The Experts below are selected from a list of 174 Experts worldwide ranked by ideXlab platform
Hiroshi Mashimo - One of the best experts on this subject based on the ideXlab platform.
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circumferential optical coherence tomography angiography Imaging of the swine esophagus using a micromotor balloon Catheter
Biomedical Optics Express, 2016Co-Authors: Osman O Ahsen, Vijaysekhar Jayaraman, Alex Cable, Hiroshi Mashimo, Benjamin Potsaid, Kaicheng Liang, Zhao Wang, Cody Cleveland, Lucas Booth, Robert LangerAbstract:We demonstrate a micromotor balloon Imaging Catheter for ultrahigh speed endoscopic optical coherence tomography (OCT) which provides wide area, circumferential structural and angiographic Imaging of the esophagus without contrast agents. Using a 1310 nm MEMS tunable wavelength swept VCSEL light source, the system has a 1.2 MHz A-scan rate and ~8.5 µm axial resolution in tissue. The micromotor balloon Catheter enables circumferential Imaging of the esophagus at 240 frames per second (fps) with a ~30 µm (FWHM) spot size. Volumetric Imaging is achieved by proximal pullback of the micromotor assembly within the balloon at 1.5 mm/sec. Volumetric data consisting of 4200 circumferential images of 5,000 A-scans each over a 2.6 cm length, covering a ~13 cm2 area is acquired in <18 seconds. A non-rigid image registration algorithm is used to suppress motion artifacts from non-uniform rotational distortion (NURD), cardiac motion or respiration. En face OCT images at various depths can be generated. OCT angiography (OCTA) is computed using intensity decorrelation between sequential pairs of circumferential scans and enables three-dimensional visualization of vasculature. Wide area volumetric OCT and OCTA Imaging of the swine esophagus in vivo is demonstrated.
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ultrahigh speed endoscopic optical coherence tomography using micromotor Imaging Catheter and vcsel technology
Biomedical Optics Express, 2013Co-Authors: Tsunghan Tsai, Vijaysekhar Jayaraman, Martin F Kraus, P J S Heim, Benjamin Potsaid, Joachim Hornegger, Yuankai K Tao, James Jiang, Chao Zhou, Hiroshi MashimoAbstract:We developed a micromotor based miniature Catheter with an outer diameter of 3.2 mm for ultrahigh speed endoscopic swept source optical coherence tomography (OCT) using a vertical cavity surface-emitting laser (VCSEL) at a 1 MHz axial scan rate. The micromotor can rotate a micro-prism at several hundred frames per second with less than 5 V drive voltage to provide fast and stable scanning, which is not sensitive to the bending of the Catheter. The side-viewing probe can be pulled back to acquire a three-dimensional (3D) data set covering a large area on the specimen. The VCSEL provides a high axial scan rate to support dense sampling under high frame rate operation. Using a high speed data acquisition system, in vivo 3D-OCT Imaging in the rabbit GI tract and ex vivo Imaging of a human colon specimen with 8 μm axial resolution, 8 μm lateral resolution and 1.2 mm depth range in tissue at a frame rate of 400 fps was demonstrated.
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ultrahigh speed endoscopic optical coherence tomography using micro motor Imaging Catheter and vcsel technology
Proceedings of SPIE, 2013Co-Authors: Tsunghan Tsai, Vijaysekhar Jayaraman, Martin F Kraus, P J S Heim, Alex Cable, Hiroshi Mashimo, Benjamin Potsaid, Joachim Hornegger, James G FujimotoAbstract:We developed a micro-motor based miniature Catheter with an outer diameter of 3mm for ultrahigh speed endoscopic optical coherence tomography (OCT) using vertical cavity surface-emitting laser (VCSEL) at a 1MHz axial scan rate. The micro-motor can rotate a micro-prism at 1,200-72,000rpm (corresponding to 20- 1,200fps) with less than 5V driving voltage to provide fast and stable scanning, which is not sensitive to the bending of the Catheter. The side-viewing probe can be pulled back for a long distance to acquire three-dimensional (3D) dataset covering a large area on the specimen. VCSEL provides high a-line rate to support dense sampling under high frame rate operation. With the use of a C++ based high speed data acquisition (DAQ) system, in vivo three-dimensional OCT Imaging in rabbit GI tract with 1.6mm depth range, 11μm axial resolution, 8μm lateral resolution, and frame rate of 400fps is demonstrated.
