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Ricardo Reyes-chilpa - One of the best experts on this subject based on the ideXlab platform.
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Strategies for the In Vitro Production of antiaddictive ibogan type alkaloids from Apocynaceae species
Plant Cell Tissue and Organ Culture (PCTOC), 2019Co-Authors: Felix Krengel, Josefina Herrera-santoyo, Teresa De Jesús Olivera-flores, Ricardo Reyes-chilpaAbstract:Monoterpenoid Indole alkaloids (MIAs) of the ibogan type, such as ibogaIne, have shown promisIng antiaddictive effects agaInst several drugs of abuse In humans and animal models of addiction. Unfortunately, International ibogaIne demand has led to the overexploitation of natural populations of the African species Tabernanthe iboga (Apocynaceae), the maIn source of this alkaloid. Therefore, it is necessary to identify alternative ibogan type alkaloid-contaInIng plant species, as well as to develop new sustaInable Production systems for said group of pharmaceutically important compounds. In this review, we focus on strategies for the In Vitro Production of the antiaddictive ibogan type MIAs coronaridIne, ibogamIne, voacangIne, and ibogaIne (collectively named “CIVI-complex”) from Apocynaceae species, with particular emphasis on the Tabernaemontana genus. SInce plant tissue culture (PTC)-related Information on the CIVI-complex is scarce, we also consider reports on the In Vitro Production of other ibogan type MIAs and where necessary, of compounds belongIng to the aspidospermatan, corynanthean, and plumeran type. This review aims at givIng an overview of potential strategies to produce antiaddictive ibogan type alkaloids from In Vitro cultures of Apocynaceae species.
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Strategies for the In Vitro Production of antiaddictive ibogan type alkaloids from Apocynaceae species
Plant Cell Tissue and Organ Culture, 2019Co-Authors: Felix Krengel, Teresa De Jesús Olivera-flores, Josefina Herrera-santoyo, Ricardo Reyes-chilpaAbstract:Monoterpenoid Indole alkaloids (MIAs) of the ibogan type, such as ibogaIne, have shown promisIng antiaddictive effects agaInst several drugs of abuse In humans and animal models of addiction. Unfortunately, International ibogaIne demand has led to the overexploitation of natural populations of the African species Tabernanthe iboga (Apocynaceae), the maIn source of this alkaloid. Therefore, it is necessary to identify alternative ibogan type alkaloid-contaInIng plant species, as well as to develop new sustaInable Production systems for said group of pharmaceutically important compounds. In this review, we focus on strategies for the In Vitro Production of the antiaddictive ibogan type MIAs coronaridIne, ibogamIne, voacangIne, and ibogaIne (collectively named “CIVI-complex”) from Apocynaceae species, with particular emphasis on the Tabernaemontana genus. SInce plant tissue culture (PTC)-related Information on the CIVI-complex is scarce, we also consider reports on the In Vitro Production of other ibogan type MIAs and where necessary, of compounds belongIng to the aspidospermatan, corynanthean, and plumeran type.
Felix Krengel - One of the best experts on this subject based on the ideXlab platform.
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Strategies for the In Vitro Production of antiaddictive ibogan type alkaloids from Apocynaceae species
Plant Cell Tissue and Organ Culture (PCTOC), 2019Co-Authors: Felix Krengel, Josefina Herrera-santoyo, Teresa De Jesús Olivera-flores, Ricardo Reyes-chilpaAbstract:Monoterpenoid Indole alkaloids (MIAs) of the ibogan type, such as ibogaIne, have shown promisIng antiaddictive effects agaInst several drugs of abuse In humans and animal models of addiction. Unfortunately, International ibogaIne demand has led to the overexploitation of natural populations of the African species Tabernanthe iboga (Apocynaceae), the maIn source of this alkaloid. Therefore, it is necessary to identify alternative ibogan type alkaloid-contaInIng plant species, as well as to develop new sustaInable Production systems for said group of pharmaceutically important compounds. In this review, we focus on strategies for the In Vitro Production of the antiaddictive ibogan type MIAs coronaridIne, ibogamIne, voacangIne, and ibogaIne (collectively named “CIVI-complex”) from Apocynaceae species, with particular emphasis on the Tabernaemontana genus. SInce plant tissue culture (PTC)-related Information on the CIVI-complex is scarce, we also consider reports on the In Vitro Production of other ibogan type MIAs and where necessary, of compounds belongIng to the aspidospermatan, corynanthean, and plumeran type. This review aims at givIng an overview of potential strategies to produce antiaddictive ibogan type alkaloids from In Vitro cultures of Apocynaceae species.
