Immunoglobulin A2

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The Experts below are selected from a list of 24 Experts worldwide ranked by ideXlab platform

Kathy D. Mccoy - One of the best experts on this subject based on the ideXlab platform.

Andrew J. Macpherson - One of the best experts on this subject based on the ideXlab platform.

Alessandro Plebani - One of the best experts on this subject based on the ideXlab platform.

  • intestinal bacteria trigger t cell independent Immunoglobulin A2 class switching by inducing epithelial cell secretion of the cytokine april
    Immunity, 2007
    Co-Authors: Bing He, Paul A Santini, Alexandros D Polydorides, Jeannelyn Santiano Estrella, Meimei Shan, Vincenzo Villanacci, Amy Chadburn, April Chiu, Wei Xu, Alessandro Plebani
    Abstract:

    Summary Bacteria colonize the intestine shortly after birth and thereafter exert several beneficial functions, including induction of protective Immunoglobulin A (IgA) antibodies. The distal intestine contains IgA 2 , which is more resistant to bacterial proteases than is IgA 1 . The mechanism by which B cells switch from IgM to IgA 2 remains unknown. We found that human intestinal epithelial cells (IECs) triggered IgA 2 class switching in B cells, including IgA 1 -expressing B cells arriving from mucosal follicles, through a CD4 + T cell-independent pathway involving a proliferation-inducing ligand (APRIL). IECs released APRIL after sensing bacteria through Toll-like receptors (TLRs) and further increased APRIL production by activating dendritic cells via thymic stromal lymphopoietin. Our data indicate that bacteria elicit IgA 2 class switching by linking lamina propria B cells with IECs through a TLR-inducible signaling program requiring APRIL. Thus, mucosal vaccines should activate IECs to induce more effective IgA 2 responses.

Bing He - One of the best experts on this subject based on the ideXlab platform.

  • intestinal bacteria trigger t cell independent Immunoglobulin A2 class switching by inducing epithelial cell secretion of the cytokine april
    Immunity, 2007
    Co-Authors: Bing He, Paul A Santini, Alexandros D Polydorides, Jeannelyn Santiano Estrella, Meimei Shan, Vincenzo Villanacci, Amy Chadburn, April Chiu, Wei Xu, Alessandro Plebani
    Abstract:

    Summary Bacteria colonize the intestine shortly after birth and thereafter exert several beneficial functions, including induction of protective Immunoglobulin A (IgA) antibodies. The distal intestine contains IgA 2 , which is more resistant to bacterial proteases than is IgA 1 . The mechanism by which B cells switch from IgM to IgA 2 remains unknown. We found that human intestinal epithelial cells (IECs) triggered IgA 2 class switching in B cells, including IgA 1 -expressing B cells arriving from mucosal follicles, through a CD4 + T cell-independent pathway involving a proliferation-inducing ligand (APRIL). IECs released APRIL after sensing bacteria through Toll-like receptors (TLRs) and further increased APRIL production by activating dendritic cells via thymic stromal lymphopoietin. Our data indicate that bacteria elicit IgA 2 class switching by linking lamina propria B cells with IECs through a TLR-inducible signaling program requiring APRIL. Thus, mucosal vaccines should activate IECs to induce more effective IgA 2 responses.

Paul A Santini - One of the best experts on this subject based on the ideXlab platform.

  • intestinal bacteria trigger t cell independent Immunoglobulin A2 class switching by inducing epithelial cell secretion of the cytokine april
    Immunity, 2007
    Co-Authors: Bing He, Paul A Santini, Alexandros D Polydorides, Jeannelyn Santiano Estrella, Meimei Shan, Vincenzo Villanacci, Amy Chadburn, April Chiu, Wei Xu, Alessandro Plebani
    Abstract:

    Summary Bacteria colonize the intestine shortly after birth and thereafter exert several beneficial functions, including induction of protective Immunoglobulin A (IgA) antibodies. The distal intestine contains IgA 2 , which is more resistant to bacterial proteases than is IgA 1 . The mechanism by which B cells switch from IgM to IgA 2 remains unknown. We found that human intestinal epithelial cells (IECs) triggered IgA 2 class switching in B cells, including IgA 1 -expressing B cells arriving from mucosal follicles, through a CD4 + T cell-independent pathway involving a proliferation-inducing ligand (APRIL). IECs released APRIL after sensing bacteria through Toll-like receptors (TLRs) and further increased APRIL production by activating dendritic cells via thymic stromal lymphopoietin. Our data indicate that bacteria elicit IgA 2 class switching by linking lamina propria B cells with IECs through a TLR-inducible signaling program requiring APRIL. Thus, mucosal vaccines should activate IECs to induce more effective IgA 2 responses.