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ultrahigh speed endoscopic optical coherence tomography using micro motor Imaging Catheter and vcsel technology
Proceedings of SPIE, 2013Co-Authors: Tsunghan Tsai, Vijaysekhar Jayaraman, Martin F Kraus, P J S Heim, Alex Cable, Hiroshi Mashimo, Benjamin Potsaid, Joachim Hornegger, James G FujimotoAbstract:We developed a micro-motor based miniature Catheter with an outer diameter of 3mm for ultrahigh speed endoscopic optical coherence tomography (OCT) using vertical cavity surface-emitting laser (VCSEL) at a 1MHz axial scan rate. The micro-motor can rotate a micro-prism at 1,200-72,000rpm (corresponding to 20- 1,200fps) with less than 5V driving voltage to provide fast and stable scanning, which is not sensitive to the bending of the Catheter. The side-viewing probe can be pulled back for a long distance to acquire three-dimensional (3D) dataset covering a large area on the specimen. VCSEL provides high a-line rate to support dense sampling under high frame rate operation. With the use of a C++ based high speed data acquisition (DAQ) system, in vivo three-dimensional OCT Imaging in rabbit GI tract with 1.6mm depth range, 11μm axial resolution, 8μm lateral resolution, and frame rate of 400fps is demonstrated.
Xingde Li - One of the best experts on this subject based on the ideXlab platform.
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Diffractive Catheter for ultrahigh-resolution spectral-domain volumetric OCT Imaging
Optics Letters, 2014Co-Authors: Jiefeng Xi, Wenxuan Liang, Lih Y. Lin, Shaoyong Yu, Anqi Zhang, Zhenyu Liu, Xingde LiAbstract:We present a novel design for an endoscopic Imaging Catheter utilizing diffractive optics for ultrahigh-resolution optical coherence tomography (OCT) Imaging at 800 nm. A diffractive microlens was developed to alleviate severe chromatic aberration when a broadband light source was employed at the 800 nm wavelength range. Combined with a home-built fiber rotary joint and a broadband Ti:sapphire laser, the Imaging Catheter achieved a lateral resolution of 6.2 μm and an axial resolution of 3.0 μm in air. The performance of the Catheter was demonstrated by three-dimensional full-circumferential endoscopic OCT Imaging of guinea pig esophagus in vivo.
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high resolution oct balloon Imaging Catheter with astigmatism correction
Optics Letters, 2009Co-Authors: Jiefeng Xi, Yicong Wu, Michael J Cobb, Joo Ha Hwang, Xingde LiAbstract:We report new optics designs for an optical coherence tomography (OCT) balloon Imaging Catheter to achieve diffraction-limited high resolution at a large working distance and enable the correction of severe astigmatism in the Catheter. The designs employed a 1 mm diameter gradient-index lens of a properly chosen pitch number and a glass rod spacer to fully utilize the available NA of the miniature optics. Astigmatism caused by the balloon tubing was analyzed, and a method based on a cylindrical reflector was proposed and demonstrated to compensate the astigmatism. A Catheter based on the new designs was successfully developed with a measured diffraction-limited lateral resolution of ~21 μm, a working distance of ~11-12 mm, and a round-shape beam profile. The performance of the OCT balloon Catheter was demonstrated by 3D full-circumferential Imaging of a swine esophagus in vivo along with a high-speed, Fourier-domain, mode-locked swept-source OCT system.
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Flexible miniature compound lens design for high-resolution optical coherence tomography balloon Imaging Catheter
Journal of Biomedical Optics, 2008Co-Authors: Henry L. Fu, Kevin Hsu, Michael J Cobb, Joo Ha Hwang, Yuxin Leng, Xingde LiAbstract:We report on a new optics design for an optical coherence tomography (OCT) balloon Imaging Catheter. The design involves a miniature compound gradient-index (GRIN) rod lens, which consists of a fiber optic mode-field reducer and relay rod lenses to achieve predictable high lateral resolution at a desired large working distance. The compound lens design significantly simplifies the engineering process for an OCT Catheter and enables 3-D full circumferential cross sectional Imaging of large luminal organs such as human esophagus. An as-designed OCT Catheter is developed and demonstrated for real-time in vivo swine esophagus Imaging in a 3-D spiral fashion.
