The Experts below are selected from a list of 16479 Experts worldwide ranked by ideXlab platform
Gregg M Janowski - One of the best experts on this subject based on the ideXlab platform.
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recent advances in the development of gtr gbr Membranes for periodontal regeneration a materials perspective
Dental Materials, 2012Co-Authors: Marco C Bottino, Vinoy Thomas, Gudrun Schmidt, Yogesh K Vohra, Michael J Kowolik, Gregg M JanowskiAbstract:UNLABELLED: Periodontitis is a major chronic inflammatory disorder that can lead to the destruction of the periodontal tissues and, ultimately, tooth loss. To date, flap debridement and/or flap curettage and periodontal regenerative therapy with Membranes and bone grafting materials have been employed with distinct levels of clinical success. Current resorbable and non-resorbable Membranes act as a physical barrier to avoid connective and epithelial tissue down-growth into the defect, favoring the regeneration of periodontal tissues. These conventional Membranes possess many structural, mechanical, and bio-functional limitations and the "Ideal" Membrane for use in periodontal regenerative therapy has yet to be developed. Based on a graded-biomaterials approach, we have hypothesized that the next-generation of guided tissue and guided bone regeneration (GTR/GBR) Membranes for periodontal tissue engineering will be a biologically active, spatially designed and functionally graded nanofibrous biomaterial that closely mimics the native extra-cellular matrix (ECM). OBJECTIVE: This review is presented in three major parts, including (1) a brief overview of the periodontium and its pathological conditions, (2) currently employed therapeutics used to regenerate the distinct periodontal tissues, and (3) a review of commercially available GTR/GBR Membranes as well as the recent advances on the processing and characterization of GTR/GBR Membranes from a materials perspective. SIGNIFICANCE: Studies of spatially designed and functionally graded Membranes (FGM) and in vitro antibacterial/cell-related research are addressed. Finally, as a future outlook, the use of hydrogels in combination with scaffold materials is highlighted as a promising approach for periodontal tissue engineering.
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recent advances in the development of gtr gbr Membranes for periodontal regeneration a materials perspective
Dental Materials, 2012Co-Authors: Marco C Bottino, Vinoy Thomas, Gudrun Schmidt, Yogesh K Vohra, Michael J Kowolik, Tienmin G Chu, Gregg M JanowskiAbstract:Abstract Periodontitis is a major chronic inflammatory disorder that can lead to the destruction of the periodontal tissues and, ultimately, tooth loss. To date, flap debridement and/or flap curettage and periodontal regenerative therapy with Membranes and bone grafting materials have been employed with distinct levels of clinical success. Current resorbable and non-resorbable Membranes act as a physical barrier to avoid connective and epithelial tissue down-growth into the defect, favoring the regeneration of periodontal tissues. These conventional Membranes possess many structural, mechanical, and bio-functional limitations and the “Ideal” Membrane for use in periodontal regenerative therapy has yet to be developed. Based on a graded-biomaterials approach, we have hypothesized that the next-generation of guided tissue and guided bone regeneration (GTR/GBR) Membranes for periodontal tissue engineering will be a biologically active, spatially designed and functionally graded nanofibrous biomaterial that closely mimics the native extra-cellular matrix (ECM). Objective This review is presented in three major parts, including (1) a brief overview of the periodontium and its pathological conditions, (2) currently employed therapeutics used to regenerate the distinct periodontal tissues, and (3) a review of commercially available GTR/GBR Membranes as well as the recent advances on the processing and characterization of GTR/GBR Membranes from a materials perspective. Significance Studies of spatially designed and functionally graded Membranes (FGM) and in vitro antibacterial/cell-related research are addressed. Finally, as a future outlook, the use of hydrogels in combination with scaffold materials is highlighted as a promising approach for periodontal tissue engineering.
Charles D Shackelford - One of the best experts on this subject based on the ideXlab platform.
