvents (odds ratio (OR) for ever-exposure: 1.7, 95% confidence interval: 1.1–2.5) and asbestos (OR: 1.6, 1.0–2.5). A significant positive trend for both probability of exposure and duration was found for exposure to solvents. A positive association between exposure to formaldehyde and laryngeal Cancer was also suggested. No association was found for exposure to arsenic and compounds, chromium and compounds, and polycyclic aromatic hydrocarbons. Analyses restricted to subjects aged 55 or more did not show elevated risks, with the exception of wood dust (OR: 1.8, 1.3-2.7). Conclusions: In our study occupational exposure to solvents was associated with an increased risk of hypopharyngeal/laryngeal Cancer. Results also provide additional evidence of an excess of risk for exposure to asbestos.
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Occupation and larynx and Hypopharynx Cancer: a job-exposure matrix approach in an international case–control study in France, Italy, Spain and Switzerland
Cancer Causes & Control, 2003Co-Authors: Franco Berrino, Paolo Boffetta, Lorenzo Richiardi, Jacques Estéve, Paola Pisani, Luc Raymond, Lourdes Zubiri, Isabella Belletti, Loredana Troschel, Nieves AscunceAbstract:Objective : To investigate the effect of exposure to occupational agents on the risk of hypopharyngeal/laryngeal Cancer. Methods : Case-control study conducted during 1979–1982 in six centres in South Europe. An occupational history and information on exposure to non-occupational factors were collected for 1010 male cases of hypopharyngeal/laryngeal Cancer as well as for 2176 population controls. The exposure to 10 occupational agents was assessed through a job-exposure matrix. As occupational histories had been collected since 1945 major analyses were restricted to subjects aged less than 55 years (315 cases and 819 controls). Results : Significant elevated risks adjusted for non-occupational variables (smoking, alcohol consumption and diet) and other occupational exposures were consistently found for organic solvents (odds ratio (OR) for ever-exposure: 1.7, 95% confidence interval: 1.1–2.5) and asbestos (OR: 1.6, 1.0–2.5). A significant positive trend for both probability of exposure and duration was found for exposure to solvents. A positive association between exposure to formaldehyde and laryngeal Cancer was also suggested. No association was found for exposure to arsenic and compounds, chromium and compounds, and polycyclic aromatic hydrocarbons. Analyses restricted to subjects aged 55 or more did not show elevated risks, with the exception of wood dust (OR: 1.8, 1.3-2.7). Conclusions : In our study occupational exposure to solvents was associated with an increased risk of hypopharyngeal/laryngeal Cancer. Results also provide additional evidence of an excess of risk for exposure to asbestos.
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Occupation and larynx and Hypopharynx Cancer: a job-exposure matrix approach in an international case-control study in France, Italy, Spain
2003Co-Authors: Franco Berrino, Paolo Boffetta, Lorenzo Richiardi, Paola Pisani, Luc Raymond, Lourdes Zubiri, Isabella Belletti, Loredana Troschel, Nieves Ascunce, Etienne GuberanlAbstract:Objective: To investigate the effect of exposure to occupational agents on the risk of hypopharyngeal/laryngeal Cancer.