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high resolution oct balloon Catheter for systematic Imaging of the esophagus
Conference on Lasers and Electro-Optics, 2007Co-Authors: Henry L. Fu, Michael J Cobb, Joo Ha Hwang, Yuxin Leng, Daniel J Macdonald, Xingde LiAbstract:An OCT balloon Imaging Catheter was developed using small compound rod lenses to achieve superb lateral resolution at a large working distance. The balloon Catheter enables systematic assessment of human esophagus for Barrett's screening.
Michael D. Lesh - One of the best experts on this subject based on the ideXlab platform.
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intracardiac echocardiography during radiofrequency Catheter ablation of cardiac arrhythmias in humans
Journal of the American College of Cardiology, 1994Co-Authors: Jonathan M Kalman, Michael Kwasman, Nelson B. Schiller, Laurence M. Epstein, Peter J. Fitzgerald, Paul G. Yock, Michael D. LeshAbstract:OBJECTIVES: The purpose of this study was to describe our preliminary experience using Catheter-based intracardiac echocardiography as an adjunct to biplane fluoroscopy for guiding radiofrequency Catheter ablation of atrial arrhythmias in the right side of the heart. BACKGROUND: Catheter ablation requires precise positioning and stable ablation electrode-endocardial contact. This procedure is currently guided by an analysis of intracardiac electrograms and fluoroscopy. However, the use of fluoroscopy does not allow the endocardium and certain anatomic landmarks to be identified and is associated with the hazards of radiation exposure. METHODS: Seventeen symptomatic patients were studied. A 10F 10-MHz intracardiac Imaging Catheter was used to visualize specific anatomic landmarks in the right atrium for directing the ablation electrode in 15 patients undergoing radiofrequency ablation of 19 arrhythmias and to assist with interatrial septal puncture in 3 patients. RESULTS: Continuous intracardiac Imaging was performed for a mean +/- SD of 63.6 +/- 39.2 min and demonstrated distal electrode-endocardial tissue contact in 81 (60%) of 134 radiofrequency applications. Movement of the Catheter was demonstrated during 36 (44%), microcavitations during 39 (48%) and thrombus during 15 (19%) of the 81 imaged applications. In 7 of 10 procedures for atrial flutter, successful ablation was directed at anatomic corridors in the right atrium visualized with intracardiac echocardiography. During ablation of atrial tachycardia, Imaging identified abnormal atrial anatomy related to previous surgery and guided successful ablation of a reentrant tachycardia circulating around these anatomic obstacles. In two procedures for slow pathway modification of atrioventricular node reentrant tachycardia, intracardiac echocardiography confirmed Catheter stability at the tricuspid annulus anterior to the coronary sinus. CONCLUSIONS: During Catheter ablation, intracardiac echocardiography augments fluoroscopy by visualizing anatomic landmarks, ensuring stable endocardial contact and assisting in transseptal puncture. Ablation of typical atrial flutter can be successfully directed at anatomic corridors identified using intracardiac Imaging.
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radiofrequency Catheter ablation guided by intracardiac echocardiography
Circulation, 1994Co-Authors: Adam P. Fitzpatrick, Michael C. Chin, Krishnankutty Sudhir, Paul G. Yock, Michael D. LeshAbstract:BACKGROUND: Radiofrequency Catheter ablation requires precise positioning of the ablation electrode. Fluoroscopically guided Catheter manipulation has limitations, and there are risks of radiation exposure. The purpose of this study was to examine the feasibility of guiding Catheter ablation within the right atrium with Catheter-based intracardiac echocardiography. METHODS AND RESULTS: A 10F, 10-MHz intracardiac Imaging Catheter was used to direct an ablation electrode at four or five anatomic landmarks in the right atrium. Thirty-eight radiofrequency energy applications were performed in nine anesthetized dogs, and 38 lesions were identified on pathological examination. Lesions were created a mean of 1.9 +/- 2.1 mm from the ultrasound-guided site. Twenty-six of 38 lesions (68%) were less than 2.2 mm from the imaged site. Intracardiac echocardiography also was used to confirm stable electrode-endocardial contact in 37 energy applications (97%) and identified Catheter movement in 9 energy applications (24%). Discrete lesions, microcavitations, and thrombi were observed in 13 (34%), 23 (61%), and 19 (50%) of 38 energy applications, respectively. Microcavitations predicted the appearance of thrombus. Fluoroscopy time required to create four or five lesions decreased from 23 minutes in the first study to less than 2 minutes in the last five studies. CONCLUSIONS: Catheter-based intracardiac echocardiography can accurately guide Catheter ablation directed at anatomic landmarks and potentially reduced ionizing radiation exposure. Intracardiac Imaging can be used to confirm endocardial contact, identify electrode movement, and directly visualize lesions. Intracardiac echocardiography also can be used to identify microcavitations, which predict thrombus formation during radiofrequency energy applications.
