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Diederick E Grobbee - One of the best experts on this subject based on the ideXlab platform.
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diabetes mellitus Impaired Glucose Tolerance and hyperinsulinemia in an elderly population the rotterdam study
American Journal of Epidemiology, 1997Co-Authors: Ronald P Stolk, H A P Pols, S W J Lamberts, P T V M De Jong, Albert Hofman, Diederick E GrobbeeAbstract:To estimate the prevalence of Glucose inTolerance in the elderly, oral Glucose Tolerance tests were performed as part of the Rotterdam Study, a population-based study in subjects aged 55 years and over, The study population consisted of 2,668 men and 3,950 women, Diabetes mellitus was defined as the use of antidiabetes medication, or a random or post-load serum Glucose level of greater than or equal to 11.1 mmol/liter, Impaired Glucose Tolerance was defined as a post-load serum Glucose between 7.8 and 11.1 mmol/liter. In men, the frequency of diabetes mellitus ranged from 5.9% in ages 85 years, and in women from 3.846 in ages 85 years; more than half of the subjects with diabetes were newly diagnosed. The prevalence of Impaired Glucose Tolerance ranged from 8.8% and 11.0% in men and women aged 85 years, The prevalence of diabetes mellitus in the total Rotterdam Study population of 7,439 elderly men and women was estimated to be 11.3% (95% confidence interval (Ci) 10.5-12.0), Waist/hip ratio, systolic blood pressure, hypertension, and number of cigarettes smoked increased with a worsening of the Glucose Tolerance from normal, hyperinsulinemia, Impaired Glucose Tolerance to diabetes in both men and women (p <0.01, adjusted for age). Body mass index was higher in subjects with Glucose inTolerance, but the frequency of obesity showed a relative decrease with worsening of Glucose Tolerance, These results show that Glucose inTolerance, especially Impaired Glucose Tolerance and undetected diabetes mellitus, is common in the elderly. Moreover, not only subjects with diabetes mellitus but also subjects with hyperinsulinemia and Impaired Glucose Tolerance have an increase of cardiovascular risk factors.
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Diabetes Mellitus, Impaired Glucose Tolerance, and Hyperinsulinemia in an Elderly Population The Rotterdam Study
American Journal of Epidemiology, 1997Co-Authors: Ronald P Stolk, H A P Pols, S W J Lamberts, P T V M De Jong, Albert Hofman, Diederick E GrobbeeAbstract:To estimate the prevalence of Glucose inTolerance in the elderly, oral Glucose Tolerance tests were performed as part of the Rotterdam Study, a population-based study in subjects aged 55 years and over, The study population consisted of 2,668 men and 3,950 women, Diabetes mellitus was defined as the use of antidiabetes medication, or a random or post-load serum Glucose level of greater than or equal to 11.1 mmol/liter, Impaired Glucose Tolerance was defined as a post-load serum Glucose between 7.8 and 11.1 mmol/liter. In men, the frequency of diabetes mellitus ranged from 5.9% in ages 85 years, and in women from 3.846 in ages 85 years; more than half of the subjects with diabetes were newly diagnosed. The prevalence of Impaired Glucose Tolerance ranged from 8.8% and 11.0% in men and women aged 85 years, The prevalence of diabetes mellitus in the total Rotterdam Study population of 7,439 elderly men and women was estimated to be 11.3% (95% confidence interval (Ci) 10.5-12.0), Waist/hip ratio, systolic blood pressure, hypertension, and number of cigarettes smoked increased with a worsening of the Glucose Tolerance from normal, hyperinsulinemia, Impaired Glucose Tolerance to diabetes in both men and women (p
Angelo Tremblay - One of the best experts on this subject based on the ideXlab platform.
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association of sleep duration with type 2 diabetes and Impaired Glucose Tolerance
Diabetologia, 2007Co-Authors: Jeanphilippe Chaput, J P Despres, Claude Bouchard, Angelo TremblayAbstract:Aims/hypothesis The aim of this study was to assess the relationship between sleep duration and type 2 diabetes or Impaired Glucose Tolerance (IGT).
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Contribution of visceral obesity to the deterioration of the metabolic risk profile in men with Impaired Glucose Tolerance.
