The Experts below are selected from a list of 42 Experts worldwide ranked by ideXlab platform
Shu-fen Liu - One of the best experts on this subject based on the ideXlab platform.
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Falsely low LDL-cholesterol concentrations and artifactual undetectable HDL-cholesterol measured by direct methods in a patient with monoclonal paraprotein.
Clinica Chimica Acta, 2005Co-Authors: Li-yu Tsai, Shih-men Tsai, Su-chen Lee, Shu-fen LiuAbstract:Abstract Introduction Multiple myeloma is a malignant Immunoproliferative Disorder with lipoprotein abnormalities. We report a case of falsely low concentrations of LDL-cholesterol (LDL-C) and artifactural undetectable HDL-cholesterol (HDL-C) as measured with direct methods in a patient of multiple myeloma with IgG κ monoclonal gammapathy and significant hyperlipidemia. Case report The patient had HDL-C and LDL-C concentrations in the 0.63–0.71 mmol/l and 2.22–2.36 mmol/l ranges, respectively, as measured by a traditional semi-quantitative electrophoresis method. The observation of falsely low concentrations of LDL-C and artifactural undetectable HDL-C might result in the mismanagement of patients of multiple myeloma with monoclonal gammapathy, because the LDL-C and HDL-C concentrations are positive and negative risk factors of cardiovascular diseases. Conclusions Care must be taken when using the homogenous method for direct measurement of LDL-cholesterol and HDL-cholesterol in patients of multiple myeloma with monoclonal paraprotein.
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Falsely low LDL-cholesterol concentrations and artifactual undetectable HDL-cholesterol measured by direct methods in a patient with monoclonal paraprotein.
Clinica chimica acta; international journal of clinical chemistry, 2005Co-Authors: Li-yu Tsai, Shih-men Tsai, Su-chen Lee, Shu-fen LiuAbstract:Multiple myeloma is a malignant Immunoproliferative Disorder with lipoprotein abnormalities. We report a case of falsely low concentrations of LDL-cholesterol (LDL-C) and artifactural undetectable HDL-cholesterol (HDL-C) as measured with direct methods in a patient of multiple myeloma with IgGkappa monoclonal gammapathy and significant hyperlipidemia. The patient had HDL-C and LDL-C concentrations in the 0.63-0.71 mmol/l and 2.22-2.36 mmol/l ranges, respectively, as measured by a traditional semi-quantitative electrophoresis method. The observation of falsely low concentrations of LDL-C and artifactural undetectable HDL-C might result in the mismanagement of patients of multiple myeloma with monoclonal gammapathy, because the LDL-C and HDL-C concentrations are positive and negative risk factors of cardiovascular diseases. Care must be taken when using the homogenous method for direct measurement of LDL-cholesterol and HDL-cholesterol in patients of multiple myeloma with monoclonal paraprotein.
Magali Colombat - One of the best experts on this subject based on the ideXlab platform.
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Light chain deposition disease involving the airways: diagnosis by fibreoptic bronchoscopy
The European respiratory journal, 2007Co-Authors: Magali Colombat, Hervé Mal, Valérie Gounant, P. Callard, Bernard MilleronAbstract:Light chain deposition disease (LCDD) infrequently affects the lungs and usually causes damage to the parenchyma, while bronchial involvement appears to be very rare. The present authors report the case of a 64-yr-old female with LCDD characterised by asymptomatic airway involvement. Ten months after excision of a poorly differentiated vaginal carcinoma, a routine chest computed tomography (CT) scan revealed two lung cysts, several bilateral nodules and diffuse bronchial thickening. Pulmonary function tests were normal. Fibreoptic bronchoscopy showed marked diffuse mucosal thickening with highly conspicuous vascular plexuses. Nonamyloidal deposits were found in the bronchial wall, but no definite diagnosis could be proposed. On follow-up, the patient was still asymptomatic and the CT scan and endoscopic appearance remained unchanged. The final diagnosis of κ LCDD was established 18 months later by another series of bronchial biopsies with frozen samples. Interestingly, electron microscopy showed dense granular deposits associated with nonamyloidal fibrils. An increased number of lung cysts were observed 32 months after identification of bronchial abnormalities, confirming the progressive nature of the disease. No extrapulmonary deposits or Immunoproliferative Disorder were found. In conclusion, light chain deposition disease, which may remain latent for several years, can entirely involve large airways and may be diagnosed by bronchial biopsy.
