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J Lassus - One of the best experts on this subject based on the ideXlab platform.
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Topical Idoxuridine for treatment of genital warts in males. A double-blind comparative study of 0.25% and 0.5% cream.
Sexually Transmitted Infections, 1990Co-Authors: H.-p. Happonen, A. Lassus, J. Santalahti, S Forsström, J LassusAbstract:Fifty heterosexual male patients with histologically verified genital warts of short duration (less than 3 months) were randomly allocated to treatment with either 0.25% or 0.5% Idoxuridine cream. The application of the cream to the warts was performed twice daily for an initial period of 14 days, whereafter patients with partial improvement or no response were retreated in the same way for another period of 14 days. Patients not completely healed after 28 days were regarded as treatment failures and withdrawn from the study. After the initial treatment period of 14 days, 19 of 25 patients (76%) treated with 0.5% Idoxuridine cream, and 9 of 25 patients (36%) treated with 0.25% Idoxuridine cream were completely healed. This difference is significant (p less than 0.01). The corresponding figures at the second follow-up examination (28 days after start of the study) were 19 of 25 (76%) and 13 of 25 (52%), respectively. At the last follow-up examination three months after start of treatment, four patients treated with 0.5% Idoxuridine cream and five patients treated with 0.25% Idoxuridine cream had a relapse. Thus, the overall rate of complete healing was 15 of 25 (60%) for the patients treated with 0.5% Idoxuridine cream and 8 of 25 (32%) for those treated with 0.25% Idoxuridine cream. The difference is significant (p less than 0.01). No adverse reactions were observed or reported by the patients.
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topical Idoxuridine for treatment of genital warts in males a double blind comparative study of 0 25 and 0 5 cream
Sexually Transmitted Infections, 1990Co-Authors: H.-p. Happonen, A. Lassus, J. Santalahti, S Forsström, J LassusAbstract:Fifty heterosexual male patients with histologically verified genital warts of short duration (less than 3 months) were randomly allocated to treatment with either 0.25% or 0.5% Idoxuridine cream. The application of the cream to the warts was performed twice daily for an initial period of 14 days, whereafter patients with partial improvement or no response were retreated in the same way for another period of 14 days. Patients not completely healed after 28 days were regarded as treatment failures and withdrawn from the study. After the initial treatment period of 14 days, 19 of 25 patients (76%) treated with 0.5% Idoxuridine cream, and 9 of 25 patients (36%) treated with 0.25% Idoxuridine cream were completely healed. This difference is significant (p less than 0.01). The corresponding figures at the second follow-up examination (28 days after start of the study) were 19 of 25 (76%) and 13 of 25 (52%), respectively. At the last follow-up examination three months after start of treatment, four patients treated with 0.5% Idoxuridine cream and five patients treated with 0.25% Idoxuridine cream had a relapse. Thus, the overall rate of complete healing was 15 of 25 (60%) for the patients treated with 0.5% Idoxuridine cream and 8 of 25 (32%) for those treated with 0.25% Idoxuridine cream. The difference is significant (p less than 0.01). No adverse reactions were observed or reported by the patients.
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Combination of laser-therapy with 0.5% Idoxuridine cream in the treatment of therapy-resistant genital warts in male patients: an open study.
Sexually Transmitted Diseases, 1990Co-Authors: H.-p. Happonen, A. Lassus, J. Santalahti, S Forsström, J LassusAbstract:Forty heterosexual male patients with therapy resistant penile warts of long duration (mean 12.9 months) were treated with carbon dioxide laser, immediately followed by topical application of 0.5% Idoxuridine cream twice daily for 14 days. In case of incomplete or no response to the initial treatment, the treatment procedure was repeated once. All patients had previously been repeatedly treated with podophyllotoxin 0.5% solution and/or carbon dioxide laser surgery. After two weeks of treatment, 32 patients (80%) were completely healed. The remaining eight patients were retreated and four weeks after the start of the study 35 patients (87.5%) showed complete response. Three months after the study had been initiated 34 patients (85%) were still completely healed. No adverse reactions were observed. It was concluded that laser surgery followed by topical application of 0.5% Idoxuridine cream for two to four weeks seems to be highly effective in the treatment of longstanding, therapy-resistant genital warts in men. Because of the uncontrolled nature of the present study and the relatively small number of patients treated, it would be important to carry out controlled studies in larger study populations and to carry out a follow-up examination of at least six months after treatment.
