Imides

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The Experts below are selected from a list of 360 Experts worldwide ranked by ideXlab platform

Hideo Togo - One of the best experts on this subject based on the ideXlab platform.

Zili Chen - One of the best experts on this subject based on the ideXlab platform.

Katsuhiko Moriyama - One of the best experts on this subject based on the ideXlab platform.

Michal Szostak - One of the best experts on this subject based on the ideXlab platform.

  • twisted n acyl hydantoins rotationally inverted urea Imides of relevance in n c o cross coupling
    Journal of Organic Chemistry, 2018
    Co-Authors: Roman Szostak, Roger A. Lalancette, Michal Szostak
    Abstract:

    We report a combined structural and computational study on the properties of twisted acyclic hydantoins. These compounds feature cyclic urea-imide moiety that is widely found in bioactive compounds and is structurally related to the classic bridged hydantoins proposed by Smissman more than 50 years ago. We demonstrate that C to N-substitution of the imide moiety in the succinimide ring to give hydantoin results in one of the most distorted acyclic amide bonds reported to date. The energetic properties of twisted acyclic hydantoins with respect to structures, resonance energies, barriers to rotation, and proton affinities are discussed. The energetic and structural properties of twisted acyclic hydantoins described provide a benchmark to facilitate the development of twisted amides based on the biorelevant cyclic urea-imide scaffold.

  • Twisted N‑Acyl-hydantoins: Rotationally Inverted Urea-Imides of Relevance in N–C(O) Cross-coupling
    2018
    Co-Authors: Roman Szostak, Roger A. Lalancette, Chengwei Liu, Michal Szostak
    Abstract:

    We report a combined structural and computational study on the properties of twisted acyclic hydantoins. These compounds feature cyclic urea-imide moiety that is widely found in bioactive compounds and is structurally related to the classic bridged hydantoins proposed by Smissman more than 50 years ago. We demonstrate that C to N-substitution of the imide moiety in the succinimide ring to give hydantoin results in one of the most distorted acyclic amide bonds reported to date. The energetic properties of twisted acyclic hydantoins with respect to structures, resonance energies, barriers to rotation, and proton affinities are discussed. The energetic and structural properties of twisted acyclic hydantoins described provide a benchmark to facilitate the development of twisted amides based on the biorelevant cyclic urea-imide scaffold

Arne Thomas - One of the best experts on this subject based on the ideXlab platform.