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Pulmonary cystic Disorder related to light chain deposition disease.
American journal of respiratory and critical care medicine, 2006Co-Authors: Magali Colombat, Marc Stern, O. Groussard, Dominique Droz, Michel Brauner, Dominique Valeyre, Hervé Mal, Camille Taillé, Isabelle Monnet, Michel FournierAbstract:Light chain deposition disease (LCDD) is a rare Disorder that very uncommonly affects the lung. We report three cases of severe cystic pulmonary LCDD leading to lung transplantation. Such a presentation has never been previously reported. The three patients present with a progressive obstructive pulmonary pattern associated with numerous cysts diffusely distributed in both lungs. The disease was histologically characterized by non-amyloid amorphous deposits in the alveolar walls, the small airways and the vessels. It was associated with emphysematous-like changes and small airway dilation. Monotypic kappa light chain fixation was demonstrated on the abnormal deposits and along the basement membranes. Electron microscopy revealed coarsely granular electron-dense deposits in the same localizations. Mild extrapulmonary deposits were found in salivary glands in one patient. No Immunoproliferative Disorder was identified. We conclude that LCDD may primarily affect the lung, present as a pulmonary cystic Disorder, and lead to severe respiratory insufficiency.
Li-yu Tsai - One of the best experts on this subject based on the ideXlab platform.
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Falsely low LDL-cholesterol concentrations and artifactual undetectable HDL-cholesterol measured by direct methods in a patient with monoclonal paraprotein.
Clinica Chimica Acta, 2005Co-Authors: Li-yu Tsai, Shih-men Tsai, Su-chen Lee, Shu-fen LiuAbstract:Abstract Introduction Multiple myeloma is a malignant Immunoproliferative Disorder with lipoprotein abnormalities. We report a case of falsely low concentrations of LDL-cholesterol (LDL-C) and artifactural undetectable HDL-cholesterol (HDL-C) as measured with direct methods in a patient of multiple myeloma with IgG κ monoclonal gammapathy and significant hyperlipidemia. Case report The patient had HDL-C and LDL-C concentrations in the 0.63–0.71 mmol/l and 2.22–2.36 mmol/l ranges, respectively, as measured by a traditional semi-quantitative electrophoresis method. The observation of falsely low concentrations of LDL-C and artifactural undetectable HDL-C might result in the mismanagement of patients of multiple myeloma with monoclonal gammapathy, because the LDL-C and HDL-C concentrations are positive and negative risk factors of cardiovascular diseases. Conclusions Care must be taken when using the homogenous method for direct measurement of LDL-cholesterol and HDL-cholesterol in patients of multiple myeloma with monoclonal paraprotein.
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Falsely low LDL-cholesterol concentrations and artifactual undetectable HDL-cholesterol measured by direct methods in a patient with monoclonal paraprotein.
Clinica chimica acta; international journal of clinical chemistry, 2005Co-Authors: Li-yu Tsai, Shih-men Tsai, Su-chen Lee, Shu-fen LiuAbstract:Multiple myeloma is a malignant Immunoproliferative Disorder with lipoprotein abnormalities. We report a case of falsely low concentrations of LDL-cholesterol (LDL-C) and artifactural undetectable HDL-cholesterol (HDL-C) as measured with direct methods in a patient of multiple myeloma with IgGkappa monoclonal gammapathy and significant hyperlipidemia. The patient had HDL-C and LDL-C concentrations in the 0.63-0.71 mmol/l and 2.22-2.36 mmol/l ranges, respectively, as measured by a traditional semi-quantitative electrophoresis method. The observation of falsely low concentrations of LDL-C and artifactural undetectable HDL-C might result in the mismanagement of patients of multiple myeloma with monoclonal gammapathy, because the LDL-C and HDL-C concentrations are positive and negative risk factors of cardiovascular diseases. Care must be taken when using the homogenous method for direct measurement of LDL-cholesterol and HDL-cholesterol in patients of multiple myeloma with monoclonal paraprotein.