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Strategies for the In Vitro Production of antiaddictive ibogan type alkaloids from Apocynaceae species
Plant Cell Tissue and Organ Culture, 2019Co-Authors: Felix Krengel, Teresa De Jesús Olivera-flores, Josefina Herrera-santoyo, Ricardo Reyes-chilpaAbstract:Monoterpenoid Indole alkaloids (MIAs) of the ibogan type, such as ibogaIne, have shown promisIng antiaddictive effects agaInst several drugs of abuse In humans and animal models of addiction. Unfortunately, International ibogaIne demand has led to the overexploitation of natural populations of the African species Tabernanthe iboga (Apocynaceae), the maIn source of this alkaloid. Therefore, it is necessary to identify alternative ibogan type alkaloid-contaInIng plant species, as well as to develop new sustaInable Production systems for said group of pharmaceutically important compounds. In this review, we focus on strategies for the In Vitro Production of the antiaddictive ibogan type MIAs coronaridIne, ibogamIne, voacangIne, and ibogaIne (collectively named “CIVI-complex”) from Apocynaceae species, with particular emphasis on the Tabernaemontana genus. SInce plant tissue culture (PTC)-related Information on the CIVI-complex is scarce, we also consider reports on the In Vitro Production of other ibogan type MIAs and where necessary, of compounds belongIng to the aspidospermatan, corynanthean, and plumeran type.
Josefina Herrera-santoyo - One of the best experts on this subject based on the ideXlab platform.
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Strategies for the In Vitro Production of antiaddictive ibogan type alkaloids from Apocynaceae species
Plant Cell Tissue and Organ Culture (PCTOC), 2019Co-Authors: Felix Krengel, Josefina Herrera-santoyo, Teresa De Jesús Olivera-flores, Ricardo Reyes-chilpaAbstract:Monoterpenoid Indole alkaloids (MIAs) of the ibogan type, such as ibogaIne, have shown promisIng antiaddictive effects agaInst several drugs of abuse In humans and animal models of addiction. Unfortunately, International ibogaIne demand has led to the overexploitation of natural populations of the African species Tabernanthe iboga (Apocynaceae), the maIn source of this alkaloid. Therefore, it is necessary to identify alternative ibogan type alkaloid-contaInIng plant species, as well as to develop new sustaInable Production systems for said group of pharmaceutically important compounds. In this review, we focus on strategies for the In Vitro Production of the antiaddictive ibogan type MIAs coronaridIne, ibogamIne, voacangIne, and ibogaIne (collectively named “CIVI-complex”) from Apocynaceae species, with particular emphasis on the Tabernaemontana genus. SInce plant tissue culture (PTC)-related Information on the CIVI-complex is scarce, we also consider reports on the In Vitro Production of other ibogan type MIAs and where necessary, of compounds belongIng to the aspidospermatan, corynanthean, and plumeran type. This review aims at givIng an overview of potential strategies to produce antiaddictive ibogan type alkaloids from In Vitro cultures of Apocynaceae species.
