The Experts below are selected from a list of 598230 Experts worldwide ranked by ideXlab platform
Uttam Kumar Mandal - One of the best experts on this subject based on the ideXlab platform.
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formulation and in Vitro Studies of a fixed dose combination of a bilayer matrix tablet containing metformin hcl as sustained release and glipizide as immediate release
Drug Development and Industrial Pharmacy, 2008Co-Authors: Uttam Kumar MandalAbstract:The emerging new fixed dose combination of metformin hydrocholride (HCl) as sustained release and glipizide as immediate release were formulated as a bilayer matrix tablet using hydroxy propyl methyl cellulose (HPMC) as the matrix-forming polymer, and the tablets were evaluated via in Vitro Studies. Three different grades of HPMC (HPMC K 4M, HPMC K 15M, and HPMC K 100M) were used. All tablet formulations yielded quality matrix preparations with satisfactory tableting properties. in Vitro release Studies were carried out at a phosphate buffer of pH 6.8 with 0.75% sodium lauryl sulphate w/v using the apparatus I (basket) as described in the . The release kinetics of metformin were evaluated using the regression coefficient analysis. There was no significant difference in drug release for different viscosity grade of HPMC with the same concentration. Tablet thus formulated provided sustained release of metformin HCl over a period of 8 hours and glipizide as immediate release.
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formulation and in Vitro Studies of a fixed dose combination of a bilayer matrix tablet containing metformin hcl as sustained release and glipizide as immediate release
Drug Development and Industrial Pharmacy, 2008Co-Authors: Uttam Kumar Mandal, Tapan Kumar PalAbstract:The emerging new fixed dose combination of metformin hydrocholride (HCl) as sustained release and glipizide as immediate release were formulated as a bilayer matrix tablet using hydroxy propyl methyl cellulose (HPMC) as the matrix-forming polymer, and the tablets were evaluated via in Vitro Studies. Three different grades of HPMC (HPMC K 4M, HPMC K 15M, and HPMC K 100M) were used. All tablet formulations yielded quality matrix preparations with satisfactory tableting properties. in Vitro release Studies were carried out at a phosphate buffer of pH 6.8 with 0.75% sodium lauryl sulphate w/v using the apparatus I (basket) as described in the United States Pharmacopeia (2000). The release kinetics of metformin were evaluated using the regression coefficient analysis. There was no significant difference in drug release for different viscosity grade of HPMC with the same concentration. Tablet thus formulated provided sustained release of metformin HCl over a period of 8 hours and glipizide as immediate release.
Tapan Kumar Pal - One of the best experts on this subject based on the ideXlab platform.
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formulation and in Vitro Studies of a fixed dose combination of a bilayer matrix tablet containing metformin hcl as sustained release and glipizide as immediate release
Drug Development and Industrial Pharmacy, 2008Co-Authors: Uttam Kumar Mandal, Tapan Kumar PalAbstract:The emerging new fixed dose combination of metformin hydrocholride (HCl) as sustained release and glipizide as immediate release were formulated as a bilayer matrix tablet using hydroxy propyl methyl cellulose (HPMC) as the matrix-forming polymer, and the tablets were evaluated via in Vitro Studies. Three different grades of HPMC (HPMC K 4M, HPMC K 15M, and HPMC K 100M) were used. All tablet formulations yielded quality matrix preparations with satisfactory tableting properties. in Vitro release Studies were carried out at a phosphate buffer of pH 6.8 with 0.75% sodium lauryl sulphate w/v using the apparatus I (basket) as described in the United States Pharmacopeia (2000). The release kinetics of metformin were evaluated using the regression coefficient analysis. There was no significant difference in drug release for different viscosity grade of HPMC with the same concentration. Tablet thus formulated provided sustained release of metformin HCl over a period of 8 hours and glipizide as immediate release.
Alicja Nowicka - One of the best experts on this subject based on the ideXlab platform.
