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Po Sing Leung - One of the best experts on this subject based on the ideXlab platform.
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moDulation of Hypovitaminosis D inDuceD islet Dysfunction anD insulin resistance through Direct suppression of the pancreatic islet renin angiotensin system in mice
Diabetologia, 2013Co-Authors: Q Cheng, B J Boucher, Po Sing LeungAbstract:Vitamin D is necessary for normal insulin action anD suppresses renin proDuction. IncreaseD renin–angiotensin system (RAS) activity causes islet Damage, incluDing reDuceD insulin secretion. We therefore sought to Determine whether Hypovitaminosis D-inDuceD upregulation of islet RAS in vivo impairs islet cell function anD increases insulin resistance, anD whether pharmacological suppression of the RAS During continuing vitamin D Deficiency might correct this. C57BL/6 mice were renDereD vitamin D-Deficient by Diet, anD glucose anD insulin tolerance was assesseD. The expression anD translation of islet functional, anD islet RAS, genes were measureD anD the effects of pharmacological renin suppression examineD. Mice with Diet-inDuceD Hypovitaminosis D DevelopeD impaireD glucose tolerance, increaseD RAS component expression anD impaireD islet function gene transcription. Treatment with pharmacological renin inhibition (aliskiren), without vitamin D status correction, reDuceD islet RAS over-reactivity, islet Dysfunction anD insulin resistance, anD improveD glucose tolerance. Upregulation of islet RAS genes can contribute to Hypovitaminosis D-inDuceD impairment of islet function anD increase insulin resistance inDepenDently of vitamin D status. Thus, our finDings support the use of RAS inhibitors in impaireD glucose homeostasis or early Diabetes. They also suggest that combining RAS inhibition with correction of Hypovitaminosis D might be useful in treating impaireD glycaemic control anD also in type 2 Diabetes prevention. However, the use of aliskiren in establisheD Diabetes is contrainDicateD Due to the increaseD risk of siDe effects such as hyperkalaemia, so other more suitable RAS blockers neeD to be iDentifieD.
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moDulation of Hypovitaminosis D inDuceD islet Dysfunction anD insulin resistance through Direct suppression of the pancreatic islet renin angiotensin system in mice
Diabetologia, 2013Co-Authors: Q Cheng, B J Boucher, Po Sing LeungAbstract:Aims/hypothesis Vitamin D is necessary for normal insulin action anD suppresses renin proDuction. IncreaseD renin–angiotensin system (RAS) activity causes islet Damage, incluDing reDuceD insulin secretion. We therefore sought to Determine whether Hypovitaminosis D-inDuceD upregulation of islet RAS in vivo impairs islet cell function anD increases insulin resistance, anD whether pharmacological suppression of the RAS During continuing vitamin D Deficiency might correct this.
Marjatta Leppilampi - One of the best experts on this subject based on the ideXlab platform.
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half of the patients with an acute hip fracture suffer from Hypovitaminosis D a prospective stuDy in southeastern finlanD
Osteoporosis International, 2005Co-Authors: Ilona Nurmi, Juhapekka Kaukonen, Peter Luthje, Helena Naboulsi, Salla Tanninen, Matti Kataja, Maijaleena Kallio, Marjatta LeppilampiAbstract:Vitamin D Deficiency may be one important contributing risk factor for an osteoporotic fracture among elDerly. We analyzeD serum 25-hyDroxyvitamin D [S-25(OH)D] status in patients with an acute hip fracture in southeastern FinlanD (61°N). Consecutive patients with a fresh hip fracture ( n =223) in two Finnish hospitals During 12 months anD 15 months were registereD prospectively. S-25(OH)D concentrations (nmol/l) were measureD by raDioimmunoassay-methoD. Hypovitaminosis D was DefineD as S-25(OH)D 74 nmol/l. The seasonal variation in S-25(OH)D concentrations was followeD. Hypovitaminosis D was founD in 53% of the patients. In 9% Hypovitaminosis D was severe. Half (50%) of the patients living in their own homes, 55% of those in resiDential homes, anD 61% of institutionalizeD elDerly haD Hypovitaminosis D. Patients who useD both vitamin D anD calcium supplement haD S-25(OH)D levels between 37.5 nmol/l anD 74 nmol/l anD >74 nmol/l more often than non-users ( Wx =3.85, p =0.0001). Most (41/61) of the patients who sustaineD the fracture During the late summer months haD S-25(OH)D concentration ≥37.5 nmol/l, whereas, in winter months the situation was quite the opposite (24/67) ( Wx =3.42, p =0.0006). Twenty-two percent (50/223) haD S-25(OH)D concentration >50 nmol/l anD four patients >78 nmol/l. Half of the patients with a hip fracture suffereD from Hypovitaminosis D. The situation was worst in institutional anD resiDential care, although there are personnel for taking care of vitamin D supplementation. In the late summer, one-thirD anD in late winter two-thirDs of the patients suffereD from Hypovitaminosis D. The geographical location of FinlanD inDicates extensive efforts to increase the use of vitamin D supplements among elDerly.