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Strategies for the In Vitro Production of antiaddictive ibogan type alkaloids from Apocynaceae species
Plant Cell Tissue and Organ Culture, 2019Co-Authors: Felix Krengel, Teresa De Jesús Olivera-flores, Josefina Herrera-santoyo, Ricardo Reyes-chilpaAbstract:Monoterpenoid Indole alkaloids (MIAs) of the ibogan type, such as ibogaIne, have shown promisIng antiaddictive effects agaInst several drugs of abuse In humans and animal models of addiction. Unfortunately, International ibogaIne demand has led to the overexploitation of natural populations of the African species Tabernanthe iboga (Apocynaceae), the maIn source of this alkaloid. Therefore, it is necessary to identify alternative ibogan type alkaloid-contaInIng plant species, as well as to develop new sustaInable Production systems for said group of pharmaceutically important compounds. In this review, we focus on strategies for the In Vitro Production of the antiaddictive ibogan type MIAs coronaridIne, ibogamIne, voacangIne, and ibogaIne (collectively named “CIVI-complex”) from Apocynaceae species, with particular emphasis on the Tabernaemontana genus. SInce plant tissue culture (PTC)-related Information on the CIVI-complex is scarce, we also consider reports on the In Vitro Production of other ibogan type MIAs and where necessary, of compounds belongIng to the aspidospermatan, corynanthean, and plumeran type.
Teresa De Jesús Olivera-flores - One of the best experts on this subject based on the ideXlab platform.
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Strategies for the In Vitro Production of antiaddictive ibogan type alkaloids from Apocynaceae species
Plant Cell Tissue and Organ Culture (PCTOC), 2019Co-Authors: Felix Krengel, Josefina Herrera-santoyo, Teresa De Jesús Olivera-flores, Ricardo Reyes-chilpaAbstract:Monoterpenoid Indole alkaloids (MIAs) of the ibogan type, such as ibogaIne, have shown promisIng antiaddictive effects agaInst several drugs of abuse In humans and animal models of addiction. Unfortunately, International ibogaIne demand has led to the overexploitation of natural populations of the African species Tabernanthe iboga (Apocynaceae), the maIn source of this alkaloid. Therefore, it is necessary to identify alternative ibogan type alkaloid-contaInIng plant species, as well as to develop new sustaInable Production systems for said group of pharmaceutically important compounds. In this review, we focus on strategies for the In Vitro Production of the antiaddictive ibogan type MIAs coronaridIne, ibogamIne, voacangIne, and ibogaIne (collectively named “CIVI-complex”) from Apocynaceae species, with particular emphasis on the Tabernaemontana genus. SInce plant tissue culture (PTC)-related Information on the CIVI-complex is scarce, we also consider reports on the In Vitro Production of other ibogan type MIAs and where necessary, of compounds belongIng to the aspidospermatan, corynanthean, and plumeran type. This review aims at givIng an overview of potential strategies to produce antiaddictive ibogan type alkaloids from In Vitro cultures of Apocynaceae species.
Rakesh Kumar Shukla - One of the best experts on this subject based on the ideXlab platform.
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Recent advances In steroidal saponIns biosynthesis and In Vitro Production
Planta, 2018Co-Authors: Swati Upadhyay, Gajendra Singh Jeena, Rakesh Kumar ShuklaAbstract:MaIn conclusionSteroidal saponIns exhibited numerous pharmacological activities due to the modification of their backbone by different cytochrome P450s (P450) and UDP glycosyltransferases (UGTs). Plant-derived steroidal saponIns are not sufficient for utilizIng them for commercial purpose so In Vitro Production of saponIn by tissue culture, root culture, embryo culture, etc, is necessary for its large-scale Production. SaponIn glycosides are the important class of plant secondary metabolites, which consists of either steroidal or terpenoidal backbone. Due to the existence of a wide range of medicInal properties, saponIn glycosides are pharmacologically very important. This review is focused on important medicInal properties of steroidal saponIn, its occurrence, and biosynthesis. In addition to this, some recently identified plants contaInIng steroidal saponIns In different parts were summarized. The high throughput transcriptome sequencIng approach elaborates our understandIng related to the secondary metabolic pathway and its regulation even In the absence of adequate genomic Information of non-model plants. The aim of this review is to encapsulate the Information related to applications of steroidal saponIn and its biosynthetic enzymes specially P450s and UGTs that are Involved at later stage modifications of saponIn backbone. Lastly, we discussed the In Vitro Production of steroidal saponIn as the plant-based Production of saponIn is time-consumIng and yield a limited amount of saponIns. A large amount of plant material has been used to Increase the Production of steroidal saponIn by employIng In Vitro culture technique, which has received a lot of attention In past two decades and provides a way to conserve medicInal plants as well as to escape them for beIng endangered.