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tooth discoloration induced by different calcium silicate based cements a systematic review of in Vitro Studies
Journal of Endodontics, 2017Co-Authors: Joanna Mozynska, Mariusz Lipski, Marcin Metlerski, Alicja NowickaAbstract:Abstract introduction On the basis of many clinical observations, some calcium silicate–based cements have a high potential for staining tooth tissue. This feature greatly limits the use of those cements, particularly for anterior teeth. This review aimed to provide a systematic evaluation of published in Vitro Studies to determine the effect of different calcium silicate–based cements on dental tissue discoloration. Methods This literature review was developed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement. The literature search was based on all publications without a year limit. The last search was performed on October 22, 2016. An electronic search was performed on MEDLinE (PubMed), Cochrane, and Scopus. The articles were selected to address the following research question: Which materials based on calcium silicate–based cements have hard tissue staining potential? The necessary information was extracted by 2 authors independently using a standardized form. Results The search resulted in 390 titles from all databases. Twenty-three Studies met the inclusion criteria. Most of the Studies exhibited a moderate risk of bias. The results indicated that some materials showed a strong potential for staining, including gray and white MTA Angelus (Londrina, PR, Brazil), gray and white ProRoot MTA (Dentsply, Tulsa, OK), and Ortho MTA (BioMTA, Seoul, Korea). individual study results showed that Biodentine (Septodont, Saint Maur des Fosses, France), Retro MTA (BioMTA), Portland cement, EndoSequence Root Repair Material (Brasseler USA, Savannah, GA), Odontocem (Australian Dental Manufacturing, Brisbane, Australia), MM-MTA (Micro Mega, Besancon Cedex, France), and MTA Ledermix (Riemser Pharma GmbH, Greiswald-insel Riems, Germany) were materials with the smallest staining potential. Conclusions This review clearly showed that some calcium silicate–based cements have a high potential for staining hard tissue. On the other hand, some showed only a small change in color, which was nearly invisible to the human eye (ΔE
Peter Cormie - One of the best experts on this subject based on the ideXlab platform.
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electric field effects on human spinal injury is there a basis in the in Vitro Studies
Developmental Neurobiology, 2008Co-Authors: Kenneth R Robinson, Peter CormieAbstract:An important basis for the clinical application of small DC electric current to mammalian spinal injury is the responses of neurons in culture to applied electric fields. Our recent finding that zebrafish neurons were unresponsive to applied fields prompted us to critically examine previous results. We conclude that compelling evidence for neuronal guidance and directional stimulation of growth toward either the cathode or anode in an electric field exists only for cultured Xenopus neurons, and not for any mammalian neurons. No basis for the reported success in treating spinal injury exists in the in Vitro Studies, and considerable research will be required if the conditions of field application in mammalian spinal injury are to be optimized.
Joanna Mozynska - One of the best experts on this subject based on the ideXlab platform.
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tooth discoloration induced by different calcium silicate based cements a systematic review of in Vitro Studies
Journal of Endodontics, 2017Co-Authors: Joanna Mozynska, Mariusz Lipski, Marcin Metlerski, Alicja NowickaAbstract:Abstract introduction On the basis of many clinical observations, some calcium silicate–based cements have a high potential for staining tooth tissue. This feature greatly limits the use of those cements, particularly for anterior teeth. This review aimed to provide a systematic evaluation of published in Vitro Studies to determine the effect of different calcium silicate–based cements on dental tissue discoloration. Methods This literature review was developed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement. The literature search was based on all publications without a year limit. The last search was performed on October 22, 2016. An electronic search was performed on MEDLinE (PubMed), Cochrane, and Scopus. The articles were selected to address the following research question: Which materials based on calcium silicate–based cements have hard tissue staining potential? The necessary information was extracted by 2 authors independently using a standardized form. Results The search resulted in 390 titles from all databases. Twenty-three Studies met the inclusion criteria. Most of the Studies exhibited a moderate risk of bias. The results indicated that some materials showed a strong potential for staining, including gray and white MTA Angelus (Londrina, PR, Brazil), gray and white ProRoot MTA (Dentsply, Tulsa, OK), and Ortho MTA (BioMTA, Seoul, Korea). individual study results showed that Biodentine (Septodont, Saint Maur des Fosses, France), Retro MTA (BioMTA), Portland cement, EndoSequence Root Repair Material (Brasseler USA, Savannah, GA), Odontocem (Australian Dental Manufacturing, Brisbane, Australia), MM-MTA (Micro Mega, Besancon Cedex, France), and MTA Ledermix (Riemser Pharma GmbH, Greiswald-insel Riems, Germany) were materials with the smallest staining potential. Conclusions This review clearly showed that some calcium silicate–based cements have a high potential for staining hard tissue. On the other hand, some showed only a small change in color, which was nearly invisible to the human eye (ΔE