H.-p. Happonen - One of the best experts on this subject based on the ideXlab platform.
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Topical Idoxuridine for treatment of genital warts in males. A double-blind comparative study of 0.25% and 0.5% cream.
Sexually Transmitted Infections, 1990Co-Authors: H.-p. Happonen, A. Lassus, J. Santalahti, S Forsström, J LassusAbstract:Fifty heterosexual male patients with histologically verified genital warts of short duration (less than 3 months) were randomly allocated to treatment with either 0.25% or 0.5% Idoxuridine cream. The application of the cream to the warts was performed twice daily for an initial period of 14 days, whereafter patients with partial improvement or no response were retreated in the same way for another period of 14 days. Patients not completely healed after 28 days were regarded as treatment failures and withdrawn from the study. After the initial treatment period of 14 days, 19 of 25 patients (76%) treated with 0.5% Idoxuridine cream, and 9 of 25 patients (36%) treated with 0.25% Idoxuridine cream were completely healed. This difference is significant (p less than 0.01). The corresponding figures at the second follow-up examination (28 days after start of the study) were 19 of 25 (76%) and 13 of 25 (52%), respectively. At the last follow-up examination three months after start of treatment, four patients treated with 0.5% Idoxuridine cream and five patients treated with 0.25% Idoxuridine cream had a relapse. Thus, the overall rate of complete healing was 15 of 25 (60%) for the patients treated with 0.5% Idoxuridine cream and 8 of 25 (32%) for those treated with 0.25% Idoxuridine cream. The difference is significant (p less than 0.01). No adverse reactions were observed or reported by the patients.
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topical Idoxuridine for treatment of genital warts in males a double blind comparative study of 0 25 and 0 5 cream
Sexually Transmitted Infections, 1990Co-Authors: H.-p. Happonen, A. Lassus, J. Santalahti, S Forsström, J LassusAbstract:Fifty heterosexual male patients with histologically verified genital warts of short duration (less than 3 months) were randomly allocated to treatment with either 0.25% or 0.5% Idoxuridine cream. The application of the cream to the warts was performed twice daily for an initial period of 14 days, whereafter patients with partial improvement or no response were retreated in the same way for another period of 14 days. Patients not completely healed after 28 days were regarded as treatment failures and withdrawn from the study. After the initial treatment period of 14 days, 19 of 25 patients (76%) treated with 0.5% Idoxuridine cream, and 9 of 25 patients (36%) treated with 0.25% Idoxuridine cream were completely healed. This difference is significant (p less than 0.01). The corresponding figures at the second follow-up examination (28 days after start of the study) were 19 of 25 (76%) and 13 of 25 (52%), respectively. At the last follow-up examination three months after start of treatment, four patients treated with 0.5% Idoxuridine cream and five patients treated with 0.25% Idoxuridine cream had a relapse. Thus, the overall rate of complete healing was 15 of 25 (60%) for the patients treated with 0.5% Idoxuridine cream and 8 of 25 (32%) for those treated with 0.25% Idoxuridine cream. The difference is significant (p less than 0.01). No adverse reactions were observed or reported by the patients.
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Combination of laser-therapy with 0.5% Idoxuridine cream in the treatment of therapy-resistant genital warts in male patients: an open study.
Sexually Transmitted Diseases, 1990Co-Authors: H.-p. Happonen, A. Lassus, J. Santalahti, S Forsström, J LassusAbstract:Forty heterosexual male patients with therapy resistant penile warts of long duration (mean 12.9 months) were treated with carbon dioxide laser, immediately followed by topical application of 0.5% Idoxuridine cream twice daily for 14 days. In case of incomplete or no response to the initial treatment, the treatment procedure was repeated once. All patients had previously been repeatedly treated with podophyllotoxin 0.5% solution and/or carbon dioxide laser surgery. After two weeks of treatment, 32 patients (80%) were completely healed. The remaining eight patients were retreated and four weeks after the start of the study 35 patients (87.5%) showed complete response. Three months after the study had been initiated 34 patients (85%) were still completely healed. No adverse reactions were observed. It was concluded that laser surgery followed by topical application of 0.5% Idoxuridine cream for two to four weeks seems to be highly effective in the treatment of longstanding, therapy-resistant genital warts in men. Because of the uncontrolled nature of the present study and the relatively small number of patients treated, it would be important to carry out controlled studies in larger study populations and to carry out a follow-up examination of at least six months after treatment.
