The Experts below are selected from a list of 10341 Experts worldwide ranked by ideXlab platform
Alan A Wilson - One of the best experts on this subject based on the ideXlab platform.
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the d2 3 dopamine receptor in pathological gambling a positron emission tomography study with 11c propyl hexahydro naphtho oxazin and 11c raclopride
Addiction, 2013Co-Authors: Isabelle Boileau, Doris Payer, Bindiya Chugani, Daniela S S Lobo, A Behzadi, Pablo Rusjan, Sylvain Houle, Alan A WilsonAbstract:Aims Pathological gambling (PG) shares diagnostic features with substance use disorder (SUD), but the neurochemical mechanisms underlying PG are poorly understood. Because dopamine (DA), a neurotransmitter implicated in reward and reinforcement, is probably involved, we used positron emission tomography (PET) to test whether PG is associated with abnormalities in D2 and D3 receptor levels, as observed in SUD. Design Case–control study comparing PG to healthy control (HC) subjects. Setting Academic research imaging centre. Participants Thirteen non-treatment-seeking males meeting DSM-IV criteria for PG, and 12 matched HC (11 of whom completed PET). Measurements Two PET scans (one with the D3 receptor preferring agonist [11C]-(+)-propyl-hexahydro-naphtho-oxazin (PHNO) and the other with [11C]raclopride) to assess D2/3 DA receptor availability, and behavioural measures (self-report questionnaires and slot-machine game) to assess subjective effects and relationships to PET measures. Findings Binding of both radiotracers did not differ between groups in striatum or substantia nigra (SN) (all P > 0.1). Across PG, [11C]-(+)-PHNO binding in SN, where the signal is attributable primarily to D3 receptors, correlated with gambling severity (r = 0.57, P = 0.04) and Impulsiveness (r = 0.65, P = 0.03). In HC, [11C]raclopride binding in dorsal striatum correlated inversely with subjective effects of gambling (r = −0.70, P = 0.03) and Impulsiveness (r = −0.70, P = 0.03). Conclusions Unlike with substance use disorder, there appear to be no marked differences in D2/D3 levels between healthy subjects and pathological gamblers, suggesting that low receptor availability may not be a necessary feature of addiction. However, relationships between [11C]-(+)-PHNO binding and gambling severity/Impulsiveness suggests involvement of the D3 receptor in impulsive/compulsive behaviours.
Jogeshwar Mukherjee - One of the best experts on this subject based on the ideXlab platform.
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striatal dopamine d2 d3 receptor availability is reduced in methamphetamine dependence and is linked to impulsivity
The Journal of Neuroscience, 2009Co-Authors: Buyean Lee, Andrew V. Bokarius, Angelo Nacca, Magnus Dahlbom, Jeanette A Mumford, John Monterosso, Edythe D. London, Judah Farahi, Russell Alan Poldrack, Jogeshwar MukherjeeAbstract:While methamphetamine addiction has been associated with both impulsivity and striatal dopamine D 2 /D 3 receptor deficits, human studies have not directly linked the latter two entities. We therefore compared methamphetamine-dependent and healthy control subjects using the Barratt Impulsiveness Scale (version 11, BIS-11) and positron emission tomography with [ 18 F]fallypride to measure striatal dopamine D 2 /D 3 receptor availability. The methamphetamine-dependent subjects reported recent use of the drug 3.3 g per week, and a history of using methamphetamine, on average, for 12.5 years. They had higher scores than healthy control subjects on all BIS-11 Impulsiveness subscales ( p 2 /D 3 receptor availability in methamphetamine-dependent than in healthy control subjects ( p 2 /D 3 receptor availability in the caudate nucleus and nucleus accumbens that reached statistical significance in methamphetamine-dependent subjects. Combining data from both groups, voxelwise analysis indicated that Impulsiveness was related to D 2 /D 3 receptor availability in left caudate nucleus and right lateral putamen/claustrum ( p p 2 /D 3 receptor availability may mediate impulsive temperament and thereby influence addiction.
