In Vivo Assay

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Maria Jose Villanuevasuarez - One of the best experts on this subject based on the ideXlab platform.

  • apple by product dietary fibre exhibits potential prebiotic and hypolipidemic effectsIn high fat fed wistar rats
    Bioactive Carbohydrates and Dietary Fibre, 2020
    Co-Authors: Inmaculada Mateosaparicio, Rocio De La Pena Armada, Maria Luisa Perezcozar, Pilar Ruperez, Araceli Redondocuenca, Maria Jose Villanuevasuarez
    Abstract:

    Abstract Apple by-product is an agro-food by-product maInly wasted or underutilized, which is IncreasIng because of the demands of consumers of apple juice or cider. This fruit residue is very rich In dietary fibre, and although the major component is the Insoluble dietary fraction (IDF), pectIns from soluble DF (SDF) comprised maInly by homogalacturonan and rhamnogalacturonan type I branched with arabInans, galactans and arabInogalactans are remarkable. These polysaccharides are used by Bifidobacterium bifidus In vitro, producIng an important amount of short chaIn fatty acids (SCFA), maInly acetate, as In the case of the In Vivo Assay with high fat diet-fed Wistar rats. Butyrate was Increased 3-fold In this In Vivo Assay IndicatIng that butyrate bacteria producers can use apple by-product. Thus, it showed a potential bifidogenic and butyrogenic effect that is pursued In the search of new prebiotics. Furthermore, apple by-product enriched diet Increased (p

Domenico Ribatti - One of the best experts on this subject based on the ideXlab platform.

  • the chick embryo chorioallantoic membrane as an In Vivo experimental model to study multiple myeloma
    The Enzymes, 2019
    Co-Authors: Domenico Ribatti, Roberto Tamma
    Abstract:

    Abstract The chick embryo chorioallantoic membrane (CAM) has long been used as an In Vivo Assay for the study of tumor angiogenesis because when tumor grafts are placed at day 6–10 days of Incubation the chick's immunocompetent system is not fully developed and the conditions for rejection have not been yet established. All studies for mammalian neoplasms, IncludIng multiple myeloma, have utilized tumor cell lInes, tumor bioptic specimens, cell suspensions derived from tumors, mouse tumor xenografts bioptic specimens. CAM can also be used to study the effects of anti-angiogenic molecules on tumor cell suspensions of tumor bioptic specimens. This review article summarizes and discussed our experience concernIng the use of the CAM to study multiple myeloma.

  • tryptase and chymase are angiogenic In Vivo In the chorioallantoic membrane Assay
    The International Journal of Developmental Biology, 2011
    Co-Authors: Domenico Ribatti, Beatrice Nico, Girolamo Ranieri, Vincenzo Benagiano, Enrico Crivellato
    Abstract:

    Human mast cells (MCs) are divided In two types dependIng on the expression of tryptase and chymase In their granules. Literature data Indicate that both tryptase and chymase are angiogenic, but there is currently no evidence of their direct angiogenic activity In Vivo. In this study, we have Investigated the capacity of tryptase and chymase to promote vasoproliferation In chick embryo chorioallantoic membrane (CAM), a well established In Vivo Assay to study angiogenesis and anti-angiogenesis. The results showed that both tryptase and chymase stimulate angiogenesis and that the response is similar to that obtaIned with vascular endothelial growth factor (VEGF), a well-known angiogenic cytokIne, and confirm the angiogenic activity of these two proteases stored In MC granules.

  • the chick embryo chorioallantoic membrane as an In Vivo Assay to study antiangiogenesis
    Pharmaceuticals, 2010
    Co-Authors: Domenico Ribatti
    Abstract:

    Antiangiogenesis, e.g., Inhibition of blood vessel growth, is beIng Investigated as a way to prevent the growth of tumors and other angiogenesis-dependent diseases. Pharmacological Inhibition Interferes with the angiogenic cascade or the immature neovasculature with synthetic or semi-synthetic substances, endogenous Inhibitors or biological antagonists. The chick embryo chorioallantoic membrane (CAM) is an extraembryonic membrane, which serves as a gas exchange surface and its function is supported by a dense capillary network. Because its extensive vascularization and easy accessibility, CAM has been used to study morphofunctional aspects of the angiogenesis process In Vivo and to study the efficacy and mechanism of action of pro- and anti-angiogenic molecules. The fields of application of CAM In the study of antiangiogenesis, IncludIng our personal experience, are illustrated In this review article.

  • the chick embryo chorioallantoic membrane In the study of tumor angiogenesis
    Romanian Journal of Morphology and Embryology, 2008
    Co-Authors: Domenico Ribatti
    Abstract:

    : The chick embryo chorioallantoic membrane (CAM) is commonly used as an experimental In Vivo Assay to study both angiogenesis and antiangiogenesis In response to tissues, cells or soluble factors. This article summarizes literature data about the use of the CAM In the study of tumor angiogenesis and particularly our experimental data concernIng the study of angiogenesis In multiple myeloma and In neuroblastoma.

Yazid Abdul Manap - One of the best experts on this subject based on the ideXlab platform.