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radiofrequency Catheter ablation guided by intracardiac echocardiography
Circulation, 1994Co-Authors: Edward W Chu, Michael C. Chin, Krishnankutty Sudhir, Paul G. Yock, Adam P. Fitzpatrick, Michael D. LeshAbstract:BACKGROUNDRadiofrequency Catheter ablation requires precise positioning of the ablation electrode. Fluoroscopically guided Catheter manipulation has limitations, and there are risks of radiation exposure. The purpose of this study was to examine the feasibility of guiding Catheter ablation within the right atrium with Catheter-based intracardiac echocardiography.METHODS AND RESULTSA 10F, 10-MHz intracardiac Imaging Catheter was used to direct an ablation electrode at four or five anatomic landmarks in the right atrium. Thirty-eight radiofrequency energy applications were performed in nine anesthetized dogs, and 38 lesions were identified on pathological examination. Lesions were created a mean of 1.9 +/- 2.1 mm from the ultrasound-guided site. Twenty-six of 38 lesions (68%) were less than 2.2 mm from the imaged site. Intracardiac echocardiography also was used to confirm stable electrode-endocardial contact in 37 energy applications (97%) and identified Catheter movement in 9 energy applications (24%). Di...
Benjamin Potsaid - One of the best experts on this subject based on the ideXlab platform.
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circumferential optical coherence tomography angiography Imaging of the swine esophagus using a micromotor balloon Catheter
Biomedical Optics Express, 2016Co-Authors: Osman O Ahsen, Vijaysekhar Jayaraman, Alex Cable, Hiroshi Mashimo, Benjamin Potsaid, Kaicheng Liang, Zhao Wang, Cody Cleveland, Lucas Booth, Robert LangerAbstract:We demonstrate a micromotor balloon Imaging Catheter for ultrahigh speed endoscopic optical coherence tomography (OCT) which provides wide area, circumferential structural and angiographic Imaging of the esophagus without contrast agents. Using a 1310 nm MEMS tunable wavelength swept VCSEL light source, the system has a 1.2 MHz A-scan rate and ~8.5 µm axial resolution in tissue. The micromotor balloon Catheter enables circumferential Imaging of the esophagus at 240 frames per second (fps) with a ~30 µm (FWHM) spot size. Volumetric Imaging is achieved by proximal pullback of the micromotor assembly within the balloon at 1.5 mm/sec. Volumetric data consisting of 4200 circumferential images of 5,000 A-scans each over a 2.6 cm length, covering a ~13 cm2 area is acquired in <18 seconds. A non-rigid image registration algorithm is used to suppress motion artifacts from non-uniform rotational distortion (NURD), cardiac motion or respiration. En face OCT images at various depths can be generated. OCT angiography (OCTA) is computed using intensity decorrelation between sequential pairs of circumferential scans and enables three-dimensional visualization of vasculature. Wide area volumetric OCT and OCTA Imaging of the swine esophagus in vivo is demonstrated.
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ultrahigh speed endoscopic optical coherence tomography using micromotor Imaging Catheter and vcsel technology
Biomedical Optics Express, 2013Co-Authors: Tsunghan Tsai, Vijaysekhar Jayaraman, Martin F Kraus, P J S Heim, Benjamin Potsaid, Joachim Hornegger, Yuankai K Tao, James Jiang, Chao Zhou, Hiroshi MashimoAbstract:We developed a micromotor based miniature Catheter with an outer diameter of 3.2 mm for ultrahigh speed endoscopic swept source optical coherence tomography (OCT) using a vertical cavity surface-emitting laser (VCSEL) at a 1 MHz axial scan rate. The micromotor can rotate a micro-prism at several hundred frames per second with less than 5 V drive voltage to provide fast and stable scanning, which is not sensitive to the bending of the Catheter. The side-viewing probe can be pulled back to acquire a three-dimensional (3D) data set covering a large area on the specimen. The VCSEL provides a high axial scan rate to support dense sampling under high frame rate operation. Using a high speed data acquisition system, in vivo 3D-OCT Imaging in the rabbit GI tract and ex vivo Imaging of a human colon specimen with 8 μm axial resolution, 8 μm lateral resolution and 1.2 mm depth range in tissue at a frame rate of 400 fps was demonstrated.