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striatal dopamine d2 d3 receptor availability is reduced in methamphetamine dependence and is linked to impulsivity
The Journal of Neuroscience, 2009Co-Authors: Buyean Lee, Andrew V. Bokarius, Angelo Nacca, Magnus Dahlbom, Jeanette A Mumford, John Monterosso, Edythe D. London, Judah Farahi, Russell Alan Poldrack, Jogeshwar MukherjeeAbstract:While methamphetamine addiction has been associated with both impulsivity and striatal dopamine D(2)/D(3) receptor deficits, human studies have not directly linked the latter two entities. We therefore compared methamphetamine-dependent and healthy control subjects using the Barratt Impulsiveness Scale (version 11, BIS-11) and positron emission tomography with [(18)F]fallypride to measure striatal dopamine D(2)/D(3) receptor availability. The methamphetamine-dependent subjects reported recent use of the drug 3.3 g per week, and a history of using methamphetamine, on average, for 12.5 years. They had higher scores than healthy control subjects on all BIS-11 Impulsiveness subscales (p < 0.001). Volume-of-interest analysis found lower striatal D(2)/D(3) receptor availability in methamphetamine-dependent than in healthy control subjects (p < 0.01) and a negative relationship between Impulsiveness and striatal D(2)/D(3) receptor availability in the caudate nucleus and nucleus accumbens that reached statistical significance in methamphetamine-dependent subjects. Combining data from both groups, voxelwise analysis indicated that Impulsiveness was related to D(2)/D(3) receptor availability in left caudate nucleus and right lateral putamen/claustrum (p < 0.05, determined by threshold-free cluster enhancement). In separate group analyses, correlations involving the head and body of the caudate and the putamen of methamphetamine-dependent subjects and the lateral putamen/claustrum of control subjects were observed at a weaker threshold (p < 0.12 corrected). The findings suggest that low striatal D(2)/D(3) receptor availability may mediate impulsive temperament and thereby influence addiction.
Suzanne Reeves - One of the best experts on this subject based on the ideXlab platform.
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limbic striatal dopamine d2 3 receptor availability is associated with non planning impulsivity in healthy adults after exclusion of potential dissimulators
Psychiatry Research-neuroimaging, 2012Co-Authors: Suzanne Reeves, Catherine Polling, Paul R A Stokes, Julia Lappin, Paul Shotbolt, Mitul A Mehta, Oliver D HowesAbstract:Positron emission tomography (PET) studies have reported an association between reduced striatal dopamine D2/3 receptor availability and higher scores on self-report measures of trait impulsivity in healthy adults. However, impulsivity is a multi-faceted construct, and it is unclear which aspect(s) of impulsivity might be driving these associations. The current study aimed to investigate the relationship between limbic (ventral) striatal D2/3 receptor availability and individual components of impulsivity (attentional, motor and non-planning) using the Barratt Impulsiveness Scale (BIS-11) and [(11)C]raclopride PET in 23 healthy volunteers. A partial correlational analysis showed a significant association between non-planning Impulsiveness (lack of forethought or 'futuring') and limbic D2/3 receptor availability, which was only apparent after the exclusion of potential dissimulators (indexed by high scores on impression management). Our findings suggest that non-planning Impulsiveness is associated with individual variation in limbic striatal D2/3 receptor availability and that different facets of impulsivity may have specific neurochemical correlates. Future studies that combine D2/3 receptor imaging with behavioral measures of impulsivity are required to further elucidate the precise relationship between individual components of trait impulsivity and brain dopaminergic function.
Buyean Lee - One of the best experts on this subject based on the ideXlab platform.
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striatal dopamine d2 d3 receptor availability is reduced in methamphetamine dependence and is linked to impulsivity
The Journal of Neuroscience, 2009Co-Authors: Buyean Lee, Andrew V. Bokarius, Angelo Nacca, Magnus Dahlbom, Jeanette A Mumford, John Monterosso, Edythe D. London, Judah Farahi, Russell Alan Poldrack, Jogeshwar MukherjeeAbstract:While methamphetamine addiction has been associated with both impulsivity and striatal dopamine D 2 /D 3 receptor deficits, human studies have not directly linked the latter two entities. We therefore compared methamphetamine-dependent and healthy control subjects using the Barratt Impulsiveness Scale (version 11, BIS-11) and positron emission tomography with [ 18 F]fallypride to measure striatal dopamine D 2 /D 3 receptor availability. The methamphetamine-dependent subjects reported recent use of the drug 3.3 g per week, and a history of using methamphetamine, on average, for 12.5 years. They had higher scores than healthy control subjects on all BIS-11 Impulsiveness subscales ( p 2 /D 3 receptor availability in methamphetamine-dependent than in healthy control subjects ( p 2 /D 3 receptor availability in the caudate nucleus and nucleus accumbens that reached statistical significance in methamphetamine-dependent subjects. Combining data from both groups, voxelwise analysis indicated that Impulsiveness was related to D 2 /D 3 receptor availability in left caudate nucleus and right lateral putamen/claustrum ( p p 2 /D 3 receptor availability may mediate impulsive temperament and thereby influence addiction.