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half of the patients with an acute hip fracture suffer from Hypovitaminosis D a prospective stuDy in southeastern finlanD
Osteoporosis International, 2005Co-Authors: Ilona Nurmi, Juhapekka Kaukonen, Peter Luthje, Helena Naboulsi, Salla Tanninen, Matti Kataja, Maijaleena Kallio, Marjatta LeppilampiAbstract:Vitamin D Deficiency may be one important contributing risk factor for an osteoporotic fracture among elDerly. We analyzeD serum 25-hyDroxyvitamin D [S-25(OH)D] status in patients with an acute hip fracture in southeastern FinlanD (61 Degrees N). Consecutive patients with a fresh hip fracture (n=223) in two Finnish hospitals During 12 months anD 15 months were registereD prospectively. S-25(OH)D concentrations (nmol/l) were measureD by raDioimmunoassay-methoD. Hypovitaminosis D was DefineD as S-25(OH)D 74 nmol/l. The seasonal variation in S-25(OH)D concentrations was followeD. Hypovitaminosis D was founD in 53% of the patients. In 9% Hypovitaminosis D was severe. Half (50%) of the patients living in their own homes, 55% of those in resiDential homes, anD 61% of institutionalizeD elDerly haD Hypovitaminosis D. Patients who useD both vitamin D anD calcium supplement haD S-25(OH)D levels between 37.5 nmol/l anD 74 nmol/l anD > 74 nmol/l more often than non-users (Wx=3.85, p=0.0001). Most (41/61) of the patients who sustaineD the fracture During the late summer months haD S-25(OH)D concentration > or = 37.5 nmol/l, whereas, in winter months the situation was quite the opposite (24/67) (Wx=3.42, p=0.0006). Twenty-two percent (50/223) haD S-25(OH)D concentration > 50 nmol/l anD four patients > 78 nmol/l. Half of the patients with a hip fracture suffereD from Hypovitaminosis D. The situation was worst in institutional anD resiDential care, although there are personnel for taking care of vitamin D supplementation. In the late summer, one-thirD anD in late winter two-thirDs of the patients suffereD from Hypovitaminosis D. The geographical location of FinlanD inDicates extensive efforts to increase the use of vitamin D supplements among elDerly.
B J Boucher - One of the best experts on this subject based on the ideXlab platform.
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moDulation of Hypovitaminosis D inDuceD islet Dysfunction anD insulin resistance through Direct suppression of the pancreatic islet renin angiotensin system in mice
Diabetologia, 2013Co-Authors: Q Cheng, B J Boucher, Po Sing LeungAbstract:Aims/hypothesis Vitamin D is necessary for normal insulin action anD suppresses renin proDuction. IncreaseD renin–angiotensin system (RAS) activity causes islet Damage, incluDing reDuceD insulin secretion. We therefore sought to Determine whether Hypovitaminosis D-inDuceD upregulation of islet RAS in vivo impairs islet cell function anD increases insulin resistance, anD whether pharmacological suppression of the RAS During continuing vitamin D Deficiency might correct this.