A. Lassus - One of the best experts on this subject based on the ideXlab platform.
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Topical Idoxuridine for treatment of genital warts in males. A double-blind comparative study of 0.25% and 0.5% cream.
Sexually Transmitted Infections, 1990Co-Authors: H.-p. Happonen, A. Lassus, J. Santalahti, S Forsström, J LassusAbstract:Fifty heterosexual male patients with histologically verified genital warts of short duration (less than 3 months) were randomly allocated to treatment with either 0.25% or 0.5% Idoxuridine cream. The application of the cream to the warts was performed twice daily for an initial period of 14 days, whereafter patients with partial improvement or no response were retreated in the same way for another period of 14 days. Patients not completely healed after 28 days were regarded as treatment failures and withdrawn from the study. After the initial treatment period of 14 days, 19 of 25 patients (76%) treated with 0.5% Idoxuridine cream, and 9 of 25 patients (36%) treated with 0.25% Idoxuridine cream were completely healed. This difference is significant (p less than 0.01). The corresponding figures at the second follow-up examination (28 days after start of the study) were 19 of 25 (76%) and 13 of 25 (52%), respectively. At the last follow-up examination three months after start of treatment, four patients treated with 0.5% Idoxuridine cream and five patients treated with 0.25% Idoxuridine cream had a relapse. Thus, the overall rate of complete healing was 15 of 25 (60%) for the patients treated with 0.5% Idoxuridine cream and 8 of 25 (32%) for those treated with 0.25% Idoxuridine cream. The difference is significant (p less than 0.01). No adverse reactions were observed or reported by the patients.
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topical Idoxuridine for treatment of genital warts in males a double blind comparative study of 0 25 and 0 5 cream
Sexually Transmitted Infections, 1990Co-Authors: H.-p. Happonen, A. Lassus, J. Santalahti, S Forsström, J LassusAbstract:Fifty heterosexual male patients with histologically verified genital warts of short duration (less than 3 months) were randomly allocated to treatment with either 0.25% or 0.5% Idoxuridine cream. The application of the cream to the warts was performed twice daily for an initial period of 14 days, whereafter patients with partial improvement or no response were retreated in the same way for another period of 14 days. Patients not completely healed after 28 days were regarded as treatment failures and withdrawn from the study. After the initial treatment period of 14 days, 19 of 25 patients (76%) treated with 0.5% Idoxuridine cream, and 9 of 25 patients (36%) treated with 0.25% Idoxuridine cream were completely healed. This difference is significant (p less than 0.01). The corresponding figures at the second follow-up examination (28 days after start of the study) were 19 of 25 (76%) and 13 of 25 (52%), respectively. At the last follow-up examination three months after start of treatment, four patients treated with 0.5% Idoxuridine cream and five patients treated with 0.25% Idoxuridine cream had a relapse. Thus, the overall rate of complete healing was 15 of 25 (60%) for the patients treated with 0.5% Idoxuridine cream and 8 of 25 (32%) for those treated with 0.25% Idoxuridine cream. The difference is significant (p less than 0.01). No adverse reactions were observed or reported by the patients.
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Combination of laser-therapy with 0.5% Idoxuridine cream in the treatment of therapy-resistant genital warts in male patients: an open study.
Sexually Transmitted Diseases, 1990Co-Authors: H.-p. Happonen, A. Lassus, J. Santalahti, S Forsström, J LassusAbstract:Forty heterosexual male patients with therapy resistant penile warts of long duration (mean 12.9 months) were treated with carbon dioxide laser, immediately followed by topical application of 0.5% Idoxuridine cream twice daily for 14 days. In case of incomplete or no response to the initial treatment, the treatment procedure was repeated once. All patients had previously been repeatedly treated with podophyllotoxin 0.5% solution and/or carbon dioxide laser surgery. After two weeks of treatment, 32 patients (80%) were completely healed. The remaining eight patients were retreated and four weeks after the start of the study 35 patients (87.5%) showed complete response. Three months after the study had been initiated 34 patients (85%) were still completely healed. No adverse reactions were observed. It was concluded that laser surgery followed by topical application of 0.5% Idoxuridine cream for two to four weeks seems to be highly effective in the treatment of longstanding, therapy-resistant genital warts in men. Because of the uncontrolled nature of the present study and the relatively small number of patients treated, it would be important to carry out controlled studies in larger study populations and to carry out a follow-up examination of at least six months after treatment.