Diabetologia, 2000Co-Authors: Agnès Pascot, Jean-pierre Després, Isabelle Lemieux, Jean Bergeron, André Nadeau, Denis Prud'homme, Angelo Tremblay, Simone LemieuxAbstract:Aims/hypothesis. Impaired Glucose Tolerance is associated with metabolic alterations which increase cardiovascular disease risk. The contribution of hyperglycaemia to this increased risk is, however, not clear. Abdominal obesity is often observed in subjects with Impaired Glucose Tolerance; our objective was therefore to find the contribution of visceral adipose tissue to the deterioration of the metabolic risk profile noted in subjects with Impaired Glucose Tolerance. Methods. We studied 284 men with a normal Glucose Tolerance and 66 men with Impaired Glucose Tolerance which was defined as a glycaemia between 7.8 and 11.1 mmol/l 2 h after a 75-g Glucose load. Results. Men with Impaired Glucose Tolerance had more visceral adipose tissue and higher concentrations of plasma Glucose and insulin in the fasting state and following a 75-g oral Glucose load than men with a normal Glucose Tolerance. They also had higher concentrations of plasma cholesterol, triglycerides, apolipoprotein B and lower concentrations of HDL-cholesterol as well as higher cholesterol:HDL-cholesterol ratios than men with a normal Glucose Tolerance. The two groups of men were then compared after a statistical adjustment for the amount of visceral adipose tissue. Although men with Impaired Glucose Tolerance still had higher fasting plasma Glucose and insulin concentrations after the adjustment for visceral adipose tissue, differences in all the variables of the lipid-lipoprotein profile were eliminated. Conclusion/interpretation. Visceral adipose tissue accumulation is an important factor in the deterioration of the plasma lipid-lipoprotein noted in men with Impaired Glucose Tolerance. [Diabetologia 2000 43: 1126–1135]
Theodore Mazzone - One of the best experts on this subject based on the ideXlab platform.
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Predictors of Stroke in Patients With Impaired Glucose Tolerance Results From the Nateglinide and Valsartan in Impaired Glucose Tolerance Outcomes Research Trial
Stroke, 2013Co-Authors: David Preiss, Steven M. Haffner, Thomas D. Giles, Laine Thomas, Rury R. Holman, Eberhard Standl, Theodore Mazzone, Guy E.h.m. Rutten, Gianni TognoniAbstract:Background and Purpose—Risk factors for stroke are well-established in general populations but sparsely studied in individuals with Impaired Glucose Tolerance. Methods—We identified predictors of stroke among participants with Impaired Glucose Tolerance in the Nateglinide and Valsartan in Impaired Glucose Tolerance Outcomes Research (NAVIGATOR) trial. Cox proportional-hazard regression models were constructed using baseline variables, including the 2 medications studied, valsartan and nateglinide. Results—Among 9306 participants, 237 experienced a stroke over 6.4 years. Predictors of stroke included classical risk factors such as existing cerebrovascular and coronary heart disease, higher pulse pressure, higher low-density lipoprotein cholesterol, older age, and atrial fibrillation. Other factors, including previous venous thromboembolism, higher waist circumference, lower estimated glomerular filtration rate, lower heart rate, and lower body mass index, provided additional important predictive informatio...
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predictors of incident heart failure hospitalizations among patients with Impaired Glucose Tolerance insight from the nateglinide and valsartan in Impaired Glucose Tolerance outcomes research study
Circulation-heart Failure, 2013Co-Authors: Y Wong, Steven M. Haffner, Laine Thomas, Eberhard Standl, Guy E.h.m. Rutten, John J V Mcmurray, Henry Krum, Adrian F Hernandez, Lawrence A Leiter, Theodore MazzoneAbstract:Background-Impaired Glucose Tolerance and metabolic syndrome are associated with increased risk of heart failure (HF). However, predictors associated with the increased risk of incident HF have not been well characterized. We aimed to identify independent predictors of incident HF hospitalization among patients with Impaired Glucose Tolerance.Methods and Results-In Nateglinide and Valsartan in Impaired Glucose Tolerance Outcomes Research (NAVIGATOR), 9306 research participants with Impaired Glucose Tolerance and >= 1 cardiovascular risk factors were randomized to valsartan versus placebo and nateglinide versus placebo in a 2x2 factorial manner, with a median follow-up of 6.5 years. Using a multivariable Cox proportional hazards model, we analyzed the relationships among baseline clinical factors and the outcome of incident HF hospitalization in patients without history of HF. Significant predictors were identified by forward selection. Increasing age, history of coronary heart disease, and atrial fibrillation or flutter were among several known independent predictors of incident HF hospitalization. Increased waist circumference (hazard ratio per 10 cm, 1.37; 95% confidence interval, 1.21-1.55; P<0.001) and increased urinary albumin-creatinine ratio (P<0.001) were identified as novel predictors. The predictive model for incident HF hospitalization showed good discrimination, with an optimism-corrected C-index of 0.79.Conclusions-Among research participants with Impaired Glucose Tolerance, there are several easily identifiable predictors of incident HF hospitalization, including traditional risk factors and novel indices of central adiposity and increased urinary albumin-creatinine ratio, which enable further risk stratification and help distinguish patients who could benefit from more aggressive risk factor management.