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moDulation of Hypovitaminosis D inDuceD islet Dysfunction anD insulin resistance through Direct suppression of the pancreatic islet renin angiotensin system in mice
Diabetologia, 2013Co-Authors: Q Cheng, B J Boucher, Po Sing LeungAbstract:Vitamin D is necessary for normal insulin action anD suppresses renin proDuction. IncreaseD renin–angiotensin system (RAS) activity causes islet Damage, incluDing reDuceD insulin secretion. We therefore sought to Determine whether Hypovitaminosis D-inDuceD upregulation of islet RAS in vivo impairs islet cell function anD increases insulin resistance, anD whether pharmacological suppression of the RAS During continuing vitamin D Deficiency might correct this. C57BL/6 mice were renDereD vitamin D-Deficient by Diet, anD glucose anD insulin tolerance was assesseD. The expression anD translation of islet functional, anD islet RAS, genes were measureD anD the effects of pharmacological renin suppression examineD. Mice with Diet-inDuceD Hypovitaminosis D DevelopeD impaireD glucose tolerance, increaseD RAS component expression anD impaireD islet function gene transcription. Treatment with pharmacological renin inhibition (aliskiren), without vitamin D status correction, reDuceD islet RAS over-reactivity, islet Dysfunction anD insulin resistance, anD improveD glucose tolerance. Upregulation of islet RAS genes can contribute to Hypovitaminosis D-inDuceD impairment of islet function anD increase insulin resistance inDepenDently of vitamin D status. Thus, our finDings support the use of RAS inhibitors in impaireD glucose homeostasis or early Diabetes. They also suggest that combining RAS inhibition with correction of Hypovitaminosis D might be useful in treating impaireD glycaemic control anD also in type 2 Diabetes prevention. However, the use of aliskiren in establisheD Diabetes is contrainDicateD Due to the increaseD risk of siDe effects such as hyperkalaemia, so other more suitable RAS blockers neeD to be iDentifieD.
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Hypovitaminosis D is associateD with reDuctions in serum apolipoprotein a i but not with fasting lipiDs in british banglaDeshis
The American Journal of Clinical Nutrition, 2005Co-Authors: Garry W John, Kate Noonan, N Mannan, B J BoucherAbstract:BACKGROUND: Although Hypovitaminosis D has been suggesteD to increase the risk of heart Disease, its relation to components of the fasting lipiD profile has not been clarifieD for specific ethnic groups. OBJECTIVE: The objective was to Determine the relation of circulating 25-hyDroxyvitamin D [25(OH)D] concentrations to fasting lipiD concentrations in South Asian subjects at risk of Hypovitaminosis D. DESIGN: The present stuDy was conDucteD in 170 British BanglaDeshi aDults, 69 men anD 101 women, from east LonDon who were free of known Diabetes or chronic DisorDers. Vitamin D repletion was assesseD by measuring fasting serum 25(OH)D concentrations. Fasting lipiD profiles were measureD as part of a stuDy of the risk factors for type 2 Diabetes anD ischemic heart Disease, which incluDeD Hypovitaminosis D. RESULTS: A univariate analysis showeD that total cholesterol, LDL cholesterol, anD both apolipoprotein (apo) A-I anD apo B concentrations correlateD Directly with serum 25(OH)D concentrations. However, a multiple regression analysis, which incluDeD all the DocumenteD risk factors for Diabetes anD ischemic heart Disease, showeD that the 25(OH)D concentration (vitamin D status) was an inDepenDent preDictor of increasing apo A-I concentrations (stanDarDizeD coefficient {szligbeta} = 0.3; P < 0.001) but not of fasting lipiD concentrations. CONCLUSIONS: In this stuDy of British South Asians, the Data showeD a positive relation of fasting apo A-I concentrations to serum 25(OH)D concentrations, inDepenDent of glycemia anD other Dietary, anthropometric, anD lifestyle risk factors for type 2 Diabetes anD ischemic heart Disease after multiple regression analyses. Subjects with Hypovitaminosis D are likely to have an increaseD risk of ischemic heart Disease inDepenDent of their increaseD risk of type 2 Diabetes.
Q Cheng - One of the best experts on this subject based on the ideXlab platform.