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theory for reactive solute transport through clay Membrane barriers
Journal of Contaminant Hydrology, 2002Co-Authors: Michael A Malusis, Charles D ShackelfordAbstract:Abstract The theoretical development for one-dimensional, coupled migration of solutes with different ionic mobilities through clay soils that behave as ion-restrictive Membranes, referred to as clay Membrane barriers (CMBs), is presented. The transport formulation is based on principles of irreversible thermodynamics and accounts explicitly for coupling effects of hyperfiltration (ultrafiltration) and chemico-osmotic counter-advection associated with clay Membrane behavior in the absence of electrical current. Since, by definition, no solute can enter a “perfect” or “Ideal” Membrane, the concept of an implicit coupling effect, such that the effective salt-diffusion coefficient, Ds* approaches zero as the chemico-osmotic efficiency coefficient, ω approaches unity is introduced. The theoretical development also illustrates that, even in the absence of Membrane behavior, traditional advective–dispersive transport theory based on a constant value of Ds* for the solutes may not be appropriate for simulating transient transport in reactive (ion exchanging) systems. This potential limitation is illustrated through simulations for solute mass flux involving the migration of a binary salt solution (KCl) through a clay barrier with exchange sites saturated with a single exchangeable cation (e.g., Na+) that enters the pore solution upon ion exchange with the salt cation (K+).
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theory for reactive solute transport through clay Membrane barriers
Journal of Contaminant Hydrology, 2002Co-Authors: Michael A Malusis, Charles D ShackelfordAbstract:The theoretical development for one-dimensional, coupled migration of solutes with different ionic mobilities through clay soils that behave as ion-restrictive Membranes, referred to as clay Membrane barriers (CMBs), is presented. The transport formulation is based on principles of irreversible thermodynamics and accounts explicitly for coupling effects of hyperfiltration (ultrafiltration) and chemico-osmotic counter-advection associated with clay Membrane behavior in the absence of electrical current. Since, by definition, no solute can enter a "perfect" or "Ideal" Membrane, the concept of an implicit coupling effect, such that the effective salt-diffusion coefficient, Ds* approaches zero as the chemico-osmotic efficiency coefficient, omega approaches unity is introduced. The theoretical development also illustrates that, even in the absence of Membrane behavior, traditional advective-dispersive transport theory based on a constant value of Ds* for the solutes may not be appropriate for simulating transient transport in reactive (ion exchanging) systems. This potential limitation is illustrated through simulations for solute mass flux involving the migration of a binary salt solution (KCl) through a clay barrier with exchange sites saturated with a single exchangeable cation (e.g., Na+) that enters the pore solution upon ion exchange with the salt cation (K+).
Marco C Bottino - One of the best experts on this subject based on the ideXlab platform.
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recent advances in the development of gtr gbr Membranes for periodontal regeneration a materials perspective
Dental Materials, 2012Co-Authors: Marco C Bottino, Vinoy Thomas, Gudrun Schmidt, Yogesh K Vohra, Michael J Kowolik, Gregg M JanowskiAbstract:UNLABELLED: Periodontitis is a major chronic inflammatory disorder that can lead to the destruction of the periodontal tissues and, ultimately, tooth loss. To date, flap debridement and/or flap curettage and periodontal regenerative therapy with Membranes and bone grafting materials have been employed with distinct levels of clinical success. Current resorbable and non-resorbable Membranes act as a physical barrier to avoid connective and epithelial tissue down-growth into the defect, favoring the regeneration of periodontal tissues. These conventional Membranes possess many structural, mechanical, and bio-functional limitations and the "Ideal" Membrane for use in periodontal regenerative therapy has yet to be developed. Based on a graded-biomaterials approach, we have hypothesized that the next-generation of guided tissue and guided bone regeneration (GTR/GBR) Membranes for periodontal tissue engineering will be a biologically active, spatially designed and functionally graded nanofibrous biomaterial that closely mimics the native extra-cellular matrix (ECM). OBJECTIVE: This review is presented in three major parts, including (1) a brief overview of the periodontium and its pathological conditions, (2) currently employed therapeutics used to regenerate the distinct periodontal tissues, and (3) a review of commercially available GTR/GBR Membranes as well as the recent advances on the processing and characterization of GTR/GBR Membranes from a materials perspective. SIGNIFICANCE: Studies of spatially designed and functionally graded Membranes (FGM) and in vitro antibacterial/cell-related research are addressed. Finally, as a future outlook, the use of hydrogels in combination with scaffold materials is highlighted as a promising approach for periodontal tissue engineering.
