The Experts below are selected from a list of 24 Experts worldwide ranked by ideXlab platform
Kathy D. Mccoy - One of the best experts on this subject based on the ideXlab platform.
-
APRIL in the Intestine: A Good Destination for Immunoglobulin A2
Immunity, 2007Co-Authors: Andrew J. Macpherson, Kathy D. MccoyAbstract:Immunoglobulin A (IgA) confers mucosal protection against bacteria in the intestine. In this issue, He et al. (2007) find that bacterial molecules promote IgA(2) generation via the cytokine APRIL, produced by intestinal epithelial and dendritic cells.
Andrew J. Macpherson - One of the best experts on this subject based on the ideXlab platform.
-
APRIL in the Intestine: A Good Destination for Immunoglobulin A2
Immunity, 2007Co-Authors: Andrew J. Macpherson, Kathy D. MccoyAbstract:Immunoglobulin A (IgA) confers mucosal protection against bacteria in the intestine. In this issue, He et al. (2007) find that bacterial molecules promote IgA(2) generation via the cytokine APRIL, produced by intestinal epithelial and dendritic cells.
Alessandro Plebani - One of the best experts on this subject based on the ideXlab platform.
-
intestinal bacteria trigger t cell independent Immunoglobulin A2 class switching by inducing epithelial cell secretion of the cytokine april
Immunity, 2007Co-Authors: Bing He, Paul A Santini, Alexandros D Polydorides, Jeannelyn Santiano Estrella, Meimei Shan, Vincenzo Villanacci, Amy Chadburn, April Chiu, Wei Xu, Alessandro PlebaniAbstract:Summary Bacteria colonize the intestine shortly after birth and thereafter exert several beneficial functions, including induction of protective Immunoglobulin A (IgA) antibodies. The distal intestine contains IgA 2 , which is more resistant to bacterial proteases than is IgA 1 . The mechanism by which B cells switch from IgM to IgA 2 remains unknown. We found that human intestinal epithelial cells (IECs) triggered IgA 2 class switching in B cells, including IgA 1 -expressing B cells arriving from mucosal follicles, through a CD4 + T cell-independent pathway involving a proliferation-inducing ligand (APRIL). IECs released APRIL after sensing bacteria through Toll-like receptors (TLRs) and further increased APRIL production by activating dendritic cells via thymic stromal lymphopoietin. Our data indicate that bacteria elicit IgA 2 class switching by linking lamina propria B cells with IECs through a TLR-inducible signaling program requiring APRIL. Thus, mucosal vaccines should activate IECs to induce more effective IgA 2 responses.
Bing He - One of the best experts on this subject based on the ideXlab platform.
-
intestinal bacteria trigger t cell independent Immunoglobulin A2 class switching by inducing epithelial cell secretion of the cytokine april
Immunity, 2007Co-Authors: Bing He, Paul A Santini, Alexandros D Polydorides, Jeannelyn Santiano Estrella, Meimei Shan, Vincenzo Villanacci, Amy Chadburn, April Chiu, Wei Xu, Alessandro PlebaniAbstract:Summary Bacteria colonize the intestine shortly after birth and thereafter exert several beneficial functions, including induction of protective Immunoglobulin A (IgA) antibodies. The distal intestine contains IgA 2 , which is more resistant to bacterial proteases than is IgA 1 . The mechanism by which B cells switch from IgM to IgA 2 remains unknown. We found that human intestinal epithelial cells (IECs) triggered IgA 2 class switching in B cells, including IgA 1 -expressing B cells arriving from mucosal follicles, through a CD4 + T cell-independent pathway involving a proliferation-inducing ligand (APRIL). IECs released APRIL after sensing bacteria through Toll-like receptors (TLRs) and further increased APRIL production by activating dendritic cells via thymic stromal lymphopoietin. Our data indicate that bacteria elicit IgA 2 class switching by linking lamina propria B cells with IECs through a TLR-inducible signaling program requiring APRIL. Thus, mucosal vaccines should activate IECs to induce more effective IgA 2 responses.
Paul A Santini - One of the best experts on this subject based on the ideXlab platform.
-
intestinal bacteria trigger t cell independent Immunoglobulin A2 class switching by inducing epithelial cell secretion of the cytokine april
Immunity, 2007Co-Authors: Bing He, Paul A Santini, Alexandros D Polydorides, Jeannelyn Santiano Estrella, Meimei Shan, Vincenzo Villanacci, Amy Chadburn, April Chiu, Wei Xu, Alessandro PlebaniAbstract:Summary Bacteria colonize the intestine shortly after birth and thereafter exert several beneficial functions, including induction of protective Immunoglobulin A (IgA) antibodies. The distal intestine contains IgA 2 , which is more resistant to bacterial proteases than is IgA 1 . The mechanism by which B cells switch from IgM to IgA 2 remains unknown. We found that human intestinal epithelial cells (IECs) triggered IgA 2 class switching in B cells, including IgA 1 -expressing B cells arriving from mucosal follicles, through a CD4 + T cell-independent pathway involving a proliferation-inducing ligand (APRIL). IECs released APRIL after sensing bacteria through Toll-like receptors (TLRs) and further increased APRIL production by activating dendritic cells via thymic stromal lymphopoietin. Our data indicate that bacteria elicit IgA 2 class switching by linking lamina propria B cells with IECs through a TLR-inducible signaling program requiring APRIL. Thus, mucosal vaccines should activate IECs to induce more effective IgA 2 responses.