Kyung Mook Choi - One of the best experts on this subject based on the ideXlab platform.
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vascular inflammation in patients with Impaired Glucose Tolerance and type 2 diabetes analysis with 18f fluorodeoxyGlucose positron emission tomography
Circulation-cardiovascular Imaging, 2010Co-Authors: Tae Nyun Kim, Sungeun Kim, Sae Jeong Yang, Hye Jin Yoo, Ji A Seo, Sin Gon Kim, Nan Hee Kim, Sei Hyun Baik, Dong Seop Choi, Kyung Mook ChoiAbstract:Background-Type 2 diabetes mellitus (T2DM) is associated with an increased risk of atherosclerotic cardiovascular disease. Vascular inflammation is a key factor in both the pathogenesis and outcome of atherosclerosis. 18 F-fluorodeoxyGlucose (FDG) positron emission tomography (PET) is a promising tool for indentifying and quantifying vascular inflammation within atherosclerotic plaques. This study was designed to examine the vascular inflammation measured using FDG-PET in patients with Impaired Glucose Tolerance and T2DM, in comparison with age- and sex-matched control subjects with normal Glucose Tolerance. Methods and Results-We investigated vascular inflammation using FDG-PET in 90 age- and sex-matched subjects with different Glucose Tolerance (30 normal Glucose Tolerance subjects, 30 Impaired Glucose Tolerance subjects, and 30 T2DM subjects). Vascular 18F-FDG uptake was measured as both the mean and maximum blood-normalized standardized uptake value, known as the target-to-background ratio (TBR). Both mean and maximum TBR measurements were significantly different, based on Glucose Tolerance, although the carotid intima-media thickness measurements were not significantly different. The maximum TBR values in patients with Impaired Glucose Tolerance and T2DM were significantly increased compared with the normal subjects. In addition, subjects with metabolic syndrome had increased maximum TBR values compared with those without metabolic syndrome. Age-, sex-, and body mass index―adjusted maximum TBR levels were positively correlated with triglyceride, hemoglobin A1c, insulin resistance, high-sensitivity C-reactive protein, and Framingham risk score and were negatively correlated with high-density lipoprotein cholesterol and adiponectin levels. Conclusions-The results of the present study suggest that Impaired Glucose Tolerance and T2DM are associated with vascular inflammation in carotid atherosclerosis detected by FDG-PET.
Richard I G Holt - One of the best experts on this subject based on the ideXlab platform.
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prevalence of diabetes and Impaired Glucose Tolerance in patients with schizophrenia
British Journal of Psychiatry, 2004Co-Authors: Chris Bushe, Richard I G HoltAbstract:Declaration of interest: C.B. is an employee of Eli Lilly & Co; R.H. has received educational grants and fees for lecturing and consultancy work from Eli Lilly & Co. Background: A number of studies have examined the prevalence of diabetes mellitus and Impaired Glucose Tolerance in general populations and in those with schizophrenia and other forms of serious mental illness. Aims: To establish whether it is possible to describe accurately comparative rates of diabetes mellitus and Impaired Glucose Tolerance in populations of people with schizophrenia and those without mental illness. Method: Review of current literature. Results: Research published in the pre-neuroleptic era suggested that people with severe mental illness were at increased risk of developing glycaemic abnormalities. Recent studies appear to confirm that the prevalence of diabetes and Impaired Glucose Tolerance may be higher in people with schizophrenia than in the general population, and suggest that patients with schizophrenia have Impaired Glucose Tolerance even before they begin treatment. Conclusions: Schizophrenia may be a significant and independent risk factor for both diabetes and Impaired Glucose Tolerance. Current data preclude precise estimates of the prevalence of these conditions among people with schizophrenia.