  • ComparIng the calcium bioavailability from two types of nano-sized enriched milk usIng In-Vivo Assay
    Food chemistry, 2016
    Co-Authors: Arezoo Erfanian, Babak Rasti, Yazid Abdul Manap
    Abstract:

    Calcium bioavailability from two types of enriched (calcium citrate and calcium carbonate) milks homogenized to a nano-sized particle distribution has been studied among 48 female Sprauge-dawley rats. Skim milk powder was enriched with some essential nutrients (InulIn, DHA & EPA, vitamIns B6, K1, and D3) as enhancers of calcium bioavailability accordIng to recommended dietary allowances of the West European and North American. Ovariectomized and ovariectomized-osteoporosis rats were used as a menopause and menopause-osteoporosis model, respectively. Although, nano-sized enriched milk powders had the greatest calcium bioavailability among the groups, but bioavailability of nano-sized calcium carbonate-enriched-milk was significantly (P < 0.05) better than nano-sized calcium citrate-enriched-milk. Moreover, the trends were similar for bone calcium, strength and morphology. Therefore, based on the current results the calcium carbonate nano-sized enriched milk could be an effective enriched milk powder In ovariectomized-osteoporosis and ovariectomized rats as a model of menopause-osteoporosis and menopause women.

Inmaculada Mateosaparicio - One of the best experts on this subject based on the ideXlab platform.

  • apple by product dietary fibre exhibits potential prebiotic and hypolipidemic effectsIn high fat fed wistar rats
    Bioactive Carbohydrates and Dietary Fibre, 2020
    Co-Authors: Inmaculada Mateosaparicio, Rocio De La Pena Armada, Maria Luisa Perezcozar, Pilar Ruperez, Araceli Redondocuenca, Maria Jose Villanuevasuarez
    Abstract:

    Abstract Apple by-product is an agro-food by-product maInly wasted or underutilized, which is IncreasIng because of the demands of consumers of apple juice or cider. This fruit residue is very rich In dietary fibre, and although the major component is the Insoluble dietary fraction (IDF), pectIns from soluble DF (SDF) comprised maInly by homogalacturonan and rhamnogalacturonan type I branched with arabInans, galactans and arabInogalactans are remarkable. These polysaccharides are used by Bifidobacterium bifidus In vitro, producIng an important amount of short chaIn fatty acids (SCFA), maInly acetate, as In the case of the In Vivo Assay with high fat diet-fed Wistar rats. Butyrate was Increased 3-fold In this In Vivo Assay IndicatIng that butyrate bacteria producers can use apple by-product. Thus, it showed a potential bifidogenic and butyrogenic effect that is pursued In the search of new prebiotics. Furthermore, apple by-product enriched diet Increased (p

Rocio De La Pena Armada - One of the best experts on this subject based on the ideXlab platform.

  • apple by product dietary fibre exhibits potential prebiotic and hypolipidemic effectsIn high fat fed wistar rats
    Bioactive Carbohydrates and Dietary Fibre, 2020
    Co-Authors: Inmaculada Mateosaparicio, Rocio De La Pena Armada, Maria Luisa Perezcozar, Pilar Ruperez, Araceli Redondocuenca, Maria Jose Villanuevasuarez
    Abstract:

    Abstract Apple by-product is an agro-food by-product maInly wasted or underutilized, which is IncreasIng because of the demands of consumers of apple juice or cider. This fruit residue is very rich In dietary fibre, and although the major component is the Insoluble dietary fraction (IDF), pectIns from soluble DF (SDF) comprised maInly by homogalacturonan and rhamnogalacturonan type I branched with arabInans, galactans and arabInogalactans are remarkable. These polysaccharides are used by Bifidobacterium bifidus In vitro, producIng an important amount of short chaIn fatty acids (SCFA), maInly acetate, as In the case of the In Vivo Assay with high fat diet-fed Wistar rats. Butyrate was Increased 3-fold In this In Vivo Assay IndicatIng that butyrate bacteria producers can use apple by-product. Thus, it showed a potential bifidogenic and butyrogenic effect that is pursued In the search of new prebiotics. Furthermore, apple by-product enriched diet Increased (p

  • Apple by-product dietary fibre exhibits potential prebiotic and hypolipidemic effectsIn high-fat fed Wistar rats
    'Elsevier BV', 2020
    Co-Authors: Mateos-aparicio Inmaculada, Rocio De La Pena Armada, Pérez-cózar, María Luisa, Rupérez Antón Pilar, Redondo Cuenca Araceli, Villanueva Suárez M. José
    Abstract:

    Apple by-product is an agro-food by-product maInly wasted or underutilized, which is IncreasIng because of the demands of consumers of apple juice or cider. This fruit residue is very rich In dietary fibre, and although the major component is the Insoluble dietary fraction (IDF), pectIns from soluble DF (SDF) comprised maInly by homogalacturonan and rhamnogalacturonan type I branched with arabInans, galactans and arabInogalactans are remarkable. These polysaccharides are used by Bifidobacterium bifidus In vitro, producIng an important amount of short chaIn fatty acids (SCFA), maInly acetate, as In the case of the In Vivo Assay with high fat diet-fed Wistar rats. Butyrate was Increased 3-fold In this In Vivo Assay IndicatIng that butyrate bacteria producers can use apple by-product. Thus, it showed a potential bifidogenic and butyrogenic effect that is pursued In the search of new prebiotics. Furthermore, apple by-product enriched diet Increased (p < 0.05) HDL and dimInished (p < 0.05) trygliceridemia and hepatic total lipids presumably because of the bile acids bIndIng effect observed, highlightIng the potential hypolipidemic effect.This work was supported by Project AGL 2016-77056R from the Spanish Agencia Estatal de Investigación (AEI) (FEDER,UE).Peer reviewe

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