J. Santalahti - One of the best experts on this subject based on the ideXlab platform.
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Topical Idoxuridine for treatment of genital warts in males. A double-blind comparative study of 0.25% and 0.5% cream.
Sexually Transmitted Infections, 1990Co-Authors: H.-p. Happonen, A. Lassus, J. Santalahti, S Forsström, J LassusAbstract:Fifty heterosexual male patients with histologically verified genital warts of short duration (less than 3 months) were randomly allocated to treatment with either 0.25% or 0.5% Idoxuridine cream. The application of the cream to the warts was performed twice daily for an initial period of 14 days, whereafter patients with partial improvement or no response were retreated in the same way for another period of 14 days. Patients not completely healed after 28 days were regarded as treatment failures and withdrawn from the study. After the initial treatment period of 14 days, 19 of 25 patients (76%) treated with 0.5% Idoxuridine cream, and 9 of 25 patients (36%) treated with 0.25% Idoxuridine cream were completely healed. This difference is significant (p less than 0.01). The corresponding figures at the second follow-up examination (28 days after start of the study) were 19 of 25 (76%) and 13 of 25 (52%), respectively. At the last follow-up examination three months after start of treatment, four patients treated with 0.5% Idoxuridine cream and five patients treated with 0.25% Idoxuridine cream had a relapse. Thus, the overall rate of complete healing was 15 of 25 (60%) for the patients treated with 0.5% Idoxuridine cream and 8 of 25 (32%) for those treated with 0.25% Idoxuridine cream. The difference is significant (p less than 0.01). No adverse reactions were observed or reported by the patients.
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topical Idoxuridine for treatment of genital warts in males a double blind comparative study of 0 25 and 0 5 cream
Sexually Transmitted Infections, 1990Co-Authors: H.-p. Happonen, A. Lassus, J. Santalahti, S Forsström, J LassusAbstract:Fifty heterosexual male patients with histologically verified genital warts of short duration (less than 3 months) were randomly allocated to treatment with either 0.25% or 0.5% Idoxuridine cream. The application of the cream to the warts was performed twice daily for an initial period of 14 days, whereafter patients with partial improvement or no response were retreated in the same way for another period of 14 days. Patients not completely healed after 28 days were regarded as treatment failures and withdrawn from the study. After the initial treatment period of 14 days, 19 of 25 patients (76%) treated with 0.5% Idoxuridine cream, and 9 of 25 patients (36%) treated with 0.25% Idoxuridine cream were completely healed. This difference is significant (p less than 0.01). The corresponding figures at the second follow-up examination (28 days after start of the study) were 19 of 25 (76%) and 13 of 25 (52%), respectively. At the last follow-up examination three months after start of treatment, four patients treated with 0.5% Idoxuridine cream and five patients treated with 0.25% Idoxuridine cream had a relapse. Thus, the overall rate of complete healing was 15 of 25 (60%) for the patients treated with 0.5% Idoxuridine cream and 8 of 25 (32%) for those treated with 0.25% Idoxuridine cream. The difference is significant (p less than 0.01). No adverse reactions were observed or reported by the patients.
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Combination of laser-therapy with 0.5% Idoxuridine cream in the treatment of therapy-resistant genital warts in male patients: an open study.
Sexually Transmitted Diseases, 1990Co-Authors: H.-p. Happonen, A. Lassus, J. Santalahti, S Forsström, J LassusAbstract:Forty heterosexual male patients with therapy resistant penile warts of long duration (mean 12.9 months) were treated with carbon dioxide laser, immediately followed by topical application of 0.5% Idoxuridine cream twice daily for 14 days. In case of incomplete or no response to the initial treatment, the treatment procedure was repeated once. All patients had previously been repeatedly treated with podophyllotoxin 0.5% solution and/or carbon dioxide laser surgery. After two weeks of treatment, 32 patients (80%) were completely healed. The remaining eight patients were retreated and four weeks after the start of the study 35 patients (87.5%) showed complete response. Three months after the study had been initiated 34 patients (85%) were still completely healed. No adverse reactions were observed. It was concluded that laser surgery followed by topical application of 0.5% Idoxuridine cream for two to four weeks seems to be highly effective in the treatment of longstanding, therapy-resistant genital warts in men. Because of the uncontrolled nature of the present study and the relatively small number of patients treated, it would be important to carry out controlled studies in larger study populations and to carry out a follow-up examination of at least six months after treatment.