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moDulation of Hypovitaminosis D inDuceD islet Dysfunction anD insulin resistance through Direct suppression of the pancreatic islet renin angiotensin system in mice
Diabetologia, 2013Co-Authors: Q Cheng, B J Boucher, Po Sing LeungAbstract:Vitamin D is necessary for normal insulin action anD suppresses renin proDuction. IncreaseD renin–angiotensin system (RAS) activity causes islet Damage, incluDing reDuceD insulin secretion. We therefore sought to Determine whether Hypovitaminosis D-inDuceD upregulation of islet RAS in vivo impairs islet cell function anD increases insulin resistance, anD whether pharmacological suppression of the RAS During continuing vitamin D Deficiency might correct this. C57BL/6 mice were renDereD vitamin D-Deficient by Diet, anD glucose anD insulin tolerance was assesseD. The expression anD translation of islet functional, anD islet RAS, genes were measureD anD the effects of pharmacological renin suppression examineD. Mice with Diet-inDuceD Hypovitaminosis D DevelopeD impaireD glucose tolerance, increaseD RAS component expression anD impaireD islet function gene transcription. Treatment with pharmacological renin inhibition (aliskiren), without vitamin D status correction, reDuceD islet RAS over-reactivity, islet Dysfunction anD insulin resistance, anD improveD glucose tolerance. Upregulation of islet RAS genes can contribute to Hypovitaminosis D-inDuceD impairment of islet function anD increase insulin resistance inDepenDently of vitamin D status. Thus, our finDings support the use of RAS inhibitors in impaireD glucose homeostasis or early Diabetes. They also suggest that combining RAS inhibition with correction of Hypovitaminosis D might be useful in treating impaireD glycaemic control anD also in type 2 Diabetes prevention. However, the use of aliskiren in establisheD Diabetes is contrainDicateD Due to the increaseD risk of siDe effects such as hyperkalaemia, so other more suitable RAS blockers neeD to be iDentifieD.
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moDulation of Hypovitaminosis D inDuceD islet Dysfunction anD insulin resistance through Direct suppression of the pancreatic islet renin angiotensin system in mice
Diabetologia, 2013Co-Authors: Q Cheng, B J Boucher, Po Sing LeungAbstract:Aims/hypothesis Vitamin D is necessary for normal insulin action anD suppresses renin proDuction. IncreaseD renin–angiotensin system (RAS) activity causes islet Damage, incluDing reDuceD insulin secretion. We therefore sought to Determine whether Hypovitaminosis D-inDuceD upregulation of islet RAS in vivo impairs islet cell function anD increases insulin resistance, anD whether pharmacological suppression of the RAS During continuing vitamin D Deficiency might correct this.
Harjit Pal Bhattoa - One of the best experts on this subject based on the ideXlab platform.
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prevalence anD seasonal variation of Hypovitaminosis D anD its relationship to bone metabolism in healthy hungarian men over 50 years of age the hunmen stuDy
Osteoporosis International, 2013Co-Authors: Harjit Pal Bhattoa, A Balogh, Endre Nagy, Janos Kappelmayer, Edit Kalina, Csaba More, Peter AntalszalmasAbstract:Summary This stuDy reports a high prevalence of Hypovitaminosis D anD low bone mineral Density (BMD) in a healthy Hungarian male cohort over 50 years of age. Men with 25-hyDroxyvitamin D levels of <75 nmol/L haD a significantly higher 10-year hip anD major osteoporotic fracture probability using the country-specific fracture risk assessment (FRAX) algorithm.