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recent advances in the development of gtr gbr Membranes for periodontal regeneration a materials perspective
Dental Materials, 2012Co-Authors: Marco C Bottino, Vinoy Thomas, Gudrun Schmidt, Yogesh K Vohra, Michael J Kowolik, Tienmin G Chu, Gregg M JanowskiAbstract:Abstract Periodontitis is a major chronic inflammatory disorder that can lead to the destruction of the periodontal tissues and, ultimately, tooth loss. To date, flap debridement and/or flap curettage and periodontal regenerative therapy with Membranes and bone grafting materials have been employed with distinct levels of clinical success. Current resorbable and non-resorbable Membranes act as a physical barrier to avoid connective and epithelial tissue down-growth into the defect, favoring the regeneration of periodontal tissues. These conventional Membranes possess many structural, mechanical, and bio-functional limitations and the “Ideal” Membrane for use in periodontal regenerative therapy has yet to be developed. Based on a graded-biomaterials approach, we have hypothesized that the next-generation of guided tissue and guided bone regeneration (GTR/GBR) Membranes for periodontal tissue engineering will be a biologically active, spatially designed and functionally graded nanofibrous biomaterial that closely mimics the native extra-cellular matrix (ECM). Objective This review is presented in three major parts, including (1) a brief overview of the periodontium and its pathological conditions, (2) currently employed therapeutics used to regenerate the distinct periodontal tissues, and (3) a review of commercially available GTR/GBR Membranes as well as the recent advances on the processing and characterization of GTR/GBR Membranes from a materials perspective. Significance Studies of spatially designed and functionally graded Membranes (FGM) and in vitro antibacterial/cell-related research are addressed. Finally, as a future outlook, the use of hydrogels in combination with scaffold materials is highlighted as a promising approach for periodontal tissue engineering.
Michael A Malusis - One of the best experts on this subject based on the ideXlab platform.
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theory for reactive solute transport through clay Membrane barriers
Journal of Contaminant Hydrology, 2002Co-Authors: Michael A Malusis, Charles D ShackelfordAbstract:Abstract The theoretical development for one-dimensional, coupled migration of solutes with different ionic mobilities through clay soils that behave as ion-restrictive Membranes, referred to as clay Membrane barriers (CMBs), is presented. The transport formulation is based on principles of irreversible thermodynamics and accounts explicitly for coupling effects of hyperfiltration (ultrafiltration) and chemico-osmotic counter-advection associated with clay Membrane behavior in the absence of electrical current. Since, by definition, no solute can enter a “perfect” or “Ideal” Membrane, the concept of an implicit coupling effect, such that the effective salt-diffusion coefficient, Ds* approaches zero as the chemico-osmotic efficiency coefficient, ω approaches unity is introduced. The theoretical development also illustrates that, even in the absence of Membrane behavior, traditional advective–dispersive transport theory based on a constant value of Ds* for the solutes may not be appropriate for simulating transient transport in reactive (ion exchanging) systems. This potential limitation is illustrated through simulations for solute mass flux involving the migration of a binary salt solution (KCl) through a clay barrier with exchange sites saturated with a single exchangeable cation (e.g., Na+) that enters the pore solution upon ion exchange with the salt cation (K+).
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theory for reactive solute transport through clay Membrane barriers
Journal of Contaminant Hydrology, 2002Co-Authors: Michael A Malusis, Charles D ShackelfordAbstract:The theoretical development for one-dimensional, coupled migration of solutes with different ionic mobilities through clay soils that behave as ion-restrictive Membranes, referred to as clay Membrane barriers (CMBs), is presented. The transport formulation is based on principles of irreversible thermodynamics and accounts explicitly for coupling effects of hyperfiltration (ultrafiltration) and chemico-osmotic counter-advection associated with clay Membrane behavior in the absence of electrical current. Since, by definition, no solute can enter a "perfect" or "Ideal" Membrane, the concept of an implicit coupling effect, such that the effective salt-diffusion coefficient, Ds* approaches zero as the chemico-osmotic efficiency coefficient, omega approaches unity is introduced. The theoretical development also illustrates that, even in the absence of Membrane behavior, traditional advective-dispersive transport theory based on a constant value of Ds* for the solutes may not be appropriate for simulating transient transport in reactive (ion exchanging) systems. This potential limitation is illustrated through simulations for solute mass flux involving the migration of a binary salt solution (KCl) through a clay barrier with exchange sites saturated with a single exchangeable cation (e.g., Na+) that enters the pore solution upon ion exchange with the salt cation (K+).