S Forsström - One of the best experts on this subject based on the ideXlab platform.
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Topical Idoxuridine for treatment of genital warts in males. A double-blind comparative study of 0.25% and 0.5% cream.
Sexually Transmitted Infections, 1990Co-Authors: H.-p. Happonen, A. Lassus, J. Santalahti, S Forsström, J LassusAbstract:Fifty heterosexual male patients with histologically verified genital warts of short duration (less than 3 months) were randomly allocated to treatment with either 0.25% or 0.5% Idoxuridine cream. The application of the cream to the warts was performed twice daily for an initial period of 14 days, whereafter patients with partial improvement or no response were retreated in the same way for another period of 14 days. Patients not completely healed after 28 days were regarded as treatment failures and withdrawn from the study. After the initial treatment period of 14 days, 19 of 25 patients (76%) treated with 0.5% Idoxuridine cream, and 9 of 25 patients (36%) treated with 0.25% Idoxuridine cream were completely healed. This difference is significant (p less than 0.01). The corresponding figures at the second follow-up examination (28 days after start of the study) were 19 of 25 (76%) and 13 of 25 (52%), respectively. At the last follow-up examination three months after start of treatment, four patients treated with 0.5% Idoxuridine cream and five patients treated with 0.25% Idoxuridine cream had a relapse. Thus, the overall rate of complete healing was 15 of 25 (60%) for the patients treated with 0.5% Idoxuridine cream and 8 of 25 (32%) for those treated with 0.25% Idoxuridine cream. The difference is significant (p less than 0.01). No adverse reactions were observed or reported by the patients.
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topical Idoxuridine for treatment of genital warts in males a double blind comparative study of 0 25 and 0 5 cream
Sexually Transmitted Infections, 1990Co-Authors: H.-p. Happonen, A. Lassus, J. Santalahti, S Forsström, J LassusAbstract:Fifty heterosexual male patients with histologically verified genital warts of short duration (less than 3 months) were randomly allocated to treatment with either 0.25% or 0.5% Idoxuridine cream. The application of the cream to the warts was performed twice daily for an initial period of 14 days, whereafter patients with partial improvement or no response were retreated in the same way for another period of 14 days. Patients not completely healed after 28 days were regarded as treatment failures and withdrawn from the study. After the initial treatment period of 14 days, 19 of 25 patients (76%) treated with 0.5% Idoxuridine cream, and 9 of 25 patients (36%) treated with 0.25% Idoxuridine cream were completely healed. This difference is significant (p less than 0.01). The corresponding figures at the second follow-up examination (28 days after start of the study) were 19 of 25 (76%) and 13 of 25 (52%), respectively. At the last follow-up examination three months after start of treatment, four patients treated with 0.5% Idoxuridine cream and five patients treated with 0.25% Idoxuridine cream had a relapse. Thus, the overall rate of complete healing was 15 of 25 (60%) for the patients treated with 0.5% Idoxuridine cream and 8 of 25 (32%) for those treated with 0.25% Idoxuridine cream. The difference is significant (p less than 0.01). No adverse reactions were observed or reported by the patients.
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Combination of laser-therapy with 0.5% Idoxuridine cream in the treatment of therapy-resistant genital warts in male patients: an open study.
Sexually Transmitted Diseases, 1990Co-Authors: H.-p. Happonen, A. Lassus, J. Santalahti, S Forsström, J LassusAbstract:Forty heterosexual male patients with therapy resistant penile warts of long duration (mean 12.9 months) were treated with carbon dioxide laser, immediately followed by topical application of 0.5% Idoxuridine cream twice daily for 14 days. In case of incomplete or no response to the initial treatment, the treatment procedure was repeated once. All patients had previously been repeatedly treated with podophyllotoxin 0.5% solution and/or carbon dioxide laser surgery. After two weeks of treatment, 32 patients (80%) were completely healed. The remaining eight patients were retreated and four weeks after the start of the study 35 patients (87.5%) showed complete response. Three months after the study had been initiated 34 patients (85%) were still completely healed. No adverse reactions were observed. It was concluded that laser surgery followed by topical application of 0.5% Idoxuridine cream for two to four weeks seems to be highly effective in the treatment of longstanding, therapy-resistant genital warts in men. Because of the uncontrolled nature of the present study and the relatively small number of patients treated, it would be important to carry out controlled studies in larger study populations and to carry out a follow-up examination of at least six months after treatment.
