The Experts below are selected from a list of 237 Experts worldwide ranked by ideXlab platform
Michael D Lockshin - One of the best experts on this subject based on the ideXlab platform.
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lupus anticoagulant Hypoprothrombinemia syndrome associated with systemic lupus erythematosus report of 2 cases and review of literature
Lupus, 1999Co-Authors: Doruk Erkan, H Bateman, Michael D LockshinAbstract:We describe two patients whose initial presentation of systemic lupus erythematosus (SLE) was accompanied by haemorrhagic episodes and significant coagulopathy. Further investigation demonstrated positive lupus anticoagulant and decreased Factor II (prothrombin) activity. Both patients were diagnosed with lupus anticoagulant–Hypoprothrombinemia syndrome (LAC–HPS) as a result of non-neutralizing antibodies directed against Factor II. LAC–HPS is a rare clinical entity that can occur in association with SLE, transient viral infections, drug reactions or even in healthy individuals. Mixing studies, which can be affected by other coagulation factor inhibitors, play an important role in the diagnosis of LAC–HPS. Factor VII level was decreased in the second patient, a finding that has not previously been reported in association with SLE. In both patients, bleeding stopped promptly and coagulation studies improved significantly with high dose corticosteroids. We discuss the pathogenesis, diagnosis and management ...
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lupus anticoagulant Hypoprothrombinemia syndrome associated with systemic lupus erythematosus report of 2 cases and review of literature
Lupus, 1999Co-Authors: Doruk Erkan, H Bateman, Michael D LockshinAbstract:We describe two patients whose initial presentation of systemic lupus erythematosus (SLE) was accompanied by haemorrhagic episodes and significant coagulopathy. Further investigation demonstrated positive lupus anticoagulant and decreased Factor II (prothrombin) activity. Both patients were diagnosed with lupus anticoagulant-Hypoprothrombinemia syndrome (LAC-HPS) as a result of non-neutralizing antibodies directed against Factor II. LAC-HPS is a rare clinical entity that can occur in association with SLE, transient viral infections, drug reactions or even in healthy individuals. Mixing studies, which can be affected by other coagulation factor inhibitors, play an important role in the diagnosis of LAC-HPS. Factor VII level was decreased in the second patient, a finding that has not previously been reported in association with SLE. In both patients, bleeding stopped promptly and coagulation studies improved significantly with high dose corticosteroids. We discuss the pathogenesis, diagnosis and management of LAC-HPS in patients with SLE.
Doruk Erkan - One of the best experts on this subject based on the ideXlab platform.
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lupus anticoagulant Hypoprothrombinemia syndrome associated with systemic lupus erythematosus report of 2 cases and review of literature
Lupus, 1999Co-Authors: Doruk Erkan, H Bateman, Michael D LockshinAbstract:We describe two patients whose initial presentation of systemic lupus erythematosus (SLE) was accompanied by haemorrhagic episodes and significant coagulopathy. Further investigation demonstrated positive lupus anticoagulant and decreased Factor II (prothrombin) activity. Both patients were diagnosed with lupus anticoagulant–Hypoprothrombinemia syndrome (LAC–HPS) as a result of non-neutralizing antibodies directed against Factor II. LAC–HPS is a rare clinical entity that can occur in association with SLE, transient viral infections, drug reactions or even in healthy individuals. Mixing studies, which can be affected by other coagulation factor inhibitors, play an important role in the diagnosis of LAC–HPS. Factor VII level was decreased in the second patient, a finding that has not previously been reported in association with SLE. In both patients, bleeding stopped promptly and coagulation studies improved significantly with high dose corticosteroids. We discuss the pathogenesis, diagnosis and management ...
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lupus anticoagulant Hypoprothrombinemia syndrome associated with systemic lupus erythematosus report of 2 cases and review of literature
Lupus, 1999Co-Authors: Doruk Erkan, H Bateman, Michael D LockshinAbstract:We describe two patients whose initial presentation of systemic lupus erythematosus (SLE) was accompanied by haemorrhagic episodes and significant coagulopathy. Further investigation demonstrated positive lupus anticoagulant and decreased Factor II (prothrombin) activity. Both patients were diagnosed with lupus anticoagulant-Hypoprothrombinemia syndrome (LAC-HPS) as a result of non-neutralizing antibodies directed against Factor II. LAC-HPS is a rare clinical entity that can occur in association with SLE, transient viral infections, drug reactions or even in healthy individuals. Mixing studies, which can be affected by other coagulation factor inhibitors, play an important role in the diagnosis of LAC-HPS. Factor VII level was decreased in the second patient, a finding that has not previously been reported in association with SLE. In both patients, bleeding stopped promptly and coagulation studies improved significantly with high dose corticosteroids. We discuss the pathogenesis, diagnosis and management of LAC-HPS in patients with SLE.
Sathish Kumar T - One of the best experts on this subject based on the ideXlab platform.
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pediatric systemic lupus erythematosus with lupus anticoagulant Hypoprothrombinemia syndrome a case series with review of literature
Lupus, 2021Co-Authors: Anu Punnen Kocheril, George Ipe Vettiyil, Anish Sam George, Sonam Shah, Tulasi Geevar, Rutvi Gautam Dave, Sathish Kumar TAbstract:IntroductionLupus anticoagulant Hypoprothrombinemia syndrome (LAHPS) is a rare phenomenon that leads to concomitant thrombosis and hemorrhage in children with SLE. LAHPS in pediatric SLE (pSLE) has...
C L Aguiar - One of the best experts on this subject based on the ideXlab platform.
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rituximab use in pediatric lupus anticoagulant Hypoprothrombinemia syndrome report of three cases and review of the literature
Lupus, 2018Co-Authors: Cetin K Gedik, S Siddique, C L AguiarAbstract:Lupus anticoagulant Hypoprothrombinemia syndrome (LA-HPS) is a rare condition that may predispose both to thrombosis and bleeding due to positive lupus anticoagulant (LA) and factor II (FII) defici...
Guido Finazzi - One of the best experts on this subject based on the ideXlab platform.
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severe bleeding due to acquired Hypoprothrombinemia lupus anticoagulant syndrome case report and review of literature
Haematologica, 1997Co-Authors: Paolo Vivaldi, G Rossetti, Monica Galli, Guido FinazziAbstract:A 17-year-old girl was admitted to our department with a hemorrhagic syndrome due to a serious coagulopathy; prothrombin time (PT) INR was 2.46 and the activated partial thromboplastin time (aPTT) ratio 3.46. Coagulation tests with pooled normal fresh plasma did not correct aPTT because of a coagulation inhibitor, and only partially corrected PT. Factor II activity reached only 5%. Diluted Russell viper venom tests (dRVVT) and kaolin clotting time (KCT) of patient plasma (PP) and of a mixture of PP/normal plasma (NP) detected the lupus anticoagulant (LA). The level of factor II antigen was 10%. We diagnosed systemic lupus erythematosus (SLE) with a rare acquired Hypoprothrombinemia-LA syndrome (HLAS). The patient was treated with corticosteroids and high-dose Ig and a normal PT value was re-established.