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ultrahigh speed endoscopic optical coherence tomography using micro motor Imaging Catheter and vcsel technology
Proceedings of SPIE, 2013Co-Authors: Tsunghan Tsai, Vijaysekhar Jayaraman, Martin F Kraus, P J S Heim, Alex Cable, Hiroshi Mashimo, Benjamin Potsaid, Joachim Hornegger, James G FujimotoAbstract:We developed a micro-motor based miniature Catheter with an outer diameter of 3mm for ultrahigh speed endoscopic optical coherence tomography (OCT) using vertical cavity surface-emitting laser (VCSEL) at a 1MHz axial scan rate. The micro-motor can rotate a micro-prism at 1,200-72,000rpm (corresponding to 20- 1,200fps) with less than 5V driving voltage to provide fast and stable scanning, which is not sensitive to the bending of the Catheter. The side-viewing probe can be pulled back for a long distance to acquire three-dimensional (3D) dataset covering a large area on the specimen. VCSEL provides high a-line rate to support dense sampling under high frame rate operation. With the use of a C++ based high speed data acquisition (DAQ) system, in vivo three-dimensional OCT Imaging in rabbit GI tract with 1.6mm depth range, 11μm axial resolution, 8μm lateral resolution, and frame rate of 400fps is demonstrated.
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ultrahigh speed endoscopic optical coherence tomography using micro motor Imaging Catheter and vcsel technology
Proceedings of SPIE, 2013Co-Authors: Tsunghan Tsai, Vijaysekhar Jayaraman, Martin F Kraus, P J S Heim, Alex Cable, Hiroshi Mashimo, Benjamin Potsaid, Joachim Hornegger, James G FujimotoAbstract:We developed a micro-motor based miniature Catheter with an outer diameter of 3mm for ultrahigh speed endoscopic optical coherence tomography (OCT) using vertical cavity surface-emitting laser (VCSEL) at a 1MHz axial scan rate. The micro-motor can rotate a micro-prism at 1,200-72,000rpm (corresponding to 20- 1,200fps) with less than 5V driving voltage to provide fast and stable scanning, which is not sensitive to the bending of the Catheter. The side-viewing probe can be pulled back for a long distance to acquire three-dimensional (3D) dataset covering a large area on the specimen. VCSEL provides high a-line rate to support dense sampling under high frame rate operation. With the use of a C++ based high speed data acquisition (DAQ) system, in vivo three-dimensional OCT Imaging in rabbit GI tract with 1.6mm depth range, 11μm axial resolution, 8μm lateral resolution, and frame rate of 400fps is demonstrated.
Vijaysekhar Jayaraman - One of the best experts on this subject based on the ideXlab platform.
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circumferential optical coherence tomography angiography Imaging of the swine esophagus using a micromotor balloon Catheter
Biomedical Optics Express, 2016Co-Authors: Osman O Ahsen, Vijaysekhar Jayaraman, Alex Cable, Hiroshi Mashimo, Benjamin Potsaid, Kaicheng Liang, Zhao Wang, Cody Cleveland, Lucas Booth, Robert LangerAbstract:We demonstrate a micromotor balloon Imaging Catheter for ultrahigh speed endoscopic optical coherence tomography (OCT) which provides wide area, circumferential structural and angiographic Imaging of the esophagus without contrast agents. Using a 1310 nm MEMS tunable wavelength swept VCSEL light source, the system has a 1.2 MHz A-scan rate and ~8.5 µm axial resolution in tissue. The micromotor balloon Catheter enables circumferential Imaging of the esophagus at 240 frames per second (fps) with a ~30 µm (FWHM) spot size. Volumetric Imaging is achieved by proximal pullback of the micromotor assembly within the balloon at 1.5 mm/sec. Volumetric data consisting of 4200 circumferential images of 5,000 A-scans each over a 2.6 cm length, covering a ~13 cm2 area is acquired in <18 seconds. A non-rigid image registration algorithm is used to suppress motion artifacts from non-uniform rotational distortion (NURD), cardiac motion or respiration. En face OCT images at various depths can be generated. OCT angiography (OCTA) is computed using intensity decorrelation between sequential pairs of circumferential scans and enables three-dimensional visualization of vasculature. Wide area volumetric OCT and OCTA Imaging of the swine esophagus in vivo is demonstrated.