Michael J Kowolik - One of the best experts on this subject based on the ideXlab platform.
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recent advances in the development of gtr gbr Membranes for periodontal regeneration a materials perspective
Dental Materials, 2012Co-Authors: Marco C Bottino, Vinoy Thomas, Gudrun Schmidt, Yogesh K Vohra, Michael J Kowolik, Gregg M JanowskiAbstract:UNLABELLED: Periodontitis is a major chronic inflammatory disorder that can lead to the destruction of the periodontal tissues and, ultimately, tooth loss. To date, flap debridement and/or flap curettage and periodontal regenerative therapy with Membranes and bone grafting materials have been employed with distinct levels of clinical success. Current resorbable and non-resorbable Membranes act as a physical barrier to avoid connective and epithelial tissue down-growth into the defect, favoring the regeneration of periodontal tissues. These conventional Membranes possess many structural, mechanical, and bio-functional limitations and the "Ideal" Membrane for use in periodontal regenerative therapy has yet to be developed. Based on a graded-biomaterials approach, we have hypothesized that the next-generation of guided tissue and guided bone regeneration (GTR/GBR) Membranes for periodontal tissue engineering will be a biologically active, spatially designed and functionally graded nanofibrous biomaterial that closely mimics the native extra-cellular matrix (ECM). OBJECTIVE: This review is presented in three major parts, including (1) a brief overview of the periodontium and its pathological conditions, (2) currently employed therapeutics used to regenerate the distinct periodontal tissues, and (3) a review of commercially available GTR/GBR Membranes as well as the recent advances on the processing and characterization of GTR/GBR Membranes from a materials perspective. SIGNIFICANCE: Studies of spatially designed and functionally graded Membranes (FGM) and in vitro antibacterial/cell-related research are addressed. Finally, as a future outlook, the use of hydrogels in combination with scaffold materials is highlighted as a promising approach for periodontal tissue engineering.
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recent advances in the development of gtr gbr Membranes for periodontal regeneration a materials perspective
Dental Materials, 2012Co-Authors: Marco C Bottino, Vinoy Thomas, Gudrun Schmidt, Yogesh K Vohra, Michael J Kowolik, Tienmin G Chu, Gregg M JanowskiAbstract:Abstract Periodontitis is a major chronic inflammatory disorder that can lead to the destruction of the periodontal tissues and, ultimately, tooth loss. To date, flap debridement and/or flap curettage and periodontal regenerative therapy with Membranes and bone grafting materials have been employed with distinct levels of clinical success. Current resorbable and non-resorbable Membranes act as a physical barrier to avoid connective and epithelial tissue down-growth into the defect, favoring the regeneration of periodontal tissues. These conventional Membranes possess many structural, mechanical, and bio-functional limitations and the “Ideal” Membrane for use in periodontal regenerative therapy has yet to be developed. Based on a graded-biomaterials approach, we have hypothesized that the next-generation of guided tissue and guided bone regeneration (GTR/GBR) Membranes for periodontal tissue engineering will be a biologically active, spatially designed and functionally graded nanofibrous biomaterial that closely mimics the native extra-cellular matrix (ECM). Objective This review is presented in three major parts, including (1) a brief overview of the periodontium and its pathological conditions, (2) currently employed therapeutics used to regenerate the distinct periodontal tissues, and (3) a review of commercially available GTR/GBR Membranes as well as the recent advances on the processing and characterization of GTR/GBR Membranes from a materials perspective. Significance Studies of spatially designed and functionally graded Membranes (FGM) and in vitro antibacterial/cell-related research are addressed. Finally, as a future outlook, the use of hydrogels in combination with scaffold materials is highlighted as a promising approach for periodontal tissue engineering.