Michel Fournier - One of the best experts on this subject based on the ideXlab platform.
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Pulmonary cystic Disorder related to light chain deposition disease.
American journal of respiratory and critical care medicine, 2006Co-Authors: Magali Colombat, Marc Stern, O. Groussard, Dominique Droz, Michel Brauner, Dominique Valeyre, Hervé Mal, Camille Taillé, Isabelle Monnet, Michel FournierAbstract:Light chain deposition disease (LCDD) is a rare Disorder that very uncommonly affects the lung. We report three cases of severe cystic pulmonary LCDD leading to lung transplantation. Such a presentation has never been previously reported. The three patients present with a progressive obstructive pulmonary pattern associated with numerous cysts diffusely distributed in both lungs. The disease was histologically characterized by non-amyloid amorphous deposits in the alveolar walls, the small airways and the vessels. It was associated with emphysematous-like changes and small airway dilation. Monotypic kappa light chain fixation was demonstrated on the abnormal deposits and along the basement membranes. Electron microscopy revealed coarsely granular electron-dense deposits in the same localizations. Mild extrapulmonary deposits were found in salivary glands in one patient. No Immunoproliferative Disorder was identified. We conclude that LCDD may primarily affect the lung, present as a pulmonary cystic Disorder, and lead to severe respiratory insufficiency.
Hervé Mal - One of the best experts on this subject based on the ideXlab platform.
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Light chain deposition disease involving the airways: diagnosis by fibreoptic bronchoscopy
The European respiratory journal, 2007Co-Authors: Magali Colombat, Hervé Mal, Valérie Gounant, P. Callard, Bernard MilleronAbstract:Light chain deposition disease (LCDD) infrequently affects the lungs and usually causes damage to the parenchyma, while bronchial involvement appears to be very rare. The present authors report the case of a 64-yr-old female with LCDD characterised by asymptomatic airway involvement. Ten months after excision of a poorly differentiated vaginal carcinoma, a routine chest computed tomography (CT) scan revealed two lung cysts, several bilateral nodules and diffuse bronchial thickening. Pulmonary function tests were normal. Fibreoptic bronchoscopy showed marked diffuse mucosal thickening with highly conspicuous vascular plexuses. Nonamyloidal deposits were found in the bronchial wall, but no definite diagnosis could be proposed. On follow-up, the patient was still asymptomatic and the CT scan and endoscopic appearance remained unchanged. The final diagnosis of κ LCDD was established 18 months later by another series of bronchial biopsies with frozen samples. Interestingly, electron microscopy showed dense granular deposits associated with nonamyloidal fibrils. An increased number of lung cysts were observed 32 months after identification of bronchial abnormalities, confirming the progressive nature of the disease. No extrapulmonary deposits or Immunoproliferative Disorder were found. In conclusion, light chain deposition disease, which may remain latent for several years, can entirely involve large airways and may be diagnosed by bronchial biopsy.
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Pulmonary cystic Disorder related to light chain deposition disease.
American journal of respiratory and critical care medicine, 2006Co-Authors: Magali Colombat, Marc Stern, O. Groussard, Dominique Droz, Michel Brauner, Dominique Valeyre, Hervé Mal, Camille Taillé, Isabelle Monnet, Michel FournierAbstract:Light chain deposition disease (LCDD) is a rare Disorder that very uncommonly affects the lung. We report three cases of severe cystic pulmonary LCDD leading to lung transplantation. Such a presentation has never been previously reported. The three patients present with a progressive obstructive pulmonary pattern associated with numerous cysts diffusely distributed in both lungs. The disease was histologically characterized by non-amyloid amorphous deposits in the alveolar walls, the small airways and the vessels. It was associated with emphysematous-like changes and small airway dilation. Monotypic kappa light chain fixation was demonstrated on the abnormal deposits and along the basement membranes. Electron microscopy revealed coarsely granular electron-dense deposits in the same localizations. Mild extrapulmonary deposits were found in salivary glands in one patient. No Immunoproliferative Disorder was identified. We conclude that LCDD may primarily affect the lung, present as a pulmonary cystic Disorder, and lead to severe respiratory insufficiency.