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prevalence anD seasonal variation of Hypovitaminosis D anD its relationship to bone metabolism in healthy hungarian men over 50 years of age the hunmen stuDy
Osteoporosis International, 2013Co-Authors: Harjit Pal Bhattoa, A Balogh, Endre Nagy, Csaba E More, Janos Kappelmayer, Edit Kalina, Peter AntalszalmasAbstract:This stuDy reports a high prevalence of Hypovitaminosis D anD low bone mineral Density (BMD) in a healthy Hungarian male cohort over 50 years of age. Men with 25-hyDroxyvitamin D levels of <75 nmol/L haD a significantly higher 10-year hip anD major osteoporotic fracture probability using the country-specific fracture risk assessment (FRAX) algorithm. The aim of this stuDy is to characterize the prevalence anD seasonal variation of Hypovitaminosis D anD its relationship to bone metabolism in healthy Hungarian men over 50 years of age. We DetermineD levels of 25-hyDroxyvitamin D (25-OH-D), PTH, osteocalcin (OC), C-terminal telopeptiDes of type-I collagen (CTX-I), procollagen type 1 amino-terminal propeptiDe (PINP), BMD at L1–L4 (LS) anD femur neck (FN), Daily Dietary calcium intake, anD the 10-year probability of hip fracture anD a major osteoporotic fracture using the country-specific FRAX algorithm in 206 ranDomly selecteD ambulatory men. The mean (range) age of the volunteers was 60 (51–81) years. The prevalence of Hypovitaminosis D (25-OH-D, <75 nmol/L) was 52.9%. The prevalence of low (T-score < −1.0) BMD at the FN anD LS was 45% anD 35.4%, respectively. The mean (range) FRAX hip fracture anD FRAX major osteoporotic fracture was 0.8% (0–9.4%) anD 3.8% (1.7–16%), respectively. On comparing the vitamin D sufficient to the insufficient group, there was a statistically significant Difference between the FRAX hip fracture anD FRAX major osteoporotic fracture inDexes. There was significant seasonal variation in the vitamin D levels; the lowest levels were measureD in winter anD the highest in summer. A high prevalence of Hypovitaminosis D anD low BMD were observeD in the stuDieD Hungarian male population. This is the first stuDy reporting higher 10-year hip anD major osteoporotic fracture probability using the country-specific FRAX algorithm in inDiviDuals with Hypovitaminosis D.
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prevalence anD seasonal variation of Hypovitaminosis D anD its relationship to bone metabolism in community Dwelling postmenopausal hungarian women
Osteoporosis International, 2004Co-Authors: Harjit Pal Bhattoa, P Bettembuk, Sanjay Ganacharya, A BaloghAbstract:Hypovitaminosis D can result in low bone mass. The prevalence of Hypovitaminosis D has public health implications, especially where Data are lacking. Since Diet anD sunlight are the two souces of vitamin D, the results obtaineD in one geographical region may not be universally applicable. The aim of this stuDy is to characterize the prevalence anD seasonal variation of Hypovitaminosis D anD its relationship to bone metabolism in community Dwelling postmenopausal Hungarian women. We DetermineD serum levels of 25-hyDroxyvitamin D (25-OH-D), PTH, osteocalcin (OC), DegraDation proDucts of C-terminal telopeptiDes of type-I collagen (CTx), Dietary calcium intake anD BMD at L2–L4 lumbar spine (LS) anD femur neck (FN) in 319 ranDomly selecteD ambulatory postmenopausal women. The prevalence of Hypovitaminosis D (serum 25-OH-D≤50 nmol/l) was 56.7%. On comparing patients with normal anD low 25-OH-D, a significant Difference was founD in age (61.6±8.5 years versus 67.3±9.9 years; P<0.001), PTH (3.9±1.9 pmol/l versus 4.3±2.7 pmol/l; P<0.05), FN BMD (0.802±0.123 g/cm2 versus 0.744±0.125 g/cm2; P<0.001) anD Dietary calcium intake (714.4±199.4 g/Day versus 607.9±233 g/Day; P<0.001). Osteoporotic patients haD a significantly lower 25-OH-D (37.6±19.8 nmol/l versus 56.4±24 nmol/l; P<0.001) anD Dietary calcium intake (519.2±244.5 mg/Day versus 718.2±164.3 mg/Day; P<0.001). After controlling for all other variables, 25-OH-D was founD to be significantly associateD with age, the average hours of sunshine in the 3 months prior to 25-OH-D level Determination anD Dietary calcium intake (r2=0.190; P<0.001). For FN BMD, significant inDepenDent preDictors were age, boDy mass inDex, 25-OH-D anD Dietary calcium intake (r2=0.435; P<0.001). The prevalence of Hypovitaminosis D During spring, summer, autumn anD winter was 71%, 46.3%, 49.4% anD 56.7%, respectively. There was significant seasonal variation in 25-OH-D, PTH, OC, calcium intake anD FN BMD. There is a high prevalence of Hypovitaminosis D in healthy postmenopausal Hungarian women, anD FN BMD is associateD with serum 25-OH-D anD Dietary calcium intake.