The Experts below are selected from a list of 5706 Experts worldwide ranked by ideXlab platform
Rayyan Manwar - One of the best experts on this subject based on the ideXlab platform.
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study the effect of the skull in light Illumination and ultrasound detection Paths in transcranial photoacoustic imaging
Photons Plus Ultrasound: Imaging and Sensing 2021, 2021Co-Authors: Rayyan Manwar, Karl Kratkiewicz, Mohammad Reza Nasiri AvanakiAbstract:Skull tissue greatly degrades the photoacoustic signal in a transcranial photoacoustic imaging system. In this study, we investigate the feasibility of transcranial photoacoustic imaging, by studying the effect of skull in both Illumination Path and acoustic detection Path, and determine the maximum skull thickness through which accurate photoacoustic imaging is feasible without any post processing.
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investigation of the effect of the skull in transcranial photoacoustic imaging a preliminary ex vivo study
Sensors, 2020Co-Authors: Rayyan Manwar, Karl Kratkiewicz, Kamran AvanakiAbstract:Although transcranial photoacoustic imaging (TCPAI) has been used in small animal brain imaging, in animals with thicker skull bones or in humans both light Illumination and ultrasound propagation Paths are affected. Hence, the PA image is largely degraded and in some cases completely distorted. This study aims to investigate and determine the maximum thickness of the skull through which photoacoustic imaging is feasible in terms of retaining the imaging target structure without incorporating any post processing. We identify the effect of the skull on both the Illumination Path and acoustic propagation Path separately and combined. In the experimental phase, the distorting effect of ex vivo sheep skull bones with thicknesses in the range of 0.7~1.3 mm are explored. We believe that the findings in this study facilitate the clinical translation of TCPAI.
Balpreet Singh Ahluwalia - One of the best experts on this subject based on the ideXlab platform.
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Structured Illumination microscopy using a photonic chip
Nature Photonics, 2020Co-Authors: Øystein Ivar Helle, Firehun Tsige Dullo, Marcel Lahrberg, Jean-claude Tinguely, Olav Gaute Hellesø, Balpreet Singh AhluwaliaAbstract:Structured Illumination microscopy (SIM) enables live-cell super-resolution imaging of subcellular structures at high speeds. At present, linear SIM uses free-space optics to illuminate the sample with the desired light patterns; however, such arrangements are prone to misalignment and add cost and complexity to the microscope. Here, we present an alternative photonic chip-based two-dimensional SIM approach (cSIM) in which the conventional glass sample slide in a microscope is replaced by a planar photonic chip that importantly both holds and illuminates the specimen. The photonic chip reduces the footprint of the light Illumination Path of SIM to around 4 × 4 cm^2. An array of optical waveguides on the chip creates standing wave interference patterns at different angles, which illuminate the sample via evanescent fields. High-refractive-index silicon nitride waveguides allow a 2.3 times enhancement in imaging spatial resolution, exceeding the usual 2 times limit of SIM. In summary, cSIM offers a simple, stable and affordable approach for performing two-dimensional super-resolution imaging over a large field of view. The use of a photonic integrated circuit to both hold a biological sample and generate the necessary light patterns for structured Illumination microscopy promises convenient super-resolution imaging.
Kamran Avanaki - One of the best experts on this subject based on the ideXlab platform.
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investigation of the effect of the skull in transcranial photoacoustic imaging a preliminary ex vivo study
Sensors, 2020Co-Authors: Rayyan Manwar, Karl Kratkiewicz, Kamran AvanakiAbstract:Although transcranial photoacoustic imaging (TCPAI) has been used in small animal brain imaging, in animals with thicker skull bones or in humans both light Illumination and ultrasound propagation Paths are affected. Hence, the PA image is largely degraded and in some cases completely distorted. This study aims to investigate and determine the maximum thickness of the skull through which photoacoustic imaging is feasible in terms of retaining the imaging target structure without incorporating any post processing. We identify the effect of the skull on both the Illumination Path and acoustic propagation Path separately and combined. In the experimental phase, the distorting effect of ex vivo sheep skull bones with thicknesses in the range of 0.7~1.3 mm are explored. We believe that the findings in this study facilitate the clinical translation of TCPAI.
Karl Kratkiewicz - One of the best experts on this subject based on the ideXlab platform.
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study the effect of the skull in light Illumination and ultrasound detection Paths in transcranial photoacoustic imaging
Photons Plus Ultrasound: Imaging and Sensing 2021, 2021Co-Authors: Rayyan Manwar, Karl Kratkiewicz, Mohammad Reza Nasiri AvanakiAbstract:Skull tissue greatly degrades the photoacoustic signal in a transcranial photoacoustic imaging system. In this study, we investigate the feasibility of transcranial photoacoustic imaging, by studying the effect of skull in both Illumination Path and acoustic detection Path, and determine the maximum skull thickness through which accurate photoacoustic imaging is feasible without any post processing.
-
investigation of the effect of the skull in transcranial photoacoustic imaging a preliminary ex vivo study
Sensors, 2020Co-Authors: Rayyan Manwar, Karl Kratkiewicz, Kamran AvanakiAbstract:Although transcranial photoacoustic imaging (TCPAI) has been used in small animal brain imaging, in animals with thicker skull bones or in humans both light Illumination and ultrasound propagation Paths are affected. Hence, the PA image is largely degraded and in some cases completely distorted. This study aims to investigate and determine the maximum thickness of the skull through which photoacoustic imaging is feasible in terms of retaining the imaging target structure without incorporating any post processing. We identify the effect of the skull on both the Illumination Path and acoustic propagation Path separately and combined. In the experimental phase, the distorting effect of ex vivo sheep skull bones with thicknesses in the range of 0.7~1.3 mm are explored. We believe that the findings in this study facilitate the clinical translation of TCPAI.
Øystein Ivar Helle - One of the best experts on this subject based on the ideXlab platform.
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Structured Illumination microscopy using a photonic chip
Nature Photonics, 2020Co-Authors: Øystein Ivar Helle, Firehun Tsige Dullo, Marcel Lahrberg, Jean-claude Tinguely, Olav Gaute Hellesø, Balpreet Singh AhluwaliaAbstract:Structured Illumination microscopy (SIM) enables live-cell super-resolution imaging of subcellular structures at high speeds. At present, linear SIM uses free-space optics to illuminate the sample with the desired light patterns; however, such arrangements are prone to misalignment and add cost and complexity to the microscope. Here, we present an alternative photonic chip-based two-dimensional SIM approach (cSIM) in which the conventional glass sample slide in a microscope is replaced by a planar photonic chip that importantly both holds and illuminates the specimen. The photonic chip reduces the footprint of the light Illumination Path of SIM to around 4 × 4 cm^2. An array of optical waveguides on the chip creates standing wave interference patterns at different angles, which illuminate the sample via evanescent fields. High-refractive-index silicon nitride waveguides allow a 2.3 times enhancement in imaging spatial resolution, exceeding the usual 2 times limit of SIM. In summary, cSIM offers a simple, stable and affordable approach for performing two-dimensional super-resolution imaging over a large field of view. The use of a photonic integrated circuit to both hold a biological sample and generate the necessary light patterns for structured Illumination microscopy promises convenient super-resolution imaging.