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ultrahigh speed endoscopic optical coherence tomography using micromotor Imaging Catheter and vcsel technology
Biomedical Optics Express, 2013Co-Authors: Tsunghan Tsai, Vijaysekhar Jayaraman, Martin F Kraus, P J S Heim, Benjamin Potsaid, Joachim Hornegger, Yuankai K Tao, James Jiang, Chao Zhou, Hiroshi MashimoAbstract:We developed a micromotor based miniature Catheter with an outer diameter of 3.2 mm for ultrahigh speed endoscopic swept source optical coherence tomography (OCT) using a vertical cavity surface-emitting laser (VCSEL) at a 1 MHz axial scan rate. The micromotor can rotate a micro-prism at several hundred frames per second with less than 5 V drive voltage to provide fast and stable scanning, which is not sensitive to the bending of the Catheter. The side-viewing probe can be pulled back to acquire a three-dimensional (3D) data set covering a large area on the specimen. The VCSEL provides a high axial scan rate to support dense sampling under high frame rate operation. Using a high speed data acquisition system, in vivo 3D-OCT Imaging in the rabbit GI tract and ex vivo Imaging of a human colon specimen with 8 μm axial resolution, 8 μm lateral resolution and 1.2 mm depth range in tissue at a frame rate of 400 fps was demonstrated.
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ultrahigh speed endoscopic optical coherence tomography using micro motor Imaging Catheter and vcsel technology
Proceedings of SPIE, 2013Co-Authors: Tsunghan Tsai, Vijaysekhar Jayaraman, Martin F Kraus, P J S Heim, Alex Cable, Hiroshi Mashimo, Benjamin Potsaid, Joachim Hornegger, James G FujimotoAbstract:We developed a micro-motor based miniature Catheter with an outer diameter of 3mm for ultrahigh speed endoscopic optical coherence tomography (OCT) using vertical cavity surface-emitting laser (VCSEL) at a 1MHz axial scan rate. The micro-motor can rotate a micro-prism at 1,200-72,000rpm (corresponding to 20- 1,200fps) with less than 5V driving voltage to provide fast and stable scanning, which is not sensitive to the bending of the Catheter. The side-viewing probe can be pulled back for a long distance to acquire three-dimensional (3D) dataset covering a large area on the specimen. VCSEL provides high a-line rate to support dense sampling under high frame rate operation. With the use of a C++ based high speed data acquisition (DAQ) system, in vivo three-dimensional OCT Imaging in rabbit GI tract with 1.6mm depth range, 11μm axial resolution, 8μm lateral resolution, and frame rate of 400fps is demonstrated.
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ultrahigh speed endoscopic optical coherence tomography using micro motor Imaging Catheter and vcsel technology
Proceedings of SPIE, 2013Co-Authors: Tsunghan Tsai, Vijaysekhar Jayaraman, Martin F Kraus, P J S Heim, Alex Cable, Hiroshi Mashimo, Benjamin Potsaid, Joachim Hornegger, James G FujimotoAbstract:We developed a micro-motor based miniature Catheter with an outer diameter of 3mm for ultrahigh speed endoscopic optical coherence tomography (OCT) using vertical cavity surface-emitting laser (VCSEL) at a 1MHz axial scan rate. The micro-motor can rotate a micro-prism at 1,200-72,000rpm (corresponding to 20- 1,200fps) with less than 5V driving voltage to provide fast and stable scanning, which is not sensitive to the bending of the Catheter. The side-viewing probe can be pulled back for a long distance to acquire three-dimensional (3D) dataset covering a large area on the specimen. VCSEL provides high a-line rate to support dense sampling under high frame rate operation. With the use of a C++ based high speed data acquisition (DAQ) system, in vivo three-dimensional OCT Imaging in rabbit GI tract with 1.6mm depth range, 11μm axial resolution, 8μm lateral resolution, and frame rate of 400fps is demonstrated.