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striatal dopamine d2 d3 receptor availability is reduced in methamphetamine dependence and is linked to impulsivity
The Journal of Neuroscience, 2009Co-Authors: Buyean Lee, Andrew V. Bokarius, Angelo Nacca, Magnus Dahlbom, Jeanette A Mumford, John Monterosso, Edythe D. London, Judah Farahi, Russell Alan Poldrack, Jogeshwar MukherjeeAbstract:While methamphetamine addiction has been associated with both impulsivity and striatal dopamine D(2)/D(3) receptor deficits, human studies have not directly linked the latter two entities. We therefore compared methamphetamine-dependent and healthy control subjects using the Barratt Impulsiveness Scale (version 11, BIS-11) and positron emission tomography with [(18)F]fallypride to measure striatal dopamine D(2)/D(3) receptor availability. The methamphetamine-dependent subjects reported recent use of the drug 3.3 g per week, and a history of using methamphetamine, on average, for 12.5 years. They had higher scores than healthy control subjects on all BIS-11 Impulsiveness subscales (p < 0.001). Volume-of-interest analysis found lower striatal D(2)/D(3) receptor availability in methamphetamine-dependent than in healthy control subjects (p < 0.01) and a negative relationship between Impulsiveness and striatal D(2)/D(3) receptor availability in the caudate nucleus and nucleus accumbens that reached statistical significance in methamphetamine-dependent subjects. Combining data from both groups, voxelwise analysis indicated that Impulsiveness was related to D(2)/D(3) receptor availability in left caudate nucleus and right lateral putamen/claustrum (p < 0.05, determined by threshold-free cluster enhancement). In separate group analyses, correlations involving the head and body of the caudate and the putamen of methamphetamine-dependent subjects and the lateral putamen/claustrum of control subjects were observed at a weaker threshold (p < 0.12 corrected). The findings suggest that low striatal D(2)/D(3) receptor availability may mediate impulsive temperament and thereby influence addiction.
Oliver D Howes - One of the best experts on this subject based on the ideXlab platform.
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limbic striatal dopamine d2 3 receptor availability is associated with non planning impulsivity in healthy adults after exclusion of potential dissimulators
Psychiatry Research-neuroimaging, 2012Co-Authors: Suzanne Reeves, Catherine Polling, Paul R A Stokes, Julia Lappin, Paul Shotbolt, Mitul A Mehta, Oliver D HowesAbstract:Positron emission tomography (PET) studies have reported an association between reduced striatal dopamine D2/3 receptor availability and higher scores on self-report measures of trait impulsivity in healthy adults. However, impulsivity is a multi-faceted construct, and it is unclear which aspect(s) of impulsivity might be driving these associations. The current study aimed to investigate the relationship between limbic (ventral) striatal D2/3 receptor availability and individual components of impulsivity (attentional, motor and non-planning) using the Barratt Impulsiveness Scale (BIS-11) and [(11)C]raclopride PET in 23 healthy volunteers. A partial correlational analysis showed a significant association between non-planning Impulsiveness (lack of forethought or 'futuring') and limbic D2/3 receptor availability, which was only apparent after the exclusion of potential dissimulators (indexed by high scores on impression management). Our findings suggest that non-planning Impulsiveness is associated with individual variation in limbic striatal D2/3 receptor availability and that different facets of impulsivity may have specific neurochemical correlates. Future studies that combine D2/3 receptor imaging with behavioral measures of impulsivity are required to further elucidate the precise relationship between individual components of trait impulsivity and brain dopaminergic function.
