The Experts below are selected from a list of 4809 Experts worldwide ranked by ideXlab platform
Stocco G. - One of the best experts on this subject based on the ideXlab platform.
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Pharmacogenomics and personalized medicine
'MDPI AG', 2020Co-Authors: Cecchin E., Stocco G.Abstract:Pharmacogenomics is one of the emerging approaches to precision medicine, tailoring drug selection and dosing to the patient\u2019s genetic features. In recent years, several pharmacogenetic guidelines have been published by international scientific consortia, but the uptake in clinical practice is still poor. Many coordinated international efforts are ongoing in order to overcome the existing barriers to pharmacogenomic implementation. On the other hand, existing validated pharmacogenomic markers can explain only a minor part of the observed clinical variability in the therapeutic outcome. New investigational approaches are warranted, including the study of the pharmacogenomic role of the Immune System Genetics and of previously neglected rare genetic variants, reported to account for a large part of the inter-individual variability in drug metabolism. In this Special Issue, we collected a series of articles covering many aspects of pharmacogenomics. These include clinical implementation of pharmacogenomics in clinical practice, development of tools or infrastractures to support this process, research of new pharmacogenomics markers to increase drug efficacy and safety, and the impact of rare genetic variants in pharmacogenomics
Cecchin E. - One of the best experts on this subject based on the ideXlab platform.
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Pharmacogenomics and personalized medicine
'MDPI AG', 2020Co-Authors: Cecchin E., Stocco G.Abstract:Pharmacogenomics is one of the emerging approaches to precision medicine, tailoring drug selection and dosing to the patient\u2019s genetic features. In recent years, several pharmacogenetic guidelines have been published by international scientific consortia, but the uptake in clinical practice is still poor. Many coordinated international efforts are ongoing in order to overcome the existing barriers to pharmacogenomic implementation. On the other hand, existing validated pharmacogenomic markers can explain only a minor part of the observed clinical variability in the therapeutic outcome. New investigational approaches are warranted, including the study of the pharmacogenomic role of the Immune System Genetics and of previously neglected rare genetic variants, reported to account for a large part of the inter-individual variability in drug metabolism. In this Special Issue, we collected a series of articles covering many aspects of pharmacogenomics. These include clinical implementation of pharmacogenomics in clinical practice, development of tools or infrastractures to support this process, research of new pharmacogenomics markers to increase drug efficacy and safety, and the impact of rare genetic variants in pharmacogenomics
Weckwerth Wolfram - One of the best experts on this subject based on the ideXlab platform.
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The Quest for System-Theoretical Medicine in the COVID-19 Era
2021Co-Authors: Tretter Felix, Wolkenhauer Olaf, Meyer-hermann Michael, Dietrich, Johannes W., Green Sara, Marcum James, Weckwerth WolframAbstract:Precision medicine and molecular Systems medicine (MSM) are highly utilized and successful approaches to improve understanding, diagnosis, and treatment of many diseases from bench-to-bedside. Especially in the COVID-19 pandemic, molecular techniques and biotechnological innovation have proven to be of utmost importance for rapid developments in disease diagnostics and treatment, including DNA and RNA sequencing technology, treatment with drugs and natural products and vaccine development. The COVID-19 crisis, however, has also demonstrated the need for Systemic thinking and transdisciplinarity and the limits of MSM: the neglect of the bio-psycho-social Systemic nature of humans and their context as the object of individual therapeutic and population-oriented interventions. COVID-19 illustrates how a medical problem requires a transdisciplinary approach in epidemiology, pathology, internal medicine, public health, environmental medicine, and socio-economic modeling. Regarding the need for conceptual integration of these different kinds of knowledge we suggest the application of general System theory (GST). This approach endorses an organism-centered view on health and disease, which according to Ludwig von Bertalanffy who was the founder of GST, we call Organismal Systems Medicine (OSM). We argue that Systems science offers wider applications in the field of pathology and can contribute to an integrative Systems medicine by (i) integration of evidence across functional and structural differentially scaled subSystems, (ii) conceptualization of complex multilevel Systems, and (iii) suggesting mechanisms and non-linear relationships underlying the observed phenomena. We underline these points with a proposal on multi-level Systems pathology including neurophysiology, endocrinology, Immune System, Genetics, and general metabolism. An integration of these areas is necessary to understand excess mortality rates and polypharmacological treatments. In the pandemic era this multi-level Systems pathology is most important to assess potential vaccines, their effectiveness, short-, and long-time adverse effects. We further argue that these conceptual frameworks are not only valid in the COVID-19 era but also important to be integrated in a medicinal curriculum
Tretter Felix - One of the best experts on this subject based on the ideXlab platform.
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The Quest for System-Theoretical Medicine in the COVID-19 Era
2021Co-Authors: Tretter Felix, Wolkenhauer Olaf, Meyer-hermann Michael, Dietrich, Johannes W., Green Sara, Marcum James, Weckwerth WolframAbstract:Precision medicine and molecular Systems medicine (MSM) are highly utilized and successful approaches to improve understanding, diagnosis, and treatment of many diseases from bench-to-bedside. Especially in the COVID-19 pandemic, molecular techniques and biotechnological innovation have proven to be of utmost importance for rapid developments in disease diagnostics and treatment, including DNA and RNA sequencing technology, treatment with drugs and natural products and vaccine development. The COVID-19 crisis, however, has also demonstrated the need for Systemic thinking and transdisciplinarity and the limits of MSM: the neglect of the bio-psycho-social Systemic nature of humans and their context as the object of individual therapeutic and population-oriented interventions. COVID-19 illustrates how a medical problem requires a transdisciplinary approach in epidemiology, pathology, internal medicine, public health, environmental medicine, and socio-economic modeling. Regarding the need for conceptual integration of these different kinds of knowledge we suggest the application of general System theory (GST). This approach endorses an organism-centered view on health and disease, which according to Ludwig von Bertalanffy who was the founder of GST, we call Organismal Systems Medicine (OSM). We argue that Systems science offers wider applications in the field of pathology and can contribute to an integrative Systems medicine by (i) integration of evidence across functional and structural differentially scaled subSystems, (ii) conceptualization of complex multilevel Systems, and (iii) suggesting mechanisms and non-linear relationships underlying the observed phenomena. We underline these points with a proposal on multi-level Systems pathology including neurophysiology, endocrinology, Immune System, Genetics, and general metabolism. An integration of these areas is necessary to understand excess mortality rates and polypharmacological treatments. In the pandemic era this multi-level Systems pathology is most important to assess potential vaccines, their effectiveness, short-, and long-time adverse effects. We further argue that these conceptual frameworks are not only valid in the COVID-19 era but also important to be integrated in a medicinal curriculum
Wolkenhauer Olaf - One of the best experts on this subject based on the ideXlab platform.
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The Quest for System-Theoretical Medicine in the COVID-19 Era
2021Co-Authors: Tretter Felix, Wolkenhauer Olaf, Meyer-hermann Michael, Dietrich, Johannes W., Green Sara, Marcum James, Weckwerth WolframAbstract:Precision medicine and molecular Systems medicine (MSM) are highly utilized and successful approaches to improve understanding, diagnosis, and treatment of many diseases from bench-to-bedside. Especially in the COVID-19 pandemic, molecular techniques and biotechnological innovation have proven to be of utmost importance for rapid developments in disease diagnostics and treatment, including DNA and RNA sequencing technology, treatment with drugs and natural products and vaccine development. The COVID-19 crisis, however, has also demonstrated the need for Systemic thinking and transdisciplinarity and the limits of MSM: the neglect of the bio-psycho-social Systemic nature of humans and their context as the object of individual therapeutic and population-oriented interventions. COVID-19 illustrates how a medical problem requires a transdisciplinary approach in epidemiology, pathology, internal medicine, public health, environmental medicine, and socio-economic modeling. Regarding the need for conceptual integration of these different kinds of knowledge we suggest the application of general System theory (GST). This approach endorses an organism-centered view on health and disease, which according to Ludwig von Bertalanffy who was the founder of GST, we call Organismal Systems Medicine (OSM). We argue that Systems science offers wider applications in the field of pathology and can contribute to an integrative Systems medicine by (i) integration of evidence across functional and structural differentially scaled subSystems, (ii) conceptualization of complex multilevel Systems, and (iii) suggesting mechanisms and non-linear relationships underlying the observed phenomena. We underline these points with a proposal on multi-level Systems pathology including neurophysiology, endocrinology, Immune System, Genetics, and general metabolism. An integration of these areas is necessary to understand excess mortality rates and polypharmacological treatments. In the pandemic era this multi-level Systems pathology is most important to assess potential vaccines, their effectiveness, short-, and long-time adverse effects. We further argue that these conceptual frameworks are not only valid in the COVID-19 era but also important to be integrated in a medicinal curriculum
